-
1
-
-
41449086790
-
Cardiac plasticity
-
Hill JA, Olson EN. Cardiac plasticity. N Engl J Med. 2008;358: 1370-1380.
-
(2008)
N Engl J Med
, vol.358
, pp. 1370-1380
-
-
Hill, J.A.1
Olson, E.N.2
-
2
-
-
33748323383
-
Regulation of cardiac hypertrophy by intra-cellular signalling pathways
-
Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intra-cellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7:589-600.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 589-600
-
-
Heineke, J.1
Molkentin, J.D.2
-
3
-
-
34447133404
-
Cardiac autophagy is a rnal-adaptive response to hemodynamic stress
-
Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Richardson JA, Le V, Levine B, Rothermel BA, Hill JA. Cardiac autophagy is a rnal-adaptive response to hemodynamic stress. J Clin Invest. 2007;117: 1782-1793.
-
(2007)
J Clin Invest
, vol.117
, pp. 1782-1793
-
-
Zhu, H.1
Tannous, P.2
Johnstone, J.L.3
Kong, Y.4
Shelton, J.M.5
Richardson, J.A.6
Le, V.7
Levine, B.8
Rothermel, B.A.9
Hill, J.A.10
-
4
-
-
35848961242
-
Myocyte autophagy in heart disease: Friend or foe?
-
Rothermel BA, Hill JA. Myocyte autophagy in heart disease: friend or foe? Autophagy. 2007;3:632-634.
-
(2007)
Autophagy
, vol.3
, pp. 632-634
-
-
Rothermel, B.A.1
Hill, J.A.2
-
5
-
-
36249025723
-
Autophagy: Process and function
-
Mizushima N. Autophagy: process and function. Genes Dev. 2007;21: 2861-2873.
-
(2007)
Genes Dev
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
6
-
-
35448981935
-
Autophagy: From phenomenology to molecular understanding in less than a decade
-
Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 2007;8:931-937.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
7
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
8
-
-
27644596641
-
Opinion: What is the role of protein aggregation in neurodegeneration?
-
Ross CA, Poirier MA. Opinion: what is the role of protein aggregation in neurodegeneration? Nat Rev Mol Cell Biol. 2005;6:891-898.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 891-898
-
-
Ross, C.A.1
Poirier, M.A.2
-
9
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
Kopito RR. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol. 2000; 10:524-530.
-
(2000)
Trends Cell Biol
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
10
-
-
0036566266
-
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
-
Ravikumar B, Duden R, Rubinsztein DC. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet. 2002;11:1107-1117.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1107-1117
-
-
Ravikumar, B.1
Duden, R.2
Rubinsztein, D.C.3
-
11
-
-
0344874551
-
Emerging role for autophagy in the removal of aggresomes in Schwann cells
-
Fortun J, Dunn WA Jr, Joy S, Li J, Notterpek L. Emerging role for autophagy in the removal of aggresomes in Schwann cells. J Neurosci. 2003;23:10672-10680.
-
(2003)
J Neurosci
, vol.23
, pp. 10672-10680
-
-
Fortun, J.1
Dunn Jr, W.A.2
Joy, S.3
Li, J.4
Notterpek, L.5
-
12
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006; 441:880-884.
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
Murata, S.4
Iwata, J.5
Tanida, I.6
Ueno, T.7
Koike, M.8
Uchiyama, Y.9
Kominami, E.10
Tanaka, K.11
-
13
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegen-erative disease in mice
-
Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegen-erative disease in mice. Nature. 2006;441:885-889.
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
Yokoyama, M.7
Mishima, K.8
Saito, I.9
Okano, H.10
Mizushima, N.11
-
14
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet. 2004;36:585-595.
-
(2004)
Nat Genet
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
Scaravilli, F.7
Easton, D.F.8
Duden, R.9
O'Kane, C.J.10
Rubinsztein, D.C.11
-
15
-
-
33645764690
-
Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure
-
Rothermel BA, Berenji K, Tannous P, Kutschke W, Dey A, Nolan B, Yoo KD, Demetroulis E, Gimbel M, Cabuay B, Karimi M, Hill JA. Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure. Physiol Genomics. 2005;23:18-27.
-
(2005)
Physiol Genomics
, vol.23
, pp. 18-27
-
-
Rothermel, B.A.1
Berenji, K.2
Tannous, P.3
Kutschke, W.4
Dey, A.5
Nolan, B.6
Yoo, K.D.7
Demetroulis, E.8
Gimbel, M.9
Cabuay, B.10
Karimi, M.11
Hill, J.A.12
-
16
-
-
0020411183
-
Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines
-
Simpson P, McGrath A, Savion S. Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ Res. 1982;51:787-801.
-
(1982)
Circ Res
, vol.51
, pp. 787-801
-
-
Simpson, P.1
McGrath, A.2
Savion, S.3
-
17
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence NF, Sampat RM, Kopito RR. Impairment of the ubiquitin-proteasome system by protein aggregation. Science. 2001;292: 1552-1555.
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
18
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19:5720-5728.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
19
-
-
1542283812
-
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
-
Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101-1111.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1101-1111
-
-
Mizushima, N.1
Yamamoto, A.2
Matsui, M.3
Yoshimori, T.4
Ohsumi, Y.5
-
20
-
-
0032576605
-
Aggresomes: A cellular response to misfolded proteins
-
Johnston JA, Ward CL, Kopito RR. Aggresomes: a cellular response to misfolded proteins. J Cell Biol. 1998; 143:1883-1898.
-
(1998)
J Cell Biol
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
Ward, C.L.2
Kopito, R.R.3
-
21
-
-
0005677775
-
3-Methyladenine: Specific inhibitor of autoph-agic/lysosomal protein degradation in isolated rat hepatocytes
-
Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autoph-agic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A. 1982;79:1889-1892.
-
(1982)
Proc Natl Acad Sci U S A
, vol.79
, pp. 1889-1892
-
-
Seglen, P.O.1
Gordon, P.B.2
-
22
-
-
0035809160
-
Two distinct Vps34 phospha-tidylinositol 3-kinase complexes function in autophagy and carboxypep-tidase Y sorting in Saccharomyces cerevisiae
-
Kihara A, Noda T, Ishihara N, Ohsumi Y. Two distinct Vps34 phospha-tidylinositol 3-kinase complexes function in autophagy and carboxypep-tidase Y sorting in Saccharomyces cerevisiae. J Cell Biol. 2001;152: 519-530.
-
(2001)
J Cell Biol
, vol.152
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
23
-
-
0035503594
-
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
-
Suzuki K, Kirisako T, Kamada Y, Mizushima N, Noda T, Ohsumi Y. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J. 2001;20: 5971-5981.
-
(2001)
EMBO J
, vol.20
, pp. 5971-5981
-
-
Suzuki, K.1
Kirisako, T.2
Kamada, Y.3
Mizushima, N.4
Noda, T.5
Ohsumi, Y.6
-
24
-
-
34548259958
-
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
-
Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 2007;282:24131-24145.
-
(2007)
J Biol Chem
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
Brech, A.4
Bruun, J.A.5
Outzen, H.6
Overvatn, A.7
Bjorkoy, G.8
Johansen, T.9
-
25
-
-
28844475400
-
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
-
Iwata A, Riley BE, Johnston JA, Kopito RR. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem. 2005;280:40282-40292.
-
(2005)
J Biol Chem
, vol.280
, pp. 40282-40292
-
-
Iwata, A.1
Riley, B.E.2
Johnston, J.A.3
Kopito, R.R.4
-
26
-
-
0037077040
-
Toxic proteins in neurodegenerative disease
-
Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science. 2002;296:1991-1995.
-
(2002)
Science
, vol.296
, pp. 1991-1995
-
-
Taylor, J.P.1
Hardy, J.2
Fischbeck, K.H.3
-
27
-
-
33845638625
-
Heart failure and protein quality control
-
Wang X, Robbins J. Heart failure and protein quality control. Circ Res. 2006;99:1315-1328.
-
(2006)
Circ Res
, vol.99
, pp. 1315-1328
-
-
Wang, X.1
Robbins, J.2
-
28
-
-
0037328263
-
Hyperu-biquitination of proteins in dilated cardiomyopathy
-
Weekes J, Morrison K, Mullen A, Wait R, Barton P, Dunn MJ. Hyperu-biquitination of proteins in dilated cardiomyopathy. Proteomics. 2003;3: 208-216.
-
(2003)
Proteomics
, vol.3
, pp. 208-216
-
-
Weekes, J.1
Morrison, K.2
Mullen, A.3
Wait, R.4
Barton, P.5
Dunn, M.J.6
-
29
-
-
0037453585
-
Myocytes die by multiple mechanisms in failing human hearts
-
Kostin S, Pool L, Elsasser A, Hein S, Drexler HC, Arnon E, Hayakawa Y, Zimmermann R, Bauer E, Klovekorn WP, Schaper J. Myocytes die by multiple mechanisms in failing human hearts. Circ Res. 2003;92: 715-724.
-
(2003)
Circ Res
, vol.92
, pp. 715-724
-
-
Kostin, S.1
Pool, L.2
Elsasser, A.3
Hein, S.4
Drexler, H.C.5
Arnon, E.6
Hayakawa, Y.7
Zimmermann, R.8
Bauer, E.9
Klovekorn, W.P.10
Schaper, J.11
-
30
-
-
0035680611
-
Aggresome formation in liver cells in response to different toxic mechanisms: Role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin
-
French BA, van Leeuwen F, Riley NE, Yuan QX, Bardag-Gorce F, Gaal K, Lue YH, Marceau N, French SW. Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin. Exp Mol Pathol. 2001;71:241-246.
-
(2001)
Exp Mol Pathol
, vol.71
, pp. 241-246
-
-
French, B.A.1
van Leeuwen, F.2
Riley, N.E.3
Yuan, Q.X.4
Bardag-Gorce, F.5
Gaal, K.6
Lue, Y.H.7
Marceau, N.8
French, S.W.9
-
31
-
-
3042711961
-
Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis
-
Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A. 2004;101:10132-10136.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 10132-10136
-
-
Sanbe, A.1
Osinska, H.2
Saffitz, J.E.3
Glabe, C.G.4
Kayed, R.5
Maloyan, A.6
Robbins, J.7
-
32
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169:425-434.
-
(2005)
J Cell Biol
, vol.169
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Chiba, T.13
-
33
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004;6:463-477.
-
(2004)
Dev Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
34
-
-
0038378519
-
Imaging 26S proteasome activity and inhibition in living mice
-
Luker GD, Pica CM, Song J, Luker KE, Piwnica-Worms D. Imaging 26S proteasome activity and inhibition in living mice. Nat Med. 2003;9: 969-973.
-
(2003)
Nat Med
, vol.9
, pp. 969-973
-
-
Luker, G.D.1
Pica, C.M.2
Song, J.3
Luker, K.E.4
Piwnica-Worms, D.5
-
35
-
-
27944450427
-
Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake
-
Chen Q, Liu JB, Horak KM, Zheng H, Kumarapeli AR, Li J, Li F, Gerdes AM, Wawrousek EF, Wang X. Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res. 2005;97:1018-1026.
-
(2005)
Circ Res
, vol.97
, pp. 1018-1026
-
-
Chen, Q.1
Liu, J.B.2
Horak, K.M.3
Zheng, H.4
Kumarapeli, A.R.5
Li, J.6
Li, F.7
Gerdes, A.M.8
Wawrousek, E.F.9
Wang, X.10
-
36
-
-
33748419472
-
The role of autophagy in alpha-1-antitrypsin deficiency: A specific cellular response in genetic diseases associated with aggregation-prone proteins
-
Perlmutter DH. The role of autophagy in alpha-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins. Autophagy. 2006;2:258-263.
-
(2006)
Autophagy
, vol.2
, pp. 258-263
-
-
Perlmutter, D.H.1
-
37
-
-
31544454404
-
Rapamycin alleviates toxicity of different aggregate-prone proteins
-
Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC. Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet. 2006; 15:433-442.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 433-442
-
-
Berger, Z.1
Ravikumar, B.2
Menzies, F.M.3
Oroz, L.G.4
Underwood, B.R.5
Pangalos, M.N.6
Schmitt, I.7
Wullner, U.8
Evert, B.O.9
O'Kane, C.J.10
Rubinsztein, D.C.11
-
38
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004;304:1500-1502.
-
(2004)
Science
, vol.304
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
Baehrecke, E.H.7
Lenardo, M.J.8
-
39
-
-
10344262564
-
Role of Bcl-2 family proteins in a non-apo-ptotic programmed cell death dependent on autophagy genes
-
Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y. Role of Bcl-2 family proteins in a non-apo-ptotic programmed cell death dependent on autophagy genes. Nat Cell Biol. 2004;6:1221-1228.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1221-1228
-
-
Shimizu, S.1
Kanaseki, T.2
Mizushima, N.3
Mizuta, T.4
Arakawa-Kobayashi, S.5
Thompson, C.B.6
Tsujimoto, Y.7
-
40
-
-
33645521571
-
Autophagic programmed cell death by selective catalase degradation
-
Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, Baehrecke EH, Lenardo M. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A. 2006; 103:4952-4957.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4952-4957
-
-
Yu, L.1
Wan, F.2
Dutta, S.3
Welsh, S.4
Liu, Z.5
Freundt, E.6
Baehrecke, E.H.7
Lenardo, M.8
-
41
-
-
34249714158
-
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
-
Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, Otsu K. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13: 619-624.
-
(2007)
Nat Med
, vol.13
, pp. 619-624
-
-
Nakai, A.1
Yamaguchi, O.2
Takeda, T.3
Higuchi, Y.4
Hikoso, S.5
Taniike, M.6
Omiya, S.7
Mizote, I.8
Matsumura, Y.9
Asahi, M.10
Nishida, K.11
Hori, M.12
Mizushima, N.13
Otsu, K.14
|