Telomere shortening in hemotopoietic stem cell transplantation: A potential mechanism for late graft failure?

Biology of Blood and Marrow Transplantation

Volumn 8, Issue 11, 2002, Pages 597-600

  Awaya, Norihiro ^a   Baerlocher, Gabriela M ^b   Manley, Thomas J ^a   Sanders, Jean E ^a   Mielcarek, Marco ^a   Torok Storb, Beverly ^a   Landsorp, Peter M ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Stem cells; Telomerase; Telomere length; Transplantation

Indexed keywords

CYCLOPHOSPHAMIDE; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; METHOTREXATE;

ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; APLASTIC ANEMIA; CASE REPORT; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL MATURATION; CELL PROLIFERATION; CELL TYPE; CHROMOSOME DOUBLING; CHROMOSOME SIZE; CHROMOSOME STRUCTURE; CONTROLLED STUDY; FIBROBLAST; GRAFT FAILURE; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HYPERSPLENISM; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LIFESPAN; MALE; PANCYTOPENIA; REVIEW; SCHOOL CHILD; SOMATIC CELL; TELOMERE; WHOLE BODY RADIATION; ADOLESCENT; CELL AGING; CHILD; GRAFT REJECTION; HISTOCOMPATIBILITY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; ULTRASTRUCTURE;

ADOLESCENT; CELL AGING; CHILD; GRAFT REJECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; TELOMERE; TRANSPLANTATION CHIMERA;

EID: 0036452397     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: 10.1053/bbmt.2002.v8.abbmt080597     Document Type: Article

References (33)

1. Greider CW, Blackburn EH. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell. 1987;51:887-898.
2. de Lange T, Shiue L, Myers RM, et al. Structure and variability of human chromosome ends. Mol Cell Biol. 1990;10:518-527.
3. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 1990;346:866-868.
4. Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ. In vivo loss of telomeric repeats with age in humans. Mutat Res. 1991;256:45-48.
5. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349-352.
6. Yang J, Chang E, Cherry AM, et al. Human endothelial cell life extension by telomerase expression. J Biol Chem. 1999;274:26141-26148.
7. Ramirez RD, Morales CP, Herbert BS, et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 2001;15:398-403.
8. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer [see comments]. Science. 1994;266:2011-2015.
9. Boklan J, Nanjangud G, MacKenzie KL, May C, Sadelain M, Moore MA. Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts. Cancer Res. 2002;62:2104-2114.
10. Kim H, Farris J, Christman SA, et al. Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase. Biochem J. 2002;365:765-772.
11. Notaro R, Cimmino A, Tabarini D, Rotoli B, Luzzatto L. In vivo telomere dynamics of human hematopoietic stem cells. Proc Natl Acad Sci U S A. 1997;94:13782-13785.
12. Akiyama M, Hoshi Y, Sakurai S, Yamada H, Yamada O, Mizoguchi H. Changes of telomere length in children after hematopoietic stem cell transplantation. Bone Marrow Transplant. 1998; 21:167-171.
13. Wynn RF, Cross MA, Hatton C, et al. Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants. Lancet. 1998;351:178-181.
14. Lee JJ, Kook H, Chung IJ, et al. Telomere length changes in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant. 1999;24:411-415.
15. Mathioudakis G, Storb R, McSweeney PA, et al. Polyclonal hematopoiesis with variable telomere shortening in human long-term allogeneic marrow graft recipients [brief report]. Blood. 2000;96:3991-3994.
16. Thornley I, Sutherland R, Wynn R, et al. Early hematopoietic reconstitution after clinical stem cell transplantation: evidence for stochastic stem cell behavior and limited acceleration in telomere loss. Blood. 2002;99:2387-2396.
17. Wynn R, Thornley I, Freedman M, Saunders EF. Telomere shortening in leucocyte subsets of long-term survivors of allogeneic bone marrow transplantation. Br J Haematol. 1999;105:997-1001.
18. Vulliamy T, Marrone A, Goldman F, et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita [see comments]. Nature. 2001;413:432-435.
19. Rufer N, Dragowska W, Thornbury G, Roosnek E, Lansdorp PM. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol. 1998;16:743-747.
20. Rufer N, Brümmendorf TH, Kolvraa S, et al. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med. 1999;190:157-167.
21. Baerlocher GM, Mak J, Tien T, Lansdorp PM. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry. 2002;47:89-99.
22. Vaziri H, Schachter F, Uchida I, et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet. 1993;52:661-667.
23. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups [see comments]. Am J Hum Genet. 1994;55:876-882.
24. Frenck RW Jr, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A. 1998;95:5607-5610.
25. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27:339-344.
26. Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science. 2002;295: 2446-2449.
27. Collins K, Mitchell JR. Telomerase in the human organism [review]. Oncogene. 2002;21:564-579.
28. Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [see comments]. Cell. 1997;91:25-34.
29. Kim SS, Kaminker P, Campisi J. Telomeres, aging and cancer: in search of a happy ending [review]. Oncogene. 2002;21:503-511.
30. Ball SE, Gibson FM, Rizzo S, Tooze JA, Marsh JC, Gordon-Smith EC. Progressive telomere shortening in aplastic anemia. Blood. 1998;91:3582-3592.
31. Leteurtre F, Li X, Guardiola P, et al. Accelerated telomere shortening and telomerase activation in Fanconi's anaemia. Br J Haematol. 1999;105:883-893.
32. Brummendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood. 2001;97:895-900.
33. Lee JJ, Kook H, Chung IJ, et al. Telomere length changes in patients with aplastic anaemia. Br J Haematol. 2001;112:1025-1030.