Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays

British Journal of Cancer

Volumn 86, Issue 4, 2002, Pages 580-586

  Biéche, Ivan ^a,b   Olivi, M ^a   Nogues C ^c   Vidaud, M ^a   Lidereau, R ^b  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

^b INSERM   (France)

^c CENTRE RENÉ HUGUENIN   (France)

Author keywords

Breast cancer; CCND1 expression; Prognostic value; Quantitative RT PCR; Rear time PCR detection

Indexed keywords

ESTROGEN RECEPTOR; GENE PRODUCT; PROTEIN CCND1; RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST TUMOR; CANCER DIAGNOSIS; CANCER SURVIVAL; CELL CYCLE; CHROMOSOME 11Q; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; FEMALE; GENE AMPLIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE DIAGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CYCLIN D1; DNA PRIMERS; DNA, NEOPLASM; FEMALE; GENES, ERBB-2; GENES, MYC; HUMANS; MIDDLE AGED; PROGNOSIS; RECEPTORS, ESTROGEN; REFERENCE VALUES; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SURVIVAL RATE;

EID: 0037065939     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600109     Document Type: Article

References (44)

1. The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci
2. Cyclin D1 protein is overexpressed in hyperplasia and intraductal carcinoma of the breast
3. 17 beta-estradiol induces cyclin-D-1 gene transcription, p36(D1)-p34(cdk4) complex activation and p105(Rb) phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer
4. Antisense to cydin D1 inhibits the growth and tumorigenicity of human colon cancer cells
5. WAFI immunohistochemical expression
6. Cyclin D1 in breast cancer
7. Cyclin D1 protein expression and function in human breast cancer
8. Novel approach to quantitative polymerase chain reaction using real-time detection: Application to the detection of gene amplification in breast cancer
9. Quantitation of myc gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay
10. Real-time reverse transcription PCR assay for future management of ERBB2-based clinical applications
11. Loss of heterozygosity at 13q14 correlates with RB1 gene underexpression in human breast cancer
12. Association of INT2/HST1 complification in primary breast cancer with hormone-dependent phenotype and poor prognosis
13. P53, through p21 (WAF1-CIP1), induces cyclin-D1 synthesis
14. Single-step method of RNA isolation by acid guanidium thlocyanate-phenol-chloroform extraction
15. A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
16. Regression models and life-tables
17. A novel method for real time quantitative RT-PCR
18. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
19. Cyclin D1 and prognosis in human breast cancer
20. Int-2 amplification in breast cancer: Association with decreased survival and relationship to amplification of c-erbB-2 and c-myc
21. Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer
22. EMS1 gene expression in primary breast cancer: Relationship to cyclin D1 and oestrogen receptor expression and patient survival
23. Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism
24. Cyclin D1 and retinoblastoma gene expression in human breast carcinoma: Correlation with tumour proliferation and oestrogen receptor status
25. Nonparametric estimation from incomplete observations
26. Overexpression of Cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer
27. Determination of the prognostic value of cyclin D1 overexpression in breast cancer
28. P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
29. Cyclins and oncogenesis
30. Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression
31. Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle
32. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4
33. Deregulation of cydin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein
34. Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element
35. Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer
36. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation
37. CCND1 mRNA overexpression is highly related to estrogen receptor positively but not to proliferative markers in primary breast cancer
38. Cydin-dependent kinases as down-stream targets of oestrogen action: Potential prognostic indicators and therapeutic targets
39. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
40. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from nonmalignant lesions
41. Inductible over-expression of cyclin D1 in breast cancer cells reverses the growth-inhibitory effects of antiestrogenes
42. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells
43. CDK-independent activation of estrogen receptor by cyclin D1
44. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1