메뉴 건너뛰기




Volumn 27, Issue 2, 1997, Pages 391-398

Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis

Author keywords

Collagen; Fibrosis; Plant alkaloid

Indexed keywords

COLLAGEN TYPE 1; DIMETHYLNITROSAMINE; HALOFUGINONE;

EID: 0030759740     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80186-9     Document Type: Article
Times cited : (113)

References (44)
  • 1
    • 33746521801 scopus 로고
    • The cellular basis of hepatic fibrosis. Mechanism and treatment strategies
    • Friedman SL. The cellular basis of hepatic fibrosis. Mechanism and treatment strategies. N Engl J Med. 328:1993;1828-1835.
    • (1993) N Engl J Med , vol.328 , pp. 1828-1835
    • Friedman, S.L.1
  • 2
    • 0025359751 scopus 로고
    • Structure of the extracellular matrix in normal and fibrotic liver: Collagens and glycoproteins
    • Achuppan D. Structure of the extracellular matrix in normal and fibrotic liver: collagens and glycoproteins. Semin Liver Dis. 10:1990;1-10.
    • (1990) Semin Liver Dis , vol.10 , pp. 1-10
    • Achuppan, D.1
  • 3
    • 0024782938 scopus 로고
    • Collagen of normal and cirrhotic human liver
    • Aycock RS, Seyer JM. Collagen of normal and cirrhotic human liver. Connect Tissue Res. 23:1989;19-31.
    • (1989) Connect Tissue Res , vol.23 , pp. 19-31
    • Aycock, R.S.1    Seyer, J.M.2
  • 4
    • 0023945925 scopus 로고
    • Changes in albumin, alpha-fetoprotein and collagen gene transcription in CCl4-induced hepatic fibrosis
    • Panduro A, Shalaby F, Biempica L, Shafritz DA. Changes in albumin, alpha-fetoprotein and collagen gene transcription in CCl4-induced hepatic fibrosis. Hepatology. 8:1988;259-266.
    • (1988) Hepatology , vol.8 , pp. 259-266
    • Panduro, A.1    Shalaby, F.2    Biempica, L.3    Shafritz, D.A.4
  • 5
    • 0027252762 scopus 로고
    • Type I collagen gene regulation and molecular pathogenesis of cirrhosis
    • Brenner DA, Westwick J, Breindl M. Type I collagen gene regulation and molecular pathogenesis of cirrhosis. Am J Physiol. 264:1993;G589-G595.
    • (1993) Am J Physiol , vol.264
    • Brenner, D.A.1    Westwick, J.2    Breindl, M.3
  • 6
    • 0028181393 scopus 로고
    • Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?
    • Bedosa P, Houglum K, Trautwein C, Holstege A, Chojkier M. Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology. 19:1994;1262-1271.
    • (1994) Hepatology , vol.19 , pp. 1262-1271
    • Bedosa, P.1    Houglum, K.2    Trautwein, C.3    Holstege, A.4    Chojkier, M.5
  • 7
    • 0025128736 scopus 로고
    • Albumin and collagen gene regulation in alcohol- And virus-induced human liver disease
    • Annoni F, Weiner FR, Colombo M, Czaja MJ, Zern AM. Albumin and collagen gene regulation in alcohol- and virus-induced human liver disease. Gastroenterology. 98:1990;197-202.
    • (1990) Gastroenterology , vol.98 , pp. 197-202
    • Annoni, F.1    Weiner, F.R.2    Colombo, M.3    Czaja, M.J.4    Zern, A.M.5
  • 8
    • 0025855367 scopus 로고
    • Transforming growth factor β and α in chronic liver-disease-effects of interferon therapy
    • Castilia A, Prieto J, Fausto N. Transforming growth factor β and α in chronic liver-disease-effects of interferon therapy. N Engl J Med. 324:1991;933-940.
    • (1991) N Engl J Med , vol.324 , pp. 933-940
    • Castilia, A.1    Prieto, J.2    Fausto, N.3
  • 9
    • 0026527581 scopus 로고
    • Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells. A potential mechanism of self-perpetuation in liver fibrogenesis
    • Bachem MG, Meyer D, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells. A potential mechanism of self-perpetuation in liver fibrogenesis. J Clin Invest. 89:1992;19-27.
    • (1992) J Clin Invest , vol.89 , pp. 19-27
    • Bachem, M.G.1    Meyer, D.2    Melchior, R.3    Sell, K.M.4    Gressner, A.M.5
  • 10
    • 0025827178 scopus 로고
    • Immunohistochemical detection of transforming growth factor β1 in fibrotic liver disease
    • Nagy P, Schaff Z, Lapis K. Immunohistochemical detection of transforming growth factor β1 in fibrotic liver disease. Hepatology. 14:1991;269-273.
    • (1991) Hepatology , vol.14 , pp. 269-273
    • Nagy, P.1    Schaff, Z.2    Lapis, K.3
  • 11
    • 0030077118 scopus 로고    scopus 로고
    • A proposed sequence of reactions leading to collagen biosynthesis, fibrosis and hypertension in alcoholics
    • Brecher AS, Hinko A, Twining SS. A proposed sequence of reactions leading to collagen biosynthesis, fibrosis and hypertension in alcoholics. J Invest Med. 44:1996;36-41.
    • (1996) J Invest Med , vol.44 , pp. 36-41
    • Brecher, A.S.1    Hinko, A.2    Twining, S.S.3
  • 13
    • 0023196358 scopus 로고
    • Gene expression of type I, III, and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat
    • Ala-Kokko L, Pihlajaniemi T, Myers JC, Kivirikko KI, Savolainen E. Gene expression of type I, III, and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat. Biochem J. 244:1987;75-79.
    • (1987) Biochem J , vol.244 , pp. 75-79
    • Ala-Kokko, L.1    Pihlajaniemi, T.2    Myers, J.C.3    Kivirikko, K.I.4    Savolainen, E.5
  • 14
    • 0030045067 scopus 로고    scopus 로고
    • Molecular characteristics of dimethylnitrosamine-induced fibrotic liver collagen
    • George J, Chandrakasan G. Molecular characteristics of dimethylnitrosamine-induced fibrotic liver collagen. Biochim Biophys Acta. 1292:1996;215-222.
    • (1996) Biochim Biophys Acta , vol.1292 , pp. 215-222
    • George, J.1    Chandrakasan, G.2
  • 16
    • 0027177097 scopus 로고
    • Cellular and molecular aspects of hepatic fibrosis
    • Burt AD. Cellular and molecular aspects of hepatic fibrosis. J Pathol. 170:1993;105-114.
    • (1993) J Pathol , vol.170 , pp. 105-114
    • Burt, A.D.1
  • 18
    • 0029053707 scopus 로고
    • Perspectives in the treatment of liver fibrosis
    • Mavier P, Mallat A. Perspectives in the treatment of liver fibrosis. J Hepatol. 22:1995;111-115.
    • (1995) J Hepatol , vol.22 , pp. 111-115
    • Mavier, P.1    Mallat, A.2
  • 19
    • 0026199498 scopus 로고
    • Increased skin tearing in broilers and reduced collagen synthesis in skin in vivo and in vitro in response to the coccidiostat halofuginone
    • Granot I, Bartov I, Plavnik I, Wax E, Hurwitz S, Pines M. Increased skin tearing in broilers and reduced collagen synthesis in skin in vivo and in vitro in response to the coccidiostat halofuginone. Poult Sci. 70:1991;1559-1563.
    • (1991) Poult Sci , vol.70 , pp. 1559-1563
    • Granot, I.1    Bartov, I.2    Plavnik, I.3    Wax, E.4    Hurwitz, S.5    Pines, M.6
  • 20
    • 0030019449 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: Effect of halofuginone
    • Levi-Schaffer F, Nagler A, Slavin S, Knopov V, Pines M. Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone. J Invest Dermatol. 106:1996;84-88.
    • (1996) J Invest Dermatol , vol.106 , pp. 84-88
    • Levi-Schaffer, F.1    Nagler, A.2    Slavin, S.3    Knopov, V.4    Pines, M.5
  • 22
    • 0030498446 scopus 로고    scopus 로고
    • Topically applied halofuginone, an inhibitor of collagen type I transcription, reduced peritendinous fibrous adhesions following surgery
    • Nyska M, Nyska A, Rivlin E, Porat S, Pines M, Shoshan S, et al. Topically applied halofuginone, an inhibitor of collagen type I transcription, reduced peritendinous fibrous adhesions following surgery. Connect Tissue Res. 34:1996;97-103.
    • (1996) Connect Tissue Res , vol.34 , pp. 97-103
    • Nyska, M.1    Nyska, A.2    Rivlin, E.3    Porat, S.4    Pines, M.5    Shoshan, S.6
  • 23
  • 24
    • 0030580036 scopus 로고    scopus 로고
    • Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: Effect of halofuginone
    • Halevy O, Nagler A, Levi-Schaffer F, Genina O, Pines M. Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone. Biochem Pharmacol. 52:1996;1057-1063.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1057-1063
    • Halevy, O.1    Nagler, A.2    Levi-Schaffer, F.3    Genina, O.4    Pines, M.5
  • 25
    • 0028912774 scopus 로고
    • Halofuginone, a specific collagen type I inhibitor, reduces anastomotic intima hyperplasia
    • Choi ET, Callow AD, Sehgal NL, Brown DM, Ryan US. Halofuginone, a specific collagen type I inhibitor, reduces anastomotic intima hyperplasia. Arch Surg. 130:1995;257-261.
    • (1995) Arch Surg , vol.130 , pp. 257-261
    • Choi, E.T.1    Callow, A.D.2    Sehgal, N.L.3    Brown, D.M.4    Ryan, U.S.5
  • 26
    • 0029146465 scopus 로고
    • Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats
    • Matsuda Y, Matsumoto K, Ichida T, Nakamura T. Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. J Biochem. 118:1995;643-649.
    • (1995) J Biochem , vol.118 , pp. 643-649
    • Matsuda, Y.1    Matsumoto, K.2    Ichida, T.3    Nakamura, T.4
  • 27
    • 0000909782 scopus 로고
    • Spectrophotometric determination of ammonia: A study of a modified Berthelot reaction using salicylate and dichloroisocyanurate
    • Krom MD. Spectrophotometric determination of ammonia: a study of a modified Berthelot reaction using salicylate and dichloroisocyanurate. Analyst. 105:1980;305-316.
    • (1980) Analyst , vol.105 , pp. 305-316
    • Krom, M.D.1
  • 28
    • 0024590462 scopus 로고
    • Estimation of collagen content of liver specimens. Variation among animals and among hepatic lobes in cirrhotic rats
    • Gascon-Barre M, Huet PM, Belgiorno J, Plourde V, Coulombe PA. Estimation of collagen content of liver specimens. Variation among animals and among hepatic lobes in cirrhotic rats. J Histochem Cytochem. 37:1989;377-381.
    • (1989) J Histochem Cytochem , vol.37 , pp. 377-381
    • Gascon-Barre, M.1    Huet, P.M.2    Belgiorno, J.3    Plourde, V.4    Coulombe, P.A.5
  • 29
    • 0029586393 scopus 로고    scopus 로고
    • Involvement of osteopontin in egg shell formation in the laying chicken
    • Pines M, Knopov V, Bar A. Involvement of osteopontin in egg shell formation in the laying chicken. Matrix Biol. 14:1996;765-771.
    • (1996) Matrix Biol , vol.14 , pp. 765-771
    • Pines, M.1    Knopov, V.2    Bar, A.3
  • 30
    • 0023425909 scopus 로고
    • A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat
    • Jezequel AM, Mancini R, Tinaldesi R, Macarri ML, Venturini C, Orlandi F. A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat. J Hepatol. 5:1987;174-181.
    • (1987) J Hepatol , vol.5 , pp. 174-181
    • Jezequel, A.M.1    Mancini, R.2    Tinaldesi, R.3    Macarri, M.L.4    Venturini, C.5    Orlandi, F.6
  • 31
    • 0021967661 scopus 로고
    • Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol
    • Hamalainen L, Oikarinen J, Kivirikko KI. Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol. J Biol Chem. 260:1985;720-725.
    • (1985) J Biol Chem , vol.260 , pp. 720-725
    • Hamalainen, L.1    Oikarinen, J.2    Kivirikko, K.I.3
  • 32
    • 0023146672 scopus 로고
    • Transcriptional and posttranscriptional effects of dexamethasone on albumin and procollagen messenger RNAs in murine schistosomiasis
    • Weiner FR, Czaja MJ, Giambrone MA, Takahashi S, Biempica L, Zern MA. Transcriptional and posttranscriptional effects of dexamethasone on albumin and procollagen messenger RNAs in murine schistosomiasis. Biochemistry. 26:1987;1557-1562.
    • (1987) Biochemistry , vol.26 , pp. 1557-1562
    • Weiner, F.R.1    Czaja, M.J.2    Giambrone, M.A.3    Takahashi, S.4    Biempica, L.5    Zern, M.A.6
  • 33
    • 0029997830 scopus 로고    scopus 로고
    • Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis
    • Gressner AM. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int. 49:1996;S39-S45.
    • (1996) Kidney Int , vol.49
    • Gressner, A.M.1
  • 34
    • 0031028794 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis, smooth muscle cell proliferation and injury induced intimal hyperplasia by halofuginone
    • Negler A, Miao HQ, Eingorn H, Pines M, Genina O, Vlodavsky I, et al. Inhibition of collagen synthesis, smooth muscle cell proliferation and injury induced intimal hyperplasia by halofuginone. Artersioscler Thromb Vasc Biol. 17:1997;194-202.
    • (1997) Artersioscler Thromb Vasc Biol , vol.17 , pp. 194-202
    • Negler, A.1    Miao, H.Q.2    Eingorn, H.3    Pines, M.4    Genina, O.5    Vlodavsky, I.6
  • 35
    • 0026646772 scopus 로고
    • The transcriptional tissue specificity of the human proa1(I) collagen gene is determined by a negative cis-regulatory element in the promoter
    • Simkevich CP, Thompson JP, Poppleton H, Raghow R. The transcriptional tissue specificity of the human proa1(I) collagen gene is determined by a negative cis-regulatory element in the promoter. Biochem J. 286:1992;179-185.
    • (1992) Biochem J , vol.286 , pp. 179-185
    • Simkevich, C.P.1    Thompson, J.P.2    Poppleton, H.3    Raghow, R.4
  • 36
    • 0028279513 scopus 로고
    • Functional analysis of human a1(I) procollagen gene promoter: Differential activity in collagen-producing and non-producing cells and response to transforming growth factor β1
    • Jimenez S, Varga J, Olsen A, Li L, Diaz A, Herhal J, et al. Functional analysis of human a1(I) procollagen gene promoter: differential activity in collagen-producing and non-producing cells and response to transforming growth factor β1. J Biol Chem. 269:1994;12684-12691.
    • (1994) J Biol Chem , vol.269 , pp. 12684-12691
    • Jimenez, S.1    Varga, J.2    Olsen, A.3    Li, L.4    Diaz, A.5    Herhal, J.6
  • 37
    • 0021989344 scopus 로고
    • Fine structural analysis of the human pro-alpha 1(I) collagen gene
    • Chu M, DeWet W, Bernard M, Ramirez F. Fine structural analysis of the human pro-alpha 1(I) collagen gene. J Biol Chem. 260:1985;2315-2320.
    • (1985) J Biol Chem , vol.260 , pp. 2315-2320
    • Chu, M.1    Dewet, W.2    Bernard, M.3    Ramirez, F.4
  • 38
    • 0022975849 scopus 로고
    • Differential binding of a CCAAT DNA binding factor to the promoters of the mouse alpha 2(I) and alpha 1(III) collagen genes
    • Hatamochi A, Paterson B, de Crombrugghe B. Differential binding of a CCAAT DNA binding factor to the promoters of the mouse alpha 2(I) and alpha 1(III) collagen genes. J Biol Chem. 261:1986;11310-11314.
    • (1986) J Biol Chem , vol.261 , pp. 11310-11314
    • Hatamochi, A.1    Paterson, B.2    De Crombrugghe, B.3
  • 39
    • 0025312258 scopus 로고
    • Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes
    • Boast SM, Su W, Ramirez F, Sanchez M, Avvedimento EV. Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes. J Biol Chem. 265:1990;13351-13356.
    • (1990) J Biol Chem , vol.265 , pp. 13351-13356
    • Boast, S.M.1    Su, W.2    Ramirez, F.3    Sanchez, M.4    Avvedimento, E.V.5
  • 40
    • 0025288992 scopus 로고
    • Two different negative and one positive regulatory factors interact with a short promoter segment of the α1(I) collagen gene
    • Karsenty G, de Crombrugghe B. Two different negative and one positive regulatory factors interact with a short promoter segment of the α1(I) collagen gene. J Biol Chem. 265:1990;9934-9942.
    • (1990) J Biol Chem , vol.265 , pp. 9934-9942
    • Karsenty, G.1    De Crombrugghe, B.2
  • 41
    • 0024556820 scopus 로고
    • Regulatory elements in the 5′-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene
    • Rippe RA, Lorenzen S, Brenner DA, Breindel M. Regulatory elements in the 5′-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Mol Cell Biol. 9:1989;2224-2227.
    • (1989) Mol Cell Biol , vol.9 , pp. 2224-2227
    • Rippe, R.A.1    Lorenzen, S.2    Brenner, D.A.3    Breindel, M.4
  • 42
    • 0026530758 scopus 로고
    • Differential utilization of regulatory domains within the α1(I) collagen promoter in osseous and fibroblastic cells
    • Palvin D, Lichtler AC, Bedalov A, Kream BE, Harrison JR, Thomas HF, et al. Differential utilization of regulatory domains within the α1(I) collagen promoter in osseous and fibroblastic cells. J Cell Biol. 116:1992;227-236.
    • (1992) J Cell Biol , vol.116 , pp. 227-236
    • Palvin, D.1    Lichtler, A.C.2    Bedalov, A.3    Kream, B.E.4    Harrison, J.R.5    Thomas, H.F.6
  • 43
    • 0026721474 scopus 로고
    • Transcriptional mechanism of type I collagen gene expression are differentially regulated by interleukin-1 beta, tumor necrosis factor beta and transforming growth factor beta in Ito cells
    • Armendariz-Borunda J, Katayama K, Seyer JM. Transcriptional mechanism of type I collagen gene expression are differentially regulated by interleukin-1 beta, tumor necrosis factor beta and transforming growth factor beta in Ito cells. J Biol Chem. 267:1992;14316-14321.
    • (1992) J Biol Chem , vol.267 , pp. 14316-14321
    • Armendariz-Borunda, J.1    Katayama, K.2    Seyer, J.M.3
  • 44
    • 0028568426 scopus 로고
    • Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression
    • Armendariz-Borunda J, Simkevich CP, Roy N, Raghow R, Kang AH, Seyer JM. Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression. Biochem J. 304:1994;817-824.
    • (1994) Biochem J , vol.304 , pp. 817-824
    • Armendariz-Borunda, J.1    Simkevich, C.P.2    Roy, N.3    Raghow, R.4    Kang, A.H.5    Seyer, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.