Pyrene·pyrene complexes at the active site of cytochrome P450 3A4: Evidence for a multiple substrate binding site

Journal of the American Chemical Society

Volumn 124, Issue 40, 2002, Pages 11866-11867

  Dabrowski, Michael J ^a,b,c   Schrag, Michael L ^a,b,c   Wienkers, Larry C ^a,b,c   Atkins, William M ^a,b,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PFIZER INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS(PYRENYL)PROPANE; CYTOCHROME P450 3A4; PROPANE; PYRENE; UNCLASSIFIED DRUG; CYP3A PROTEIN, HUMAN; CYTOCHROME P450; PYRENE DERIVATIVE;

AEROBIC METABOLISM; ARTICLE; BINDING SITE; CHEMICAL BINDING; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; MOLECULAR INTERACTION; PHOTOACTIVATION; CHEMISTRY; METABOLISM; SPECTROFLUOROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY;

BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; PYRENES; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0037048522     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja027552x     Document Type: Article

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