Ubiquitin receptors and protein quality control

Journal of Molecular and Cellular Cardiology

Volumn 55, Issue 1, 2013, Pages 73-84

  Wang, Xuejun ^a   Terpstra, Erin J M ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Autophagy; P62; Proteasome; Ubiquilin; Ubiquitin

Indexed keywords

CARRIER PROTEIN; CHAPERONE; DESMIN; POLYUBIQUITIN; PRESENILIN 1; PRESENILIN 2; PROTEASOME; PROTEIN P62; RECEPTOR; UBIQUILIN; UBIQUILIN 1; UBIQUILIN 2; UBIQUILIN 3; UBIQUILIN 4; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN RECEPTOR; UNCLASSIFIED DRUG;

AGGRESOME; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CHAPERONE-MEDIATED AUTOPHAGY; DEMENTIA; DEUBIQUITINATION; DRUG TARGETING; GENETIC POLYMORPHISM; HEART DISEASE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; LYSOSOME; MACROAUTOPHAGY; MISSENSE MUTATION; MITOPHAGY; MOLECULAR MECHANICS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN MODIFICATION; PROTEIN QUALITY; QUALITY CONTROL; REVIEW; UBIQUITINATION;

ANIMALS; HEART DISEASES; HUMANS; LYSOSOMES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEOLYSIS; UBIQUITIN; UBIQUITINATION;

EID: 84872679130     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.09.012     Document Type: Review

References (158)

1. Schubert U., Anton L.C., Gibbs J., Norbury C.C., Yewdell J.W., Bennink J.R. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 2000, 404:770-774.
2. Wang X., Su H., Ranek M.J. Protein quality control and degradation in cardiomyocytes. J Mol Cell Cardiol 2008, 45:11-27.
3. Portbury A.L., Ronnebaum S.M., Zungu M., Patterson C., Willis M.S. Back to your heart: ubiquitin proteasome system-regulated signal transduction. J Mol Cell Cardiol 2012, 52:526-537.
4. Sowa M.E., Bennett E.J., Gygi S.P., Harper J.W. Defining the human deubiquitinating enzyme interaction landscape. Cell 2009, 138:389-403.
5. Lee D.Y., Brown E.J. Ubiquilins in the crosstalk among proteolytic pathways. Biol Chem 2012, 393:441-447.
6. Scruggs S.B., Zong N.C., Wang D., Stefani E., Ping P. Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics. Am J Physiol Heart Circ Physiol 2012, 303:H9-H18.
7. Kaushik S., Cuervo A.M. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol 2012, 22:407-417.
8. Kopito R.R. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 2000, 10:524-530.
9. Bence N.F., Sampat R.M., Kopito R.R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292:1552-1555.
10. Chen Q., Liu J.B., Horak K.M., Zheng H., Kumarapeli A.R., Li J., et al. Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res 2005, 97:1018-1026.
11. Ciechanover A. Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Neurodegener Dis 2012, 10:7-22.
12. Wang X., Li J., Zheng H., Su H., Powell S.R. Proteasome functional insufficiency in cardiac pathogenesis. Am J Physiol Heart Circ Physiol 2011, 301:H2207-H2219.
13. Clague M.J., Urbe S. Ubiquitin: same molecule, different degradation pathways. Cell 2010, 143:682-685.
14. Qian S.B., McDonough H., Boellmann F., Cyr D.M., Patterson C. CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature 2006, 440:551-555.
15. Ravid T., Hochstrasser M. Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol 2008, 9:679-690.
16. Brodsky J.L., Skach W.R. Protein folding and quality control in the endoplasmic reticulum: recent lessons from yeast and mammalian cell systems. Curr Opin Cell Biol 2011, 23:464-475.
17. Fredrickson E.K., Rosenbaum J.C., Locke M.N., Milac T.I., Gardner R.G. Exposed hydrophobicity is a key determinant of nuclear quality control degradation. Mol Biol Cell 2011, 22:2384-2395.
18. Heck J.W., Cheung S.K., Hampton R.Y. Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proc Natl Acad Sci U S A 2010, 107:1106-1111.
19. Prasad R., Kawaguchi S., Ng D.T. A nucleus-based quality control mechanism for cytosolic proteins. Mol Biol Cell 2010, 21:2117-2127.
20. Connell P., Ballinger C.A., Jiang J., Wu Y., Thompson L.J., Hohfeld J., et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 2001, 3:93-96.
21. Min J.N., Whaley R.A., Sharpless N.E., Lockyer P., Portbury A.L., Patterson C. CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol Cell Biol 2008, 28:4018-4025.
22. Bengtson M.H., Joazeiro C.A. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 2010, 467:470-473.
23. Eisele F., Wolf D.H. Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett 2008, 582:4143-4146.
24. Fang N.N., Ng A.H., Measday V., Mayor T. Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins. Nat Cell Biol 2011, 13:1344-1352.
25. Le N.T., Takei Y., Shishido T., Woo C.H., Chang E., Heo K.S., et al. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res 2012, 110:536-550.
26. Zhang C., Xu Z., He X.R., Michael L.H., Patterson C. CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice. Am J Physiol Heart Circ Physiol 2005, 288:H2836-H2842.
27. Rafiq K., Guo J., Vlasenko L., Guo X., Kolpakov M.A., Sanjay A., et al. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. J Biol Chem 2012, 287:5327-5339.
28. Baskin K.K., Taegtmeyer H. AMP-activated protein kinase regulates E3 ligases in rodent heart. Circ Res 2011, 109:1153-1161.
29. Willis M.S., Ike C., Li L., Wang D.Z., Glass D.J., Patterson C. Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res 2007, 100:456-459.
30. Chen S.N., Czernuszewicz G., Tan Y., Lombardi R., Jin J., Willerson J.T., et al. Human molecular genetic and functional studies identify TRIM63, encoding muscle RING finger protein 1, as a novel gene for human hypertrophic cardiomyopathy. Circ Res 2012, 111:907-919.
31. Reyes-Turcu F.E., Ventii K.H., Wilkinson K.D. Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem 2009, 78:363-397.
32. Ventii K.H., Wilkinson K.D. Protein partners of deubiquitinating enzymes. Biochem J 2008, 414:161-175.
33. Burnett B., Li F., Pittman R.N. The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity. Hum Mol Genet 2003, 12:3195-3205.
34. Warrick J.M., Morabito L.M., Bilen J., Gordesky-Gold B., Faust L.Z., Paulson H.L., et al. Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. Mol Cell 2005, 18:37-48.
35. Winborn B.J., Travis S.M., Todi S.V., Scaglione K.M., Xu P., Williams A.J., et al. The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem 2008, 283:26436-26443.
36. Kuhlbrodt K., Janiesch P.C., Kevei E., Segref A., Barikbin R., Hoppe T. The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol 2011, 13:273-281.
37. Durcan T.M., Kontogiannea M., Thorarinsdottir T., Fallon L., Williams A.J., Djarmati A., et al. The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. Hum Mol Genet 2011, 20:141-154.
38. Scaglione K.M., Zavodszky E., Todi S.V., Patury S., Xu P., Rodriguez-Lebron E., et al. Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Mol Cell 2011, 43:599-612.
39. Todi S.V., Scaglione K.M., Blount J.R., Basrur V., Conlon K.P., Pastore A., et al. Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. J Biol Chem 2010, 285:39303-39313.
40. Todi S.V., Winborn B.J., Scaglione K.M., Blount J.R., Travis S.M., Paulson H.L. Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. EMBO J 2009, 28:372-382.
41. Wang H., Ying Z., Wang G. Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains. J Biol Chem 2012, 287:28576-28585.
42. Weekes J., Morrison K., Mullen A., Wait R., Barton P., Dunn M.J. Hyperubiquitination of proteins in dilated cardiomyopathy. Proteomics 2003, 3:208-216.
43. Cilenti L., Balakrishnan M.P., Wang X.L., Ambivero C., Sterlicchi M., del Monte F., et al. Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. J Mol Cell Cardiol 2011, 50:652-661.
44. Cooper E.M., Cutcliffe C., Kristiansen T.Z., Pandey A., Pickart C.M., Cohen R.E. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J 2009, 28:621-631.
45. Walters K.J., Kleijnen M.F., Goh A.M., Wagner G., Howley P.M. Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. Biochemistry 2002, 41:1767-1777.
46. Hirano Y., Yoshinaga S., Ogura K., Yokochi M., Noda Y., Sumimoto H., et al. Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5. J Biol Chem 2004, 279:31883-31890.
47. Seibenhener M.L., Babu J.R., Geetha T., Wong H.C., Krishna N.R., Wooten M.W. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol 2004, 24:8055-8068.
48. Liu J., Chen Q., Huang W., Horak K.M., Zheng H., Mestril R., et al. Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts. FASEB J 2006, 20:362-364.
49. Depre C., Wang Q., Yan L., Hedhli N., Peter P., Chen L., et al. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation 2006, 114:1821-1828.
50. Conklin D., Holderman S., Whitmore T.E., Maurer M., Feldhaus A.L. Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain. Gene 2000, 249:91-98.
51. Ko H.S., Uehara T., Tsuruma K., Nomura Y. Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. FEBS Lett 2004, 566:110-114.
52. Bertram L., Hiltunen M., Parkinson M., Ingelsson M., Lange C., Ramasamy K., et al. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med 2005, 352:884-894.
53. Mah A.L., Perry G., Smith M.A., Monteiro M.J. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol 2000, 151:847-862.
54. Deng H.X., Chen W., Hong S.T., Boycott K.M., Gorrie G.H., Siddique N., et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature 2011, 477:211-215.
55. Beverly L.J., Lockwood W.W., Shah P.P., Erdjument-Bromage H., Varmus H. Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proc Natl Acad Sci U S A 2012, 109:E119-E126.
56. Li D., Parks S.B., Kushner J.D., Nauman D., Burgess D., Ludwigsen S., et al. Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet 2006, 79:1030-1039.
57. Gianni D., Li A., Tesco G., McKay K.M., Moore J., Raygor K., et al. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation 2010, 121:1216-1226.
58. Massey L.K., Mah A.L., Ford D.L., Miller J., Liang J., Doong H., et al. Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins. J Alzheimers Dis 2004, 6:79-92.
59. Zhang D., Raasi S., Fushman D. Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains. J Mol Biol 2008, 377:162-180.
60. Heir R., Ablasou C., Dumontier E., Elliott M., Fagotto-Kaufmann C., Bedford F.K. The UBL domain of PLIC-1 regulates aggresome formation. EMBO Rep 2006, 7:1252-1258.
61. Hiltunen M., Lu A., Thomas A.V., Romano D.M., Kim M., Jones P.B., et al. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem 2006, 281:32240-32253.
62. Stieren E.S., El Ayadi A., Xiao Y., Siller E., Landsverk M.L., Oberhauser A.F., et al. Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein. J Biol Chem 2011, 286:35689-35698.
63. Lim P.J., Danner R., Liang J., Doong H., Harman C., Srinivasan D., et al. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol 2009, 187:201-217.
64. Kleijnen M.F., Shih A.H., Zhou P., Kumar S., Soccio R.E., Kedersha N.L., et al. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol Cell 2000, 6:409-419.
65. Kim S.H., Shi Y., Hanson K.A., Williams L.M., Sakasai R., Bowler M.J., et al. Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1. J Biol Chem 2009, 284:8083-8092.
66. Rothenberg C., Srinivasan D., Mah L., Kaushik S., Peterhoff C.M., Ugolino J., et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 2010, 19:3219-3232.
67. N'Diaye E.N., Kajihara K.K., Hsieh I., Morisaki H., Debnath J., Brown E.J. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep 2009, 10:173-179.
68. Wang H., Lim P.J., Yin C., Rieckher M., Vogel B.E., Monteiro M.J. Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin. Hum Mol Genet 2006, 15:1025-1041.
69. Wang H., Monteiro M.J. Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity. Exp Cell Res 2007, 313:2810-2820.
70. Ganguly A., Feldman R.M., Guo M. ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila. Hum Mol Genet 2008, 17:293-302.
71. Viswanathan J., Haapasalo A., Bottcher C., Miettinen R., Kurkinen K.M., Lu A., et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 2011, 12:330-348.
72. Wang X., Osinska H., Dorn G.W., Nieman M., Lorenz J.N., Gerdes A.M., et al. Mouse model of desmin-related cardiomyopathy. Circulation 2001, 103:2402-2407.
73. Ichimura Y., Komatsu M. Selective degradation of p62 by autophagy. Semin Immunopathol 2010, 32:431-436.
74. Ichimura Y., Kominami E., Tanaka K., Komatsu M. Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy 2008, 4:1063-1066.
75. Ichimura Y., Kumanomidou T., Sou Y.S., Mizushima T., Ezaki J., Ueno T., et al. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem 2008, 283:22847-22857.
76. Riley B.E., Kaiser S.E., Shaler T.A., Ng A.C., Hara T., Hipp M.S., et al. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 2010, 191:537-552.
77. Deretic V. A master conductor for aggregate clearance by autophagy. Dev Cell 2010, 18:694-696.
78. Filimonenko M., Isakson P., Finley K.D., Anderson M., Jeong H., Melia T.J., et al. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell 2010, 38:265-279.
79. Zheng Q., Su H., Ranek M.J., Wang X. Autophagy and p62 in cardiac proteinopathy. Circ Res 2011, 109:296-308.
80. Zheng Q., Wang X. Autophagy and the ubiquitin-proteasome system in cardiac dysfunction. Panminerva Med 2010, 52:9-25.
81. Komatsu M., Waguri S., Koike M., Sou Y.S., Ueno T., Hara T., et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007, 131:1149-1163.
82. Korolchuk V.I., Mansilla A., Menzies F.M., Rubinsztein D.C. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell 2009, 33:517-527.
83. Fecto F., Yan J., Vemula S.P., Liu E., Yang Y., Chen W., et al. SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch Neurol 2011, 68:1440-1446.
84. Fecto F., Siddique T. UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia. Muscle Nerve 2012, 45:157-162.
85. Wang X., Robbins J. Heart failure and protein quality control. Circ Res 2006, 99:1315-1328.
86. Nagaoka U., Kim K., Jana N.R., Doi H., Maruyama M., Mitsui K., et al. Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions. J Neurochem 2004, 91:57-68.
87. Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005, 171:603-614.
88. Nakai A., Yamaguchi O., Takeda T., Higuchi Y., Hikoso S., Taniike M., et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007, 13:619-624.
89. Su H., Li F., Ranek M.J., Wei N., Wang X. COP9 signalosome regulates autophagosome maturation. Circulation 2011, 124:2117-2128.
90. Nakaso K., Yoshimoto Y., Nakano T., Takeshima T., Fukuhara Y., Yasui K., et al. Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease. Brain Res 2004, 1012:42-51.
91. Kuusisto E., Suuronen T., Salminen A. Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. Biochem Biophys Res Commun 2001, 280:223-228.
92. Schlossarek S., Englmann D.R., Sultan K.R., Sauer M., Eschenhagen T., Carrier L. Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy. Basic Res Cardiol 2012, 107:1-13.
93. Cullinan S.B., Gordan J.D., Jin J., Harper J.W., Diehl J.A. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 2004, 24:8477-8486.
94. Kobayashi A., Kang M.I., Okawa H., Ohtsuji M., Zenke Y., Chiba T., et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004, 24:7130-7139.
95. Jain A., Lamark T., Sjottem E., Larsen K.B., Awuh J.A., Overvatn A., et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 2010, 285:22576-22591.
96. Su H., Wang X. p62 stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress. Trends Cardiovasc Med 2011, 21:224-228.
97. Johansen T., Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011, 7:279-296.
98. Matsumoto G., Wada K., Okuno M., Kurosawa M., Nukina N. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell 2011, 44:279-289.
99. Glickman M.H., Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002, 82:373-428.
100. Tanahashi N., Murakami Y., Minami Y., Shimbara N., Hendil K.B., Tanaka K. Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis. J Biol Chem 2000, 275:14336-14345.
101. Hendil K.B., Khan S., Tanaka K. Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes. Biochem J 1998, 332:749-754.
102. Pickering A.M., Davies K.J. Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci 2012, 109:227-248.
103. Rosenzweig R., Bronner V., Zhang D., Fushman D., Glickman M.H. Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome. J Biol Chem 2012, 287:14659-14671.
104. Matiuhin Y., Kirkpatrick D.S., Ziv I., Kim W., Dakshinamurthy A., Kleifeld O., et al. Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome. Mol Cell 2008, 32:415-425.
105. Yao T., Cohen R.E. A cryptic protease couples deubiquitination and degradation by the proteasome. Nature 2002, 419:403-407.
106. Lee B.H., Lee M.J., Park S., Oh D.C., Elsasser S., Chen P.C., et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 2010, 467:179-184.
107. Ahmad K. Proteasome inhibitor for treatment of multiple myeloma. Lancet Oncol 2005, 6:546.
108. Kloetzel P.M. Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII. Nat Immunol 2004, 5:661-669.
109. Preckel T., Fung-Leung W.P., Cai Z., Vitiello A., Salter-Cid L., Winqvist O., et al. Impaired immunoproteasome assembly and immune responses in PA28-/- mice. Science 1999, 286:2162-2165.
110. Chen X., Barton L.F., Chi Y., Clurman B.E., Roberts J.M. Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol Cell 2007, 26:843-852.
111. Li J., Horak K.M., Su H., Sanbe A., Robbins J., Wang X. Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice. J Clin Invest 2011, 121:3689-3700.
112. Li J., Powell S.R., Wang X. Enhancement of proteasome function by PA28α overexpression protects against oxidative stress. FASEB J 2011, 25:883-893.
113. Seifert U., Bialy L.P., Ebstein F., Bech-Otschir D., Voigt A., Schroter F., et al. Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 2010, 142:613-624.
114. Hussong S.A., Kapphahn R.J., Phillips S.L., Maldonado M., Ferrington D.A. Immunoproteasome deficiency alters retinal proteasome's response to stress. J Neurochem 2010, 113:1481-1490.
115. Pickering A.M., Koop A.L., Teoh C.Y., Ermak G., Grune T., Davies K.J. The immunoproteasome, the 20S proteasome and the PA28alphabeta proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J 2010, 432:585-594.
116. Dohmen R.J., Willers I., Marques A.J. Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function. Biochim Biophys Acta 2007, 1773:1599-1604.
117. Meiners S., Heyken D., Weller A., Ludwig A., Stangl K., Kloetzel P.M., et al. Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes. J Biol Chem 2003, 278:21517-21525.
118. Su H., Wang X. The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective. Cardiovasc Res 2010, 85:253-262.
119. Radhakrishnan S.K., Lee C.S., Young P., Beskow A., Chan J.Y., Deshaies R.J. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol Cell 2010, 38:17-28.
120. Lee C.S., Lee C., Hu T., Nguyen J.M., Zhang J., Martin M.V., et al. Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A 2011, 108:8408-8413.
121. Tsuchiya Y., Morita T., Kim M., Iemura S., Natsume T., Yamamoto M., et al. Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms. Mol Cell Biol 2011, 31:4500-4512.
122. Biswas M., Phan D., Watanabe M., Chan J.Y. The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J Biol Chem 2011, 286:39282-39289.
123. Steffen J., Seeger M., Koch A., Kruger E. Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. Mol Cell 2010, 40:147-158.
124. Kiffin R., Christian C., Knecht E., Cuervo A.M. Activation of chaperone-mediated autophagy during oxidative stress. Mol Biol Cell 2004, 15:4829-4840.
125. Zhang C., Cuervo A.M. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 2008, 14:959-965.
126. Massey A.C., Kaushik S., Sovak G., Kiffin R., Cuervo A.M. Consequences of the selective blockage of chaperone-mediated autophagy. Proc Natl Acad Sci U S A 2006, 103:5805-5810.
127. Kaushik S., Massey A.C., Mizushima N., Cuervo A.M. Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell 2008, 19:2179-2192.
128. Cuervo A.M., Stefanis L., Fredenburg R., Lansbury P.T., Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004, 305:1292-1295.
129. Martinez-Vicente M., Talloczy Z., Kaushik S., Massey A.C., Mazzulli J., Mosharov E.V., et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 2008, 118:777-788.
130. Mizushima N., Yamamoto A., Matsui M., Yoshimori T., Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004, 15:1101-1111.
131. Perry C.N., Kyoi S., Hariharan N., Takagi H., Sadoshima J., Gottlieb R.A. Novel methods for measuring cardiac autophagy in vivo. Methods Enzymol 2009, 453:325-342.
132. Hariharan N., Zhai P., Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal 2011, 14:2179-2190.
133. Narendra D.P., Jin S.M., Tanaka A., Suen D.F., Gautier C.A., Shen J., et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010, 8:e1000298.
134. Ashrafi G., Schwarz T.L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2012, [Epub ahead of print]. 10.1038/cdd.2012.81.
135. Tanaka A., Cleland M.M., Xu S., Narendra D.P., Suen D.F., Karbowski M., et al. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 2010, 191:1367-1380.
136. Chan N.C., Salazar A.M., Pham A.H., Sweredoski M.J., Kolawa N.J., Graham R.L., et al. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 2011, 20:1726-1737.
137. Narendra D., Kane L.A., Hauser D.N., Fearnley I.M., Youle R.J. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010, 6:1090-1106.
138. Huang C., Andres A.M., Ratliff E.P., Hernandez G., Lee P., Gottlieb R.A. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One 2011, 6:e20975.
139. Hoshino A., Matoba S., Iwai-Kanai E., Nakamura H., Kimata M., Nakaoka M., et al. p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol 2012, 52:175-184.
140. Lamark T., Johansen T. Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol 2012, 2012:736905.
141. Tannous P., Zhu H., Johnstone J.L., Shelton J.M., Rajasekaran N.S., Benjamin I.J., et al. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A 2008, 105:9745-9750.
142. Pattison J.S., Osinska H., Robbins J. Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circ Res 2011, 109:151-160.
143. Su H., Wang X. Autophagy and p62 in cardiac protein quality control. Autophagy 2011, 7:1382-1383.
144. Sanbe A., Osinska H., Saffitz J.E., Glabe C.G., Kayed R., Maloyan A., et al. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A 2004, 101:10132-10136.
145. McLendon P.M., Robbins J. Desmin-related cardiomyopathy: an unfolding story. Am J Physiol Heart Circ Physiol 2011, 301:H1220-H1228.
146. Kumarapeli A.R., Horak K.M., Glasford J.W., Li J., Chen Q., Liu J., et al. A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin. FASEB J 2005, 19:2051-2053.
147. Li Y.F., Wang X. The role of the proteasome in heart disease. Biochim Biophys Acta 2011, 1809:141-149.
148. Liu J., Tang M., Mestril R., Wang X. Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes. J Mol Cell Cardiol 2006, 40:451-454.
149. Tian Z., Zheng H., Li J., Li Y.F., Su H., Wang X. Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in mice. Circ Res 2012, 111:532-542.
150. Schlossarek S., Englmann D.R., Sultan K.R., Sauer M., Eschenhagen T., Carrier L. Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy. Basic Res Cardiol 2012, 107:235.
151. Ma X., Liu H., Foyil S.R., Godar R.J., Weinheimer C.J., Hill J.A., et al. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation 2012, 125:3170-3181.
152. Divald A., Kivity S., Wang P., Hochhauser E., Roberts B., Teichberg S., et al. Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circ Res 2010, 106:1829-1838.
153. Tannous P., Zhu H., Nemchenko A., Berry J.M., Johnstone J.L., Shelton J.M., et al. Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation 2008, 117:3070-3078.
154. Tang M., Li J., Huang W., Su H., Liang Q., Tian Z., et al. Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovasc Res 2010, 88:424-433.
155. Kumarapeli A.R., Su H., Huang W., Tang M., Zheng H., Horak K.M., et al. Alpha B-crystallin suppresses pressure overload cardiac hypertrophy. Circ Res 2008, 103:1473-1482.
156. Molkentin J.D., Lu J.R., Antos C.L., Markham B., Richardson J., Robbins J., et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998, 93:215-228.
157. Hedhli N., Depre C. Proteasome inhibitors and cardiac cell growth. Cardiovasc Res 2010, 85:321-329.
158. Hedhli N., Lizano P., Hong C., Fritzky L.F., Dhar S.K., Liu H., et al. Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. Am J Physiol Heart Circ Physiol 2008, 295:H1385-H1393.