Interleukin-17F suppresses hepatocarcinoma cell growth via inhibition of tumor angiogenesis

Cancer Investigation

Volumn 28, Issue 6, 2010, Pages 598-607

  Xie, Yufeng ^a   Sheng, Weihua ^a   Xiang, Jim ^b   Ye, Zhenmin ^b   Yang, Jicheng ^a  

^a SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Angiogenesis; Anti tumor effect; Hepatocarcinoma; Human interleukin 17F; Retroviral vector

Indexed keywords

INTERLEUKIN 17F; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; RETROVIRUS VECTOR; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIANGIOGENIC GENE THERAPY; ARTICLE; CANCER INHIBITION; CANCER SIZE; CANCER TISSUE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MICROVASCULATURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPERNATANT; TRANSGENE; TUMOR VASCULARIZATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-17; INTERLEUKIN-6; INTERLEUKIN-8; LIVER NEOPLASMS; MICE; MICE, NUDE; MICROVESSELS; NEOVASCULARIZATION, PATHOLOGIC; RNA, MESSENGER; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77953195599     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357900903287030     Document Type: Article

References (44)

1. Rouvier, E.; Luciani, M.F.; Mattei, M.G.; Denizot, F.; Golstein, P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol 1993, 150(12), 5445-5456.
2. Moseley, T.A.; Haudenschild, D.R.; Rose, L.; Reddi, A.H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 2003, 14(2), 155-174.
3. Starnes, T.; Robertson, M.J.; Sledge, G.; Kelich, S.; Nakshatri, H.; Broxmeyer, H.E.; Hromas R. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol 2001, 167(8), 4137-4140. (Pubitemid 32954284)
4. Kawaguchi, M.; Onuchic, L.F.; Li, X.D.; Essayan, D.M.; Schroeder, J.; Xiao, H.Q.; Liu, M.C.; Krishnaswamy, G.; Germino, G.; Huang, S.K. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J Immunol 2001, 167(8), 4430-4435.
5. Hymowitz, S.G.; Filvaroff, E.H.; Yin, J.P.; Lee, J.; Cai, L.; Risser, P.; Maruoka, M.; Mao, W.; Foster, J.; Kelley, R.F.; Pan, G.; Gurney, A.L.; de Vos, A.M.; Starovasnik, M.A. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 2001, 20(19), 5332-5341.
6. Kawaguchi, M.; Kokubu, F.; Odaka, M.; Watanabe, S.; Suzuki, S.; Ieki, K.; Matsukura, S.; Kurokawa, M.; Adachi, M.; Huang, S.K. Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway. J Allergy Clin Immunol 2004, 114(2), 444-450.
7. Kawaguchi, M.; Kokubu, F.; Matsukura, S.; Ieki, K.; Odaka, M.; Watanabe, S.; Suzuki, S.; Adachi, M.; Huang, S.K. Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2 pathway. J Pharmacol Exp Ther 2003, 307(3), 1213-1220.
8. Dong, C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 2006, 6(4), 329-333.
9. Weaver, C.T.; Harrington, L.E.; Mangan, P.R.; Gavrieli, M.; Murphy, K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006, 24(6), 677-688.
10. Akimzhanov, A.M.; Yang, X.O.; Dong, C. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem 2007, 282(9), 5969-5972.
11. Chang, S.H.; Dong, C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res 2007, 17(5), 435-440.
12. Wright, J.F.; Guo, Y.; Quazi, A.; Luxenberg, D.P.; Bennett, F.; Ross, J.F.; Qiu, Y.; Whitters, M.J.; Tomkinson, K.N.; Dunussi-Joannopoulos, K.; Carreno, B.M.; Collins, M.; Wolfman, N.M. Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J Biol Chem 2007, 282(18), 13447-13455.
13. Livak, K.J.; Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25(4), 402-408.
14. Weidner, N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 1995, 36(2), 169-180.
15. Toy, D.; Kugler, D.; Wolfson, M.; Vanden Bos, T.; Gurgel, J.; Derry, J.; Tocker, J.; Peschon, J. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol 2006, 177(1), 36-39.
16. Yang, X.O.; Chang, S.H.; Park, H.; Nurieva, R.; Shah, B.; Acero, L.; Wang, Y.H.; Schluns, K.S.; Broaddus, R.R.; Zhu, Z.; Dong, C. Regulation of inflammatory responses by IL-17F. J Exp Med 2008, 205(5), 1063-1075.
17. Parkin, D.M.; Bray, F.; Ferlay, J.; Pisani, P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001, 94(2), 153-156.
18. El-Serag, H.B.; Davila, J.A.; Petersen, N.J.; McGlynn, K.A. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med 2003, 139(10), 817-823.
19. Tabor, E. Tumor suppressor genes, growth factor genes, and oncogenes in hepatitis B virus-associated hepatocellular carcinoma. J Med Virol 1994, 42(4), 357-365.
20. Hurwitz, H.; Fehrenbacher, L.; Novotny, W.; Cartwright, T.; Hainsworth, J.; Heim, W.; Berlin, J.; Baron, A.; Griffing, S.; Holmgren, E.; Ferrara, N.; Fyfe, G.; Rogers, B.; Ross, R.; Kabbinavar, F. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350(23), 2335-2342.
21. Kabbinavar, F.F.; Hambleton, J.; Mass, R.D.; Hurwitz, H.I.; Bergsland, E.; Sarkar, S. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 2005, 23(16), 3706-3712.
22. Johnson, D.H.; Fehrenbacher, L.; Novotny, W.F.; Herbst, R.S.; Nemunaitis, J.J.; Jablons, D.M.; Langer, C.J.; DeVore, R.F. 3rd; Gaudreault, J.; Damico, L.A.; Holmgren, E.; Kabbinavar, F. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004, 22(11), 2184-2191.
23. Motro, B.; Itin, A.; Sachs, L.; Keshet, E. Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci USA 1990, 87(8), 3092-3096.
24. Lin, Y.; Huang, R.; Chen, L.; Li, S.; Shi, Q.; Jordan, C.; Huang, R.P. Identification of interleukin-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays. Int J Cancer 2004, 109(4), 507-515.
25. Strieter, R.M.; Kunkel, S.L.; Elner, V.M.; Martonyi, C.L.; Koch, A.E.; Polverini, P.J.; Elner, S.G. Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol 1992, 141(6), 1279-1284.
26. Dvorak, H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002, 20(21), 4368-4380.
27. Brat, D.J.; Bellail, A.C.; Van Meir, E.G. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 2005, 7(2), 122-133.
28. Belperio, J.A.; Keane, M.P.; Arenberg, D.A.; Addison, C.L.; Ehlert, J.E.; Burdick, M.D.; Strieter, R.M. CXC chemokines in angiogenesis. J Leukoc Biol 2000, 68(1), 1-8.
29. Yuan, A.; Chen, J.J.; Yao, P.L.; Yang, P.C. The role of interleukin-8 in cancer cells and microenvironment interaction. Front Biosci 2005, 10, 853-865.
30. Zhou, Z.; Zhou, R.R.; Guan, H.; Bucana, C.D.; Kleinerman, E.S. E1A gene therapy inhibits angiogenesis in a Ewing's sarcoma animal model. Mol Cancer Ther 2003, 2(12), 1313-1319.
31. Yao, D.F.; Wu, X.H.; Zhu, Y.; Shi, G.S.; Dong, Z.Z.; Yao, D.B.; Wu, W.; Qiu, L.W.; Meng, X.Y. Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinico-pathologic features in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2005, 4(2), 220-226.
32. Iavarone, M.; Lampertico, P.; Iannuzzi, F.; Manenti, E.; Donato, M.F.; Arosio, E.; Bertolini, F.; Primignani, M.; Sangiovanni, A.; Colombo, M. Increased expression of vascular endothelial growth factor in small hepatocellular carcinoma. J Viral Hepat 2007, 14(2), 133-139.
33. Horree, N.; van Diest, P.J.; van der Groep, P.; Sie-Go, D.M.; Heintz, A.P. Hypoxia and angiogenesis in endometrioid endometrial carcinogenesis. Cell Oncol 2007, 29(3), 219-227.
34. Mobius, C.; Demuth, C.; Aigner, T.; Wiedmann, M.; Wittekind, C.; Mossner, J.; Hauss, J.; Witzigmann, H. Evaluation of VEGF A expression and microvascular density as prognostic factors in extrahepatic cholangiocarcinoma. Eur J Surg Oncol 2007, 33(8), 1025-1029.
35. El-Gohary, Y.M.; Silverman, J.F.; Olson, P.R.; Liu, Y.L.; Cohen, J.K.; Miller, R.; Saad, R.S. Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in prostatic adenocarcinoma. Am J Clin Pathol 2007, 127(4), 572-579.
36. Kopfstein, L.; Veikkola, T.; Djonov, V.G.; Baeriswyl, V.; Schomber, T.; Strittmatter, K.; Stacker, S.A.; Achen, M.G.; Alitalo, K.; Christofori, G. Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis. Am J Pathol 2007, 170(4), 1348-1361. (Pubitemid 47339341)
37. Nikiteas, N.I.; Tzanakis, N.; Theodoropoulos, G.; Atsaves, V.; Christoni, Z.; Karakitsos, P.; Lazaris A.C.; Papachristodoulou, A.; Klonaris, C.; Gazouli, M. Vascular endothelial growth factor and endoglin (CD-105) in gastric cancer. Gastric Cancer 2007, 10(1), 12-17.
38. Djordjevic, G.; Mozetic, V.; Mozetic, D.V.; Licul, V.; Ilijas, K.M.; Mustac, E.; Oguic, R.; Fuckar, Z.; Jonjic, N. Prognostic significance of vascular endothelial growth factor expression in clear cell renal cell carcinoma. Pathol Res Pract 2007, 203(2), 99-106.
39. Hirahara, N.; Nio, Y.; Sasaki, S.; Minari, Y.; Takamura, M.; Iguchi, C.; Dong, M.; Yamasawa, K.; Tamura, K. Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumor-specific immunity in mice. Oncology 2001, 61(1), 79-89.
40. Benchetrit, F.; Ciree, A.; Vives, V.; Warnier, G.; Gey, A.; Sautes-Fridman, C.; Fossiez, F.; Haicheur, N.; Fridman, W.H.; Tartour, E. Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. Blood 2002, 99(6), 2114-2121.
41. Tartour, E.; Fossiez, F.; Joyeux, I.; Galinha, A.; Gey, A.; Claret, E.; Sastre-Garau, X.; Couturier, J.; Mosseri, V.; Vives, V.; Banchereau, J.; Fridman, W.H.; Wijdenes, J.; Lebecque, S.; Sautes-Fridman, C. Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res 1999, 59(15), 3698-3704.
42. Numasaki, M.; Fukushi, J.; Ono, M.; Narula, S.K.; Zavodny, P.J.; Kudo, T.; Robbins, P.D.; Tahara, H.; Lotze, M.T. Interleukin-17 promotes angiogenesis and tumor growth. Blood 2003, 101(7), 2620-2627.
43. Numasaki, M.; Watanabe, M.; Suzuki, T.; Takahashi, H.; Nakamura, A.; McAllister, F.; Hishinuma, T.; Goto, J.; Lotze, M.T.; Kolls, J.K.; Sasaki, H. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol 2005, 175(9), 6177-6189.
44. Kryczek, I.; Wei, S.; Szeliga, W.; Vatan, L.; Zou, W. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood 2009, 114(2), 357-359.