Defining the structural consequences of mechanism-based inactivation of mammalian cytochrome P450 2B4 using resonance Raman spectroscopy

Journal of the American Chemical Society

Volumn 132, Issue 5, 2010, Pages 1494-1495

  Mak, Piotr J ^a   Zhang, Haoming ^b   Hollenberg, Paul F ^b   Kincaid, James R ^a  

^a Marquette University   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DRUG-DRUG INTERACTIONS; FUNCTIONAL PROPERTIES; GAIN INSIGHT; MODIFIED ENZYMES; PHENYLACETYLENES; PROTEIN RESIDUES; REACTIVE SPECIES; RESONANCE RAMAN SPECTROSCOPY; STRUCTURAL BASIS;

ACETYLENE; AROMATIC HYDROCARBONS; ELECTRON TRANSITIONS; ENZYMES; MAMMALS; PORPHYRINS; RAMAN SCATTERING; RAMAN SPECTROSCOPY; RESONANCE; SUBSTRATES;

DRUG INTERACTIONS;

CYTOCHROME P450 2B4;

ARTICLE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; RAMAN SPECTROMETRY;

ACETYLENE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; PROTEIN CONFORMATION; SPECTRUM ANALYSIS, RAMAN;

EID: 76149134076     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja910276s     Document Type: Article

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