메뉴 건너뛰기




Volumn 12, Issue 9, 2012, Pages 1095-1118

Angiogenesis in hepatocellular carcinoma: A potential target for chemoprevention and therapy

Author keywords

Angiogenesis; Anti angiogenic agents; Chemoprevention; Hepatocellular carcinoma; Treatment; Vascular endothelial growth factor

Indexed keywords

ADIPONECTIN; ALPHA INTERFERON; ANGIOPEPTIN; ANGIOSTATIN; BACITRACIN; BETA INTERFERON; BEVACIZUMAB; DOVITINIB; ENDOSTATIN; FARNOQUINONE; FINGOLIMOD; FLUOROURACIL; FORETINIB; FUMAGILLOL CHLOROACETYLCARBAMATE; HALOFUGINONE; HYPOXIA INDUCIBLE FACTOR; INTERLEUKIN 12; INTERLEUKIN 17F; INTERLEUKIN 24; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OCTREOTIDE; PERINDOPRIL; PLACEBO; RAPAMYCIN; SORAFENIB; SUNITINIB; SURAMIN; THALIDOMIDE; TRIENTINE; UNINDEXED DRUG; VATALANIB;

EID: 84872577704     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800912803987887     Document Type: Review
Times cited : (48)

References (221)
  • 2
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag, H. B.; Rudolph, K. L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132, 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 4
    • 75149163334 scopus 로고    scopus 로고
    • Aging of hepatitis C virus (HCV)-infected persons in the United States: A multiple cohort model of HCV prevalence and disease progression
    • Davis, G. L.; Alter, M. J.; El-Serag, H.; Poynard, T.; Jennings, L. W. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 2010, 138, 513-521.
    • (2010) Gastroenterology , vol.138 , pp. 513-521
    • Davis, G.L.1    Alter, M.J.2    El-Serag, H.3    Poynard, T.4    Jennings, L.W.5
  • 5
    • 0021680014 scopus 로고
    • Relevance of nitrosamines to human cancer
    • Bartsch, H.; Montesano, R. Relevance of nitrosamines to human cancer. Carcinogenesis 1984, 5, 1381-1393.
    • (1984) Carcinogenesis , vol.5 , pp. 1381-1393
    • Bartsch, H.1    Montesano, R.2
  • 6
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet, J. M.; Burroughs, A.; Bruix, J. Hepatocellular carcinoma. Lancet 2003, 362, 1907-1917.
    • (2003) Lancet , vol.362 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 8
    • 67650938576 scopus 로고    scopus 로고
    • Hepatocellular carcinoma-epidemiological trends and risk factors
    • Schütte, K.; Bornschein, J.; Malfertheiner, P. Hepatocellular carcinoma-epidemiological trends and risk factors. Dig. Dis. 2009, 27, 80-92.
    • (2009) Dig. Dis , vol.27 , pp. 80-92
    • Schütte, K.1    Bornschein, J.2    Malfertheiner, P.3
  • 9
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Bruix, J.; Sherman, M. Management of hepatocellular carcinoma. Hepatology 2005, 42, 1208-1236.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 10
    • 77950612887 scopus 로고    scopus 로고
    • Where are we in the chemoprevention of hepatocellular carcinoma?
    • Lu S. C. Where are we in the chemoprevention of hepatocellular carcinoma? Hepatology 2010, 51, 734-736.
    • (2010) Hepatology , vol.51 , pp. 734-736
    • Lu, S.C.1
  • 12
    • 79551525006 scopus 로고    scopus 로고
    • Chemoprevention of hepatocellular carcinoma in chronic hepatitis C
    • Morgan T. R. Chemoprevention of hepatocellular carcinoma in chronic hepatitis C. Recent Results Cancer Res. 2011, 188, 85-99.
    • (2011) Recent Results Cancer Res , vol.188 , pp. 85-99
    • Morgan, T.R.1
  • 13
    • 33749261599 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma
    • Pang, R., Poon, R. T. P. Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma. Cancer Lett. 2006, 242, 151-167.
    • (2006) Cancer Lett , vol.242 , pp. 151-167
    • Pang, R.1    Poon, R.T.P.2
  • 14
    • 77958088824 scopus 로고    scopus 로고
    • Angiogenesis: Multiple masks in hepatocellular carcinoma and liver regeneration
    • Chen, J. A.; Shi, M.; Li, J. Q.; Qian, C. N. Angiogenesis: multiple masks in hepatocellular carcinoma and liver regeneration. Hepatol. Int. 2010, 4, 537-47.
    • (2010) Hepatol. Int , vol.4 , pp. 537-547
    • Chen, J.A.1    Shi, M.2    Li, J.Q.3    Qian, C.N.4
  • 16
    • 0028827625 scopus 로고
    • Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo
    • Asahara, T.; Bauters, C.; Zheng, L. P.; Takeshita, S.; Bunting, S.; Ferrara, N.; Symes, J. F.; Isner, J. M. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation 1995, 92, II365-371.
    • (1995) Circulation , vol.92
    • Asahara, T.1    Bauters, C.2    Zheng, L.P.3    Takeshita, S.4    Bunting, S.5    Ferrara, N.6    Symes, J.F.7    Isner, J.M.8
  • 17
    • 3042761526 scopus 로고    scopus 로고
    • Angiogenesis in hepatocellular carcinoma: The retrospectives and perspectives
    • Sung, H. S.; Tang, Z. Y. Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives. J. Cancer Res. Clin. Oncol. 2004, 130, 307-319.
    • (2004) J. Cancer Res. Clin. Oncol , vol.130 , pp. 307-319
    • Sung, H.S.1    Tang, Z.Y.2
  • 18
    • 33645880784 scopus 로고    scopus 로고
    • Current status and perspective of antiangiogenic therapy for cancer: Hepatocellular carcinoma
    • Tanaka, S.; Arii, S. Current status and perspective of antiangiogenic therapy for cancer: hepatocellular carcinoma. Int. J. Clin. Oncol. 2006, 11, 82-89.
    • (2006) Int. J. Clin. Oncol , vol.11 , pp. 82-89
    • Tanaka, S.1    Arii, S.2
  • 20
    • 59749083509 scopus 로고    scopus 로고
    • New strategy of antiangiogenic therapy for hepatocellular carcinoma
    • Wu, X. Z. New strategy of antiangiogenic therapy for hepatocellular carcinoma. Neoplasma 2008, 6, 472-481.
    • (2008) Neoplasma , vol.6 , pp. 472-481
    • Wu, X.Z.1
  • 22
    • 0004623809 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis
    • Park, Y. N.; Kim, Y. B.; Yang, K. M.; Park, C. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch. Pathol. Lab. Med. 2000, 124, 1061-1065.
    • (2000) Arch. Pathol. Lab. Med , vol.124 , pp. 1061-1065
    • Park, Y.N.1    Kim, Y.B.2    Yang, K.M.3    Park, C.4
  • 23
    • 34447106967 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha expression in experimental cirrhosis: Correlation with vascular endothelial growth factor expression and angiogenesis
    • Bozova, S.; Elpek, G. O. Hypoxia-inducible factor-1alpha expression in experimental cirrhosis: correlation with vascular endothelial growth factor expression and angiogenesis. APMIS 2007, 115, 795-801.
    • (2007) APMIS , vol.115 , pp. 795-801
    • Bozova, S.1    Elpek, G.O.2
  • 24
    • 66649084445 scopus 로고    scopus 로고
    • Expression and correlation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and microvessel density in experimental rat hepatocarcinogenesis
    • Wang, W.; Xu, G.L.; Jia, W. D.; Wang, Z. H.; Li, J. S.; Ma, J. L.; Ge, Y. S.; Xie, S. X.; Yu, J. H. Expression and correlation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and microvessel density in experimental rat hepatocarcinogenesis. J. Int. Med. Res. 2009, 37, 417-425.
    • (2009) J. Int. Med. Res , vol.37 , pp. 417-425
    • Wang, W.1    Xu, G.L.2    Jia, W.D.3    Wang, Z.H.4    Li, J.S.5    Ma, J.L.6    Ge, Y.S.7    Xie, S.X.8    Yu, J.H.9
  • 25
    • 84872584969 scopus 로고    scopus 로고
    • Angioprevention is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis
    • Bishayee, A.; Petit, D. M.; Samtani, K. Angioprevention is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis. J. Carcinog. Mutagen. 2010, 1, 102.
    • (2010) J. Carcinog. Mutagen , vol.1 , pp. 102
    • Bishayee, A.1    Petit, D.M.2    Samtani, K.3
  • 26
    • 0036136731 scopus 로고    scopus 로고
    • 'Angioprevention': Angiogenesis is a common and key target for cancer chemopreventive agents
    • Tosetti, F.; Ferrari, N.; de Flora, S.; Albini, A. 'Angioprevention': angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J. 2002, 16, 2-16.
    • (2002) FASEB J , vol.16 , pp. 2-16
    • Tosetti, F.1    Ferrari, N.2    de Flora, S.3    Albini, A.4
  • 27
    • 0032998680 scopus 로고    scopus 로고
    • Microvessel density of hepatocellular carcinoma: Its relationship with prognosis
    • Sun, H. C.; Tang, Z. Y.; Li, X.M.; Zhou, Y. N.; Sun, B. R.; Ma, Z. C. Microvessel density of hepatocellular carcinoma: its relationship with prognosis. J. Cancer Res. Clin. Oncol. 1999, 125, 419-426.
    • (1999) J. Cancer Res. Clin. Oncol , vol.125 , pp. 419-426
    • Sun, H.C.1    Tang, Z.Y.2    Li, X.M.3    Zhou, Y.N.4    Sun, B.R.5    Ma, Z.C.6
  • 28
    • 33947590737 scopus 로고    scopus 로고
    • Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma
    • Sun, B.; Zhang, S.; Zhang, D.; Du, J.; Guo, H.; Zhao, X.; Zhang, W.; Hao, X. Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma. Oncol. Rep. 2006, 16, 693-698.
    • (2006) Oncol. Rep , vol.16 , pp. 693-698
    • Sun, B.1    Zhang, S.2    Zhang, D.3    Du, J.4    Guo, H.5    Zhao, X.6    Zhang, W.7    Hao, X.8
  • 29
    • 50849120002 scopus 로고    scopus 로고
    • Jr. VEGF receptor protein-kinases: Structure and regulation
    • Roskoski, R. Jr. VEGF receptor protein-kinases: structure and regulation. Biochem. Biophys Res. Commun. 2008, 375, 287-291.
    • (2008) Biochem. Biophys Res. Commun , vol.375 , pp. 287-291
    • Roskoski, R.1
  • 30
    • 70350507211 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in the management of hepatocellular carcinoma
    • Kaseb, A. O.; Hanbali, A.; Cotant, M.; Hassan, M. M.; Wollner, I.; Philip, P. A. Vascular endothelial growth factor in the management of hepatocellular carcinoma. Cancer 2009, 115, 4895-4906.
    • (2009) Cancer , vol.115 , pp. 4895-4906
    • Kaseb, A.O.1    Hanbali, A.2    Cotant, M.3    Hassan, M.M.4    Wollner, I.5    Philip, P.A.6
  • 31
    • 79958121732 scopus 로고    scopus 로고
    • VEGF/VEGFR pathway inhibitors as anti-angiogenic agents
    • Sharma, P. S.; Sharma, R.; Tyagi, T. VEGF/VEGFR pathway inhibitors as anti-angiogenic agents. Curr. Cancer Drug Targets 2011, 11, 624-653.
    • (2011) Curr. Cancer Drug Targets , vol.11 , pp. 624-653
    • Sharma, P.S.1    Sharma, R.2    Tyagi, T.3
  • 32
    • 67650305795 scopus 로고    scopus 로고
    • Targeting angiogenesis in hepatocellular carcinoma: Focus of VEGR and becacizumab
    • Finn, R. S.; Zhu, A. X. Targeting angiogenesis in hepatocellular carcinoma: focus of VEGR and becacizumab. Expert. Rev. Anticancer Ther. 2009, 9, 503-509.
    • (2009) Expert. Rev. Anticancer Ther , vol.9 , pp. 503-509
    • Finn, R.S.1    Zhu, A.X.2
  • 35
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteosome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda, S.; Caro, J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteosome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 1997, 272, 22642-22647.
    • (1997) J. Biol. Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 36
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulator in angiogenesis
    • Harris, A. L. Hypoxia-a key regulator in angiogenesis. Nat. Rev. Cancer 2002, 2, 38-47.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 37
    • 33745138232 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxiainducible factor 1
    • Hirota, K.; Semenza, G. L. Regulation of angiogenesis by hypoxiainducible factor 1. Crit. Rev. Oncol. Hematol. 2006, 59, 15-26.
    • (2006) Crit. Rev. Oncol. Hematol , vol.59 , pp. 15-26
    • Hirota, K.1    Semenza, G.L.2
  • 38
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
    • Kamura, T.; Sato, S.; Iwai, K.; Czyzyk-Krzeska, M.; Conaway, R. C.; Conaway, J. W. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA 2000, 97, 10430-10435.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10430-10435
    • Kamura, T.1    Sato, S.2    Iwai, K.3    Czyzyk-Krzeska, M.4    Conaway, R.C.5    Conaway, J.W.6
  • 39
    • 0035955663 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide
    • Sandau, K. B.; Zhou, J.; Kietzmann, T.; Brüne, B. Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide. J. Biol. Chem. 2001, 276, 39805-38911.
    • (2001) J. Biol. Chem , vol.276 , pp. 38911-39805
    • Sandau, K.B.1    Zhou, J.2    Kietzmann, T.3    Brüne, B.4
  • 40
    • 3442881606 scopus 로고    scopus 로고
    • The potential role of hypoxia inducible factor 1in tumor progression after hypoxia and chemotherapy in hepatocellular carcinoma
    • Yang, Z. F.; Poon, R. T.; To, J.; Ho, D. W.; Fan, S. T. The potential role of hypoxia inducible factor 1in tumor progression after hypoxia and chemotherapy in hepatocellular carcinoma. Cancer Res. 2004, 64, 5496-5503.
    • (2004) Cancer Res , vol.64 , pp. 5496-5503
    • Yang, Z.F.1    Poon, R.T.2    To, J.3    Ho, D.W.4    Fan, S.T.5
  • 41
    • 17144364359 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival
    • Huang, G.; Yang, L.; Lu, W. Expression of hypoxia-inducible factor 1and vascular endothelial growth factor in hepatocellular carcinoma: impact on neovascularization and survival. World J. Gastroenterol. 2005, 11, 1705-1708.
    • (2005) World J. Gastroenterol , vol.11 , pp. 1705-1708
    • Huang, G.1    Yang, L.2    Lu, W.3
  • 43
    • 0035256554 scopus 로고    scopus 로고
    • Expression and function of interleukin-8 in human hepatocellular carcinoma
    • Akiba, J.; Yano, H.; Ogasawara, S.; Higaki, K.; Kojiro, M. Expression and function of interleukin-8 in human hepatocellular carcinoma. Int. J. Oncol. 2001, 18, 257-264.
    • (2001) Int. J. Oncol , vol.18 , pp. 257-264
    • Akiba, J.1    Yano, H.2    Ogasawara, S.3    Higaki, K.4    Kojiro, M.5
  • 44
    • 25144507526 scopus 로고    scopus 로고
    • Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis
    • Kubo, F.; Ueno, S.; Hiwatashi, K.; Sakoda, M.; Kawaida, K.; Nuruki, K.; Aikou, T. Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis. Ann. Surg. Oncol. 2005, 12, 800-807.
    • (2005) Ann. Surg. Oncol , vol.12 , pp. 800-807
    • Kubo, F.1    Ueno, S.2    Hiwatashi, K.3    Sakoda, M.4    Kawaida, K.5    Nuruki, K.6    Aikou, T.7
  • 45
    • 31544468915 scopus 로고    scopus 로고
    • Cyclooxygenase-2 in hepatocellular carcinoma
    • Wu, T. Cyclooxygenase-2 in hepatocellular carcinoma. Cancer Treat. Rev. 2006, 32, 28-44.
    • (2006) Cancer Treat. Rev , vol.32 , pp. 28-44
    • Wu, T.1
  • 46
    • 33845875713 scopus 로고    scopus 로고
    • Potential involvement of the cyclooxygenase-2 pathway in hepatocellular carcinoma-associated angiogenesis
    • Zhao, Q. T.; Yue, S. Q.; Cui, Z.; Wang, Q.; Cui, X.; Zhai, H. H.; Zhang, L. H.; Dou, K. F. Potential involvement of the cyclooxygenase-2 pathway in hepatocellular carcinoma-associated angiogenesis. Life Sci. 2007, 80, 484-492.
    • (2007) Life Sci , vol.80 , pp. 484-492
    • Zhao, Q.T.1    Yue, S.Q.2    Cui, Z.3    Wang, Q.4    Cui, X.5    Zhai, H.H.6    Zhang, L.H.7    Dou, K.F.8
  • 47
    • 1842852639 scopus 로고    scopus 로고
    • Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma
    • Cheng, A. S.; Chan, H. L.; To, K. F.; Leung, W. K.; Chan, K. K.; Liew, C. T.; Sung, J. J. Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. Int. J. Oncol. 2004, 24, 853-860.
    • (2004) Int. J. Oncol , vol.24 , pp. 853-860
    • Cheng, A.S.1    Chan, H.L.2    To, K.F.3    Leung, W.K.4    Chan, K.K.5    Liew, C.T.6    Sung, J.J.7
  • 48
    • 17144403485 scopus 로고    scopus 로고
    • Tumor cyclooxygenase-2 levels correlate with tumor invasiveness in human hepatocellular carcinoma
    • Tang, T. C.; Poon, R. T.; Lau, C. P.; Xie, D.; Fan, S. T. Tumor cyclooxygenase-2 levels correlate with tumor invasiveness in human hepatocellular carcinoma. World J. Gastroenterol. 2005, 11, 1896-1902.
    • (2005) World J. Gastroenterol , vol.11 , pp. 1896-1902
    • Tang, T.C.1    Poon, R.T.2    Lau, C.P.3    Xie, D.4    Fan, S.T.5
  • 49
    • 33751423908 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice
    • Denda, A.; Kitayama, W.; Kishida, H.; Murata, N.; Tamura, K.; Kusuoka, O.; Tsutsumi, M.; Nishikawa, F.; Kita, E.; Nakae, D.; Konishi, Y.; Kuniyasu, H. Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice. Nitric Oxide 2007, 16, 164-176.
    • (2007) Nitric Oxide , vol.16 , pp. 164-176
    • Denda, A.1    Kitayama, W.2    Kishida, H.3    Murata, N.4    Tamura, K.5    Kusuoka, O.6    Tsutsumi, M.7    Nishikawa, F.8    Kita, E.9    Nakae, D.10    Konishi, Y.11    Kuniyasu, H.12
  • 51
    • 0034906314 scopus 로고    scopus 로고
    • Coexpression of inducible nitric oxide synthase and COX 2 in hepatocellular carcinoma and surrounding liver: Possible involvement of COX-2 in the angiogenesis of hepatitis C viruspositive cases
    • Rahman, M. A.; Dhar, D. K.; Yamaguchi, E.; Maruyama, S.; Sato, T.; Hayashi, H.; Ono, T.; Yamanoi, A.; Kohno, H.; Nagasue, N. Coexpression of inducible nitric oxide synthase and COX 2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C viruspositive cases. Clin. Cancer Res. 2001, 7, 1325-1332.
    • (2001) Clin. Cancer Res , vol.7 , pp. 1325-1332
    • Rahman, M.A.1    Dhar, D.K.2    Yamaguchi, E.3    Maruyama, S.4    Sato, T.5    Hayashi, H.6    Ono, T.7    Yamanoi, A.8    Kohno, H.9    Nagasue, N.10
  • 52
    • 33746036817 scopus 로고    scopus 로고
    • Clinical value of apoptosis and angiogenesis factors in estimating the prognosis of hepatocellular carcinoma
    • Guo, R. P.; Zhong, C.; Shi, M.; Zhang, C. Q.; Wei, W.; Zhang, Y. Q.; Li, J. Q. Clinical value of apoptosis and angiogenesis factors in estimating the prognosis of hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 2006, 132, 547-555.
    • (2006) J. Cancer Res. Clin. Oncol , vol.132 , pp. 547-555
    • Guo, R.P.1    Zhong, C.2    Shi, M.3    Zhang, C.Q.4    Wei, W.5    Zhang, Y.Q.6    Li, J.Q.7
  • 53
    • 4043104624 scopus 로고    scopus 로고
    • The role of angiostatin, vascular endothelial growth factor, matrix metalloproteinase 9 and 12 in the angiogenesis of hepatocellular carcinoma
    • Kim, S.; Park, H. S.; Son, H. J.; Moon, W. S. The role of angiostatin, vascular endothelial growth factor, matrix metalloproteinase 9 and 12 in the angiogenesis of hepatocellular carcinoma. Korean J. Hepatol. 2004, 10, 62-72.
    • (2004) Korean J. Hepatol , vol.10 , pp. 62-72
    • Kim, S.1    Park, H.S.2    Son, H.J.3    Moon, W.S.4
  • 54
    • 28644433990 scopus 로고    scopus 로고
    • Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma
    • Sun, M. H.; Han, X. C.; Jia, M. K.; Jiang, W. D.; Wang, M.; Zhang, H.; Han, G,; Jiang, Y. Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma. World J. Gastroenterol. 2005, 11, 5931-5937.
    • (2005) World J. Gastroenterol , vol.11 , pp. 5931-5937
    • Sun, M.H.1    Han, X.C.2    Jia, M.K.3    Jiang, W.D.4    Wang, M.5    Zhang, H.6    Han, G.7    Jiang, Y.8
  • 55
    • 0034544619 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma
    • Tai, D. I.; Tsai, S. L.; Chang, Y. H.; Huang, S. N.; Chen, T. C.; Chang, K. S.; Liaw, Y. F. Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma. Cancer 2000, 89, 2274-2281.
    • (2000) Cancer , vol.89 , pp. 2274-2281
    • Tai, D.I.1    Tsai, S.L.2    Chang, Y.H.3    Huang, S.N.4    Chen, T.C.5    Chang, K.S.6    Liaw, Y.F.7
  • 56
    • 33645457576 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB in human hepatocellular carcinoma: Evidence of a cytoprotective role
    • Qiao, L.; Zhang, H.; Yu, J.; Francisco, R.; Dent, P.; Ebert, M. P.; Röcken, C.; Farrell, G. Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role. Hum. Gene Ther. 2006, 17, 280-290.
    • (2006) Hum. Gene Ther , vol.17 , pp. 280-290
    • Qiao, L.1    Zhang, H.2    Yu, J.3    Francisco, R.4    Dent, P.5    Ebert, M.P.6    Röcken, C.7    Farrell, G.8
  • 57
    • 37549004392 scopus 로고    scopus 로고
    • Nuclear factor-κB: From bench to bedside
    • Sethi, G.; Sung, B.; Aggarwal, B. B. Nuclear factor-κB: from bench to bedside. Exp. Biol. Med. 2008, 233, 21-31.
    • (2008) Exp. Biol. Med , vol.233 , pp. 21-31
    • Sethi, G.1    Sung, B.2    Aggarwal, B.B.3
  • 58
    • 70449404610 scopus 로고    scopus 로고
    • Nuclear factor-kappa B links carcicinogenesis and chemopreventive agents
    • Ralhan, R.; Pandey, M. K.; Aggarwal, B. B. Nuclear factor-kappa B links carcicinogenesis and chemopreventive agents. Front. Biosci. (Schol. Ed.) 2009, 1, 45-60.
    • (2009) Front. Biosci. (Schol. Ed.) , vol.1 , pp. 45-60
    • Ralhan, R.1    Pandey, M.K.2    Aggarwal, B.B.3
  • 59
    • 1142275252 scopus 로고    scopus 로고
    • Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma
    • Futakuchi, M.; Ogawa, K.; Tamano, S.; Takahashi, S.; Shirai, T. Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. Cancer Sci. 2004, 95, 18-24.
    • (2004) Cancer Sci , vol.95 , pp. 18-24
    • Futakuchi, M.1    Ogawa, K.2    Tamano, S.3    Takahashi, S.4    Shirai, T.5
  • 60
    • 77952163228 scopus 로고    scopus 로고
    • The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs
    • Liu, L. P.; Liang, H. F.; Chen, X. P.; Zhang, W. G.; Yang, S. L.; Xu, T.; Ren, L. The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs. Cancer Invest. 2010, 28, 443-451.
    • (2010) Cancer Invest , vol.28 , pp. 443-451
    • Liu, L.P.1    Liang, H.F.2    Chen, X.P.3    Zhang, W.G.4    Yang, S.L.5    Xu, T.6    Ren, L.7
  • 61
    • 0141651577 scopus 로고    scopus 로고
    • Plateletderived endothelial cell growth factor (PD-ECGF) is up-regulated in human hepatocellular carcinoma (HCC) and the corresponding hepatitis liver
    • Morinaga, S.; Yamamoto, Y.; Noguchi, Y.; Imada, T.; Rino, Y.; Akaike, M.; Sugimasa, Y.; Takemiya, S.; Takanashi, Y. Plateletderived endothelial cell growth factor (PD-ECGF) is up-regulated in human hepatocellular carcinoma (HCC) and the corresponding hepatitis liver. Hepatogastroenterology 2003, 50, 1521-1526.
    • (2003) Hepatogastroenterology , vol.50 , pp. 1521-1526
    • Morinaga, S.1    Yamamoto, Y.2    Noguchi, Y.3    Imada, T.4    Rino, Y.5    Akaike, M.6    Sugimasa, Y.7    Takemiya, S.8    Takanashi, Y.9
  • 62
    • 21644487583 scopus 로고    scopus 로고
    • Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinoma
    • Ezaki, T.; Ikegami, T.; Maeda, T.; Yamada, T.; Ishida, T.; Hashizume, M.; Maehara, Y. Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinoma. Int. J. Clin. Oncol. 2005, 10, 171-176.
    • (2005) Int. J. Clin. Oncol , vol.10 , pp. 171-176
    • Ezaki, T.1    Ikegami, T.2    Maeda, T.3    Yamada, T.4    Ishida, T.5    Hashizume, M.6    Maehara, Y.7
  • 64
    • 0034906312 scopus 로고    scopus 로고
    • The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma
    • El-Assal, O. N.; Yamanoi, A.; Ono, T.; Kohno, H.; Nagasue, N. The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma. Clin. Cancer Res. 2001, 7, 1299-1305.
    • (2001) Clin. Cancer Res , vol.7 , pp. 1299-1305
    • El-Assal, O.N.1    Yamanoi, A.2    Ono, T.3    Kohno, H.4    Nagasue, N.5
  • 65
    • 0027297822 scopus 로고
    • Sinusoidal capillarization of human hepatocellular carcinoma: Possible promotion by fibroblast growth factor
    • Motoo, Y.; Sawabu, N.; Yamaguchi, Y.; Terada, T.; Nakanuma, Y. Sinusoidal capillarization of human hepatocellular carcinoma: possible promotion by fibroblast growth factor. Oncology 1993, 50, 270-274.
    • (1993) Oncology , vol.50 , pp. 270-274
    • Motoo, Y.1    Sawabu, N.2    Yamaguchi, Y.3    Terada, T.4    Nakanuma, Y.5
  • 66
    • 85047696179 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine
    • Horiguchi, N.; Takayama, H.; Toyoda, M.; Otsuka, T.; Fukusato, T.; Merlino, G.; Takagi, H; Mori, M. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine. Oncogene 2002, 21, 1791-1799.
    • (2002) Oncogene , vol.21 , pp. 1791-1799
    • Horiguchi, N.1    Takayama, H.2    Toyoda, M.3    Otsuka, T.4    Fukusato, T.5    Merlino, G.6    Takagi, H.7    Mori, M.8
  • 67
    • 4043074287 scopus 로고    scopus 로고
    • TGFbeta1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-beta1-enhanced cell migration in SMMC-7721 cells
    • Xu, Z.; Shen, M. X.; Ma, D. Z.; Wang, L. Y.; Zha, X. L. TGFbeta1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-beta1-enhanced cell migration in SMMC-7721 cells. Cell Res. 2003, 13, 343-350.
    • (2003) Cell Res , vol.13 , pp. 343-350
    • Xu, Z.1    Shen, M.X.2    Ma, D.Z.3    Wang, L.Y.4    Zha, X.L.5
  • 68
    • 0028952342 scopus 로고
    • Positive correlation of plasma transforming growth factor-beta 1 levels with tumor vascularity in hepatocellular carcinoma
    • Ito, N.; Kawata, S.; Tamura, S.; Shirai, Y.; Kiso, S.; Tsushima, H.; Matsuzawa, Y. Positive correlation of plasma transforming growth factor-beta 1 levels with tumor vascularity in hepatocellular carcinoma. Cancer Lett. 1995, 89, 45-48.
    • (1995) Cancer Lett , vol.89 , pp. 45-48
    • Ito, N.1    Kawata, S.2    Tamura, S.3    Shirai, Y.4    Kiso, S.5    Tsushima, H.6    Matsuzawa, Y.7
  • 70
    • 0037902227 scopus 로고    scopus 로고
    • Tumoral angiogenesis and tissue factor expression during hepatocellular carcinoma progression in a transgenic mouse model
    • Dupuy, E.; Hainaud, P.; Villemain, A.; Bodevin-Phèdre, E.; Brouland, J. P.; Briand, P.; Tobelem, G. Tumoral angiogenesis and tissue factor expression during hepatocellular carcinoma progression in a transgenic mouse model. J. Hepatol. 2003, 38, 793-802.
    • (2003) J. Hepatol , vol.38 , pp. 793-802
    • Dupuy, E.1    Hainaud, P.2    Villemain, A.3    Bodevin-Phèdre, E.4    Brouland, J.P.5    Briand, P.6    Tobelem, G.7
  • 71
    • 0242525613 scopus 로고    scopus 로고
    • Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma
    • Poon, R. T.; Lau, C. P.; Ho, J. W.; Yu, W. C.; Fan, S. T.; Wong, J. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin. Cancer Res. 2003, 9, 5339-5345.
    • (2003) Clin. Cancer Res , vol.9 , pp. 5339-5345
    • Poon, R.T.1    Lau, C.P.2    Ho, J.W.3    Yu, W.C.4    Fan, S.T.5    Wong, J.6
  • 75
    • 0023181351 scopus 로고
    • Tissue distribution and developmental expression of the messenger RNA encoding angiogenin
    • Weiner, H. L.; Weiner, L. H.; Swain, J. L. Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Science 1987, 237, 280-282.
    • (1987) Science , vol.237 , pp. 280-282
    • Weiner, H.L.1    Weiner, L.H.2    Swain, J.L.3
  • 78
    • 0036362236 scopus 로고    scopus 로고
    • Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth
    • Lawler, J. Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J. Cell Mol. Med. 2002, 6, 1-12.
    • (2002) J. Cell Mol. Med , vol.6 , pp. 1-12
    • Lawler, J.1
  • 81
    • 0033984320 scopus 로고    scopus 로고
    • Implications of human macrophage metalloelastase and vascular endothelial growth factor gene expression in angiogenesis of hepatocellular carcinoma
    • Gorrin-Rivas, M. J.; Arii, S.; Mori, A.; Takeda, Y.; Mizumoto, M.; Furutani, M.; Imamura, M. Implications of human macrophage metalloelastase and vascular endothelial growth factor gene expression in angiogenesis of hepatocellular carcinoma. Ann. Surg. 2000, 231, 67-73.
    • (2000) Ann. Surg , vol.231 , pp. 67-73
    • Gorrin-Rivas, M.J.1    Arii, S.2    Mori, A.3    Takeda, Y.4    Mizumoto, M.5    Furutani, M.6    Imamura, M.7
  • 83
    • 0035132924 scopus 로고    scopus 로고
    • Tumor progression is associated with a significant decrease in the expression of the endostatin precursor collagen XVIII in human hepatocellular carcinomas
    • Musso, O.; Rehn, M.; Théret, N.; Turlin, B.; Bioulac-Sage, P.; Lotrian, D.; Campion, J. P.; Pihlajaniemi, T.; Clément, B. Tumor progression is associated with a significant decrease in the expression of the endostatin precursor collagen XVIII in human hepatocellular carcinomas. Cancer Res. 2001, 61, 45-49.
    • (2001) Cancer Res , vol.61 , pp. 45-49
    • Musso, O.1    Rehn, M.2    Théret, N.3    Turlin, B.4    Bioulac-Sage, P.5    Lotrian, D.6    Campion, J.P.7    Pihlajaniemi, T.8    Clément, B.9
  • 85
    • 0034907881 scopus 로고    scopus 로고
    • The angiotensin-I-converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: Possible role of the vascular endothelial growth factor
    • Yoshiji, H.; Kuriyama, S.; Kawata. M.; Yoshii, J.; Ikenaka, Y.; Noguchi, R.; Nakatani, T.; Tsujinoue, H.; Fukui, H. The angiotensin-I-converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: possible role of the vascular endothelial growth factor. Clin. Cancer Res. 2001, 7, 1073-1078.
    • (2001) Clin. Cancer Res , vol.7 , pp. 1073-1078
    • Yoshiji, H.1    Kuriyama, S.2    Kawata, M.3    Yoshii, J.4    Ikenaka, Y.5    Noguchi, R.6    Nakatani, T.7    Tsujinoue, H.8    Fukui, H.9
  • 86
    • 0036617271 scopus 로고    scopus 로고
    • Suppression of the reninangiotensin system attenuates vascular endothelial growth factormediated tumor development and angiogenesis in murine hepatocellular carcinoma cells
    • Yoshiji, H.; Yoshii, J.; Ikenaka, Y.; Noguchi, R.; Yanase, K.; Tsujinoue, H.; Imazu, H.; Fukui, H. Suppression of the reninangiotensin system attenuates vascular endothelial growth factormediated tumor development and angiogenesis in murine hepatocellular carcinoma cells. Int. J. Oncol. 2002, 20, 1227-1231.
    • (2002) Int. J. Oncol , vol.20 , pp. 1227-1231
    • Yoshiji, H.1    Yoshii, J.2    Ikenaka, Y.3    Noguchi, R.4    Yanase, K.5    Tsujinoue, H.6    Imazu, H.7    Fukui, H.8
  • 89
    • 15044356179 scopus 로고    scopus 로고
    • Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice
    • Yoshiji, H.; Noguchi, R.; Kuriyama, S.; Yoshii, J.; Ikenaka, Y. Combination of interferon and angiotensin-converting enzyme inhibitor, perindopril, suppresses liver carcinogenesis and angiogenesis in mice. Oncol. Rep. 2005, 13, 491-495.
    • (2005) Oncol. Rep , vol.13 , pp. 491-495
    • Yoshiji, H.1    Noguchi, R.2    Kuriyama, S.3    Yoshii, J.4    Ikenaka, Y.5
  • 90
    • 0042252159 scopus 로고    scopus 로고
    • Vitamin K cuts hepatocellular carcinoma mortality
    • Jancin, B. Vitamin K cuts hepatocellular carcinoma mortality. Fam. Pract. News 2002, 32.
    • (2002) Fam. Pract. News , pp. 32
    • Jancin, B.1
  • 93
    • 33947720545 scopus 로고    scopus 로고
    • Synergistic inhibition of hepatocellular carcinoma growth and hepatocarcinogenesis by combination of 5-fluorouracil and angiotensin-converting enzyme inhibitor via anti-angiogenic activities
    • Yanase, K.; Yoshiji, H.; Ikenaka, Y.; Noguchi, R.; Kitade, M.; Kaji, K.; Yoshii, J.; Namisaki, T.; Yamazaki, M.; Asada, K.; Tsujimoto, T.; Akahane, T.; Uemura, M.; Fukui, H. Synergistic inhibition of hepatocellular carcinoma growth and hepatocarcinogenesis by combination of 5-fluorouracil and angiotensin-converting enzyme inhibitor via anti-angiogenic activities. Oncol. Rep. 2007, 17, 441-446.
    • (2007) Oncol. Rep , vol.17 , pp. 441-446
    • Yanase, K.1    Yoshiji, H.2    Ikenaka, Y.3    Noguchi, R.4    Kitade, M.5    Kaji, K.6    Yoshii, J.7    Namisaki, T.8    Yamazaki, M.9    Asada, K.10    Tsujimoto, T.11    Akahane, T.12    Uemura, M.13    Fukui, H.14
  • 95
    • 21044453333 scopus 로고    scopus 로고
    • Inhibitory effect of adeno-associated virus-mediated gene transfer of human endostatin on hepatocellular carcinoma
    • Liu, H.; Peng, C. H.; Liu, Y. B.; Wu, Y. L.; Zhao, Z. M.; Wang, Y.; Han, B. S. Inhibitory effect of adeno-associated virus-mediated gene transfer of human endostatin on hepatocellular carcinoma. World J. Gastroenterol. 2005, 11, 3331-3334.
    • (2005) World J. Gastroenterol , vol.11 , pp. 3331-3334
    • Liu, H.1    Peng, C.H.2    Liu, Y.B.3    Wu, Y.L.4    Zhao, Z.M.5    Wang, Y.6    Han, B.S.7
  • 96
    • 0025204095 scopus 로고
    • Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
    • Ingber, D.; Fujita, T.; Kishimoto, S.; Sudo, K.; Kanamaru, T.; Brem, H.; Folkman, J. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990, 348, 555-557.
    • (1990) Nature , vol.348 , pp. 555-557
    • Ingber, D.1    Fujita, T.2    Kishimoto, S.3    Sudo, K.4    Kanamaru, T.5    Brem, H.6    Folkman, J.7
  • 98
    • 0034131857 scopus 로고    scopus 로고
    • Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats
    • Kin, M.; Torimura, T.; Ueno, T.; Nakamura, T.; Ogata, R.; Sakamoto, M.; Tamaki, S.; Sata, M. Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats. Int. J. Oncol. 2000, 16, 375-382.
    • (2000) Int. J. Oncol , vol.16 , pp. 375-382
    • Kin, M.1    Torimura, T.2    Ueno, T.3    Nakamura, T.4    Ogata, R.5    Sakamoto, M.6    Tamaki, S.7    Sata, M.8
  • 99
    • 33845687007 scopus 로고    scopus 로고
    • Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism
    • Mauriz, J. L.; Gonzalez, P.; Duran, M. C.; Molpeceres, V.; Culebras, J. M.; Gonzalez-Gallego, J. Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism. Transl. Res. 2007, 149, 46-53.
    • (2007) Transl. Res , vol.149 , pp. 46-53
    • Mauriz, J.L.1    Gonzalez, P.2    Duran, M.C.3    Molpeceres, V.4    Culebras, J.M.5    Gonzalez-Gallego, J.6
  • 100
    • 0027276747 scopus 로고
    • Angiogenesis inhibitors of microbial origin
    • Terano, H.; Shibata, T.; Otsuka, T. Angiogenesis inhibitors of microbial origin. Drug Future 1993, 18, 239.
    • (1993) Drug Future , vol.18 , pp. 239
    • Terano, H.1    Shibata, T.2    Otsuka, T.3
  • 101
    • 71649103286 scopus 로고    scopus 로고
    • Anti-angiogenic therapy on hepatocellular carcinoma development and progression
    • Ishii, Y.; Sakamoto, T.; Ito, R.; Yanaga, K. Anti-angiogenic therapy on hepatocellular carcinoma development and progression. J. Surg. Res. 2010, 158, 69-76.
    • (2010) J. Surg. Res , vol.158 , pp. 69-76
    • Ishii, Y.1    Sakamoto, T.2    Ito, R.3    Yanaga, K.4
  • 103
    • 37649022050 scopus 로고    scopus 로고
    • Antitumor and antiangiogenic activities of anti-vascular endothelial growth factor hairpin ribozyme in human hepatocellular carcinoma cell cultures and xenografts
    • Li, L. H.; Guo, Z. J.; Yan, L. L.; Yang, J. C.; Xie, Y. F.; Sheng, W. H.; Huang, Z. H.; Wang XH. Antitumor and antiangiogenic activities of anti-vascular endothelial growth factor hairpin ribozyme in human hepatocellular carcinoma cell cultures and xenografts. World J. Gastroenterol. 2007, 13, 6425-6432.
    • (2007) World J. Gastroenterol , vol.13 , pp. 6425-6432
    • Li, L.H.1    Guo, Z.J.2    Yan, L.L.3    Yang, J.C.4    Xie, Y.F.5    Sheng, W.H.6    Huang, Z.H.7    Wang, X.H.8
  • 104
    • 84862751803 scopus 로고    scopus 로고
    • A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts
    • Wang, L.; Park, H.; Chhim, S.; Ding, Y.; Jiang, W.; Queen, C.; Kim, K. J. A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts. Mol. Cancer Ther. 2012, 11, 864-872.
    • (2012) Mol. Cancer Ther , vol.11 , pp. 864-872
    • Wang, L.1    Park, H.2    Chhim, S.3    Ding, Y.4    Jiang, W.5    Queen, C.6    Kim, K.J.7
  • 105
    • 77950263970 scopus 로고    scopus 로고
    • Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptorimmunoglobulin fusion protein
    • Zhang, D.; Li, B.; Shi, J.; Zhao, L.; Zhang, X.; Wang, C.; Hou, S.; Qian, W.; Kou, G.; Wang, H.; Guo, Y. Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptorimmunoglobulin fusion protein. Cancer Res. 2010, 70, 2495-2503.
    • (2010) Cancer Res , vol.70 , pp. 2495-2503
    • Zhang, D.1    Li, B.2    Shi, J.3    Zhao, L.4    Zhang, X.5    Wang, C.6    Hou, S.7    Qian, W.8    Kou, G.9    Wang, H.10    Guo, Y.11
  • 106
    • 0037704549 scopus 로고    scopus 로고
    • Mechanism of interferon alpha on inhibition of metastasis and angiogenesis of hepatocellular carcinoma after curative resection in nude mice
    • Wang, L.; Wu, W. Z.; Sun, H. C.; Wu, X. F.; Qin, L. X.; Liu, Y. K.; Liu, K. D.; Tang, Z. Y. Mechanism of interferon alpha on inhibition of metastasis and angiogenesis of hepatocellular carcinoma after curative resection in nude mice. J. Gastrointest. Surg. 2003, 7, 587-594.
    • (2003) J. Gastrointest. Surg , vol.7 , pp. 587-594
    • Wang, L.1    Wu, W.Z.2    Sun, H.C.3    Wu, X.F.4    Qin, L.X.5    Liu, Y.K.6    Liu, K.D.7    Tang, Z.Y.8
  • 108
    • 9144260053 scopus 로고    scopus 로고
    • IL-12 gene therapy is an effective therapeutic strategy for hepatocellular carcinoma in immunosuppressed mice
    • Harada, N.; Shimada, M.; Okano, S.; Suehiro, T.; Soejima, Y.; Tomita, Y.; Maehara, Y. IL-12 gene therapy is an effective therapeutic strategy for hepatocellular carcinoma in immunosuppressed mice. J. Immunol. 2004, 173, 6635-6644.
    • (2004) J. Immunol , vol.173 , pp. 6635-6644
    • Harada, N.1    Shimada, M.2    Okano, S.3    Suehiro, T.4    Soejima, Y.5    Tomita, Y.6    Maehara, Y.7
  • 110
    • 77953195599 scopus 로고    scopus 로고
    • Interleukin-17F suppresses hepatocarcinoma cell growth via inhibition of tumor angiogenesis
    • Xie, Y.; Sheng, W.; Xiang, J.; Ye, Z.; Yang, J. Interleukin-17F suppresses hepatocarcinoma cell growth via inhibition of tumor angiogenesis. Cancer Invest. 2010, 28, 598-607.
    • (2010) Cancer Invest , vol.28 , pp. 598-607
    • Xie, Y.1    Sheng, W.2    Xiang, J.3    Ye, Z.4    Yang, J.5
  • 112
    • 34247881993 scopus 로고    scopus 로고
    • Adenovirusmediated Il-24 expression suppresses hepatocellular carcinoma growth via induction of cell apoptosis and cycling arrest and reduction of angiogenesis
    • Wang, X.; Ye, Z.; Zhong, J.; Xiang, J.; Yang J. Adenovirusmediated Il-24 expression suppresses hepatocellular carcinoma growth via induction of cell apoptosis and cycling arrest and reduction of angiogenesis. Cancer Biother. Radiopharm. 2007, 22, 56-63.
    • (2007) Cancer Biother. Radiopharm , vol.22 , pp. 56-63
    • Wang, X.1    Ye, Z.2    Zhong, J.3    Xiang, J.4    Yang, J.5
  • 114
    • 0344443651 scopus 로고    scopus 로고
    • Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    • Sanchez, T.; Estrada-Hernandez, T.; Paik, J. H.; Wu, M. T.; Venkataraman, K.; Brinkmann, V.; Claffey, K.; Hla, T. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J. Biol. Chem. 2003, 278, 47281-47290.
    • (2003) J. Biol. Chem , vol.278 , pp. 47281-47290
    • Sanchez, T.1    Estrada-Hernandez, T.2    Paik, J.H.3    Wu, M.T.4    Venkataraman, K.5    Brinkmann, V.6    Claffey, K.7    Hla, T.8
  • 115
    • 33644697587 scopus 로고    scopus 로고
    • Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma
    • Ho, J. W.; Man, K.; Sun, C. K.; Lee, T. K.; Poon, R. T.; Fan, S. T. Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Mol. Cancer Ther. 2005, 4, 1430-1438.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1430-1438
    • Ho, J.W.1    Man, K.2    Sun, C.K.3    Lee, T.K.4    Poon, R.T.5    Fan, S.T.6
  • 118
    • 0041409832 scopus 로고    scopus 로고
    • Effect of octreotide on angiogenesis induced by hepatocellular carcinoma in vivo
    • Jia, W. D.; Xu, G. L.; Sun, H. C.; Wang, L.; Xu, R. N.; Xue, Q. Effect of octreotide on angiogenesis induced by hepatocellular carcinoma in vivo. Hepatobiliary Pancreat. Dis. Int. 2003, 2, 404-409.
    • (2003) Hepatobiliary Pancreat. Dis. Int , vol.2 , pp. 404-409
    • Jia, W.D.1    Xu, G.L.2    Sun, H.C.3    Wang, L.4    Xu, R.N.5    Xue, Q.6
  • 119
    • 10744230216 scopus 로고    scopus 로고
    • Octreotide acts as an antitumor angiogenesis compound and suppresses tumor growth in nude mice bearing human hepatocellular carcinoma xenografts
    • Jia, W. D.; Xu, G. L.; Xu, R. N.; Sun, H. C.; Wang, L.; Yu, J. H.; Wang, J.; Li, J. S.; Zhai, Z. M.; Xue, Q. Octreotide acts as an antitumor angiogenesis compound and suppresses tumor growth in nude mice bearing human hepatocellular carcinoma xenografts. J. Cancer Res. Clin. Oncol. 2003, 129, 327-334.
    • (2003) J. Cancer Res. Clin. Oncol , vol.129 , pp. 327-334
    • Jia, W.D.1    Xu, G.L.2    Xu, R.N.3    Sun, H.C.4    Wang, L.5    Yu, J.H.6    Wang, J.7    Li, J.S.8    Zhai, Z.M.9    Xue, Q.10
  • 120
  • 121
    • 84857357820 scopus 로고    scopus 로고
    • Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma
    • Huynh, H.; Chow, P. K.; Tai, W. M.; Choo, S. P.; Chung, A. Y.; Ong, H. S.; Soo, K. C.; Ong, R.; Linnartz, R.; Shi, M. M. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J. Hepatol. 2012, 56, 595-601.
    • (2012) J. Hepatol , vol.56 , pp. 595-601
    • Huynh, H.1    Chow, P.K.2    Tai, W.M.3    Choo, S.P.4    Chung, A.Y.5    Ong, H.S.6    Soo, K.C.7    Ong, R.8    Linnartz, R.9    Shi, M.M.10
  • 122
    • 84861535274 scopus 로고    scopus 로고
    • Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
    • Huynh, H.; Ong, R.; Soo, K. C. Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma. Angiogenesis 2012, 15, 59-70.
    • (2012) Angiogenesis , vol.15 , pp. 59-70
    • Huynh, H.1    Ong, R.2    Soo, K.C.3
  • 123
    • 18144401256 scopus 로고    scopus 로고
    • Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
    • Liu, Y.; Poon, R. T.; Li, Q.; Kok, T. W.; Lau, C.; Fan, S. T. Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res. 2005, 65, 3691-3699.
    • (2005) Cancer Res , vol.65 , pp. 3691-3699
    • Liu, Y.1    Poon, R.T.2    Li, Q.3    Kok, T.W.4    Lau, C.5    Fan, S.T.6
  • 125
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu, L.; Cao, Y.; Chen, C.; Zhang, X.; McNabola, A.; Wilkie, D.; Wilhelm, S.; Lynch, M.; Carter, C. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006, 66, 11851-11858.
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 126
    • 52649085241 scopus 로고    scopus 로고
    • Effect of rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma
    • Wang, Z.; Zhou, J.; Fan, J.; Qiu, S. J.; Yu, Y.; Huang, X. W.; Tang, Z. Y. Effect of rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma. Clin. Cancer Res. 2008, 14, 5124-5130.
    • (2008) Clin. Cancer Res , vol.14 , pp. 5124-5130
    • Wang, Z.1    Zhou, J.2    Fan, J.3    Qiu, S.J.4    Yu, Y.5    Huang, X.W.6    Tang, Z.Y.7
  • 127
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre, S.; Demetri, G.; Sargent, W.; Raymond, E. Molecular basis for sunitinib efficacy and future clinical development. Nat. Rev. Drug Discov. 2007, 6, 734-745.
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 130
    • 32844454531 scopus 로고    scopus 로고
    • Wnt/Frizzled signaling in hepatocellular carcinoma
    • Lee, H. C.; Kim, M.; Wands, J.R. Wnt/Frizzled signaling in hepatocellular carcinoma. Front. Biosci. 2006, 11, 1901-1915.
    • (2006) Front. Biosci , vol.11 , pp. 1901-1915
    • Lee, H.C.1    Kim, M.2    Wands, J.R.3
  • 131
    • 79952043062 scopus 로고    scopus 로고
    • Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad
    • Nejak-Bowen, K. N.; Monga, S. P. Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin. Cancer Biol. 2011, 21, 44-58.
    • (2011) Semin. Cancer Biol , vol.21 , pp. 44-58
    • Nejak-Bowen, K.N.1    Monga, S.P.2
  • 133
    • 76049087581 scopus 로고    scopus 로고
    • Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling
    • Man, K.; Ng, K. T.; Xu, A.; Cheng, Q.; Lo, C. M.; Xiao, J. W.; Sun, B. S.; Lim, Z. X.; Cheung, J. S.; Wu, E. X.; Sun, C. K.; Poon, R. T.; Fan, S. T. Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling. Clin. Cancer Res. 2010, 16, 967-977.
    • (2010) Clin. Cancer Res , vol.16 , pp. 967-977
    • Man, K.1    Ng, K.T.2    Xu, A.3    Cheng, Q.4    Lo, C.M.5    Xiao, J.W.6    Sun, B.S.7    Lim, Z.X.8    Cheung, J.S.9    Wu, E.X.10    Sun, C.K.11    Poon, R.T.12    Fan, S.T.13
  • 134
    • 33745936962 scopus 로고    scopus 로고
    • Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice
    • Liu, B.; Pan, S.; Dong, X.; Qiao, H.; Jiang, H.; Krissansen, G. W.; Sun X. Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice. Cancer Sci. 2006, 97, 675-681.
    • (2006) Cancer Sci , vol.97 , pp. 675-681
    • Liu, B.1    Pan, S.2    Dong, X.3    Qiao, H.4    Jiang, H.5    Krissansen, G.W.6    Sun, X.7
  • 135
    • 84862777172 scopus 로고    scopus 로고
    • Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition
    • Yu, S. J.; Yoon, J. H.; Yang, J. I., Cho, E. J.; Kwak, M. S.; Jang, E. S.; Lee, J. H.; Kim, Y. J.; Lee, H. S.; Kim, C. Y. Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition. J. Bioenerg. Biomembr. 2012, 44, 101-115.
    • (2012) J. Bioenerg. Biomembr , vol.44 , pp. 101-115
    • Yu, S.J.1    Yoon, J.H.2    Yang, J.I.3    Cho, E.J.4    Kwak, M.S.5    Jang, E.S.6    Lee, J.H.7    Kim, Y.J.8    Lee, H.S.9    Kim, C.Y.10
  • 136
    • 0027251836 scopus 로고
    • A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
    • Davies, B.; Brown, P. D.; East, N.; Crimmin, M. J.; Balkwill, F. R. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 1993, 53, 2087-2091.
    • (1993) Cancer Res , vol.53 , pp. 2087-2091
    • Davies, B.1    Brown, P.D.2    East, N.3    Crimmin, M.J.4    Balkwill, F.R.5
  • 137
    • 0031669587 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20
    • Bu, W.; Tang, Z. Y.; Sun, F. X.; Ye, S. L.; Liu, K. D.; Xue, Q.; Chen, J.; Gao, D. M. Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20. Hepatogastroenterology 1998, 45, 1056-1061.
    • (1998) Hepatogastroenterology , vol.45 , pp. 1056-1061
    • Bu, W.1    Tang, Z.Y.2    Sun, F.X.3    Ye, S.L.4    Liu, K.D.5    Xue, Q.6    Chen, J.7    Gao, D.M.8
  • 138
    • 0038047688 scopus 로고    scopus 로고
    • Italian BCAA Study Group. Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: A double-blind, randomized trial
    • Marchesini, G.; Bianchi, G.; Merli, M.; Amodio, P.; Panella, C.; Loguercio, C.; Rossi Fanelli, F.; Abbiati, R.; Italian BCAA Study Group. Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial. Gastroenterology 2003, 124, 1792-1801.
    • (2003) Gastroenterology , vol.124 , pp. 1792-1801
    • Marchesini, G.1    Bianchi, G.2    Merli, M.3    Amodio, P.4    Panella, C.5    Loguercio, C.6    Rossi Fanelli, F.7    Abbiati, R.8
  • 141
    • 77953324172 scopus 로고    scopus 로고
    • Attenuation of insulin-resistance-based hepatocarcinogenesis and angiogenesis by combined treatment with branched-chain amino acids and angiotensin-converting enzyme inhibitor in obese diabetic rats
    • Yoshiji, H.; Noguchi, R.; Kaji, K.; Ikenaka, Y.; Shirai, Y.; Namisaki, T.; Kitade, M.; Tsujimoto, T.; Kawaratani, H.; Fukui, H. Attenuation of insulin-resistance-based hepatocarcinogenesis and angiogenesis by combined treatment with branched-chain amino acids and angiotensin-converting enzyme inhibitor in obese diabetic rats. J. Gastroenterol. 2010, 45, 443-450.
    • (2010) J. Gastroenterol , vol.45 , pp. 443-450
    • Yoshiji, H.1    Noguchi, R.2    Kaji, K.3    Ikenaka, Y.4    Shirai, Y.5    Namisaki, T.6    Kitade, M.7    Tsujimoto, T.8    Kawaratani, H.9    Fukui, H.10
  • 142
    • 0030759740 scopus 로고    scopus 로고
    • Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis
    • Pines, M.; Knopov, V.; Genina, O.; Lavelin, I.; Nagler, A. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis. J. Hepatol. 1997, 27, 391-398.
    • (1997) J. Hepatol , vol.27 , pp. 391-398
    • Pines, M.1    Knopov, V.2    Genina, O.3    Lavelin, I.4    Nagler, A.5
  • 143
    • 0035142629 scopus 로고    scopus 로고
    • Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats
    • Bruck, R.; Genina, O.; Aeed, H.; Alexiev, R.; Nagler, A.; Avni, Y.; Pines, M. Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatology 2001, 33, 379-386.
    • (2001) Hepatology , vol.33 , pp. 379-386
    • Bruck, R.1    Genina, O.2    Aeed, H.3    Alexiev, R.4    Nagler, A.5    Avni, Y.6    Pines, M.7
  • 144
    • 33646414772 scopus 로고    scopus 로고
    • Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition
    • Taras, D.; Blanc, J. F.; Rullier, A.; Dugot-Senant, N.; Laurendeau, I.; Bièche, I.; Pines, M.; Rosenbaum J. Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. Neoplasia 2006, 8, 312-318.
    • (2006) Neoplasia , vol.8 , pp. 312-318
    • Taras, D.1    Blanc, J.F.2    Rullier, A.3    Dugot-Senant, N.4    Laurendeau, I.5    Bièche, I.6    Pines, M.7    Rosenbaum, J.8
  • 146
    • 0042206622 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and angiogenesis-dependent tumor growth by the cryptic kringle fragments of human apolipoprotein(a)
    • Kim, J. S.; Chang, J. H.; Yu, H. K.; Ahn, J. H.; Yum, J. S.; Lee, S. K.; Jung, K. H.; Park, D. H.; Yoon, Y.; Byun, S. M.; Chung S. I. Inhibition of angiogenesis and angiogenesis-dependent tumor growth by the cryptic kringle fragments of human apolipoprotein(a). J. Biol. Chem. 2003, 278, 29000-29008.
    • (2003) J. Biol. Chem , vol.278 , pp. 29000-29008
    • Kim, J.S.1    Chang, J.H.2    Yu, H.K.3    Ahn, J.H.4    Yum, J.S.5    Lee, S.K.6    Jung, K.H.7    Park, D.H.8    Yoon, Y.9    Byun, S.M.10    Chung, S.I.11
  • 147
    • 4944230455 scopus 로고    scopus 로고
    • Suppression of colorectal cancer liver metastasis and extension of survival by expression of apolipoprotein(a) kringles
    • Yu, H. K.; Kim, J. S.; Lee, H. J.; Ahn, J. H.; Lee, S. K.; Hong, S. W.; Yoon, Y. Suppression of colorectal cancer liver metastasis and extension of survival by expression of apolipoprotein(a) kringles. Cancer Res. 2004, 64, 7092-7098.
    • (2004) Cancer Res , vol.64 , pp. 7092-7098
    • Yu, H.K.1    Kim, J.S.2    Lee, H.J.3    Ahn, J.H.4    Lee, S.K.5    Hong, S.W.6    Yoon, Y.7
  • 148
    • 33646578180 scopus 로고    scopus 로고
    • Adenoassociated virus-mediated expression of apolipoprotein (a) kringles suppresses hepatocellular carcinoma growth in mice
    • Lee, K.; Yun, S. T.; Kim, Y. G.; Yoon, Y.; Jo, E. C. Adenoassociated virus-mediated expression of apolipoprotein (a) kringles suppresses hepatocellular carcinoma growth in mice. Hepatology 2006, 43, 1063-1073.
    • (2006) Hepatology , vol.43 , pp. 1063-1073
    • Lee, K.1    Yun, S.T.2    Kim, Y.G.3    Yoon, Y.4    Jo, E.C.5
  • 149
    • 0032910586 scopus 로고    scopus 로고
    • Effect of antiangiogenic agents on experimental animal models of hepatocarcinoma
    • Qin, L. X.; Tang, Z. Y.; Li, X. M.; Bu, W.; Xia, J. L. Effect of antiangiogenic agents on experimental animal models of hepatocarcinoma. Ann. Acad. Med. Singapore 1999, 28, 147-151.
    • (1999) Ann. Acad. Med. Singapore , vol.28 , pp. 147-151
    • Qin, L.X.1    Tang, Z.Y.2    Li, X.M.3    Bu, W.4    Xia, J.L.5
  • 151
    • 12344321483 scopus 로고    scopus 로고
    • Effects of thalidomide on angiogenesis and tumor growth and metastasis of human hepatocellular carcinoma in nude mice
    • Zhang, Z. L.; Liu, Z. S.; Sun, Q. Effects of thalidomide on angiogenesis and tumor growth and metastasis of human hepatocellular carcinoma in nude mice. World J. Gastroenterol. 2005, 11, 216-220.
    • (2005) World J. Gastroenterol , vol.11 , pp. 216-220
    • Zhang, Z.L.1    Liu, Z.S.2    Sun, Q.3
  • 153
    • 0020000982 scopus 로고
    • Role of prostaglandin E1 and copper in angiogenesis
    • Ziche, M.; Jones, J.; Gullino, P. M. Role of prostaglandin E1 and copper in angiogenesis. J. Natl. Cancer Inst. 1982, 69, 475-482.
    • (1982) J. Natl. Cancer Inst , vol.69 , pp. 475-482
    • Ziche, M.1    Jones, J.2    Gullino, P.M.3
  • 157
    • 0037058676 scopus 로고    scopus 로고
    • The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production
    • Moriguchi, M.; Nakajima, T.; Kimura, H.; Watanabe, T.; Takashima, H.; Mitsumoto, Y.; Katagishi, T.; Okanoue, T.; Kagawa, K. The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production. Int. J. Cancer 2002, 102, 445-452.
    • (2002) Int. J. Cancer , vol.102 , pp. 445-452
    • Moriguchi, M.1    Nakajima, T.2    Kimura, H.3    Watanabe, T.4    Takashima, H.5    Mitsumoto, Y.6    Katagishi, T.7    Okanoue, T.8    Kagawa, K.9
  • 158
    • 0037446897 scopus 로고    scopus 로고
    • Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    • Sudhakar, A.; Sugimoto, H.; Yang, C.; Lively, J.; Zeisberg, M.; Kalluri, R. Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc. Natl. Acad. Sci. USA 2003, 100, 4766-4771.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4766-4771
    • Sudhakar, A.1    Sugimoto, H.2    Yang, C.3    Lively, J.4    Zeisberg, M.5    Kalluri, R.6
  • 160
    • 77950462129 scopus 로고    scopus 로고
    • Chemopreventive effect of bacoside A on N-nitrosodiethylamineinduced hepatocarcinogenesis in rats
    • Janani, P.; Sivakumari, K.; Geetha, A.; Ravisankar, B.; Parthasarathy, C. Chemopreventive effect of bacoside A on N-nitrosodiethylamineinduced hepatocarcinogenesis in rats. J. Cancer Res. Clin. Oncol. 2010, 136, 759-770.
    • (2010) J. Cancer Res. Clin. Oncol , vol.136 , pp. 759-770
    • Janani, P.1    Sivakumari, K.2    Geetha, A.3    Ravisankar, B.4    Parthasarathy, C.5
  • 161
    • 77249140494 scopus 로고    scopus 로고
    • Bacoside A downregulates matrix metalloproteinases 2 and 9 in DENA-induced hepatocellular carcinoma
    • Janani, P.; Sivakumari, K.; Geetha, A.; Ravisankar, B.; Parthasarathy, C. Bacoside A downregulates matrix metalloproteinases 2 and 9 in DENA-induced hepatocellular carcinoma. Cell Biochem. Funct. 2010, 28, 164-169.
    • (2010) Cell Biochem. Funct , vol.28 , pp. 164-169
    • Janani, P.1    Sivakumari, K.2    Geetha, A.3    Ravisankar, B.4    Parthasarathy, C.5
  • 163
    • 75149149835 scopus 로고    scopus 로고
    • Chitosan nanoparticles inhibit the growth of human hepatocellular carcinoma xenografts through an antiangiogenic mechanism
    • Xu, Y.; Wen, Z.; Xu, Z. Chitosan nanoparticles inhibit the growth of human hepatocellular carcinoma xenografts through an antiangiogenic mechanism. Anticancer Res. 2010, 30, 5103-5110.
    • (2010) Anticancer Res , vol.30 , pp. 5103-5110
    • Xu, Y.1    Wen, Z.2    Xu, Z.3
  • 165
    • 33644797877 scopus 로고    scopus 로고
    • Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice
    • Yoysungnoen, P.; Wirachwong, P.; Bhattarakosol, P.; Niimi, H.; Patumraj, S.; Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. Clin. Hemorheol. Microcirc. 2006, 34, 109-115.
    • (2006) Clin. Hemorheol. Microcirc , vol.34 , pp. 109-115
    • Yoysungnoen, P.1    Wirachwong, P.2    Bhattarakosol, P.3    Niimi, H.4    Patumraj, S.5
  • 166
    • 44849122833 scopus 로고    scopus 로고
    • Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice
    • Yoysungnoen, P.; Wirachwong, P.; Changtam, C.; Suksamrarn, A.; Patumraj S. Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. World J. Gasterenterol. 2008, 14, 2003-2009.
    • (2008) World J. Gasterenterol , vol.14 , pp. 2003-2009
    • Yoysungnoen, P.1    Wirachwong, P.2    Changtam, C.3    Suksamrarn, A.4    Patumraj, S.5
  • 167
    • 70349585440 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis
    • Shirakami, Y.; Shimizu, M.; Adachi, S.; Sakai, H.; Nakagawa, T.; Yasuda, Y.; Tsurumi, H.; Hara, Y.; Moriwaki, H. (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis. Cancer Sci. 2009, 10, 1957-1962.
    • (2009) Cancer Sci , vol.10 , pp. 1957-1962
    • Shirakami, Y.1    Shimizu, M.2    Adachi, S.3    Sakai, H.4    Nakagawa, T.5    Yasuda, Y.6    Tsurumi, H.7    Hara, Y.8    Moriwaki, H.9
  • 168
    • 24944575266 scopus 로고    scopus 로고
    • Comparative evaluation of the chemopreventive efficacy of green and black tea polyphenols in the hamster buccal pouch carcinogenesis model
    • Chandra Mohan, K. V.; Hara, Y.; Abraham, S. K.; Nagini, S. Comparative evaluation of the chemopreventive efficacy of green and black tea polyphenols in the hamster buccal pouch carcinogenesis model. Clin. Biochem. 2005, 38, 879-886.
    • (2005) Clin. Biochem , vol.38 , pp. 879-886
    • Chandra Mohan, K.V.1    Hara, Y.2    Abraham, S.K.3    Nagini, S.4
  • 169
    • 67650886038 scopus 로고    scopus 로고
    • Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model
    • Murugan, R. S.; Vinothini, G.; Hara, Y.; Nagini S. Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model. Anticancer Res. 2009, 29, 2301-2305.
    • (2009) Anticancer Res , vol.29 , pp. 2301-2305
    • Murugan, R.S.1    Vinothini, G.2    Hara, Y.3    Nagini, S.4
  • 170
    • 31344441221 scopus 로고    scopus 로고
    • Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis
    • Gu, Y.; Zhu, C.; Iwamoto, H.; Chen, J. S.; Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. World J. Gasteroenterol. 2005, 11, 6512-5517.
    • (2005) World J. Gasteroenterol , vol.11 , pp. 5517-6512
    • Gu, Y.1    Zhu, C.2    Iwamoto, H.3    Chen, J.S.4
  • 171
    • 78650582952 scopus 로고    scopus 로고
    • Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: Role of Akt and nuclear factor-κB
    • Ma, Y.; Wang, J.; Liu, L.; Zhu, H.; Chen, X.; Pan, S.; Sun, X.; Jiang, H. Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-κB. Cancer Lett. 2011, 301, 75-84.
    • (2011) Cancer Lett , vol.301 , pp. 75-84
    • Ma, Y.1    Wang, J.2    Liu, L.3    Zhu, H.4    Chen, X.5    Pan, S.6    Sun, X.7    Jiang, H.8
  • 172
  • 173
    • 67349224725 scopus 로고    scopus 로고
    • Morin regulates the expression of NF-B-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma
    • Sivaramakrishnan, V.; Devaraj, S. N. Morin regulates the expression of NF-B-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem.-Biol. Interact. 2009, 180, 353-359.
    • (2009) Chem.-Biol. Interact , vol.180 , pp. 353-359
    • Sivaramakrishnan, V.1    Devaraj, S.N.2
  • 175
    • 62549154478 scopus 로고    scopus 로고
    • Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: Inhibition of cell proliferation and induction of apoptosis
    • Bishayee, A.; Dhir, N. Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis. Chem. Biol. Interact. 2009, 10, 131-144.
    • (2009) Chem. Biol. Interact , vol.10 , pp. 131-144
    • Bishayee, A.1    Dhir, N.2
  • 176
    • 77953229913 scopus 로고    scopus 로고
    • Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis
    • Bishayee, A.; Barnes, K. F.; Bhatia, D.; Darvesh, A. S.; Carroll, R.T. Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. Cancer Prev. Res. 2010, 3, 753-763.
    • (2010) Cancer Prev. Res , vol.3 , pp. 753-763
    • Bishayee, A.1    Barnes, K.F.2    Bhatia, D.3    Darvesh, A.S.4    Carroll, R.T.5
  • 177
    • 77953231047 scopus 로고    scopus 로고
    • Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis
    • Bishayee, A.; Waghray, A.; Barnes, K. F.; Mbimba T.; Bhatia D.; Chatterjee, M.; Darvesh, A. S. Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis. Pharm. Res. 2010, 27, 1080-1091.
    • (2010) Pharm. Res , vol.27 , pp. 1080-1091
    • Bishayee, A.1    Waghray, A.2    Barnes, K.F.3    Mbimba, T.4    Bhatia, D.5    Chatterjee, M.6    Darvesh, A.S.7
  • 178
    • 79251543646 scopus 로고    scopus 로고
    • Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-B-mediated mechanism
    • Yu, H. B.; Zhang, H. F.; Zhang, X.; Li, D. Y.; Xue, H.Z.; Pan, C. E.; Zhao, S. H. Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-B-mediated mechanism. Hepato-Gastroenterology 2010, 57, 1241-1246.
    • (2010) Hepato-Gastroenterology , vol.57 , pp. 1241-1246
    • Yu, H.B.1    Zhang, H.F.2    Zhang, X.3    Li, D.Y.4    Xue, H.Z.5    Pan, C.E.6    Zhao, S.H.7
  • 179
    • 77951663321 scopus 로고    scopus 로고
    • Selenium in the prevention and treatment of hepatocellular carcinoma
    • Darvesh, A. S.; Bishayee, A. Selenium in the prevention and treatment of hepatocellular carcinoma. Anti-Cancer Agents Med. Chem. 2010, 10, 338-345.
    • (2010) Anti-Cancer Agents Med. Chem , vol.10 , pp. 338-345
    • Darvesh, A.S.1    Bishayee, A.2
  • 181
    • 33645419548 scopus 로고    scopus 로고
    • Effect of seleniumenriched malt on hepatocarcinogenesis, paraneoplastic syndrome and the hormones regulating blood glucose in rats treated by diethylnitrosamine
    • Liu, J. G.; Zhao, H. J.; Liu, Y. J.; Wang, X. L. Effect of seleniumenriched malt on hepatocarcinogenesis, paraneoplastic syndrome and the hormones regulating blood glucose in rats treated by diethylnitrosamine. Life Sci. 2006, 78, 2315-2321.
    • (2006) Life Sci , vol.78 , pp. 2315-2321
    • Liu, J.G.1    Zhao, H.J.2    Liu, Y.J.3    Wang, X.L.4
  • 182
    • 73449102474 scopus 로고    scopus 로고
    • Effect of seleniumenriched malt on VEGF and several relevant angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats
    • Liu, J. G.; Zhao, H. J.; Liu, Y.J.; Wang, X. L. Effect of seleniumenriched malt on VEGF and several relevant angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. J. Trace Elem. Med. Biol. 2010, 24, 52-57.
    • (2010) J. Trace Elem. Med. Biol , vol.24 , pp. 52-57
    • Liu, J.G.1    Zhao, H.J.2    Liu, Y.J.3    Wang, X.L.4
  • 183
    • 84868205248 scopus 로고    scopus 로고
    • Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats
    • in press. PMID: 22425635
    • Liu, J. G.; Zhao, H. J.; Liu, Y. J.; Liu, Y. W.; Wang, X. L. Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. J. Trace Elem. Med. Biol. 2012, in press. PMID: 22425635
    • (2012) J. Trace Elem. Med. Biol
    • Liu, J.G.1    Zhao, H.J.2    Liu, Y.J.3    Liu, Y.W.4    Wang, X.L.5
  • 184
    • 33646828371 scopus 로고    scopus 로고
    • Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats
    • Ramakrishnan, G.; Raghavendran, H. R.; Vinodhkumar, R.; Devaki, T. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem. Biol. Interact. 2006, 161, 104-114.
    • (2006) Chem. Biol. Interact , vol.161 , pp. 104-114
    • Ramakrishnan, G.1    Raghavendran, H.R.2    Vinodhkumar, R.3    Devaki, T.4
  • 186
    • 64649086559 scopus 로고    scopus 로고
    • Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis
    • Ramakrishnan, G.; Jagan, S.; Kamaraj, S.; Anandakumar, P.; Devaki, T. Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis. Invest. New Drugs 2009, 27, 233-240.
    • (2009) Invest. New Drugs , vol.27 , pp. 233-240
    • Ramakrishnan, G.1    Jagan, S.2    Kamaraj, S.3    Anandakumar, P.4    Devaki, T.5
  • 187
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta, L. G.; Chen, H.; O'Conner, S. J.; Chisholm, V.; Meng, Y. G.; Krummen, L.; Winkler, M.; Ferrara, N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997, 57, 4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Conner, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 191
    • 40349112983 scopus 로고    scopus 로고
    • Early antiangiogenic activity of bevacizumab evaluated by computed tomography perfusion scan in patients with advanced hepatocellular carcinoma
    • Zhu, A. X.; Holalkere, N. S.; Muzikansky, A.; Horgan, K.; Sahani, D. V. Early antiangiogenic activity of bevacizumab evaluated by computed tomography perfusion scan in patients with advanced hepatocellular carcinoma. Oncologist 2008, 13, 120-125.
    • (2008) Oncologist , vol.13 , pp. 120-125
    • Zhu, A.X.1    Holalkere, N.S.2    Muzikansky, A.3    Horgan, K.4    Sahani, D.V.5
  • 192
    • 60549098640 scopus 로고    scopus 로고
    • Sorafenib: A review of its use in advanced hepatocellular carcinoma
    • Keating, G. M.; Santoro, A. Sorafenib: a review of its use in advanced hepatocellular carcinoma. Drugs 2009, 69, 223-240.
    • (2009) Drugs , vol.69 , pp. 223-240
    • Keating, G.M.1    Santoro, A.2
  • 193
    • 34247857540 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: A review of four phase I trials in patients with advanced refractory solid tumors
    • Strumberg, D.; Clark, J. W.; Awada, A.; Moore, M. J.; Richly, H.; Hendlisz, A.; Hirte, A. W.; Eder, J. P.; Lenz, H. J.; Schwartz, B. Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors. Oncologist 2007, 12, 426-437.
    • (2007) Oncologist , vol.12 , pp. 426-437
    • Strumberg, D.1    Clark, J.W.2    Awada, A.3    Moore, M.J.4    Richly, H.5    Hendlisz, A.6    Hirte, A.W.7    Eder, J.P.8    Lenz, H.J.9    Schwartz, B.10
  • 197
    • 73349110120 scopus 로고    scopus 로고
    • Sunitinib in hepatocellular carcinoma: Redefining appropriate dosing, schedule, and activity end points
    • Faivre, S. J.; Bouattour, M.; Dreyer, C.; Raymond, E. Sunitinib in hepatocellular carcinoma: redefining appropriate dosing, schedule, and activity end points. J. Clin. Oncol. 2009, 27, 248-252.
    • (2009) J. Clin. Oncol , vol.27 , pp. 248-252
    • Faivre, S.J.1    Bouattour, M.2    Dreyer, C.3    Raymond, E.4
  • 199
    • 69549131042 scopus 로고    scopus 로고
    • Development of sunitinib in hepatocellular carcinoma: Rationale, early clinical experience, and correlative studies
    • Zhu, A. X.; Duda, D. G.; Sahani, D. V.; Jain, R. K. Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies. Cancer J. 2009, 5, 263-268.
    • (2009) Cancer J , vol.5 , pp. 263-268
    • Zhu, A.X.1    Duda, D.G.2    Sahani, D.V.3    Jain, R.K.4
  • 201
    • 0037099598 scopus 로고    scopus 로고
    • PTK787/ZK222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
    • Drevs, J.; Muller-Driver, R.; Wittig, C.; Fuxius, S.; Esser, N.; Hugenschmidt, H.; Konerding, M. A.; Allergrini, P. R.; Wood, J.; Hennig, J.; Unger, C.; Marme, D. PTK787/ZK222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. Cancer Res. 2002, 62, 4015-4022.
    • (2002) Cancer Res , vol.62 , pp. 4015-4022
    • Drevs, J.1    Muller-Driver, R.2    Wittig, C.3    Fuxius, S.4    Esser, N.5    Hugenschmidt, H.6    Konerding, M.A.7    Allergrini, P.R.8    Wood, J.9    Hennig, J.10    Unger, C.11    Marme, D.12
  • 202
    • 18144401256 scopus 로고    scopus 로고
    • Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
    • Liu, Y.; Poon, R. T.; Li, Q.; Kok, T. W.; Lau, C.; Fan, S. T. Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res. 2005, 65, 3691-3699.
    • (2005) Cancer Res , vol.65 , pp. 3691-3699
    • Liu, Y.1    Poon, R.T.2    Li, Q.3    Kok, T.W.4    Lau, C.5    Fan, S.T.6
  • 204
    • 39849106728 scopus 로고    scopus 로고
    • Influence of hepatic dysfunction on safety, tolerability, and pharmacokinetics (PK) of PTK787/ZK222584 in patients with unresectable hepatocellular carcinoma
    • Koch, I.; Baron, A.; Roberts, S.; Junker, U.; Palacay-Ramona, M.; Manson, E.; Kay, A.; Wiedenmann, B.; Laurent, D.; Cebon, J. Influence of hepatic dysfunction on safety, tolerability, and pharmacokinetics (PK) of PTK787/ZK222584 in patients with unresectable hepatocellular carcinoma. J. Clin. Oncol. 2005, 23, 4134.
    • (2005) J. Clin. Oncol , vol.23 , pp. 4134
    • Koch, I.1    Baron, A.2    Roberts, S.3    Junker, U.4    Palacay-Ramona, M.5    Manson, E.6    Kay, A.7    Wiedenmann, B.8    Laurent, D.9    Cebon, J.10
  • 205
    • 78249288161 scopus 로고    scopus 로고
    • Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma
    • Yau, T.; Chan, P.; Pang, R.; Ng, K.; Fan, S. T.; Poon, R. T. Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma. Cancer 2010, 116, 5022-5029.
    • (2010) Cancer , vol.116 , pp. 5022-5029
    • Yau, T.1    Chan, P.2    Pang, R.3    Ng, K.4    Fan, S.T.5    Poon, R.T.6
  • 207
    • 85027956130 scopus 로고    scopus 로고
    • Activity of thalidomide and capecitabine in patients with advanced hepatocellular carcinoma
    • Ang, S. F.; Tan, S. H.; Toh, H. C.; Poon, D. Y.; Ong, S. Y.; Foo, K. F.; Choo, S. P. Activity of thalidomide and capecitabine in patients with advanced hepatocellular carcinoma. Am. J. Clin. Oncol. 2012, 35, 222-227.
    • (2012) Am. J. Clin. Oncol , vol.35 , pp. 222-227
    • Ang, S.F.1    Tan, S.H.2    Toh, H.C.3    Poon, D.Y.4    Ong, S.Y.5    Foo, K.F.6    Choo, S.P.7
  • 209
    • 77958030144 scopus 로고    scopus 로고
    • Inhibitory effect of thalidomide on growth of human hepatoma cell line SMMC-7721 cells
    • Sun, P.; Zhang, L. M.; Sun, D. J.; Dong, L. L. Inhibitory effect of thalidomide on growth of human hepatoma cell line SMMC-7721 cells. Zhonghua Zhong Liu Za Zhi 2009, 31, 582-586.
    • (2009) Zhonghua Zhong Liu Za Zhi , vol.31 , pp. 582-586
    • Sun, P.1    Zhang, L.M.2    Sun, D.J.3    Dong, L.L.4
  • 211
    • 17644376932 scopus 로고    scopus 로고
    • Effect of thalidomide in hepatocellular carcinoma: Assessment with power Doppler US and analysis of circulating angiogenic factors
    • Hsu, C.; Chen, C. N.; Chen, L. T.; Wu, C. Y.; Hsieh, F. J.; Cheng, A. L. Effect of thalidomide in hepatocellular carcinoma: assessment with power Doppler US and analysis of circulating angiogenic factors. Radiology 2005, 235, 509-516.
    • (2005) Radiology , vol.235 , pp. 509-516
    • Hsu, C.1    Chen, C.N.2    Chen, L.T.3    Wu, C.Y.4    Hsieh, F.J.5    Cheng, A.L.6
  • 212
    • 10844248554 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma
    • Lin, A. Y.; Brophy, N.; Fisher, G. A.; So, S.; Biggs, C.; Yock, T. I.; Levitt, L. Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma. Cancer 2004, 119-125.
    • (2004) Cancer , pp. 119-125
    • Lin, A.Y.1    Brophy, N.2    Fisher, G.A.3    So, S.4    Biggs, C.5    Yock, T.I.6    Levitt, L.7
  • 214
    • 37149051789 scopus 로고    scopus 로고
    • Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma
    • Yau, T.; Chan, P.; Wong, H.; Ng, K. K.; Chok, S. H.; Cheung, T. T.; Lam, V.; Epstein, R. J.; Fan, S. T.; Poon, R. T. P. Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma. Oncology 2007, 72, 67-71.
    • (2007) Oncology , vol.72 , pp. 67-71
    • Yau, T.1    Chan, P.2    Wong, H.3    Ng, K.K.4    Chok, S.H.5    Cheung, T.T.6    Lam, V.7    Epstein, R.J.8    Fan, S.T.9    Poon, R.T.P.10
  • 216
    • 47549118684 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with tegafur/uracil administration after transcatheter arterial chemoembolization for advanced hepatocellular carcinoma
    • Ueda, H.; Tanaka, H.; Kida, Y.; Fukuchi, H.; Ichinose, M. Adjuvant chemotherapy with tegafur/uracil administration after transcatheter arterial chemoembolization for advanced hepatocellular carcinoma. Oncol. Reports 2008, 19, 1355-1361.
    • (2008) Oncol. Reports , vol.19 , pp. 1355-1361
    • Ueda, H.1    Tanaka, H.2    Kida, Y.3    Fukuchi, H.4    Ichinose, M.5
  • 217
    • 77957559384 scopus 로고    scopus 로고
    • Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma
    • Shao, Y. Y.; Lin, Z. Z.; Hsu, C.; Shen, C. Y.; Hsu, C.C.; Cheng, A. L. Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma. Cancer 2010, 116, 4590-4596.
    • (2010) Cancer , vol.116 , pp. 4590-4596
    • Shao, Y.Y.1    Lin, Z.Z.2    Hsu, C.3    Shen, C.Y.4    Hsu, C.C.5    Cheng, A.L.6
  • 219
    • 79955580873 scopus 로고    scopus 로고
    • HCC and angiogenesis: Possible targets and future directions
    • Zhu, A. X.; Duda, D. G.; Sahani, D. V.; Jain, R. K. HCC and angiogenesis: possible targets and future directions. Nature Revs. Clin. Oncol. 2011, 8, 292-302.
    • (2011) Nature Revs. Clin. Oncol , vol.8 , pp. 292-302
    • Zhu, A.X.1    Duda, D.G.2    Sahani, D.V.3    Jain, R.K.4
  • 220
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet, P.; Jain, R. K. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011, 473, 298-307.
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 221
    • 84855317068 scopus 로고    scopus 로고
    • Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer
    • Reuben, S. C.; Gopalan, A.; Petit, D. M.; Bishayee, A. Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer. Mol. Nutr. Food Res. 2012, 56, 14-29.
    • (2012) Mol. Nutr. Food Res , vol.56 , pp. 14-29
    • Reuben, S.C.1    Gopalan, A.2    Petit, D.M.3    Bishayee, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.