Threonine-205 in the F helix of P450 2B1 contributes to androgen 16β-hydroxylation activity and mechanism-based inactivation

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 2, 2003, Pages 744-751

  Lin, Hsia Lien ^a   Zhang, Haoming ^b   Waskell, Lucy ^b   Hollenberg, Paul F ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MSRB III ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYNYLNAPHTHALENE; 7 ETHOXY 4 (TRIFLUOROMETHYL)COUMARIN; ANDROGEN; ANDROSTENEDIONE; BENZPHETAMINE; COUMARIN; CYTOCHROME P450 2B1; ETHINYLESTRADIOL; NAPHTHALENE DERIVATIVE; TESTOSTERONE; THREONINE; THREONINE 205; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; DEMETHYLATION; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME SPECIFICITY; F HELIX; HORMONE METABOLISM; HYDROXYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOCHEMISTRY;

ANDROGENS; ANIMALS; BLOTTING, WESTERN; CYTOCHROME P-450 CYP2B1; ESCHERICHIA COLI; HYDROXYLATION; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; RECOMBINANT PROTEINS; STEROID HYDROXYLASES; THREONINE;

EID: 0038637141     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.050260     Document Type: Article

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