Concise review: Hematopoietic stem cell aging, life span, and transplantation

Stem Cells Translational Medicine

Volumn 1, Issue 9, 2012, Pages 651-657

  van Zant, Gary ^a   Liang, Ying ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Aging; Gene therapy; Hematopoietic stem cells; Stem cell transplantation

Indexed keywords

CD34 ANTIGEN; FLT3 LIGAND; PLEIOTROPHIN; PROSTAGLANDIN E2; PROTEIN KINASE LKB1; STEM CELL FACTOR; THROMBOPOIETIN; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL AGING; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; GENETIC VARIABILITY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC SYSTEM; HISTONE MODIFICATION; HUMAN; IMMUNE RESPONSE; MICROARRAY ANALYSIS; NONHUMAN; STEM CELL NICHE; TELOMERE; AGING; CELL DIFFERENTIATION; CELL LINEAGE; CYTOLOGY; PHYSIOLOGY; REVIEW;

AGING; CELL AGING; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; GENETIC VARIATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS;

EID: 84873029501     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2012-0033     Document Type: Article

References (88)

1. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003;425:968-973.
2. Berkahn L, Keating A. Hematopoiesis in the elderly. Hematology 2004;9:159-163.
3. Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: Is it ever too old to become young again? Nat Rev Immunol 2009;9:57-62.
4. Han S, Yang K, Ozen Z et al. Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. J Immunol 2003;170: 1267-1273.
5. Franceschi C, Capri M, Monti D et al. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007;128:92-105.
6. Mocchegiani E, Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell 2004;3:177-184.
7. Uyemura K, Castle SC, Makinodan T. The frail elderly: Role of dendritic cells in the susceptibility of infection. Mech Ageing Dev 2002; 123:955-962.
8. Pang WW, Price EA, Sahoo D et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA 2011;108:20012-20017.
9. Kuranda K, Vargaftig J, de la Rochere P et al. Age-related changes in human hematopoietic stem/progenitor cells. Aging Cell 2011;10: 542-546.
10. Notta F, Doulatov S, Laurenti E et al. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011;333:218-221.
11. Morrison SJ, Wandycz AM, Akashi K et al. The aging of hematopoietic stem cells. Nat Med 1996;2:1011-1016.
12. de Haan G, Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 1999;93:3294-3301.
13. Sudo K, Ema H, Morita Y et al. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 2000;192:1273-1280.
14. Geiger H, True JM, de Haan G et al. Ageand stage-specific regulation patterns in the hematopoietic stem cell hierarchy. Blood 2001;98:2966-2972.
15. Henckaerts E, Geiger H, Langer JC et al. Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokines. Blood 2002;99: 3947-3954.
16. Kim M, Moon HB, Spangrude GJ. Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann NY Acad Sci 2003; 996:195-208.
17. Dykstra B, Olthof S, Schreuder J et al. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med 2011;208:2691-2703.
18. Muller-Sieburg C, Sieburg HB. Stem cell aging: Survival of the laziest? Cell Cycle 2008;7: 3798-3804.
19. Beerman I, Bhattacharya D, Zandi S et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci USA 2010;107:5465-5470.
20. Cho RH, Sieburg HB, Muller-Sieburg CE. A new mechanism for the aging of hematopoietic stem cells: Aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 2008;111:5553-5561.
21. Morita Y, Ema H, Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med 2010;207:1173-1182.
22. World Health Organization. Definition of an older or elderly person. Available at http://www.who.int/healthinfo/survey/ageingdefnolder/en/index.html. Accessed August 3, 2012.
23. Cavazzana-Calvo M, Fischer A, Bushman FD et al. Is normal hematopoiesis maintained solely by long-term multipotent stem cells? Blood 2011;117:4420-4424.
24. Dykstra B, Kent D, Bowie M et al. Longterm propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 2007;1:218-229.
25. Nijnik A, Woodbine L, Marchetti C et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 2007;447:686-690.
26. Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010;464:520-528.
27. Yahata T, Takanashi T, Muguruma Y et al. Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 2011;118:2941-2950.
28. Mantel C, Messina-Graham S, Moh A et al. Mouse hematopoietic cell-targeted STAT3 deletion: Stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. Blood 2012 [Epub ahead of print].
29. Liang Y, Van Zant G, Szilvassy SJ. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 2005;106:1479-1487.
30. Xing Z, Ryan MA, Daria D et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 2006;108:2190-2197.
31. Chambers SM, Shaw CA, Gatza C et al. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 2007;5:e201.
32. Wagner W, Bork S, Horn P et al. Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One 2009;4:e5846.
33. Rossi DJ, Bryder D, Zahn JM et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005; 102:9194-9199.
34. Wang J, Sun Q, Morita Y et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell 2012;148:1001-1014.
35. Florian MC, Dorr K, Niebel A et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012;10: 520-530.
36. Rando TA, Chang HY. Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock. Cell 2012;148:46-57.
37. Fraga MF, Ballestar E, Paz MF et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005;102:10604-10609.
38. Trowbridge JJ, Snow JW, Kim J et al. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell 2009;5:442-449.
39. Tadokoro Y, Ema H, Okano M et al. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med 2007;204: 715-722.
40. Andäng M, Hjerling-Leffler J, Moliner A et al. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature 2008;451:460-464.
41. Creyghton MP, Markoulaki S, Levine SS et al. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell 2008;135:649-661.
42. Rogakou EP, Sekeri-Pataryas KE. Histone variants of H2A and H3 families are regulated during in vitro aging in the same manner as during differentiation. Exp Gerontol 1999;34: 741-754.
43. Ji H, Ehrlich LI, Seita J et al. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature 2010;467:338-342.
44. Wilson NK, Foster SD, Wang X et al. Combinatorial transcriptional control in blood stem/progenitor cells: Genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 2010;7:532-544.
45. Hodges E, Molaro A, Dos Santos CO et al. Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment. Mol Cell 2011;44:17-28.
46. Kunisaki Y, Frenette PS. The secrets of the bone marrow niche: Enigmatic niche brings challenge for HSC expansion. Nat Med 2012; 18:864-865.
47. Xie Y, Yin T, Wiegraebe W et al. Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 2009;457:97-101.
48. Sugiyama T, Kohara H, Noda M et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977-988.
49. Méndez-Ferrer S, Michurina TV, Ferraro F et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010;466:829-834.
50. Yamazaki S, Ema H, Karlsson G et al. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 2011;147:1146-1158.
51. Ding L, Saunders TL, Enikolopov G et al. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 2012;481: 457-462.
52. Stolzing A, Jones E, McGonagle D et al. Age-related changes in human bone marrowderived mesenchymal stem cells: Consequences for cell therapies. Mech Ageing Dev 2008;129:163-173.
53. Moerman EJ, Teng K, Lipschitz DA et al. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell 2004;3:379-389.
54. Yamazaki S, Iwama A, Takayanagi S et al. TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood 2009;113:1250-1256.
55. Ju Z, Jiang H, Jaworski M et al. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med 2007;13:742-747.
56. Giaimo S, d'Adda di Fagagna F. Is cellular senescence an example of antagonistic pleiotropy? Aging Cell 2012;11:378-383.
57. Rando TA. Stem cells, ageing and the quest for immortality. Nature 2006;441:1080-1086.
58. Garinis GA, van der Horst GT, Vijg J et al. DNA damage and ageing: New-age ideas for an age-old problem. Nat Cell Biol 2008;10:1241-1247.
59. Rera M, Bahadorani S, Cho J et al. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab 2011;14:623-634.
60. Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010;468:653-658.
61. Gurumurthy S, Xie SZ, Alagesan B et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 2010;468: 659-663.
62. Gan B, Hu J, Jiang S et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010;468: 701-704.
63. de Haan G, Gelman R, Watson A et al. A putative gene causes variability in lifespan among genotypically identical mice. Nat Genet 1998;19:114-116.
64. De Haan G, Van Zant G. Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span. FASEB J 1999;13:707-713.
65. Lang DH, Gerhard GS, Griffith JW et al. Quantitative trait loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice. Aging Clin Exp Res 2010;22:8-19.
66. Daley GQ, Scadden DT. Prospects for stem cell-based therapy. Cell 2008;132:544-548.
67. Artz AS. From biology to clinical practice: Aging and hematopoietic cell transplantation. Biol Blood Marrow Transplant 2012;18:S40-S45.
68. Kollman C, Howe CW, Anasetti C et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: The effect of donor age. Blood 2001;98:2043-2051.
69. Vaziri H, Dragowska W, Allsopp RC et al. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994;91:9857-9860.
70. Awaya N, Baerlocher GM, Manley TJ et al. Telomere shortening in hematopoietic stem cell transplantation: A potential mechanism for late graft failure? Biol Blood Marrow Transplant 2002;8:597-600.
71. Akiyama M, Hoshi Y, Sakurai S et al. Changes of telomere length in children after hematopoietic stem cell transplantation. Bone Marrow Transplant 1998;21:167-171.
72. Wagner JE, Gluckman E. Umbilical cord blood transplantation: The first 20 years. Semin Hematol 2010;47:3-12.
73. Delaney C, Heimfeld S, Brashem-Stein C et al. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010;16: 232-236.
74. Goessling W, Allen RS, Guan X et al. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell 2011;8:445-458.
75. Zhang CC, Kaba M, Iizuka S et al. Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood 2008;111:3415-3423.
76. Himburg HA, Muramoto GG, Daher P et al. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med 2010;16:475-482.
77. Zheng J, Umikawa M, Cui C et al. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature 2012;485:656-660.
78. Boitano AE, Wang J, Romeo R et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010;329:1345-1348.
79. Campbell TB, Hangoc G, Liu Y et al. Inhibition of CD26 in human cord blood CD34 cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice. Stem Cells Dev 2007;16:347-354.
80. Martin MA, Bhatia M. Analysis of the human fetal liver hematopoietic microenvironment. Stem Cells Dev 2005;14:493-504.
81. Parmar S, de Lima M, Deeg HJ et al. Hematopoietic stem cell transplantation for myelodysplastic syndrome: A review. Semin Oncol 2011;38:693-704.
82. Mineishi S. Overcoming the age barrier in hematopoietic stem cell transplantation: Progress, but still a long way to go. JAMA 2011; 306:1918-1920.
83. Adams GB, Martin RP, Alley IR et al. Therapeutic targeting of a stem cell niche. Nat Biotechnol 2007;25:238-243.
84. Conboy IM, Conboy MJ, Wagers AJ et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005;433:760-764.
85. Song Z, Zhang J, Ju Z et al. Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function. Aging Cell 2012;11: 449-455.
86. Wagers AJ. The stem cell niche in regenerative medicine. Cell Stem Cell 2012;10:362-369.
87. Christopherson KW 2nd, Hangoc G, Mantel CR et al. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004;305:1000-1003.
88. Doulatov S, Notta F, Laurenti E et al. Hematopoiesis: A human perspective. Cell Stem Cell 2012;10:120-136.