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Volumn 507, Issue 1, 2011, Pages 135-143

Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes

(4) Zhang, Haoming a Lin, Hsia Lien a Kenaan, Cesar a Hollenberg, Paul F a

a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL (United States)

Author keywords

Active site; Cytochrome P450; Mechanism based inactivation; Specific inhibitor; tert Butylphenylacetylene; Thr302

Indexed keywords

ACETYLENE; CYTOCHROME P450 2B1; CYTOCHROME P450 2B4; CYTOCHROME P450 2B6; THREONINE; ACETYLENE DERIVATIVE; CYTOCHROME P450 2B; TERT BUTYLPHENYLACETYLENE; UNCLASSIFIED DRUG;

CRYSTALLOGRAPHY; HUMAN; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; REVIEW; SPECTROSCOPY; BINDING SITE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME INACTIVATION; ENZYME KINETICS; PROTEIN FAMILY; SITE DIRECTED MUTAGENESIS;

ACETYLENE; AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SUBSTRATE SPECIFICITY; THREONINE;

MAMMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 79951566203 PISSN: 00039861 EISSN: 10960384 Source Type: Journal
DOI: 10.1016/j.abb.2010.09.006 Document Type: Review

Times cited : (15)

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