메뉴 건너뛰기




Volumn 127, Issue 1, 2010, Pages 21-31

Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: Effects on prognosis and cell invasion

Author keywords

Cell invasion; Ovarian cancer; Pak1; Pak2; Phosphorylation; Prognosis

Indexed keywords

CARBOPLATIN; P21 ACTIVATED KINASE 1; P21 ACTIVATED KINASE 2; PACLITAXEL; SERINE; THREONINE; VASCULOTROPIN; P21 ACTIVATED KINASE; PAK1 PROTEIN, HUMAN; PAK2 PROTEIN, HUMAN; PRIMER DNA;

EID: 77953465926     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25005     Document Type: Article
Times cited : (82)

References (46)
  • 2
    • 0043240182 scopus 로고    scopus 로고
    • Ovarian cancer: Strategies for overcoming resistance to chemotherapy
    • Agarwal R, Kaye SB. Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat Rev Cancer 2003;3:502-16.
    • (2003) Nat Rev Cancer , vol.3 , pp. 502-516
    • Agarwal, R.1    Kaye, S.B.2
  • 3
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science 1998;279:509-14.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 4
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem 2003;72:743-81.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 6
    • 16844382968 scopus 로고    scopus 로고
    • Signaling intricacies take center stage in cancer cells
    • Kumar R, Hung MC. Signaling intricacies take center stage in cancer cells. Cancer Res 2005;65:2511-15.
    • (2005) Cancer Res , vol.65 , pp. 2511-2515
    • Kumar, R.1    Hung, M.C.2
  • 7
    • 33745684525 scopus 로고    scopus 로고
    • Barnes CJ. p21-activated kinases in cancer
    • Kumar R, Gururaj AE, Barnes CJ. p21-activated kinases in cancer. Nat Rev Cancer 2006;6:459-71.
    • (2006) Nat Rev Cancer , vol.6 , pp. 459-471
    • Kumar, R.1    Gururaj, A.E.2
  • 8
    • 0041423391 scopus 로고    scopus 로고
    • Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
    • Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, Ruffalo T, King W, Wilber K, Mihatsch MJ, Moch H. Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol 2003;163:985-92.
    • (2003) Am J Pathol , vol.163 , pp. 985-992
    • Schraml, P.1    Schwerdtfeger, G.2    Burkhalter, F.3    Raggi, A.4    Schmidt, D.5    Ruffalo, T.6    King, W.7    Wilber, K.8    Mihatsch, M.J.9    Moch, H.10
  • 10
    • 33745776277 scopus 로고    scopus 로고
    • Analysis of gene amplification and prognostic markers in ovarian cancer using comparative genomic hybridization for microarrays and immunohistochemical analysis for tissue microarrays
    • Mayr D, Kanitz V, Anderegg B, Luthardt B, Engel J, Lohrs U, Amann G, Diebold J. Analysis of gene amplification and prognostic markers in ovarian cancer using comparative genomic hybridization for microarrays and immunohistochemical analysis for tissue microarrays. Am J Clin Pathol 2006;126:101-9.
    • (2006) Am J Clin Pathol , vol.126 , pp. 101-109
    • Mayr, D.1    Kanitz, V.2    Anderegg, B.3    Luthardt, B.4    Engel, J.5    Lohrs, U.6    Amann, G.7    Diebold, J.8
  • 11
    • 33646682385 scopus 로고    scopus 로고
    • PAK1 hyperactivation is sufficient for mammary gland tumor formation
    • Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 2006;25:2931-6.
    • (2006) Oncogene , vol.25 , pp. 2931-2936
    • Wang, R.A.1    Zhang, H.2    Balasenthil, S.3    Medina, D.4    Kumar, R.5
  • 13
    • 44949176114 scopus 로고    scopus 로고
    • Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms
    • Coniglio SJ, Zavarella S, Symons MH. Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol 2008;28:4162-72.
    • (2008) Mol Cell Biol , vol.28 , pp. 4162-4172
    • Coniglio, S.J.1    Zavarella, S.2    Symons, M.H.3
  • 14
    • 53149084888 scopus 로고    scopus 로고
    • Overexpression of NANOG in gestational trophoblastic diseases: Effect on apoptosis cell invasion, and clinical outcome
    • Siu MK, Wong ES, Chan HY, Ngan HY, Chan KY, Cheung AN. Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. Am J Pathol 2008;173:1165-72.
    • (2008) Am J Pathol , vol.173 , pp. 1165-1172
    • Siu, M.K.1    Wong, E.S.2    Chan, H.Y.3    Ngan, H.Y.4    Chan, K.Y.5    Cheung, A.N.6
  • 15
    • 2542451854 scopus 로고    scopus 로고
    • Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions
    • Stofega MR, Sanders LC, Gardiner EM, Bokoch GM. Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell 2004;15:2965-77.
    • (2004) Mol Biol Cell , vol.15 , pp. 2965-2977
    • Stofega, M.R.1    Sanders, L.C.2    Gardiner, E.M.3    Bokoch, G.M.4
  • 16
    • 58949099404 scopus 로고    scopus 로고
    • Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis - A differential expression and functional analysis
    • Chan QK, Ngan HY, Ip PP, Liu VW, Xue WC, Cheung AN. Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis - a differential expression and functional analysis. Carcinogenesis 2009;30:114-21.
    • (2009) Carcinogenesis , vol.30 , pp. 114-121
    • Chan, Q.K.1    Ngan, H.Y.2    Ip, P.P.3    Liu, V.W.4    Xue, W.C.5    Cheung, A.N.6
  • 17
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
    • Liao X, Siu MK, Au CW, Wong E, Chan HY, Ip P, Ngan HY, Cheung AN. Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009;30:131-40.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3    Wong, E.4    Chan, H.Y.5    Ip, P.6    Ngan, H.Y.7    Cheung, A.N.8
  • 20
    • 67349117959 scopus 로고    scopus 로고
    • Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
    • Au CW, Siu MK, Liao X, Wong ES, Ngan HY, Tam KF, Chan DC, Chan QK, Cheung AN. Tyrosine kinase B receptor and BDNF expression in ovarian cancers - effect on cell migration, angiogenesis and clinical outcome. Cancer Lett 2009;281:151-61.
    • (2009) Cancer Lett , vol.281 , pp. 151-161
    • Au, C.W.1    Siu, M.K.2    Liao, X.3    Wong, E.S.4    Ngan, H.Y.5    Tam, K.F.6    Chan, D.C.7    Chan, Q.K.8    Cheung, A.N.9
  • 22
    • 0035992369 scopus 로고    scopus 로고
    • CA125 response is associated with estrogen receptor expression in a phase II trial of letrozole in ovarian cancer: Identification of an endocrine-sensitive subgroup
    • Bowman A, Gabra H, Langdon SP, Lessells A, Stewart M, Young A, Smyth JF. CA125 response is associated with estrogen receptor expression in a phase II trial of letrozole in ovarian cancer: identification of an endocrine-sensitive subgroup. Clin Cancer Res 2002;8:2233-9.
    • (2002) Clin Cancer Res , vol.8 , pp. 2233-2239
    • Bowman, A.1    Gabra, H.2    Langdon, S.P.3    Lessells, A.4    Stewart, M.5    Young, A.6    Smyth, J.F.7
  • 27
    • 35548968519 scopus 로고    scopus 로고
    • Synergistic effects of epidermal growth factor and hepatocyte growth factor on human ovarian cancer cell invasion and migration: Role of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase
    • Zhou HY, Pon YL, Wong AS. Synergistic effects of epidermal growth factor and hepatocyte growth factor on human ovarian cancer cell invasion and migration: role of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase. Endocrinology 2007;148:5195-208.
    • (2007) Endocrinology , vol.148 , pp. 5195-5208
    • Zhou, H.Y.1    Pon, Y.L.2    Wong, A.S.3
  • 28
    • 31544438864 scopus 로고    scopus 로고
    • Vascular endothelial growth factorregulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases
    • Wang FQ, So J, Reierstad S, Fishman DA. Vascular endothelial growth factorregulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases. Int J Cancer 2006;118:879-88.
    • (2006) Int J Cancer , vol.118 , pp. 879-888
    • Wang, F.Q.1    So, J.2    Reierstad, S.3    Fishman, D.A.4
  • 29
    • 0028280052 scopus 로고
    • Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma
    • Moser TL, Young TN, Rodriguez GC, Pizzo SV, Bast RC, Jr., Stack MS. Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma. Int J Cancer 1994;56:552-9.
    • (1994) Int J Cancer , vol.56 , pp. 552-559
    • Moser, T.L.1    Young, T.N.2    Rodriguez, G.C.3    Pizzo, S.V.4    Bast Jr., R.C.5    Stack, M.S.6
  • 30
    • 0042588489 scopus 로고    scopus 로고
    • Characterization of gelatinases linked to extracellular matrix invasion in ovarian adenocarcinoma: Purification of matrix metalloproteinase 2
    • Young TN, Rodriguez GC, Rinehart AR, Bast RC, Jr, Pizzo SV, Stack MS. Characterization of gelatinases linked to extracellular matrix invasion in ovarian adenocarcinoma: purification of matrix metalloproteinase 2. Gynecol Oncol 1996;62:89-99.
    • (1996) Gynecol Oncol , vol.62 , pp. 89-99
    • Young, T.N.1    Rodriguez, G.C.2    Rinehart, A.R.3    Bast Jr., R.C.4    Pizzo, S.V.5    Stack, M.S.6
  • 31
    • 1542305671 scopus 로고    scopus 로고
    • Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells
    • Tanaka Y, Kobayashi H, Suzuki M, Kanayama N, Terao T. Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells. J Biol Chem 2004;279:8567-76.
    • (2004) J Biol Chem , vol.279 , pp. 8567-8576
    • Tanaka, Y.1    Kobayashi, H.2    Suzuki, M.3    Kanayama, N.4    Terao, T.5
  • 32
    • 0032865917 scopus 로고    scopus 로고
    • Hepatocyte growth factor (HGF) in ovarian epithelial tumour fluids stimulates the migration of ovarian carcinoma cells
    • Sowter HM, Corps AN, Smith SK. Hepatocyte growth factor (HGF) in ovarian epithelial tumour fluids stimulates the migration of ovarian carcinoma cells. Int J Cancer 1999;83:476-80.
    • (1999) Int J Cancer , vol.83 , pp. 476-480
    • Sowter, H.M.1    Corps, A.N.2    Smith, S.K.3
  • 33
  • 34
    • 0037454765 scopus 로고    scopus 로고
    • Quantitative analysis of follicle-stimulating hormone receptor in ovarian epithelial tumors: A novel approach to explain the field effect of ovarian cancer development in secondary mullerian systems
    • Wang J, Lin L, Parkash V, Schwartz PE, Lauchlan SC, Zheng W. Quantitative analysis of follicle-stimulating hormone receptor in ovarian epithelial tumors: a novel approach to explain the field effect of ovarian cancer development in secondary mullerian systems. Int J Cancer 2003;103:328-34.
    • (2003) Int J Cancer , vol.103 , pp. 328-334
    • Wang, J.1    Lin, L.2    Parkash, V.3    Schwartz, P.E.4    Lauchlan, S.C.5    Zheng, W.6
  • 35
    • 33745618981 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility
    • Yang CQ, Chan KY, Ngan HY, Khoo US, Chiu PM, Chan QK, Xue WC, Cheung AN. Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility. Carcinogenesis 2006;27:1502-6.
    • (2006) Carcinogenesis , vol.27 , pp. 1502-1506
    • Yang, C.Q.1    Chan, K.Y.2    Ngan, H.Y.3    Khoo, U.S.4    Chiu, P.M.5    Chan, Q.K.6    Xue, W.C.7    Cheung, A.N.8
  • 36
    • 53849096674 scopus 로고    scopus 로고
    • Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma
    • Davidson B, Shih IM, Wang TL. Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma. Hum Pathol 2008;39:1630-6.
    • (2008) Hum Pathol , vol.39 , pp. 1630-1636
    • Davidson, B.1    Shih, I.M.2    Wang, T.L.3
  • 37
    • 0037162288 scopus 로고    scopus 로고
    • Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis
    • Banerjee M, Worth D, Prowse DM, Nikolic M. Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis. Curr Biol 2002;12:1233-9.
    • (2002) Curr Biol , vol.12 , pp. 1233-1239
    • Banerjee, M.1    Worth, D.2    Prowse, D.M.3    Nikolic, M.4
  • 38
    • 12544256298 scopus 로고    scopus 로고
    • Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
    • Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM. Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. J Biol Chem 2005;280:2055-64.
    • (2005) J Biol Chem , vol.280 , pp. 2055-2064
    • Sundberg-Smith, L.J.1    Doherty, J.T.2    Mack, C.P.3    Taylor, J.M.4
  • 40
    • 34547734371 scopus 로고    scopus 로고
    • Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity
    • Rayala SK, Kumar R. Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity. Biomed Pharmacother 2007;61:408-11.
    • (2007) Biomed Pharmacother , vol.61 , pp. 408-411
    • Rayala, S.K.1    Kumar, R.2
  • 41
    • 24044525271 scopus 로고    scopus 로고
    • Nuclear localization and chromatin targets of p21-activated kinase 1
    • Singh RR, Song C, Yang Z, Kumar R. Nuclear localization and chromatin targets of p21-activated kinase 1. J Biol Chem 2005;280:18130-7.
    • (2005) J Biol Chem , vol.280 , pp. 18130-18137
    • Singh, R.R.1    Song, C.2    Yang, Z.3    Kumar, R.4
  • 42
    • 0242664130 scopus 로고    scopus 로고
    • Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration
    • Zhou GL, Zhuo Y, King CC, Fryer BH, Bokoch GM, Field J. Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol 2003;23:8058-69.
    • (2003) Mol Cell Biol , vol.23 , pp. 8058-8069
    • Zhou, G.L.1    Zhuo, Y.2    King, C.C.3    Fryer, B.H.4    Bokoch, G.M.5    Field, J.6
  • 43
    • 0030923795 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in early stage ovarian carcinoma
    • DOI 10.1002/(SICI)1097-0142(19970701)80:1<98::AID-CNCR13>3.0.CO;2-A
    • Paley PJ, Staskus KA, Gebhard K, Mohanraj D, Twiggs LB, Carson LF, Ramakrishnan S. Vascular endothelial growth factor expression in early stage ovarian carcinoma. Cancer 1997;80:98-106. (Pubitemid 27270925)
    • (1997) Cancer , vol.80 , Issue.1 , pp. 98-106
    • Paley, P.J.1    Staskus, K.A.2    Gebhard, K.3    Mohanraj, D.4    Twiggs, L.B.5    Carson, L.F.6    Ramakrishnan, S.7
  • 45
    • 41949100602 scopus 로고    scopus 로고
    • An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
    • Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol 2008;15:322-31.
    • (2008) Chem Biol , vol.15 , pp. 322-331
    • Deacon, S.W.1    Beeser, A.2    Fukui, J.A.3    Rennefahrt, U.E.4    Myers, C.5    Chernoff, J.6    Peterson, J.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.