Quantitative Trait Loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice

Aging Clinical and Experimental Research

Volumn 22, Issue 1, 2010, Pages 8-19

  Lang, Dean H ^a   Gerhard, Glenn S ^b,c   Griffith, James W ^b   Vogler, George P ^a   Vandenbergh, David J ^a   Blizard, David A ^a   Stout, Joseph T ^a   Lakoski, Joan M ^d   McClearn, Gerald E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c WEIS CENTER FOR RESEARCH   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Aging; Composite interval mapping; Genetics; QTL

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 16; CHROMOSOME 2; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME DELETION X; CONTROLLED STUDY; DEATH; FEMALE; FERRANS AND POWERS QUALITY OF LIFE INDEX; GENDER IDENTITY; GENE LOCUS; GENETIC ASSOCIATION; LIFESPAN; LONGEVITY; MALE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT LOCUS;

ANIMALIA; MUS;

EID: 77951927560     PISSN: 15940667     EISSN: 17208319     Source Type: Journal    
DOI: 10.1007/BF03324809     Document Type: Article

References (45)

1. Robertson A. The nature of quantitative genetic variation. In Brink RA, ed. Heritage from Mendel. Madison: The University of Wisconsin Press, 1967: 265-280
2. Dewhirst FE, Chien CC, Paster BJ et al. Phytogeny of the defined murine microbiota: altered Schaedler flora. Appl Environ Microbiol 1999; 65: 3287-3292
3. Williams RW, Gu J, Qi S, Lu L. The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. Genome Biology 2001; 2: research 0046.1-0046.18.
4. Wang S, Basten CJ, Zeng ZB. Windows QTL Cartographer 2.0. Department of Statistics, North Carolina State University, Raleigh, NC (2001-2004) (http://statgen.ncsu.edu/qtlcart/WQTLCart.htm) Release Date 2-20-103
5. Zeng ZB. Precision Mapping of Quantitative Trait Loci. Genetics 1994; 136: 1457-1468 (Pubitemid 24097872)
6. Broman KW. Review of statistical methods for QTL mapping in experimental crosses. Lab Animal 2001; 30: 44-52. (Pubitemid 33303397)
7. Lander ES, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247
8. Gelman R, Watson A, Bronson R, Yunis E. Murine chromosomal regions correlated with longevity. Genetics 1988; 118: 693-704.
9. de Haan G, Gelman R, Watson A, Yunis E, Van Zant G. A putative gene causes variability in lifespan among genotypically identical mice. Nat Genet 1998; 19: 114-116
10. JAX® Mice Database, htt://jaxmice.jax.org/strain/000040.html (9/26/2007).
11. Miller RA, Chrisp C, Jackson AU, Burke D. Marker loci associated with life span in genetically heterogeneous mice. J Gerontol Med Sci 1998; 53A: M257-63. (Pubitemid 28354742)
12. Mooijaart SP, van Heemst D, Schreuder J et al. Variation in the SHC1 gene and longevity in humans. Exp Gerontol 2004; 39: 263-268 (Pubitemid 38169419)
13. de Haan G, Van Zant G. Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span. FASEB J 1999; 13: 707-713 (Pubitemid 29156402)
14. Jackson AU, Galecki AT, Burke DT, Miller RA. Mouse loci associated with life span exhibit sex-specific and epistatic effects. J Gerontol Series A Biol Sci Med Sci 2002; 57: B9-15.
15. Vieira C, Pasyukova EG, Zeng ZB et al. Genotype-Environment Interaction for Quantitative Trait Loci Affecting Life Span in Drosophila Melanogaster. Genetics 2000; 154: 213-227 (Pubitemid 30045914)
16. Klebanov S, Astle CM, Roderick TH et al. Maximum life spans in mice are extended by wild strain alleles. Exp Biol Med 2001; 226: 854-859 (Pubitemid 34053236)
17. Niedernhofer LJ, Garinis GA, Raams A et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006; 444: 1038-1043 (Pubitemid 46018517)
18. Weeda G, Donker I, de Wit J et al. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol 1997; 7: 427-439 (Pubitemid 27274796)
19. De Luca M, Roshina NV, Geiger-Thomsberry GL et al. Dopa decarboxylase (Ddc) affects variation in Drosophila longevity. Nat Genet 2003; 34: 429-433 (Pubitemid 36935336)
20. Hsu HC, Mountz JD, Williams RW et al. Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11. Mech Ageing Dev 2002; 123: 1145-1158
21. Tripodis N, Hart AA, Finjneman RJ, Demant P. Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst 2001; 93: 1484-1491 (Pubitemid 32982678)
22. Reed T, Dick DM, Uniacke SK, Foroud T, Nichols WC. Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging. J Gerontol Series A Biol Sci Med Sci 2004; 59: 227-232 (Pubitemid 38375335)
23. Wang Y, Nose M, Kamoto T, Nishimura M, Hiai H. Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol 1997; 6: 1791-1798 (Pubitemid 27527942)
24. Maddatu TP, Garvey SM, Schroeder DG et al. Dilated cardiomyopathy in the nmd mouse: transgenic rescue and QTLs that improve cardiac function and survival. Hum Mol Genet 2005; 21: 3179-3189
25. Lipman R, Galecki A, Burke DT, Miller RA. Genetic loci that influence cause of death in a heterogeneous mouse stock. J Gerontol Series A Biol Sci Med Sci 2004; 59: 977-983 (Pubitemid 39441786)
26. Henchaerts E, Langer JC, Snoeck HW. Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in life span are closely linked at multiple loci in BXD recombinant inbred mice. Blood 2004; 104: 374-379
27. Van Zant G. Genetic control of stem cells: implications for aging. Int J Hematol 2003; 77: 29-36. (Pubitemid 37127583)
28. de Haan G, Bystrykh LV, Weersing E et al. A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover. Blood 2002; 100: 2056-2062 (Pubitemid 35001237)
29. Johannes F, Blizard DA, Lionikas A et al. QTL influencing base-line hematocrit in the C57BL/6J and DBA/2J lineage: age-related effects. Mammalian Genome 2006; 17: 689-699 (Pubitemid 43911486)
30. Chen J, Astle CM, Harrison DE. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp Hematol 2003; 31: 1097-1103 (Pubitemid 37329754)
31. Koizumi A, Weindruch R, Walford RL. Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr 1987; 117: 361-367 (Pubitemid 17047085)
32. Minotti G, Aust SD. Redox cycling of iron and lipid peroxidation. Lipids 1992; 27: 219-226
33. Gerhard GS, Kaufmann EJ, Wang X et al. Genetic differences in hepatic lipid peroxidation potential and iron levels in mice. Mech Ageing Dev 2002; 123: 167-176 (Pubitemid 33097563)
34. Doria G, Biozzi G, Mouton D, Covelli V. Genetic control of immune responsiveness, aging and tumor incidence. Mech Ageing Dev 1997; 96: 1-13. (Pubitemid 27279813)
35. Puel A, Groot PC, Lathrop MG, Demant P, Mouton D. Mapping of genes controlling quantitative antibody production in Biozzi mice. J Immunol 1995; 154: 5799-5805
36. Walford RL, Bergmann K. Influences of genes associated with the main histocompatibility complex on the deoxyribonucleic acid excision repair capacity and bleomycin sensitivity in mouse lymphocytes. Tissue Antigens 1979; 14: 336-342 (Pubitemid 10191918)
37. Hart RW, Setlow RB. Correlation between deoxyribonucleic acid, excision repair and life span in a number of mammalian species. Proc Natl Acad Sci 1974; 71: 2169-2173
38. Kasahara M, Watanabe Y, Sumasu M, Nagata T. A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Proc Natl Acad Sci 2002; 99: 13687-13692 (Pubitemid 35215442)
39. Holzenberger M, Dupont J, Ducos B et al. IGF-1 receptor regulates life span and resistance to oxidative stress in mice. Nature 2003; 421: 182-187 (Pubitemid 36090987)
40. Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003; 299: 572-574 (Pubitemid 36135156)
41. Maier B, Gluba W, Bernier B et al. Modulation of mammalian life span by the short isoform of p53. Gene Develop 2004; 18: 306-319 (Pubitemid 38199255)
42. Mouse Genome Informatics (MGI), http://www.informatics.jax.org (12-08-08)
43. Luo J, Nikolaev AY, Imai S et al. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 2001; 107: 137-148 (Pubitemid 33035941)
44. Lin SJ, Defossez PA, Guarente L. Requirement of NAD and DIR2 for life-span extension by caloric restriction in Saccharomyces cerevisiae. Science 2000; 289: 2126-2128
45. Picard F, Kurtev M, Chung N et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004; 429: 771-776 (Pubitemid 38833129)