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Volumn 30, Issue 21, 2010, Pages 5057-5070

Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CORTACTIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN E; CYCLIN E1; RETINOBLASTOMA PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CDKN1B PROTEIN, HUMAN; CDKN1C PROTEIN, HUMAN; CTTN PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PRIMER DNA; RHOA PROTEIN, HUMAN; SIGNAL PEPTIDE;

EID: 77957832068     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00249-10     Document Type: Article
Times cited : (26)

References (57)
  • 1
    • 47149085982 scopus 로고    scopus 로고
    • P21 and p27: Roles in carcinogenesis and drug resistance
    • Abukhdeir, A. M., and B. H. Park. 2008. P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev. Mol. Med. 10:e19.
    • (2008) Expert Rev. Mol. Med. , vol.10
    • Abukhdeir, A.M.1    Park, B.H.2
  • 2
    • 0037040984 scopus 로고    scopus 로고
    • p21Cip1 promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    • Alt, J. R., A. B. Gladden, and J. A. Diehl. 2002. p21Cip1 promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export. J. Biol. Chem. 277:8517-8523.
    • (2002) J. Biol. Chem. , vol.277 , pp. 8517-8523
    • Alt, J.R.1    Gladden, A.B.2    Diehl, J.A.3
  • 4
    • 0033527066 scopus 로고    scopus 로고
    • An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation
    • Bowden, E. T., M. Barth, D. Thomas, R. I. Glazer, and S. C. Mueller. 1999. An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene 18:4440-4449.
    • (1999) Oncogene , vol.18 , pp. 4440-4449
    • Bowden, E.T.1    Barth, M.2    Thomas, D.3    Glazer, R.I.4    Mueller, S.C.5
  • 7
    • 0033176887 scopus 로고    scopus 로고
    • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • Carrano, A. C., E. Eytan, A. Hershko, and M. Pagano. 1999. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1:193-199.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 193-199
    • Carrano, A.C.1    Eytan, E.2    Hershko, A.3    Pagano, M.4
  • 8
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng, M., P. Olivier, J. A. Diehl, M. Fero, M. F. Roussel, J. M. Roberts, and C. J. Sherr. 1999. The p21(Cip1) and p27(Kip1) CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1571-1583.
    • (1999) EMBO J. , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 9
    • 59649084693 scopus 로고    scopus 로고
    • Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon
    • Clark, E. S., B. Brown, A. S. Whigham, A. Kochaishvili, W. G. Yarbrough, and A. M. Weaver. 2009. Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon. Oncogene 28:431-444.
    • (2009) Oncogene , vol.28 , pp. 431-444
    • Clark, E.S.1    Brown, B.2    Whigham, A.S.3    Kochaishvili, A.4    Yarbrough, W.G.5    Weaver, A.M.6
  • 10
    • 44149106941 scopus 로고    scopus 로고
    • A new role for cortactin in invadopodia: Regulation of protease secretion
    • Clark, E. S., and A. M. Weaver. 2008. A new role for cortactin in invadopodia: regulation of protease secretion. Eur. J. Cell Biol. 87:581-590.
    • (2008) Eur. J. Cell Biol. , vol.87 , pp. 581-590
    • Clark, E.S.1    Weaver, A.M.2
  • 11
    • 34249320529 scopus 로고    scopus 로고
    • Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia
    • Clark, E. S., A. S. Whigham, W. G. Yarbrough, and A. M. Weaver. 2007. Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. Cancer Res. 67:4227-4235.
    • (2007) Cancer Res. , vol.67 , pp. 4227-4235
    • Clark, E.S.1    Whigham, A.S.2    Yarbrough, W.G.3    Weaver, A.M.4
  • 13
    • 33745055712 scopus 로고    scopus 로고
    • The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27 Kip1 levels by distinct mechanisms
    • Croft, D. R., and M. F. Olson. 2006. The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol. Cell. Biol. 26:4612-4627.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 4612-4627
    • Croft, D.R.1    Olson, M.F.2
  • 14
    • 4344674527 scopus 로고    scopus 로고
    • Cortactin signalling and dynamic actin networks
    • Daly, R. J. 2004. Cortactin signalling and dynamic actin networks. Biochem. J. 382:13-25.
    • (2004) Biochem. J. , vol.382 , pp. 13-25
    • Daly, R.J.1
  • 15
    • 0036197606 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
    • Edlund, S., M. Landstrom, C. H. Heldin, and P. Aspenstrom. 2002. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol. Biol. Cell 13:902-914.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 902-914
    • Edlund, S.1    Landstrom, M.2    Heldin, C.H.3    Aspenstrom, P.4
  • 17
    • 35648943165 scopus 로고    scopus 로고
    • mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration
    • Gupton, S. L., K. Eisenmann, A. S. Alberts, and C. M. Waterman-Storer. 2007. mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration. J. Cell Sci. 120:3475-3487.
    • (2007) J. Cell Sci. , vol.120 , pp. 3475-3487
    • Gupton, S.L.1    Eisenmann, K.2    Alberts, A.S.3    Waterman-Storer, C.M.4
  • 18
    • 40349116256 scopus 로고    scopus 로고
    • Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: Comparison with epidermal growth factor receptor status
    • Hofman, P., C. Butori, K. Havet, V. Hofman, E. Selva, N. Guevara, J. Santini, and E. Van Obberghen-Schilling. 2008. Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status. Br. J. Cancer. 98:956-964.
    • (2008) Br. J. Cancer , vol.98 , pp. 956-964
    • Hofman, P.1    Butori, C.2    Havet, K.3    Hofman, V.4    Selva, E.5    Guevara, N.6    Santini, J.7    Van Obberghen-Schilling, E.8
  • 19
    • 0032476012 scopus 로고    scopus 로고
    • The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells
    • Huang, C., J. Liu, C. C. Haudenschild, and X. Zhan. 1998. The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J. Biol. Chem. 273:25770-25776.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25770-25776
    • Huang, C.1    Liu, J.2    Haudenschild, C.C.3    Zhan, X.4
  • 20
    • 0030724968 scopus 로고    scopus 로고
    • EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer
    • Hui, R., D. H. Campbell, C. S. Lee, K. McCaul, D. J. Horsfall, E. A. Musgrove, R. J. Daly, R. Seshadri, and R. L. Sutherland. 1997. EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer. Oncogene 15:1617-1623.
    • (1997) Oncogene , vol.15 , pp. 1617-1623
    • Hui, R.1    Campbell, D.H.2    Lee, C.S.3    McCaul, K.4    Horsfall, D.J.5    Musgrove, E.A.6    Daly, R.J.7    Seshadri, R.8    Sutherland, R.L.9
  • 23
    • 0027331855 scopus 로고
    • State of p53, Rb and DCC tumor suppressor genes in human oral cancer cell lines
    • Kim, M. S., S. L. Li, C. N. Bertolami, H. M. Cherrick, and N. H. Park. 1993. State of p53, Rb and DCC tumor suppressor genes in human oral cancer cell lines. Anticancer Res. 13:1405-1413.
    • (1993) Anticancer Res. , vol.13 , pp. 1405-1413
    • Kim, M.S.1    Li, S.L.2    Bertolami, C.N.3    Cherrick, H.M.4    Park, N.H.5
  • 27
    • 0036837872 scopus 로고    scopus 로고
    • Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21 Cip1/Waf1in phorbol 12-myristate-13-acetate-induced apoptotic cells
    • Lai, J. M., S. Wu, D. Y. Huang, and Z. F. Chang. 2002. Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21 Cip1/Waf1 in phorbol 12-myristate-13-acetate-induced apoptotic cells. Mol. Cell. Biol. 22:7581-7592.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7581-7592
    • Lai, J.M.1    Wu, S.2    Huang, D.Y.3    Chang, Z.F.4
  • 28
    • 70449522183 scopus 로고    scopus 로고
    • Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers
    • Liu, H. S., H. H. Lu, M. T. Lui, E. H. Yu, W. Shen, Y. P. Chen, K. W. Chang, and H. F. Tu. 2009. Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers. Oral Oncol. 45:1032-1036.
    • (2009) Oral Oncol. , vol.45 , pp. 1032-1036
    • Liu, H.S.1    Lu, H.H.2    Lui, M.T.3    Yu, E.H.4    Shen, W.5    Chen, Y.P.6    Chang, K.W.7    Tu, H.F.8
  • 29
    • 33749554505 scopus 로고    scopus 로고
    • CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis
    • Luo, C., H. Pan, M. Mines, K. Watson, J. Zhang, and G. H. Fan. 2006. CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis. J. Biol. Chem. 281:30081-30093.
    • (2006) J. Biol. Chem. , vol.281 , pp. 30081-30093
    • Luo, C.1    Pan, H.2    Mines, M.3    Watson, K.4    Zhang, J.5    Fan, G.H.6
  • 30
    • 33846225205 scopus 로고    scopus 로고
    • Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance
    • Luo, M. L., X. M. Shen, Y. Zhang, F. Wei, X. Xu, Y. Cai, X. Zhang, Y. T. Sun, Q. M. Zhan, M. Wu, and M. R. Wang. 2006. Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res. 66:11690-11699.
    • (2006) Cancer Res. , vol.66 , pp. 11690-11699
    • Luo, M.L.1    Shen, X.M.2    Zhang, Y.3    Wei, F.4    Xu, X.5    Cai, Y.6    Zhang, X.7    Sun, Y.T.8    Zhan, Q.M.9    Wu, M.10    Wang, M.R.11
  • 31
    • 2942707853 scopus 로고    scopus 로고
    • Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition
    • Mammoto, A., S. Huang, K. Moore, P. Oh, and D. E. Ingber. 2004. Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J. Biol. Chem. 279:26323-26330.
    • (2004) J. Biol. Chem. , vol.279 , pp. 26323-26330
    • Mammoto, A.1    Huang, S.2    Moore, K.3    Oh, P.4    Ingber, D.E.5
  • 32
    • 0035861565 scopus 로고    scopus 로고
    • Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27Kip1 association with cyclin E-Cdk2
    • Musgrove, E. A., L. J. Hunter, C. S. Lee, A. Swarbrick, R. Hui, and R. L. Sutherland. 2001. Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27Kip1 association with cyclin E-Cdk2. J. Biol. Chem. 276:47675-47683.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47675-47683
    • Musgrove, E.A.1    Hunter, L.J.2    Lee, C.S.3    Swarbrick, A.4    Hui, R.5    Sutherland, R.L.6
  • 33
    • 0032537819 scopus 로고    scopus 로고
    • Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
    • Olson, M. F., H. F. Paterson, and C. J. Marshall. 1998. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394:295-299.
    • (1998) Nature , vol.394 , pp. 295-299
    • Olson, M.F.1    Paterson, H.F.2    Marshall, C.J.3
  • 35
    • 0032566062 scopus 로고    scopus 로고
    • Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro
    • Patel, A. S., G. L. Schechter, W. J. Wasilenko, and K. D. Somers. 1998. Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro. Oncogene 16:3227-3232.
    • (1998) Oncogene , vol.16 , pp. 3227-3232
    • Patel, A.S.1    Schechter, G.L.2    Wasilenko, W.J.3    Somers, K.D.4
  • 37
    • 34249937178 scopus 로고    scopus 로고
    • The ATR pathway: Fine-tuning the fork
    • Amst.
    • Paulsen, R. D., and K. A. Cimprich. 2007. The ATR pathway: fine-tuning the fork. DNA Repair (Amst.) 6:953-966.
    • (2007) DNA Repair , vol.6 , pp. 953-966
    • Paulsen, R.D.1    Cimprich, K.A.2
  • 39
    • 0033870355 scopus 로고    scopus 로고
    • EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck
    • Rodrigo, J. P., L. A. Garcia, S. Ramos, P. S. Lazo, and C. Suarez. 2000. EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. Clin. Cancer Res. 6:3177-3182.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3177-3182
    • Rodrigo, J.P.1    Garcia, L.A.2    Ramos, S.3    Lazo, P.S.4    Suarez, C.5
  • 41
    • 0033545354 scopus 로고    scopus 로고
    • Transformation mediated by RhoA requires activity of ROCK kinases
    • Sahai, E., T. Ishizaki, S. Narumiya, and R. Treisman. 1999. Transformation mediated by RhoA requires activity of ROCK kinases. Curr. Biol. 9:136-145.
    • (1999) Curr. Biol. , vol.9 , pp. 136-145
    • Sahai, E.1    Ishizaki, T.2    Narumiya, S.3    Treisman, R.4
  • 42
    • 0035865137 scopus 로고    scopus 로고
    • Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
    • Sahai, E., M. F. Olson, and C. J. Marshall. 2001. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 20:755-766.
    • (2001) EMBO J. , vol.20 , pp. 755-766
    • Sahai, E.1    Olson, M.F.2    Marshall, C.J.3
  • 43
    • 0029043876 scopus 로고
    • The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes - A review
    • Schuuring, E. 1995. The involvement of the chromosome 11q13 region in human malignancies: cyclin D1 and EMS1 are two new candidate oncogenes - a review. Gene 159:83-96.
    • (1995) Gene , vol.159 , pp. 83-96
    • Schuuring, E.1
  • 44
    • 0242664602 scopus 로고    scopus 로고
    • Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1
    • Shang, X., Y. T. Zhou, and B. C. Low. 2003. Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. J. Biol. Chem. 278:45903-45914.
    • (2003) J. Biol. Chem. , vol.278 , pp. 45903-45914
    • Shang, X.1    Zhou, Y.T.2    Low, B.C.3
  • 46
    • 0034059206 scopus 로고    scopus 로고
    • Cooperation of p27Kip1and p18INK4cin progestin-mediated cell cycle arrest in T-47D breast cancer cells
    • Swarbrick, A., C. S. Lee, R. L. Sutherland, and E. A. Musgrove. 2000. Cooperation of p27Kip1 and p18INK4c in progestin-mediated cell cycle arrest in T-47D breast cancer cells. Mol. Cell. Biol. 20:2581-2591.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2581-2591
    • Swarbrick, A.1    Lee, C.S.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 48
    • 17144399942 scopus 로고    scopus 로고
    • Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor
    • Timpson, P., D. K. Lynch, D. Schramek, F. Walker, and R. J. Daly. 2005. Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor. Cancer Res. 65:3273-3280.
    • (2005) Cancer Res. , vol.65 , pp. 3273-3280
    • Timpson, P.1    Lynch, D.K.2    Schramek, D.3    Walker, F.4    Daly, R.J.5
  • 49
    • 35148821848 scopus 로고    scopus 로고
    • Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib
    • Timpson, P., A. S. Wilson, G. M. Lehrbach, R. L. Sutherland, E. A. Musgrove, and R. J. Daly. 2007. Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib. Cancer Res. 67:9304-9314.
    • (2007) Cancer Res. , vol.67 , pp. 9304-9314
    • Timpson, P.1    Wilson, A.S.2    Lehrbach, G.M.3    Sutherland, R.L.4    Musgrove, E.A.5    Daly, R.J.6
  • 50
    • 0033578073 scopus 로고    scopus 로고
    • p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
    • Tsvetkov, L. M., K. H. Yeh, S. J. Lee, H. Sun, and H. Zhang. 1999. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol. 9:661-664.
    • (1999) Curr. Biol. , vol.9 , pp. 661-664
    • Tsvetkov, L.M.1    Yeh, K.H.2    Lee, S.J.3    Sun, H.4    Zhang, H.5
  • 51
    • 0037114750 scopus 로고    scopus 로고
    • Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: Implication of the cortical-actin binding protein cortactin
    • DOI 10.1182/blood.V100.13.4462
    • Vidal, C., B. Geny, J. Melle, M. Jandrot-Perrus, and M. Fontenay-Roupie. 2002. Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the corticalactin binding protein cortactin. Blood 100:4462-4469. (Pubitemid 35429686)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4462-4469
    • Vidal, C.1    Geny, B.2    Melle, J.3    Jandrot-Perrus, M.4    Fontenay-Roupie, M.5
  • 52
    • 0017737265 scopus 로고
    • Hydroxyurea: Induction of breaks in template strands of replicating DNA
    • Walker, I. G., R. W. Yatscoff, and R. Sridhar. 1977. Hydroxyurea: induction of breaks in template strands of replicating DNA. Biochem. Biophys. Res. Commun. 77:403-408.
    • (1977) Biochem. Biophys. Res. Commun. , vol.77 , pp. 403-408
    • Walker, I.G.1    Yatscoff, R.W.2    Sridhar, R.3
  • 53
    • 44449137944 scopus 로고    scopus 로고
    • Centrosome separation driven by actin-microfilaments during mitosis is mediated by centrosome-associated tyrosine-phosphorylated cortactin
    • Wang, W., L. Chen, Y. Ding, J. Jin, and K. Liao. 2008. Centrosome separation driven by actin-microfilaments during mitosis is mediated by centrosome-associated tyrosine-phosphorylated cortactin. J. Cell Sci. 121:1334-1343.
    • (2008) J. Cell Sci. , vol.121 , pp. 1334-1343
    • Wang, W.1    Chen, L.2    Ding, Y.3    Jin, J.4    Liao, K.5
  • 54
    • 44149091903 scopus 로고    scopus 로고
    • Cortactin in tumor invasiveness
    • Weaver, A. M. 2008. Cortactin in tumor invasiveness. Cancer Lett. 265:157-166.
    • (2008) Cancer Lett. , vol.265 , pp. 157-166
    • Weaver, A.M.1
  • 55
    • 0031453368 scopus 로고    scopus 로고
    • Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
    • Weber, J. D., W. Hu, S. C. Jefcoat, Jr., D. M. Raben, and J. J. Baldassare. 1997. Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J. Biol. Chem. 272:32966-32971.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32966-32971
    • Weber, J.D.1    Hu, W.2    Jefcoat Jr., S.C.3    Raben, D.M.4    Baldassare, J.J.5
  • 56
    • 1642273620 scopus 로고    scopus 로고
    • Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation
    • Welsh, C. F. 2004. Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation. Breast Cancer Res. Treat 84:33-42.
    • (2004) Breast Cancer Res. Treat , vol.84 , pp. 33-42
    • Welsh, C.F.1


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