-
1
-
-
0037308133
-
Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
-
Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology. 2003;37:429-442.
-
(2003)
Hepatology
, vol.37
, pp. 429-442
-
-
Llovet, J.M.1
Bruix, J.2
-
2
-
-
54449083925
-
Molecular targeted therapies in hepatocellular carcinoma
-
Llovet JM, Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology. 2008;48:1312-1327.
-
(2008)
Hepatology
, vol.48
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
3
-
-
33646567160
-
Systematic review: Evidence- based management of hepatocellular carcinoma - an updated analysis of randomized controlled trials
-
Lopez PM, Villanueva A, Llovet JM. Systematic review: evidence- based management of hepatocellular carcinoma - an updated analysis of randomized controlled trials. Aliment Pharmacol Ther. 2006;23:1535-1547.
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1535-1547
-
-
Lopez, P.M.1
Villanueva, A.2
Llovet, J.M.3
-
4
-
-
27144557565
-
A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/ doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma
-
Yeo W, Mok TS, Zee B, et al. A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/ doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J Natl Cancer Inst. 2005;97:1532-1538.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1532-1538
-
-
Yeo, W.1
Mok, T.S.2
Zee, B.3
-
5
-
-
0023936352
-
Clinical trials in primary hepatocellular carcinoma: Current status and future directions
-
Nerenstone SR, Ihde DC, Friedman MA. Clinical trials in primary hepatocellular carcinoma: current status and future directions. Cancer Treat Rev. 1988;15:1-31.
-
(1988)
Cancer Treat Rev
, vol.15
, pp. 1-31
-
-
Nerenstone, S.R.1
Ihde, D.C.2
Friedman, M.A.3
-
6
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009; 10:25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
-
7
-
-
73049092595
-
Geographic difference in survival outcome for advanced hepatocellular carcinoma: Implications on future clinical trial design
-
Hsu C, Shen YC, Cheng CC, Hu FC, Cheng AL. Geographic difference in survival outcome for advanced hepatocellular carcinoma: implications on future clinical trial design. Contemp Clin Trials. 2010;31:55-61.
-
(2010)
Contemp Clin Trials
, vol.31
, pp. 55-61
-
-
Hsu, C.1
Shen, Y.C.2
Cheng, C.C.3
Hu, F.C.4
Cheng, A.L.5
-
8
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
9
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008; 359:378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
10
-
-
10844248554
-
Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma
-
Lin AY, Brophy N, Fisher GA, et al. Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma. Cancer. 2005;103:119-125.
-
(2005)
Cancer
, vol.103
, pp. 119-125
-
-
Lin, A.Y.1
Brophy, N.2
Fisher, G.A.3
-
11
-
-
67651165187
-
Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: An open-label, multicentre, phase II study
-
Faivre S, Raymond E, Boucher E, et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol. 2009;10:794-800.
-
(2009)
Lancet Oncol
, vol.10
, pp. 794-800
-
-
Faivre, S.1
Raymond, E.2
Boucher, E.3
-
12
-
-
74549223962
-
An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC)
-
abstract Abstract 4577
-
Raoul JL, Finn RS, Kang YK, et al. An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC) [abstract]. J Clin Oncol. 2009;27(15S). Abstract 4577.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Raoul, J.L.1
Finn, R.S.2
Kang, Y.K.3
-
13
-
-
46449091500
-
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
-
Siegel AB, Cohen EI, Ocean A, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol. 2008;26: 2992-2998.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2992-2998
-
-
Siegel, A.B.1
Cohen, E.I.2
Ocean, A.3
-
14
-
-
69249149754
-
A phase II study of ABT- 869 in hepatocellular carcinoma (HCC): Interim analysis
-
abstract Abstract 4581
-
Toh H, Chen P, Carr BI, et al. A phase II study of ABT- 869 in hepatocellular carcinoma (HCC): interim analysis [abstract]. J Clin Oncol. 2009;27(15S). Abstract 4581.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Toh, H.1
Chen, P.2
Carr, B.I.3
-
15
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study
-
Zhu AX, Sahani DV, Duda DG, et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol. 2009;27:3027-3035.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3027-3035
-
-
Zhu, A.X.1
Sahani, D.V.2
Duda, D.G.3
-
16
-
-
28844480321
-
Management of hepatocellular carcinoma
-
Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208-1236.
-
(2005)
Hepatology
, vol.42
, pp. 1208-1236
-
-
Bruix, J.1
Sherman, M.2
-
17
-
-
0035041150
-
Postoperative detection of alpha-fetoprotein mRNA in blood as a predictor for metastatic recurrence of hepatocellular carcinoma
-
Minata M, Nishida N, Komeda T, et al. Postoperative detection of alpha-fetoprotein mRNA in blood as a predictor for metastatic recurrence of hepatocellular carcinoma. J Gastroenterol Hepatol. 2001;16:445-451.
-
(2001)
J Gastroenterol Hepatol
, vol.16
, pp. 445-451
-
-
Minata, M.1
Nishida, N.2
Komeda, T.3
-
18
-
-
0036203231
-
Alpha-fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: A prospective study
-
Ijichi M, Takayama T, Matsumura M, Shiratori Y, Omata M, Makuuchi M. Alpha-fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: a prospective study. Hepatology. 2002;35:853-860.
-
(2002)
Hepatology
, vol.35
, pp. 853-860
-
-
Ijichi, M.1
Takayama, T.2
Matsumura, M.3
Shiratori, Y.4
Omata, M.5
Makuuchi, M.6
-
19
-
-
4544301860
-
High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: Significance of hepatitis virus infection, age, p53 and betacatenin mutations
-
Peng SY, Chen WJ, Lai PL, Jeng YM, Sheu JC, Hsu HC. High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and betacatenin mutations. Int J Cancer. 2004;112:44-50.
-
(2004)
Int J Cancer
, vol.112
, pp. 44-50
-
-
Peng, S.Y.1
Chen, W.J.2
Lai, P.L.3
Jeng, Y.M.4
Sheu, J.C.5
Hsu, H.C.6
-
20
-
-
4944234987
-
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
-
Poon RT, Ho JW, Tong CS, Lau C, Ng IO, Fan ST. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br J Surg. 2004;91:1354-1360.
-
(2004)
Br J Surg
, vol.91
, pp. 1354-1360
-
-
Poon, R.T.1
Ho, J.W.2
Tong, C.S.3
Lau, C.4
Ng, I.O.5
Fan, S.T.6
-
21
-
-
35448954436
-
Alpha fetoprotein, ultrasound, computerized tomography and magnetic resonance imaging for detection of hepatocellular carcinoma in patients with advanced cirrhosis
-
Snowberger N, Chinnakotla S, Lepe RM, et al. Alpha fetoprotein, ultrasound, computerized tomography and magnetic resonance imaging for detection of hepatocellular carcinoma in patients with advanced cirrhosis. Aliment Pharmacol Ther. 2007;26:1187-1194.
-
(2007)
Aliment Pharmacol Ther
, vol.26
, pp. 1187-1194
-
-
Snowberger, N.1
Chinnakotla, S.2
Lepe, R.M.3
-
22
-
-
57049179579
-
Serum alpha-fetoprotein level per tumor volume reflects prognosis in patients with hepatocellular carcinoma after curative hepatectomy
-
Furihata T, Sawada T, Kita J, et al. Serum alpha-fetoprotein level per tumor volume reflects prognosis in patients with hepatocellular carcinoma after curative hepatectomy. Hepatogastroenterology. 2008;55:1705-1709.
-
(2008)
Hepatogastroenterology
, vol.55
, pp. 1705-1709
-
-
Furihata, T.1
Sawada, T.2
Kita, J.3
-
23
-
-
58749090909
-
New utility of an old marker: Serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy
-
Chan SL, Mo FK, Johnson PJ, et al. New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy. J Clin Oncol. 2009;27:446-452.
-
(2009)
J Clin Oncol
, vol.27
, pp. 446-452
-
-
Chan, S.L.1
Mo, F.K.2
Johnson, P.J.3
-
24
-
-
68449100731
-
Serum alpha-fetoprotein response as a surrogate for clinical outcome in patients receiving systemic therapy for advanced hepatocellular carcinoma
-
Vora SR, Zheng H, Stadler ZK, Fuchs CS, Zhu AX. Serum alpha-fetoprotein response as a surrogate for clinical outcome in patients receiving systemic therapy for advanced hepatocellular carcinoma. Oncologist. 2009;14:717-725.
-
(2009)
Oncologist
, vol.14
, pp. 717-725
-
-
Vora, S.R.1
Zheng, H.2
Stadler, Z.K.3
Fuchs, C.S.4
Zhu, A.X.5
-
25
-
-
77953124105
-
Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
-
Hsu CH, Shen YC, Lin ZZ, et al. Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma. J Hepatol. 2010;53:126-131.
-
(2010)
J Hepatol
, vol.53
, pp. 126-131
-
-
Hsu, C.H.1
Shen, Y.C.2
Lin, Z.Z.3
-
26
-
-
84984578313
-
Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
-
Hsu CH, Yang TS, Hsu C, et al. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer. 2010; 102:981-986.
-
(2010)
Br J Cancer
, vol.102
, pp. 981-986
-
-
Hsu, C.H.1
Yang, T.S.2
Hsu, C.3
-
27
-
-
77957552789
-
Thalidomide plus tegafur/ uracil for the treatment of advanced/metastatic hepatocellular carcinoma (HCC): A phase II single-arm study
-
abstract. Abstract 15598
-
Hsu C, Chang D, Lin Z, et al. Thalidomide plus tegafur/ uracil for the treatment of advanced/metastatic hepatocellular carcinoma (HCC): a phase II single-arm study [abstract]. J Clin Oncol. 2008;26(May 26 suppl). Abstract 15598.
-
(2008)
J Clin Oncol
, vol.26
, Issue.MAY 26 SUPPL.
-
-
Hsu, C.1
Chang, D.2
Lin, Z.3
-
28
-
-
2942615257
-
The anti-angiogenic basis of metronomic chemotherapy
-
Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4:423-436.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
29
-
-
0034032882
-
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
-
Browder T, Butterfield CE, Kraling BM, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 2000;60: 1878-1886.
-
(2000)
Cancer Res
, vol.60
, pp. 1878-1886
-
-
Browder, T.1
Butterfield, C.E.2
Kraling, B.M.3
-
30
-
-
1642368865
-
Thrombospondin- 1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
-
Hamano Y, Sugimoto H, Soubasakos MA, et al. Thrombospondin- 1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res. 2004;64:1570-1574.
-
(2004)
Cancer Res
, vol.64
, pp. 1570-1574
-
-
Hamano, Y.1
Sugimoto, H.2
Soubasakos, M.A.3
-
31
-
-
0035503538
-
Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
-
Takahashi N, Haba A, Matsuno F, Seon BK. Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res. 2001;61:7846-7854.
-
(2001)
Cancer Res
, vol.61
, pp. 7846-7854
-
-
Takahashi, N.1
Haba, A.2
Matsuno, F.3
Seon, B.K.4
-
32
-
-
0036152447
-
Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts
-
Klement G, Huang P, Mayer B, et al. Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin Cancer Res. 2002;8:221-232.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 221-232
-
-
Klement, G.1
Huang, P.2
Mayer, B.3
-
33
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92: 205-216.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
34
-
-
0031782818
-
A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients
-
The Cancer of the Liver Italian Program (CLIP) investigators
-
The Cancer of the Liver Italian Program (CLIP) investigators. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology. 1998;28: 751-755.
-
(1998)
Hepatology
, vol.28
, pp. 751-755
-
-
-
35
-
-
23844534451
-
Alpha-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma
-
Chen LT, Liu TW, Chao Y, et al. Alpha-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma. Aliment Pharmacol Ther. 2005;22:217-226.
-
(2005)
Aliment Pharmacol Ther
, vol.22
, pp. 217-226
-
-
Chen, L.T.1
Liu, T.W.2
Chao, Y.3
-
36
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360:1408-1417.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
37
-
-
35148820611
-
Molecular and cellular biomarkers for angiogenesis in clinical oncology
-
Bertolini F, Mancuso P, Shaked Y, Kerbel RS. Molecular and cellular biomarkers for angiogenesis in clinical oncology. Drug Discov Today. 2007;12:806-812.
-
(2007)
Drug Discov Today
, vol.12
, pp. 806-812
-
-
Bertolini, F.1
Mancuso, P.2
Shaked, Y.3
Kerbel, R.S.4
|