Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: Covalent modification of prosthetic heme versus apoprotein

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 2, 2009, Pages 392-403

  Lin, Hsia Lien ^a   Zhang, Haoming ^a   Noon, Kathleen R ^a   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE DERIVATIVE; APOPROTEIN; CARBON; CYTOCHROME P450 2B1; GLUTATHIONE; HEME; OXYGEN; TERT BUTYL 1 METHYL 2 PROPYNYLETHER; TERT BUTYLPHENYLACETYLENE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CHEMICAL REACTION; CONTROLLED STUDY; COVALENT BOND; ENZYME INACTIVATION; ENZYME SUBSTRATE; ENZYME SUBUNIT; LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; MUTANT; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY; TANDEM MASS SPECTROMETRY; WILD TYPE;

ACETYLENE; ALKYNES; AMINO ACID SUBSTITUTION; APOPROTEINS; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2B1; ENZYME INHIBITORS; ETHERS; GLUTATHIONE; HEME; HUMANS; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; MUTATION; OXYGEN; PROTEIN CONFORMATION; SOLUBILITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 70350443423     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.158782     Document Type: Article

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