-
1
-
-
58149239733
-
Roles of TGF-beta family signaling in stem cell renewal and differentiation
-
T. Watabe, and K. Miyazono Roles of TGF-beta family signaling in stem cell renewal and differentiation Cell Res. 19 2009 103 115
-
(2009)
Cell Res.
, vol.19
, pp. 103-115
-
-
Watabe, T.1
Miyazono, K.2
-
2
-
-
24644507896
-
The disparate role of BMP in stem cell biology
-
A.C. Varga, and J.L. Wrana The disparate role of BMP in stem cell biology Oncogene 24 2005 5713 5721
-
(2005)
Oncogene
, vol.24
, pp. 5713-5721
-
-
Varga, A.C.1
Wrana, J.L.2
-
3
-
-
33947656333
-
Nodal signaling: Developmental roles and regulation
-
M.M. Shen Nodal signaling: developmental roles and regulation Development 134 2007 1023 1034
-
(2007)
Development
, vol.134
, pp. 1023-1034
-
-
Shen, M.M.1
-
4
-
-
47549090432
-
TGFbeta in Cancer
-
J. Massague TGFbeta in Cancer Cell 134 2008 215 230
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massague, J.1
-
5
-
-
0031685620
-
TGF-beta signal transduction
-
J. Massague TGF-beta signal transduction Annu. Rev. Biochem. 67 1998 753 791
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 753-791
-
-
Massague, J.1
-
6
-
-
79961139550
-
TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions
-
J.F. Santibanez, M. Quintanilla, and C. Bernabeu TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions Clin. Sci. 121 2011 233 251
-
(2011)
Clin. Sci.
, vol.121
, pp. 233-251
-
-
Santibanez, J.F.1
Quintanilla, M.2
Bernabeu, C.3
-
7
-
-
0346254671
-
New class of transforming growth factors potentiated by epidermal growth factor: Isolation from non-neoplastic tissues
-
A.B. Roberts, M.A. Anzano, L.C. Lamb, J.M. Smith, and M.B. Sporn New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues Proc. Natl. Acad. Sci. U. S. A. 78 1981 5339 5343
-
(1981)
Proc. Natl. Acad. Sci. U. S. A.
, vol.78
, pp. 5339-5343
-
-
Roberts, A.B.1
Anzano, M.A.2
Lamb, L.C.3
Smith, J.M.4
Sporn, M.B.5
-
8
-
-
0019465899
-
Transforming growth factor production by chemically transformed cells
-
H.L. Moses, E.L. Branum, J.A. Proper, and R.A. Robinson Transforming growth factor production by chemically transformed cells Cancer Res. 41 1981 2842 2848
-
(1981)
Cancer Res.
, vol.41
, pp. 2842-2848
-
-
Moses, H.L.1
Branum, E.L.2
Proper, J.A.3
Robinson, R.A.4
-
9
-
-
0037204990
-
Signal transduction by the TGF-beta superfamily
-
L. Attisano, and J.L. Wrana Signal transduction by the TGF-beta superfamily Science 296 2002 1646 1647
-
(2002)
Science
, vol.296
, pp. 1646-1647
-
-
Attisano, L.1
Wrana, J.L.2
-
10
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Y. Shi, and J. Massague Mechanisms of TGF-beta signaling from cell membrane to the nucleus Cell 113 2003 685 700
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
11
-
-
0033952923
-
Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping
-
D.B. Constam, and E.J. Robertson Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping Development 127 2000 245 254
-
(2000)
Development
, vol.127
, pp. 245-254
-
-
Constam, D.B.1
Robertson, E.J.2
-
12
-
-
0028170226
-
Mechanism of activation of the TGF-beta receptor
-
J.L. Wrana, L. Attisano, R. Wieser, F. Ventura, and J. Massague Mechanism of activation of the TGF-beta receptor Nature 370 1994 341 347
-
(1994)
Nature
, vol.370
, pp. 341-347
-
-
Wrana, J.L.1
Attisano, L.2
Wieser, R.3
Ventura, F.4
Massague, J.5
-
13
-
-
0030427867
-
Signal transduction by members of the transforming growth factor-beta superfamily
-
L. Attisano, and J.L. Wrana Signal transduction by members of the transforming growth factor-beta superfamily Cytokine Growth Factor Rev. 7 1996 327 339
-
(1996)
Cytokine Growth Factor Rev.
, vol.7
, pp. 327-339
-
-
Attisano, L.1
Wrana, J.L.2
-
15
-
-
0034252221
-
Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal
-
M. Watanabe, N. Masuyama, M. Fukuda, and E. Nishida Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal EMBO Rep. 1 2000 176 182
-
(2000)
EMBO Rep.
, vol.1
, pp. 176-182
-
-
Watanabe, M.1
Masuyama, N.2
Fukuda, M.3
Nishida, E.4
-
16
-
-
0036670359
-
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus
-
L. Xu, Y. Kang, S. Col, and J. Massague Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus Mol. Cell 10 2002 271 282
-
(2002)
Mol. Cell
, vol.10
, pp. 271-282
-
-
Xu, L.1
Kang, Y.2
Col, S.3
Massague, J.4
-
17
-
-
58149264873
-
Nucleocytoplasmic shuttling of Smad proteins
-
C.S. Hill Nucleocytoplasmic shuttling of Smad proteins Cell Res. 19 2009 36 46
-
(2009)
Cell Res.
, vol.19
, pp. 36-46
-
-
Hill, C.S.1
-
18
-
-
46049087598
-
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
-
X. Varelas, R. Sakuma, P. Samavarchi-Tehrani, R. Peerani, B.M. Rao, J. Dembowy, M.B. Yaffe, P.W. Zandstra, and J.L. Wrana TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal Nat. Cell Biol. 10 2008 837 848
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 837-848
-
-
Varelas, X.1
Sakuma, R.2
Samavarchi-Tehrani, P.3
Peerani, R.4
Rao, B.M.5
Dembowy, J.6
Yaffe, M.B.7
Zandstra, P.W.8
Wrana, J.L.9
-
19
-
-
78649969033
-
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway
-
X. Varelas, P. Samavarchi-Tehrani, M. Narimatsu, A. Weiss, K. Cockburn, B.G. Larsen, J. Rossant, and J.L. Wrana The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway Dev. Cell 19 2010 831 844
-
(2010)
Dev. Cell
, vol.19
, pp. 831-844
-
-
Varelas, X.1
Samavarchi-Tehrani, P.2
Narimatsu, M.3
Weiss, A.4
Cockburn, K.5
Larsen, B.G.6
Rossant, J.7
Wrana, J.L.8
-
20
-
-
33646950265
-
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
-
X. Lin, X. Duan, Y.Y. Liang, Y. Su, K.H. Wrighton, J. Long, M. Hu, C.M. Davis, J. Wang, F.C. Brunicardi, Y. Shi, Y.G. Chen, A. Meng, and X.H. Feng PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling Cell 125 2006 915 928
-
(2006)
Cell
, vol.125
, pp. 915-928
-
-
Lin, X.1
Duan, X.2
Liang, Y.Y.3
Su, Y.4
Wrighton, K.H.5
Long, J.6
Hu, M.7
Davis, C.M.8
Wang, J.9
Brunicardi, F.C.10
Shi, Y.11
Chen, Y.G.12
Meng, A.13
Feng, X.H.14
-
21
-
-
58149239730
-
Phospho-control of TGF-beta superfamily signaling
-
K.H. Wrighton, X. Lin, and X.H. Feng Phospho-control of TGF-beta superfamily signaling Cell Res. 19 2009 8 20
-
(2009)
Cell Res.
, vol.19
, pp. 8-20
-
-
Wrighton, K.H.1
Lin, X.2
Feng, X.H.3
-
23
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
-
H. Hayashi, S. Abdollah, Y. Qiu, J. Cai, Y.Y. Xu, B.W. Grinnell, M.A. Richardson, J.N. Topper, M.A. Gimbrone Jr., J.L. Wrana, and D. Falb The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling Cell 89 1997 1165 1173
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone Jr., M.A.9
Wrana, J.L.10
Falb, D.11
-
24
-
-
0030611757
-
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
-
A. Nakao, M. Afrakhte, A. Moren, T. Nakayama, J.L. Christian, R. Heuchel, S. Itoh, M. Kawabata, N.E. Heldin, C.H. Heldin, and P. ten Dijke Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling Nature 389 1997 631 635
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Moren, A.3
Nakayama, T.4
Christian, J.L.5
Heuchel, R.6
Itoh, S.7
Kawabata, M.8
Heldin, N.E.9
Heldin, C.H.10
Ten Dijke, P.11
-
25
-
-
0032489280
-
Induction of Smad6 mRNA by bone morphogenetic proteins
-
M. Takase, T. Imamura, T.K. Sampath, K. Takeda, H. Ichijo, K. Miyazono, and M. Kawabata Induction of Smad6 mRNA by bone morphogenetic proteins Biochem. Biophys. Res. Commun. 244 1998 26 29
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.244
, pp. 26-29
-
-
Takase, M.1
Imamura, T.2
Sampath, T.K.3
Takeda, K.4
Ichijo, H.5
Miyazono, K.6
Kawabata, M.7
-
26
-
-
0033549789
-
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
H. Zhu, P. Kavsak, S. Abdollah, J.L. Wrana, and G.H. Thomsen A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation Nature 400 1999 687 693
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.5
-
27
-
-
70350785179
-
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling
-
S. Gao, C. Alarcón, G. Sapkota, S. Rahman, P.-Y. Chen, N. Goerner, M.J. Macias, H. Erdjument-Bromage, P. Tempst, and J. Massagué Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling Mol. Cell 36 2009 457 468
-
(2009)
Mol. Cell
, vol.36
, pp. 457-468
-
-
Gao, S.1
Alarcón, C.2
Sapkota, G.3
Rahman, S.4
Chen, P.-Y.5
Goerner, N.6
MacIas, M.J.7
Erdjument-Bromage, H.8
Tempst, P.9
Massagué, J.10
-
28
-
-
79957596419
-
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFbeta signalling and EMT
-
S.M. Soond, and A. Chantry Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFbeta signalling and EMT Oncogene 30 2011 2451 2462
-
(2011)
Oncogene
, vol.30
, pp. 2451-2462
-
-
Soond, S.M.1
Chantry, A.2
-
29
-
-
1842591240
-
The Nedd4 family of E3 ubiquitin ligases: Functional diversity within a common modular architecture
-
R.J. Ingham, G. Gish, and T. Pawson The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture Oncogene 23 2004 1972 1984
-
(2004)
Oncogene
, vol.23
, pp. 1972-1984
-
-
Ingham, R.J.1
Gish, G.2
Pawson, T.3
-
30
-
-
70350785179
-
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
-
S. Gao, C. Alarcon, G. Sapkota, S. Rahman, P.Y. Chen, N. Goerner, M.J. Macias, H. Erdjument-Bromage, P. Tempst, and J. Massague Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling Mol. Cell 36 2009 457 468
-
(2009)
Mol. Cell
, vol.36
, pp. 457-468
-
-
Gao, S.1
Alarcon, C.2
Sapkota, G.3
Rahman, S.4
Chen, P.Y.5
Goerner, N.6
MacIas, M.J.7
Erdjument-Bromage, H.8
Tempst, P.9
Massague, J.10
-
31
-
-
36248995245
-
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
-
L.C. Fuentealba, E. Eivers, A. Ikeda, C. Hurtado, H. Kuroda, E.M. Pera, and E.M. De Robertis Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal Cell 131 2007 980 993
-
(2007)
Cell
, vol.131
, pp. 980-993
-
-
Fuentealba, L.C.1
Eivers, E.2
Ikeda, A.3
Hurtado, C.4
Kuroda, H.5
Pera, E.M.6
De Robertis, E.M.7
-
32
-
-
70350780570
-
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
-
C. Alarcon, A.I. Zaromytidou, Q. Xi, S. Gao, J. Yu, S. Fujisawa, A. Barlas, A.N. Miller, K. Manova-Todorova, M.J. Macias, G. Sapkota, D. Pan, and J. Massague Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways Cell 139 2009 757 769
-
(2009)
Cell
, vol.139
, pp. 757-769
-
-
Alarcon, C.1
Zaromytidou, A.I.2
Xi, Q.3
Gao, S.4
Yu, J.5
Fujisawa, S.6
Barlas, A.7
Miller, A.N.8
Manova-Todorova, K.9
MacIas, M.J.10
Sapkota, G.11
Pan, D.12
Massague, J.13
-
33
-
-
17044365440
-
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
-
S. Dupont, L. Zacchigna, M. Cordenonsi, S. Soligo, M. Adorno, M. Rugge, and S. Piccolo Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase Cell 121 2005 87 99
-
(2005)
Cell
, vol.121
, pp. 87-99
-
-
Dupont, S.1
Zacchigna, L.2
Cordenonsi, M.3
Soligo, S.4
Adorno, M.5
Rugge, M.6
Piccolo, S.7
-
34
-
-
58149093172
-
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
-
S. Dupont, A. Mamidi, M. Cordenonsi, M. Montagner, L. Zacchigna, M. Adorno, G. Martello, M.J. Stinchfield, S. Soligo, L. Morsut, M. Inui, S. Moro, N. Modena, F. Argenton, S.J. Newfeld, and S. Piccolo FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination Cell 136 2009 123 135
-
(2009)
Cell
, vol.136
, pp. 123-135
-
-
Dupont, S.1
Mamidi, A.2
Cordenonsi, M.3
Montagner, M.4
Zacchigna, L.5
Adorno, M.6
Martello, G.7
Stinchfield, M.J.8
Soligo, S.9
Morsut, L.10
Inui, M.11
Moro, S.12
Modena, N.13
Argenton, F.14
Newfeld, S.J.15
Piccolo, S.16
-
35
-
-
77955753654
-
Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo
-
L. Morsut, K.P. Yan, E. Enzo, M. Aragona, S.M. Soligo, O. Wendling, M. Mark, K. Khetchoumian, G. Bressan, P. Chambon, S. Dupont, R. Losson, and S. Piccolo Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo Development 137 2010 2571 2578
-
(2010)
Development
, vol.137
, pp. 2571-2578
-
-
Morsut, L.1
Yan, K.P.2
Enzo, E.3
Aragona, M.4
Soligo, S.M.5
Wendling, O.6
Mark, M.7
Khetchoumian, K.8
Bressan, G.9
Chambon, P.10
Dupont, S.11
Losson, R.12
Piccolo, S.13
-
36
-
-
79959891289
-
Recruitment of TIF1gamma to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities
-
E. Agricola, R.A. Randall, T. Gaarenstroom, S. Dupont, and C.S. Hill Recruitment of TIF1gamma to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities Mol. Cell 43 2011 85 96
-
(2011)
Mol. Cell
, vol.43
, pp. 85-96
-
-
Agricola, E.1
Randall, R.A.2
Gaarenstroom, T.3
Dupont, S.4
Hill, C.S.5
-
37
-
-
84455167662
-
A poised chromatin platform for TGF-beta access to master regulators
-
Q. Xi, Z. Wang, A.I. Zaromytidou, X.H. Zhang, L.F. Chow-Tsang, J.X. Liu, H. Kim, A. Barlas, K. Manova-Todorova, V. Kaartinen, L. Studer, W. Mark, D.J. Patel, and J. Massague A poised chromatin platform for TGF-beta access to master regulators Cell 147 2011 1511 1524
-
(2011)
Cell
, vol.147
, pp. 1511-1524
-
-
Xi, Q.1
Wang, Z.2
Zaromytidou, A.I.3
Zhang, X.H.4
Chow-Tsang, L.F.5
Liu, J.X.6
Kim, H.7
Barlas, A.8
Manova-Todorova, K.9
Kaartinen, V.10
Studer, L.11
Mark, W.12
Patel, D.J.13
Massague, J.14
-
39
-
-
0032110463
-
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
-
E. Labbe, C. Silvestri, P.A. Hoodless, J.L. Wrana, and L. Attisano Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2 Mol. Cell 2 1998 109 120
-
(1998)
Mol. Cell
, vol.2
, pp. 109-120
-
-
Labbe, E.1
Silvestri, C.2
Hoodless, P.A.3
Wrana, J.L.4
Attisano, L.5
-
40
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
L. Zawel, J.L. Dai, P. Buckhaults, S. Zhou, K.W. Kinzler, B. Vogelstein, and S.E. Kern Human Smad3 and Smad4 are sequence-specific transcription activators Mol. Cell 1 1998 611 617
-
(1998)
Mol. Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
42
-
-
79551592864
-
Pluripotency factors regulate definitive endoderm specification through eomesodermin
-
A.K. Teo, S.J. Arnold, M.W. Trotter, S. Brown, L.T. Ang, Z. Chng, E.J. Robertson, N.R. Dunn, and L. Vallier Pluripotency factors regulate definitive endoderm specification through eomesodermin Genes Dev. 25 2011 238 250
-
(2011)
Genes Dev.
, vol.25
, pp. 238-250
-
-
Teo, A.K.1
Arnold, S.J.2
Trotter, M.W.3
Brown, S.4
Ang, L.T.5
Chng, Z.6
Robertson, E.J.7
Dunn, N.R.8
Vallier, L.9
-
43
-
-
80155137594
-
Master transcription factors determine cell-type-specific responses to TGF-beta signaling
-
A.C. Mullen, D.A. Orlando, J.J. Newman, J. Loven, R.M. Kumar, S. Bilodeau, J. Reddy, M.G. Guenther, R.P. DeKoter, and R.A. Young Master transcription factors determine cell-type-specific responses to TGF-beta signaling Cell 147 2011 565 576
-
(2011)
Cell
, vol.147
, pp. 565-576
-
-
Mullen, A.C.1
Orlando, D.A.2
Newman, J.J.3
Loven, J.4
Kumar, R.M.5
Bilodeau, S.6
Reddy, J.7
Guenther, M.G.8
Dekoter, R.P.9
Young, R.A.10
-
44
-
-
33745892388
-
Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells
-
A. Suzuki, A. Raya, Y. Kawakami, M. Morita, T. Matsui, K. Nakashima, F.H. Gage, C. Rodriguez-Esteban, and J.C. Izpisua Belmonte Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells Proc. Natl. Acad. Sci. U. S. A. 103 2006 10294 10299
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10294-10299
-
-
Suzuki, A.1
Raya, A.2
Kawakami, Y.3
Morita, M.4
Matsui, T.5
Nakashima, K.6
Gage, F.H.7
Rodriguez-Esteban, C.8
Izpisua Belmonte, J.C.9
-
45
-
-
67650096520
-
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
-
L. Vallier, S. Mendjan, S. Brown, Z. Chng, A. Teo, L.E. Smithers, M.W. Trotter, C.H. Cho, A. Martinez, P. Rugg-Gunn, G. Brons, and R.A. Pedersen Activin/Nodal signalling maintains pluripotency by controlling Nanog expression Development 136 2009 1339 1349
-
(2009)
Development
, vol.136
, pp. 1339-1349
-
-
Vallier, L.1
Mendjan, S.2
Brown, S.3
Chng, Z.4
Teo, A.5
Smithers, L.E.6
Trotter, M.W.7
Cho, C.H.8
Martinez, A.9
Rugg-Gunn, P.10
Brons, G.11
Pedersen, R.A.12
-
47
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
X. Chen, H. Xu, P. Yuan, F. Fang, M. Huss, V.B. Vega, E. Wong, Y.L. Orlov, W. Zhang, J. Jiang, Y.H. Loh, H.C. Yeo, Z.X. Yeo, V. Narang, K.R. Govindarajan, B. Leong, A. Shahab, Y. Ruan, G. Bourque, W.K. Sung, N.D. Clarke, C.L. Wei, and H.H. Ng Integration of external signaling pathways with the core transcriptional network in embryonic stem cells Cell 133 2008 1106 1117
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
Vega, V.B.6
Wong, E.7
Orlov, Y.L.8
Zhang, W.9
Jiang, J.10
Loh, Y.H.11
Yeo, H.C.12
Yeo, Z.X.13
Narang, V.14
Govindarajan, K.R.15
Leong, B.16
Shahab, A.17
Ruan, Y.18
Bourque, G.19
Sung, W.K.20
Clarke, N.D.21
Wei, C.L.22
Ng, H.H.23
more..
-
48
-
-
80155123782
-
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
-
E. Trompouki, T.V. Bowman, L.N. Lawton, Z.P. Fan, D.C. Wu, A. DiBiase, C.S. Martin, J.N. Cech, A.K. Sessa, J.L. Leblanc, P. Li, E.M. Durand, C. Mosimann, G.C. Heffner, G.Q. Daley, R.F. Paulson, R.A. Young, and L.I. Zon Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration Cell 147 2011 577 589
-
(2011)
Cell
, vol.147
, pp. 577-589
-
-
Trompouki, E.1
Bowman, T.V.2
Lawton, L.N.3
Fan, Z.P.4
Wu, D.C.5
Dibiase, A.6
Martin, C.S.7
Cech, J.N.8
Sessa, A.K.9
Leblanc, J.L.10
Li, P.11
Durand, E.M.12
Mosimann, C.13
Heffner, G.C.14
Daley, G.Q.15
Paulson, R.F.16
Young, R.A.17
Zon, L.I.18
-
49
-
-
79960888524
-
Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
-
S. Brown, A. Teo, S. Pauklin, N. Hannan, C.H. Cho, B. Lim, L. Vardy, N.R. Dunn, M. Trotter, R. Pedersen, and L. Vallier Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors Stem Cells 29 2011 1176 1185
-
(2011)
Stem Cells
, vol.29
, pp. 1176-1185
-
-
Brown, S.1
Teo, A.2
Pauklin, S.3
Hannan, N.4
Cho, C.H.5
Lim, B.6
Vardy, L.7
Dunn, N.R.8
Trotter, M.9
Pedersen, R.10
Vallier, L.11
-
50
-
-
80051537445
-
Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
-
S.W. Kim, S.J. Yoon, E. Chuong, C. Oyolu, A.E. Wills, R. Gupta, and J. Baker Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs Dev. Biol. 357 2011 492 504
-
(2011)
Dev. Biol.
, vol.357
, pp. 492-504
-
-
Kim, S.W.1
Yoon, S.J.2
Chuong, E.3
Oyolu, C.4
Wills, A.E.5
Gupta, R.6
Baker, J.7
-
51
-
-
0033529565
-
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
-
R.D. Kornberg, and Y. Lorch Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome Cell 98 1999 285 294
-
(1999)
Cell
, vol.98
, pp. 285-294
-
-
Kornberg, R.D.1
Lorch, Y.2
-
52
-
-
77957970498
-
Epigenetic modifications in pluripotent and differentiated cells
-
A. Meissner Epigenetic modifications in pluripotent and differentiated cells Nat. Biotechnol. 28 2010 1079 1088
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 1079-1088
-
-
Meissner, A.1
-
54
-
-
0032528236
-
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation
-
X.H. Feng, Y. Zhang, R.Y. Wu, and R. Derynck The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation Genes Dev. 12 1998 2153 2163
-
(1998)
Genes Dev.
, vol.12
, pp. 2153-2163
-
-
Feng, X.H.1
Zhang, Y.2
Wu, R.Y.3
Derynck, R.4
-
55
-
-
0032527756
-
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300
-
R. Janknecht, N.J. Wells, and T. Hunter TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300 Genes Dev. 12 1998 2114 2119
-
(1998)
Genes Dev.
, vol.12
, pp. 2114-2119
-
-
Janknecht, R.1
Wells, N.J.2
Hunter, T.3
-
56
-
-
80052874703
-
Prodomains regulate the synthesis, extracellular localisation and activity of TGF-beta superfamily ligands
-
C.A. Harrison, S.L. Al-Musawi, and K.L. Walton Prodomains regulate the synthesis, extracellular localisation and activity of TGF-beta superfamily ligands Growth Factors 29 2011 174 186
-
(2011)
Growth Factors
, vol.29
, pp. 174-186
-
-
Harrison, C.A.1
Al-Musawi, S.L.2
Walton, K.L.3
-
57
-
-
0033545215
-
Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases
-
D.B. Constam, and E.J. Robertson Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases J. Cell Biol. 144 1999 139 149
-
(1999)
J. Cell Biol.
, vol.144
, pp. 139-149
-
-
Constam, D.B.1
Robertson, E.J.2
-
58
-
-
77957319456
-
Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos
-
L. Zakin, E.Y. Chang, J.L. Plouhinec, and E.M. De Robertis Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos Dev. Biol. 347 2010 204 215
-
(2010)
Dev. Biol.
, vol.347
, pp. 204-215
-
-
Zakin, L.1
Chang, E.Y.2
Plouhinec, J.L.3
De Robertis, E.M.4
-
59
-
-
33746435907
-
Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning
-
D. Mesnard, M. Guzman-Ayala, and D.B. Constam Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning Development 133 2006 2497 2505
-
(2006)
Development
, vol.133
, pp. 2497-2505
-
-
Mesnard, D.1
Guzman-Ayala, M.2
Constam, D.B.3
-
60
-
-
34447527158
-
Derivation of pluripotent epiblast stem cells from mammalian embryos
-
I.G. Brons, L.E. Smithers, M.W. Trotter, P. Rugg-Gunn, B. Sun, S.M. Chuva de Sousa Lopes, S.K. Howlett, A. Clarkson, L. Ahrlund-Richter, R.A. Pedersen, and L. Vallier Derivation of pluripotent epiblast stem cells from mammalian embryos Nature 448 2007 191 195
-
(2007)
Nature
, vol.448
, pp. 191-195
-
-
Brons, I.G.1
Smithers, L.E.2
Trotter, M.W.3
Rugg-Gunn, P.4
Sun, B.5
Chuva De Sousa Lopes, S.M.6
Howlett, S.K.7
Clarkson, A.8
Ahrlund-Richter, L.9
Pedersen, R.A.10
Vallier, L.11
-
61
-
-
34447528757
-
New cell lines from mouse epiblast share defining features with human embryonic stem cells
-
P.J. Tesar, J.G. Chenoweth, F.A. Brook, T.J. Davies, E.P. Evans, D.L. Mack, R.L. Gardner, and R.D. McKay New cell lines from mouse epiblast share defining features with human embryonic stem cells Nature 448 2007 196 199
-
(2007)
Nature
, vol.448
, pp. 196-199
-
-
Tesar, P.J.1
Chenoweth, J.G.2
Brook, F.A.3
Davies, T.J.4
Evans, E.P.5
MacK, D.L.6
Gardner, R.L.7
McKay, R.D.8
-
62
-
-
79952174848
-
Isolation of epiblast stem cells from preimplantation mouse embryos
-
F.J. Najm, J.G. Chenoweth, P.D. Anderson, J.H. Nadeau, R.W. Redline, R.D. McKay, and P.J. Tesar Isolation of epiblast stem cells from preimplantation mouse embryos Cell Stem Cell 8 2011 318 325
-
(2011)
Cell Stem Cell
, vol.8
, pp. 318-325
-
-
Najm, F.J.1
Chenoweth, J.G.2
Anderson, P.D.3
Nadeau, J.H.4
Redline, R.W.5
McKay, R.D.6
Tesar, P.J.7
-
63
-
-
33745618439
-
Building the mouse gastrula: Signals, asymmetry and lineages
-
P.P. Tam, D.A. Loebel, and S.S. Tanaka Building the mouse gastrula: signals, asymmetry and lineages Curr. Opin. Genet. Dev. 16 2006 419 425
-
(2006)
Curr. Opin. Genet. Dev.
, vol.16
, pp. 419-425
-
-
Tam, P.P.1
Loebel, D.A.2
Tanaka, S.S.3
-
64
-
-
34247226529
-
Gene function in mouse embryogenesis: Get set for gastrulation
-
P.P. Tam, and D.A. Loebel Gene function in mouse embryogenesis: get set for gastrulation Nat. Rev. Genet. 8 2007 368 381
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 368-381
-
-
Tam, P.P.1
Loebel, D.A.2
-
65
-
-
0030932236
-
Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
-
I. Varlet, J. Collignon, and E.J. Robertson nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation Development 124 1997 1033 1044
-
(1997)
Development
, vol.124
, pp. 1033-1044
-
-
Varlet, I.1
Collignon, J.2
Robertson, E.J.3
-
66
-
-
0035873224
-
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
-
P.A. Hoodless, M. Pye, C. Chazaud, E. Labbe, L. Attisano, J. Rossant, and J.L. Wrana FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse Genes Dev. 15 2001 1257 1271
-
(2001)
Genes Dev.
, vol.15
, pp. 1257-1271
-
-
Hoodless, P.A.1
Pye, M.2
Chazaud, C.3
Labbe, E.4
Attisano, L.5
Rossant, J.6
Wrana, J.L.7
-
67
-
-
0035872927
-
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
-
M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh, and H. Hamada The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse Genes Dev. 15 2001 1242 1256
-
(2001)
Genes Dev.
, vol.15
, pp. 1242-1256
-
-
Yamamoto, M.1
Meno, C.2
Sakai, Y.3
Shiratori, H.4
Mochida, K.5
Ikawa, Y.6
Saijoh, Y.7
Hamada, H.8
-
68
-
-
0033564874
-
Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements
-
D.P. Norris, and E.J. Robertson Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements Genes Dev. 13 1999 1575 1588
-
(1999)
Genes Dev.
, vol.13
, pp. 1575-1588
-
-
Norris, D.P.1
Robertson, E.J.2
-
69
-
-
35548939055
-
BMP signalling inhibits premature neural differentiation in the mouse embryo
-
A. Di-Gregorio, M. Sancho, D.W. Stuckey, L.A. Crompton, J. Godwin, Y. Mishina, and T.A. Rodriguez BMP signalling inhibits premature neural differentiation in the mouse embryo Development 134 2007 3359 3369
-
(2007)
Development
, vol.134
, pp. 3359-3369
-
-
Di-Gregorio, A.1
Sancho, M.2
Stuckey, D.W.3
Crompton, L.A.4
Godwin, J.5
Mishina, Y.6
Rodriguez, T.A.7
-
70
-
-
0034193390
-
BMP type II receptor is required for gastrulation and early development of mouse embryos
-
H. Beppu, M. Kawabata, T. Hamamoto, A. Chytil, O. Minowa, T. Noda, and K. Miyazono BMP type II receptor is required for gastrulation and early development of mouse embryos Dev. Biol. 221 2000 249 258
-
(2000)
Dev. Biol.
, vol.221
, pp. 249-258
-
-
Beppu, H.1
Kawabata, M.2
Hamamoto, T.3
Chytil, A.4
Minowa, O.5
Noda, T.6
Miyazono, K.7
-
71
-
-
6244256053
-
Bmpr encodes a type i bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
-
Y. Mishina, A. Suzuki, N. Ueno, and R.R. Behringer Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis Genes Dev. 9 1995 3027 3037
-
(1995)
Genes Dev.
, vol.9
, pp. 3027-3037
-
-
Mishina, Y.1
Suzuki, A.2
Ueno, N.3
Behringer, R.R.4
-
72
-
-
0029149656
-
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
-
G. Winnier, M. Blessing, P.A. Labosky, and B.L. Hogan Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse Genes Dev. 9 1995 2105 2116
-
(1995)
Genes Dev.
, vol.9
, pp. 2105-2116
-
-
Winnier, G.1
Blessing, M.2
Labosky, P.A.3
Hogan, B.L.4
-
73
-
-
0347765701
-
Cadherin-mediated cell interaction regulates germ cell determination in mice
-
D. Okamura, T. Kimura, T. Nakano, and Y. Matsui Cadherin-mediated cell interaction regulates germ cell determination in mice Development 130 2003 6423 6430
-
(2003)
Development
, vol.130
, pp. 6423-6430
-
-
Okamura, D.1
Kimura, T.2
Nakano, T.3
Matsui, Y.4
-
74
-
-
0034465667
-
Requirement of Bmp8b for the generation of primordial germ cells in the mouse
-
Y. Ying, X.M. Liu, A. Marble, K.A. Lawson, and G.Q. Zhao Requirement of Bmp8b for the generation of primordial germ cells in the mouse Mol. Endocrinol. 14 2000 1053 1063
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 1053-1063
-
-
Ying, Y.1
Liu, X.M.2
Marble, A.3
Lawson, K.A.4
Zhao, G.Q.5
-
75
-
-
0036803298
-
SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast
-
K. Hayashi, T. Kobayashi, T. Umino, R. Goitsuka, Y. Matsui, and D. Kitamura SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast Mech. Dev. 118 2002 99 109
-
(2002)
Mech. Dev.
, vol.118
, pp. 99-109
-
-
Hayashi, K.1
Kobayashi, T.2
Umino, T.3
Goitsuka, R.4
Matsui, Y.5
Kitamura, D.6
-
76
-
-
0033558165
-
Bmp4 is required for the generation of primordial germ cells in the mouse embryo
-
K.A. Lawson, N.R. Dunn, B.A. Roelen, L.M. Zeinstra, A.M. Davis, C.V. Wright, J.P. Korving, and B.L. Hogan Bmp4 is required for the generation of primordial germ cells in the mouse embryo Genes Dev. 13 1999 424 436
-
(1999)
Genes Dev.
, vol.13
, pp. 424-436
-
-
Lawson, K.A.1
Dunn, N.R.2
Roelen, B.A.3
Zeinstra, L.M.4
Davis, A.M.5
Wright, C.V.6
Korving, J.P.7
Hogan, B.L.8
-
77
-
-
0035189927
-
Embryo-derived stem cells: Of mice and men
-
A.G. Smith Embryo-derived stem cells: of mice and men Annu. Rev. Cell Dev. Biol. 17 2001 435 462
-
(2001)
Annu. Rev. Cell Dev. Biol.
, vol.17
, pp. 435-462
-
-
Smith, A.G.1
-
79
-
-
84856078085
-
A family business: Stem cell progeny join the niche to regulate homeostasis
-
Y.C. Hsu, and E. Fuchs A family business: stem cell progeny join the niche to regulate homeostasis Nat. Rev. Mol. Cell Biol. 13 2012 103 114
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 103-114
-
-
Hsu, Y.C.1
Fuchs, E.2
-
80
-
-
79958263078
-
Strategies for homeostatic stem cell self-renewal in adult tissues
-
B.D. Simons, and H. Clevers Strategies for homeostatic stem cell self-renewal in adult tissues Cell 145 2011 851 862
-
(2011)
Cell
, vol.145
, pp. 851-862
-
-
Simons, B.D.1
Clevers, H.2
-
82
-
-
78149487692
-
Pluripotency and cellular reprogramming: Facts, hypotheses, unresolved issues
-
J.H. Hanna, K. Saha, and R. Jaenisch Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues Cell 143 2010 508 525
-
(2010)
Cell
, vol.143
, pp. 508-525
-
-
Hanna, J.H.1
Saha, K.2
Jaenisch, R.3
-
83
-
-
39349106325
-
Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
-
C.E. Murry, and G. Keller Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development Cell 132 2008 661 680
-
(2008)
Cell
, vol.132
, pp. 661-680
-
-
Murry, C.E.1
Keller, G.2
-
84
-
-
84855410062
-
Editorial: Our top 10 developments in stem cell biology over the last 30 years
-
L. Armstrong, M. Lako, N. Buckley, T.R. Lappin, M.J. Murphy, J.A. Nolta, M. Pittenger, and M. Stojkovic Editorial: our top 10 developments in stem cell biology over the last 30 years Stem Cells 30 2012 2 9
-
(2012)
Stem Cells
, vol.30
, pp. 2-9
-
-
Armstrong, L.1
Lako, M.2
Buckley, N.3
Lappin, T.R.4
Murphy, M.J.5
Nolta, J.A.6
Pittenger, M.7
Stojkovic, M.8
-
85
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
86
-
-
39149086020
-
Induction of pluripotent stem cells from fibroblast cultures
-
K. Takahashi, K. Okita, M. Nakagawa, and S. Yamanaka Induction of pluripotent stem cells from fibroblast cultures Nat. Protoc. 2 2007 3081 3089
-
(2007)
Nat. Protoc.
, vol.2
, pp. 3081-3089
-
-
Takahashi, K.1
Okita, K.2
Nakagawa, M.3
Yamanaka, S.4
-
87
-
-
79952660821
-
Control of the embryonic stem cell state
-
R.A. Young Control of the embryonic stem cell state Cell 144 2011 940 954
-
(2011)
Cell
, vol.144
, pp. 940-954
-
-
Young, R.A.1
-
88
-
-
39149130361
-
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
-
R. Jaenisch, and R. Young Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming Cell 132 2008 567 582
-
(2008)
Cell
, vol.132
, pp. 567-582
-
-
Jaenisch, R.1
Young, R.2
-
89
-
-
0034028901
-
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
-
H. Niwa, J. Miyazaki, and A.G. Smith Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells Nat. Genet. 24 2000 372 376
-
(2000)
Nat. Genet.
, vol.24
, pp. 372-376
-
-
Niwa, H.1
Miyazaki, J.2
Smith, A.G.3
-
90
-
-
79958263080
-
Pluripotency factors in embryonic stem cells regulate differentiation into germ layers
-
M. Thomson, S.J. Liu, L.N. Zou, Z. Smith, A. Meissner, and S. Ramanathan Pluripotency factors in embryonic stem cells regulate differentiation into germ layers Cell 145 2011 875 889
-
(2011)
Cell
, vol.145
, pp. 875-889
-
-
Thomson, M.1
Liu, S.J.2
Zou, L.N.3
Smith, Z.4
Meissner, A.5
Ramanathan, S.6
-
91
-
-
84859539293
-
Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells
-
Z. Wang, E. Oron, B. Nelson, S. Razis, and N. Ivanova Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells Cell Stem Cell 10 2012 440 454
-
(2012)
Cell Stem Cell
, vol.10
, pp. 440-454
-
-
Wang, Z.1
Oron, E.2
Nelson, B.3
Razis, S.4
Ivanova, N.5
-
92
-
-
84855476375
-
Oct4 links multiple epigenetic pathways to the pluripotency network
-
J. Ding, H. Xu, F. Faiola, A. Ma'ayan, and J. Wang Oct4 links multiple epigenetic pathways to the pluripotency network Cell Res. 22 2012 155 167
-
(2012)
Cell Res.
, vol.22
, pp. 155-167
-
-
Ding, J.1
Xu, H.2
Faiola, F.3
Ma'Ayan, A.4
Wang, J.5
-
93
-
-
79960764496
-
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor
-
H. Hirai, P. Karian, and N. Kikyo Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor Biochem. J. 438 2011 11 23
-
(2011)
Biochem. J.
, vol.438
, pp. 11-23
-
-
Hirai, H.1
Karian, P.2
Kikyo, N.3
-
94
-
-
0344845415
-
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
-
Q.L. Ying, J. Nichols, I. Chambers, and A. Smith BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3 Cell 115 2003 281 292
-
(2003)
Cell
, vol.115
, pp. 281-292
-
-
Ying, Q.L.1
Nichols, J.2
Chambers, I.3
Smith, A.4
-
95
-
-
57449090247
-
Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity
-
B. Greber, H. Lehrach, and J. Adjaye Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity Stem Cells Dev. 17 2008 1065 1077
-
(2008)
Stem Cells Dev.
, vol.17
, pp. 1065-1077
-
-
Greber, B.1
Lehrach, H.2
Adjaye, J.3
-
96
-
-
48149098004
-
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs
-
R.H. Xu, T.L. Sampsell-Barron, F. Gu, S. Root, R.M. Peck, G. Pan, J. Yu, J. Antosiewicz-Bourget, S. Tian, R. Stewart, and J.A. Thomson NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs Cell Stem Cell 3 2008 196 206
-
(2008)
Cell Stem Cell
, vol.3
, pp. 196-206
-
-
Xu, R.H.1
Sampsell-Barron, T.L.2
Gu, F.3
Root, S.4
Peck, R.M.5
Pan, G.6
Yu, J.7
Antosiewicz-Bourget, J.8
Tian, S.9
Stewart, R.10
Thomson, J.A.11
-
97
-
-
77953365784
-
Extrinsic regulation of pluripotent stem cells
-
M.F. Pera, and P.P. Tam Extrinsic regulation of pluripotent stem cells Nature 465 2010 713 720
-
(2010)
Nature
, vol.465
, pp. 713-720
-
-
Pera, M.F.1
Tam, P.P.2
-
98
-
-
80855165240
-
Roles of FGF signaling in stem cell self-renewal, senescence and aging
-
D.L. Coutu, and J. Galipeau Roles of FGF signaling in stem cell self-renewal, senescence and aging Aging 3 2011 920 933
-
(2011)
Aging
, vol.3
, pp. 920-933
-
-
Coutu, D.L.1
Galipeau, J.2
-
99
-
-
0034794417
-
Feeder-free growth of undifferentiated human embryonic stem cells
-
C. Xu, M.S. Inokuma, J. Denham, K. Golds, P. Kundu, J.D. Gold, and M.K. Carpenter Feeder-free growth of undifferentiated human embryonic stem cells Nat. Biotechnol. 19 2001 971 974
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 971-974
-
-
Xu, C.1
Inokuma, M.S.2
Denham, J.3
Golds, K.4
Kundu, P.5
Gold, J.D.6
Carpenter, M.K.7
-
100
-
-
34548307176
-
IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro
-
S.C. Bendall, M.H. Stewart, P. Menendez, D. George, K. Vijayaragavan, T. Werbowetski-Ogilvie, V. Ramos-Mejia, A. Rouleau, J. Yang, M. Bosse, G. Lajoie, and M. Bhatia IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro Nature 448 2007 1015 1021
-
(2007)
Nature
, vol.448
, pp. 1015-1021
-
-
Bendall, S.C.1
Stewart, M.H.2
Menendez, P.3
George, D.4
Vijayaragavan, K.5
Werbowetski-Ogilvie, T.6
Ramos-Mejia, V.7
Rouleau, A.8
Yang, J.9
Bosse, M.10
Lajoie, G.11
Bhatia, M.12
-
101
-
-
27644486756
-
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
-
L. Vallier, M. Alexander, and R.A. Pedersen Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells J. Cell Sci. 118 2005 4495 4509
-
(2005)
J. Cell Sci.
, vol.118
, pp. 4495-4509
-
-
Vallier, L.1
Alexander, M.2
Pedersen, R.A.3
-
102
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
N. Sato, L. Meijer, L. Skaltsounis, P. Greengard, and A.H. Brivanlou Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor Nat. Med. 10 2004 55 63
-
(2004)
Nat. Med.
, vol.10
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
103
-
-
34249311572
-
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
-
B.W. Doble, S. Patel, G.A. Wood, L.K. Kockeritz, and J.R. Woodgett Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines Dev. Cell 12 2007 957 971
-
(2007)
Dev. Cell
, vol.12
, pp. 957-971
-
-
Doble, B.W.1
Patel, S.2
Wood, G.A.3
Kockeritz, L.K.4
Woodgett, J.R.5
-
104
-
-
78650730724
-
The origin and identity of embryonic stem cells
-
J. Nichols, and A. Smith The origin and identity of embryonic stem cells Development 138 2011 3 8
-
(2011)
Development
, vol.138
, pp. 3-8
-
-
Nichols, J.1
Smith, A.2
-
105
-
-
0019826665
-
Establishment in culture of pluripotential cells from mouse embryos
-
M.J. Evans, and M.H. Kaufman Establishment in culture of pluripotential cells from mouse embryos Nature 292 1981 154 156
-
(1981)
Nature
, vol.292
, pp. 154-156
-
-
Evans, M.J.1
Kaufman, M.H.2
-
106
-
-
0001007610
-
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
-
G.R. Martin Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells Proc. Natl. Acad. Sci. U. S. A. 78 1981 7634 7638
-
(1981)
Proc. Natl. Acad. Sci. U. S. A.
, vol.78
, pp. 7634-7638
-
-
Martin, G.R.1
-
107
-
-
44349170450
-
The ground state of embryonic stem cell self-renewal
-
Q.L. Ying, J. Wray, J. Nichols, L. Batlle-Morera, B. Doble, J. Woodgett, P. Cohen, and A. Smith The ground state of embryonic stem cell self-renewal Nature 453 2008 519 523
-
(2008)
Nature
, vol.453
, pp. 519-523
-
-
Ying, Q.L.1
Wray, J.2
Nichols, J.3
Batlle-Morera, L.4
Doble, B.5
Woodgett, J.6
Cohen, P.7
Smith, A.8
-
108
-
-
70350627509
-
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells
-
S. Bao, F. Tang, X. Li, K. Hayashi, A. Gillich, K. Lao, and M.A. Surani Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells Nature 461 2009 1292 1295
-
(2009)
Nature
, vol.461
, pp. 1292-1295
-
-
Bao, S.1
Tang, F.2
Li, X.3
Hayashi, K.4
Gillich, A.5
Lao, K.6
Surani, M.A.7
-
109
-
-
54949141186
-
The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells
-
Y.F. Chou, H.H. Chen, M. Eijpe, A. Yabuuchi, J.G. Chenoweth, P. Tesar, J. Lu, R.D. McKay, and N. Geijsen The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells Cell 135 2008 449 461
-
(2008)
Cell
, vol.135
, pp. 449-461
-
-
Chou, Y.F.1
Chen, H.H.2
Eijpe, M.3
Yabuuchi, A.4
Chenoweth, J.G.5
Tesar, P.6
Lu, J.7
McKay, R.D.8
Geijsen, N.9
-
110
-
-
84856798558
-
Mouse pluripotent stem cells at a glance
-
S. Pauklin, R.A. Pedersen, and L. Vallier Mouse pluripotent stem cells at a glance J. Cell Sci. 124 2011 3727 3732
-
(2011)
J. Cell Sci.
, vol.124
, pp. 3727-3732
-
-
Pauklin, S.1
Pedersen, R.A.2
Vallier, L.3
-
111
-
-
74949142886
-
Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination
-
T. Fei, K. Xia, Z. Li, B. Zhou, S. Zhu, H. Chen, J. Zhang, Z. Chen, H. Xiao, J.D. Han, and Y.G. Chen Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination Genome Res. 20 2010 36 44
-
(2010)
Genome Res.
, vol.20
, pp. 36-44
-
-
Fei, T.1
Xia, K.2
Li, Z.3
Zhou, B.4
Zhu, S.5
Chen, H.6
Zhang, J.7
Chen, Z.8
Xiao, H.9
Han, J.D.10
Chen, Y.G.11
-
112
-
-
34547624303
-
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
-
T.S. Mikkelsen, M. Ku, D.B. Jaffe, B. Issac, E. Lieberman, G. Giannoukos, P. Alvarez, W. Brockman, T.K. Kim, R.P. Koche, W. Lee, E. Mendenhall, A. O'Donovan, A. Presser, C. Russ, X. Xie, A. Meissner, M. Wernig, R. Jaenisch, C. Nusbaum, E.S. Lander, and B.E. Bernstein Genome-wide maps of chromatin state in pluripotent and lineage-committed cells Nature 448 2007 553 560
-
(2007)
Nature
, vol.448
, pp. 553-560
-
-
Mikkelsen, T.S.1
Ku, M.2
Jaffe, D.B.3
Issac, B.4
Lieberman, E.5
Giannoukos, G.6
Alvarez, P.7
Brockman, W.8
Kim, T.K.9
Koche, R.P.10
Lee, W.11
Mendenhall, E.12
O'Donovan, A.13
Presser, A.14
Russ, C.15
Xie, X.16
Meissner, A.17
Wernig, M.18
Jaenisch, R.19
Nusbaum, C.20
Lander, E.S.21
Bernstein, B.E.22
more..
-
113
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
B.E. Bernstein, T.S. Mikkelsen, X. Xie, M. Kamal, D.J. Huebert, J. Cuff, B. Fry, A. Meissner, M. Wernig, K. Plath, R. Jaenisch, A. Wagschal, R. Feil, S.L. Schreiber, and E.S. Lander A bivalent chromatin structure marks key developmental genes in embryonic stem cells Cell 125 2006 315 326
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
Mikkelsen, T.S.2
Xie, X.3
Kamal, M.4
Huebert, D.J.5
Cuff, J.6
Fry, B.7
Meissner, A.8
Wernig, M.9
Plath, K.10
Jaenisch, R.11
Wagschal, A.12
Feil, R.13
Schreiber, S.L.14
Lander, E.S.15
-
114
-
-
84860351082
-
The transcriptional and epigenomic foundations of ground state pluripotency
-
H. Marks, T. Kalkan, R. Menafra, S. Denissov, K. Jones, H. Hofemeister, J. Nichols, A. Kranz, A.F. Stewart, A. Smith, and H.G. Stunnenberg The transcriptional and epigenomic foundations of ground state pluripotency Cell 149 2012 590 604
-
(2012)
Cell
, vol.149
, pp. 590-604
-
-
Marks, H.1
Kalkan, T.2
Menafra, R.3
Denissov, S.4
Jones, K.5
Hofemeister, H.6
Nichols, J.7
Kranz, A.8
Stewart, A.F.9
Smith, A.10
Stunnenberg, H.G.11
-
115
-
-
33846798108
-
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells
-
K. Ogawa, A. Saito, H. Matsui, H. Suzuki, S. Ohtsuka, D. Shimosato, Y. Morishita, T. Watabe, H. Niwa, and K. Miyazono Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells J. Cell Sci. 120 2007 55 65
-
(2007)
J. Cell Sci.
, vol.120
, pp. 55-65
-
-
Ogawa, K.1
Saito, A.2
Matsui, H.3
Suzuki, H.4
Ohtsuka, S.5
Shimosato, D.6
Morishita, Y.7
Watabe, T.8
Niwa, H.9
Miyazono, K.10
-
116
-
-
78649847411
-
Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells
-
T. Fei, S. Zhu, K. Xia, J. Zhang, Z. Li, J.D. Han, and Y.G. Chen Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells Cell Res. 20 2010 1306 1318
-
(2010)
Cell Res.
, vol.20
, pp. 1306-1318
-
-
Fei, T.1
Zhu, S.2
Xia, K.3
Zhang, J.4
Li, Z.5
Han, J.D.6
Chen, Y.G.7
-
117
-
-
79959814756
-
Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions
-
K.L. Lee, S.K. Lim, Y.L. Orlov, Y. Yit le, H. Yang, L.T. Ang, L. Poellinger, and B. Lim Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions PLoS Genet. 7 2011 e1002130
-
(2011)
PLoS Genet.
, vol.7
, pp. 1002130
-
-
Lee, K.L.1
Lim, S.K.2
Orlov, Y.L.3
Yit Le, Y.4
Yang, H.5
Ang, L.T.6
Poellinger, L.7
Lim, B.8
-
118
-
-
77449161605
-
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells
-
B. Greber, G. Wu, C. Bernemann, J.Y. Joo, D.W. Han, K. Ko, N. Tapia, D. Sabour, J. Sterneckert, P. Tesar, and H.R. Scholer Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells Cell Stem Cell 6 2010 215 226
-
(2010)
Cell Stem Cell
, vol.6
, pp. 215-226
-
-
Greber, B.1
Wu, G.2
Bernemann, C.3
Joo, J.Y.4
Han, D.W.5
Ko, K.6
Tapia, N.7
Sabour, D.8
Sterneckert, J.9
Tesar, P.10
Scholer, H.R.11
-
119
-
-
68949141428
-
Germ cell specification in mice
-
M. Saitou Germ cell specification in mice Curr. Opin. Genet. Dev. 19 2009 386 395
-
(2009)
Curr. Opin. Genet. Dev.
, vol.19
, pp. 386-395
-
-
Saitou, M.1
-
120
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
Itskovitz-Eldor, J.2
Shapiro, S.S.3
Waknitz, M.A.4
Swiergiel, J.J.5
Marshall, V.S.6
Jones, J.M.7
-
121
-
-
2542601547
-
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
-
R. Brandenberger, H. Wei, S. Zhang, S. Lei, J. Murage, G.J. Fisk, Y. Li, C. Xu, R. Fang, K. Guegler, M.S. Rao, R. Mandalam, J. Lebkowski, and L.W. Stanton Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nat. Biotechnol. 22 2004 707 716
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 707-716
-
-
Brandenberger, R.1
Wei, H.2
Zhang, S.3
Lei, S.4
Murage, J.5
Fisk, G.J.6
Li, Y.7
Xu, C.8
Fang, R.9
Guegler, K.10
Rao, M.S.11
Mandalam, R.12
Lebkowski, J.13
Stanton, L.W.14
-
122
-
-
7244240749
-
Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3
-
D. Besser Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3 J. Biol. Chem. 279 2004 45076 45084
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45076-45084
-
-
Besser, D.1
-
123
-
-
16244400050
-
TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
-
D. James, A.J. Levine, D. Besser, and A. Hemmati-Brivanlou TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells Development 132 2005 1273 1282
-
(2005)
Development
, vol.132
, pp. 1273-1282
-
-
James, D.1
Levine, A.J.2
Besser, D.3
Hemmati-Brivanlou, A.4
-
124
-
-
37349052866
-
Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm
-
J.R. Smith, L. Vallier, G. Lupo, M. Alexander, W.A. Harris, and R.A. Pedersen Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm Dev. Biol. 313 2008 107 117
-
(2008)
Dev. Biol.
, vol.313
, pp. 107-117
-
-
Smith, J.R.1
Vallier, L.2
Lupo, G.3
Alexander, M.4
Harris, W.A.5
Pedersen, R.A.6
-
125
-
-
25144525014
-
Core transcriptional regulatory circuitry in human embryonic stem cells
-
L.A. Boyer, T.I. Lee, M.F. Cole, S.E. Johnstone, S.S. Levine, J.P. Zucker, M.G. Guenther, R.M. Kumar, H.L. Murray, R.G. Jenner, D.K. Gifford, D.A. Melton, R. Jaenisch, and R.A. Young Core transcriptional regulatory circuitry in human embryonic stem cells Cell 122 2005 947 956
-
(2005)
Cell
, vol.122
, pp. 947-956
-
-
Boyer, L.A.1
Lee, T.I.2
Cole, M.F.3
Johnstone, S.E.4
Levine, S.S.5
Zucker, J.P.6
Guenther, M.G.7
Kumar, R.M.8
Murray, H.L.9
Jenner, R.G.10
Gifford, D.K.11
Melton, D.A.12
Jaenisch, R.13
Young, R.A.14
-
126
-
-
77954100084
-
Transposable elements have rewired the core regulatory network of human embryonic stem cells
-
G. Kunarso, N.Y. Chia, J. Jeyakani, C. Hwang, X. Lu, Y.S. Chan, H.H. Ng, and G. Bourque Transposable elements have rewired the core regulatory network of human embryonic stem cells Nat. Genet. 42 2010 631 634
-
(2010)
Nat. Genet.
, vol.42
, pp. 631-634
-
-
Kunarso, G.1
Chia, N.Y.2
Jeyakani, J.3
Hwang, C.4
Lu, X.5
Chan, Y.S.6
Ng, H.H.7
Bourque, G.8
-
127
-
-
77953466536
-
Nuclear reprogramming to a pluripotent state by three approaches
-
S. Yamanaka, and H.M. Blau Nuclear reprogramming to a pluripotent state by three approaches Nature 465 2010 704 712
-
(2010)
Nature
, vol.465
, pp. 704-712
-
-
Yamanaka, S.1
Blau, H.M.2
-
128
-
-
69949104478
-
Adult mice generated from induced pluripotent stem cells
-
M.J. Boland, J.L. Hazen, K.L. Nazor, A.R. Rodriguez, W. Gifford, G. Martin, S. Kupriyanov, and K.K. Baldwin Adult mice generated from induced pluripotent stem cells Nature 461 2009 91 94
-
(2009)
Nature
, vol.461
, pp. 91-94
-
-
Boland, M.J.1
Hazen, J.L.2
Nazor, K.L.3
Rodriguez, A.R.4
Gifford, W.5
Martin, G.6
Kupriyanov, S.7
Baldwin, K.K.8
-
129
-
-
69949089630
-
IPS cells produce viable mice through tetraploid complementation
-
X.Y. Zhao, W. Li, Z. Lv, L. Liu, M. Tong, T. Hai, J. Hao, C.L. Guo, Q.W. Ma, L. Wang, F. Zeng, and Q. Zhou iPS cells produce viable mice through tetraploid complementation Nature 461 2009 86 90
-
(2009)
Nature
, vol.461
, pp. 86-90
-
-
Zhao, X.Y.1
Li, W.2
Lv, Z.3
Liu, L.4
Tong, M.5
Hai, T.6
Hao, J.7
Guo, C.L.8
Ma, Q.W.9
Wang, L.10
Zeng, F.11
Zhou, Q.12
-
130
-
-
84855397933
-
Concise review: Embryonic stem cells versus induced pluripotent stem cells: The game is on
-
M.C. Puri, and A. Nagy Concise review: Embryonic stem cells versus induced pluripotent stem cells: the game is on Stem Cells 30 2012 10 14
-
(2012)
Stem Cells
, vol.30
, pp. 10-14
-
-
Puri, M.C.1
Nagy, A.2
-
131
-
-
84855416431
-
Concise review: Induced pluripotent stem cells versus embryonic stem cells: Close enough or yet too far apart?
-
J. Bilic, and J.C. Izpisua Belmonte Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart? Stem Cells 30 2012 33 41
-
(2012)
Stem Cells
, vol.30
, pp. 33-41
-
-
Bilic, J.1
Izpisua Belmonte, J.C.2
-
132
-
-
77952425747
-
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
-
M. Stadtfeld, E. Apostolou, H. Akutsu, A. Fukuda, P. Follett, S. Natesan, T. Kono, T. Shioda, and K. Hochedlinger Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells Nature 465 2010 175 181
-
(2010)
Nature
, vol.465
, pp. 175-181
-
-
Stadtfeld, M.1
Apostolou, E.2
Akutsu, H.3
Fukuda, A.4
Follett, P.5
Natesan, S.6
Kono, T.7
Shioda, T.8
Hochedlinger, K.9
-
133
-
-
74049124993
-
Single-gene transgenic mouse strains for reprogramming adult somatic cells
-
B.W. Carey, S. Markoulaki, C. Beard, J. Hanna, and R. Jaenisch Single-gene transgenic mouse strains for reprogramming adult somatic cells Nat. Methods 7 2010 56 59
-
(2010)
Nat. Methods
, vol.7
, pp. 56-59
-
-
Carey, B.W.1
Markoulaki, S.2
Beard, C.3
Hanna, J.4
Jaenisch, R.5
-
134
-
-
82755185948
-
Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells
-
B.W. Carey, S. Markoulaki, J.H. Hanna, D.A. Faddah, Y. Buganim, J. Kim, K. Ganz, E.J. Steine, J.P. Cassady, M.P. Creyghton, G.G. Welstead, Q. Gao, and R. Jaenisch Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells Cell Stem Cell 9 2011 588 598
-
(2011)
Cell Stem Cell
, vol.9
, pp. 588-598
-
-
Carey, B.W.1
Markoulaki, S.2
Hanna, J.H.3
Faddah, D.A.4
Buganim, Y.5
Kim, J.6
Ganz, K.7
Steine, E.J.8
Cassady, J.P.9
Creyghton, M.P.10
Welstead, G.G.11
Gao, Q.12
Jaenisch, R.13
-
135
-
-
64749083939
-
PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
-
K. Woltjen, I.P. Michael, P. Mohseni, R. Desai, M. Mileikovsky, R. Hamalainen, R. Cowling, W. Wang, P. Liu, M. Gertsenstein, K. Kaji, H.K. Sung, and A. Nagy piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells Nature 458 2009 766 770
-
(2009)
Nature
, vol.458
, pp. 766-770
-
-
Woltjen, K.1
Michael, I.P.2
Mohseni, P.3
Desai, R.4
Mileikovsky, M.5
Hamalainen, R.6
Cowling, R.7
Wang, W.8
Liu, P.9
Gertsenstein, M.10
Kaji, K.11
Sung, H.K.12
Nagy, A.13
-
136
-
-
77956320116
-
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
-
P. Samavarchi-Tehrani, A. Golipour, L. David, H.K. Sung, T.A. Beyer, A. Datti, K. Woltjen, A. Nagy, and J.L. Wrana Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming Cell Stem Cell 7 2010 64 77
-
(2010)
Cell Stem Cell
, vol.7
, pp. 64-77
-
-
Samavarchi-Tehrani, P.1
Golipour, A.2
David, L.3
Sung, H.K.4
Beyer, T.A.5
Datti, A.6
Woltjen, K.7
Nagy, A.8
Wrana, J.L.9
-
137
-
-
77957551870
-
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
-
R. Li, J. Liang, S. Ni, T. Zhou, X. Qing, H. Li, W. He, J. Chen, F. Li, Q. Zhuang, B. Qin, J. Xu, W. Li, J. Yang, Y. Gan, D. Qin, S. Feng, H. Song, D. Yang, B. Zhang, L. Zeng, L. Lai, M.A. Esteban, and D. Pei A mesenchymal-to- epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts Cell Stem Cell 7 2010 51 63
-
(2010)
Cell Stem Cell
, vol.7
, pp. 51-63
-
-
Li, R.1
Liang, J.2
Ni, S.3
Zhou, T.4
Qing, X.5
Li, H.6
He, W.7
Chen, J.8
Li, F.9
Zhuang, Q.10
Qin, B.11
Xu, J.12
Li, W.13
Yang, J.14
Gan, Y.15
Qin, D.16
Feng, S.17
Song, H.18
Yang, D.19
Zhang, B.20
Zeng, L.21
Lai, L.22
Esteban, M.A.23
Pei, D.24
more..
-
138
-
-
77952172633
-
Dynamic single-cell imaging of direct reprogramming reveals an early specifying event
-
Z.D. Smith, I. Nachman, A. Regev, and A. Meissner Dynamic single-cell imaging of direct reprogramming reveals an early specifying event Nat. Biotechnol. 28 2010 521 526
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 521-526
-
-
Smith, Z.D.1
Nachman, I.2
Regev, A.3
Meissner, A.4
-
139
-
-
77952768290
-
Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression
-
J.L. Yori, E. Johnson, G. Zhou, M.K. Jain, and R.A. Keri Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression J. Biol. Chem. 285 2010 16854 16863
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 16854-16863
-
-
Yori, J.L.1
Johnson, E.2
Zhou, G.3
Jain, M.K.4
Keri, R.A.5
-
140
-
-
78650881444
-
BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone
-
J. Chen, J. Liu, J. Yang, Y. Chen, S. Ni, H. Song, L. Zeng, K. Ding, and D. Pei BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone Cell Res. 21 2011 205 212
-
(2011)
Cell Res.
, vol.21
, pp. 205-212
-
-
Chen, J.1
Liu, J.2
Yang, J.3
Chen, Y.4
Ni, S.5
Song, H.6
Zeng, L.7
Ding, K.8
Pei, D.9
-
141
-
-
70350732790
-
A chemical platform for improved induction of human iPSCs
-
T. Lin, R. Ambasudhan, X. Yuan, W. Li, S. Hilcove, R. Abujarour, X. Lin, H.S. Hahm, E. Hao, A. Hayek, and S. Ding A chemical platform for improved induction of human iPSCs Nat. Methods 6 2009 805 808
-
(2009)
Nat. Methods
, vol.6
, pp. 805-808
-
-
Lin, T.1
Ambasudhan, R.2
Yuan, X.3
Li, W.4
Hilcove, S.5
Abujarour, R.6
Lin, X.7
Hahm, H.S.8
Hao, E.9
Hayek, A.10
Ding, S.11
-
142
-
-
70350536767
-
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog
-
J.K. Ichida, J. Blanchard, K. Lam, E.Y. Son, J.E. Chung, D. Egli, K.M. Loh, A.C. Carter, F.P. Di Giorgio, K. Koszka, D. Huangfu, H. Akutsu, D.R. Liu, L.L. Rubin, and K. Eggan A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog Cell Stem Cell 5 2009 491 503
-
(2009)
Cell Stem Cell
, vol.5
, pp. 491-503
-
-
Ichida, J.K.1
Blanchard, J.2
Lam, K.3
Son, E.Y.4
Chung, J.E.5
Egli, D.6
Loh, K.M.7
Carter, A.C.8
Di Giorgio, F.P.9
Koszka, K.10
Huangfu, D.11
Akutsu, H.12
Liu, D.R.13
Rubin, L.L.14
Eggan, K.15
-
143
-
-
73049086022
-
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2
-
W. Li, H. Zhou, R. Abujarour, S. Zhu, J. Young Joo, T. Lin, E. Hao, H.R. Scholer, A. Hayek, and S. Ding Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2 Stem Cells 27 2009 2992 3000
-
(2009)
Stem Cells
, vol.27
, pp. 2992-3000
-
-
Li, W.1
Zhou, H.2
Abujarour, R.3
Zhu, S.4
Young Joo, J.5
Lin, T.6
Hao, E.7
Scholer, H.R.8
Hayek, A.9
Ding, S.10
-
144
-
-
70350571742
-
Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc
-
N. Maherali, and K. Hochedlinger Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc Curr. Biol. 19 2009 1718 1723
-
(2009)
Curr. Biol.
, vol.19
, pp. 1718-1723
-
-
Maherali, N.1
Hochedlinger, K.2
-
145
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
J.P. Thiery, and J.P. Sleeman Complex networks orchestrate epithelial-mesenchymal transitions Nat. Rev. Mol. Cell Biol. 7 2006 131 142
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
146
-
-
61749097816
-
Tgf-beta superfamily signaling in embryonic development and homeostasis
-
M.Y. Wu, and C.S. Hill Tgf-beta superfamily signaling in embryonic development and homeostasis Dev. Cell 16 2009 329 343
-
(2009)
Dev. Cell
, vol.16
, pp. 329-343
-
-
Wu, M.Y.1
Hill, C.S.2
-
147
-
-
0025166072
-
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate
-
J.B. Green, and J.C. Smith Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate Nature 347 1990 391 394
-
(1990)
Nature
, vol.347
, pp. 391-394
-
-
Green, J.B.1
Smith, J.C.2
-
148
-
-
0036638778
-
The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
-
D.P. Norris, J. Brennan, E.K. Bikoff, and E.J. Robertson The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo Development 129 2002 3455 3468
-
(2002)
Development
, vol.129
, pp. 3455-3468
-
-
Norris, D.P.1
Brennan, J.2
Bikoff, E.K.3
Robertson, E.J.4
-
149
-
-
24044443920
-
Germ layer induction from embryonic stem cells
-
P. Gadue, T.L. Huber, M.C. Nostro, S. Kattman, and G.M. Keller Germ layer induction from embryonic stem cells Exp. Hematol. 33 2005 955 964
-
(2005)
Exp. Hematol.
, vol.33
, pp. 955-964
-
-
Gadue, P.1
Huber, T.L.2
Nostro, M.C.3
Kattman, S.4
Keller, G.M.5
-
150
-
-
1842853507
-
BMP4 initiates human embryonic stem cell differentiation to trophoblast
-
R.H. Xu, X. Chen, D.S. Li, R. Li, G.C. Addicks, C. Glennon, T.P. Zwaka, and J.A. Thomson BMP4 initiates human embryonic stem cell differentiation to trophoblast Nat. Biotechnol. 20 2002 1261 1264
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 1261-1264
-
-
Xu, R.H.1
Chen, X.2
Li, D.S.3
Li, R.4
Addicks, G.C.5
Glennon, C.6
Zwaka, T.P.7
Thomson, J.A.8
-
151
-
-
39349091570
-
Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells
-
P. Zhang, J. Li, Z. Tan, C. Wang, T. Liu, L. Chen, J. Yong, W. Jiang, X. Sun, L. Du, M. Ding, and H. Deng Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells Blood 111 2008 1933 1941
-
(2008)
Blood
, vol.111
, pp. 1933-1941
-
-
Zhang, P.1
Li, J.2
Tan, Z.3
Wang, C.4
Liu, T.5
Chen, L.6
Yong, J.7
Jiang, W.8
Sun, X.9
Du, L.10
Ding, M.11
Deng, H.12
-
152
-
-
84866407537
-
Model systems for studying trophoblast differentiation from human pluripotent stem cells
-
T. Ezashi, B.P. Telugu, and R.M. Roberts Model systems for studying trophoblast differentiation from human pluripotent stem cells Cell Tissue Res. 349 2012 809 824
-
(2012)
Cell Tissue Res.
, vol.349
, pp. 809-824
-
-
Ezashi, T.1
Telugu, B.P.2
Roberts, R.M.3
-
153
-
-
28644448149
-
Efficient differentiation of human embryonic stem cells to definitive endoderm
-
K.A. D'Amour, A.D. Agulnick, S. Eliazer, O.G. Kelly, E. Kroon, and E.E. Baetge Efficient differentiation of human embryonic stem cells to definitive endoderm Nat. Biotechnol. 23 2005 1534 1541
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1534-1541
-
-
D'Amour, K.A.1
Agulnick, A.D.2
Eliazer, S.3
Kelly, O.G.4
Kroon, E.5
Baetge, E.E.6
-
154
-
-
62149125434
-
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
-
S.M. Chambers, C.A. Fasano, E.P. Papapetrou, M. Tomishima, M. Sadelain, and L. Studer Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling Nat. Biotechnol. 27 2009 275 280
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 275-280
-
-
Chambers, S.M.1
Fasano, C.A.2
Papapetrou, E.P.3
Tomishima, M.4
Sadelain, M.5
Studer, L.6
-
155
-
-
83555164640
-
FGF signalling inhibits neural induction in human embryonic stem cells
-
B. Greber, P. Coulon, M. Zhang, S. Moritz, S. Frank, A.J. Muller-Molina, M.J. Arauzo-Bravo, D.W. Han, H.C. Pape, and H.R. Scholer FGF signalling inhibits neural induction in human embryonic stem cells EMBO J. 30 2011 4874 4884
-
(2011)
EMBO J.
, vol.30
, pp. 4874-4884
-
-
Greber, B.1
Coulon, P.2
Zhang, M.3
Moritz, S.4
Frank, S.5
Muller-Molina, A.J.6
Arauzo-Bravo, M.J.7
Han, D.W.8
Pape, H.C.9
Scholer, H.R.10
-
156
-
-
33745256758
-
Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo
-
A. Camus, A. Perea-Gomez, A. Moreau, and J. Collignon Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo Dev. Biol. 295 2006 743 755
-
(2006)
Dev. Biol.
, vol.295
, pp. 743-755
-
-
Camus, A.1
Perea-Gomez, A.2
Moreau, A.3
Collignon, J.4
-
157
-
-
0036546980
-
Neural induction, the default model and embryonic stem cells
-
I. Munoz-Sanjuan, and A.H. Brivanlou Neural induction, the default model and embryonic stem cells Nat. Rev. Neurosci. 3 2002 271 280
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 271-280
-
-
Munoz-Sanjuan, I.1
Brivanlou, A.H.2
-
158
-
-
33244485265
-
The interpretation of morphogen gradients
-
H.L. Ashe, and J. Briscoe The interpretation of morphogen gradients Development 133 2006 385 394
-
(2006)
Development
, vol.133
, pp. 385-394
-
-
Ashe, H.L.1
Briscoe, J.2
-
159
-
-
79551597211
-
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
-
S.J. Kattman, A.D. Witty, M. Gagliardi, N.C. Dubois, M. Niapour, A. Hotta, J. Ellis, and G. Keller Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines Cell Stem Cell 8 2011 228 240
-
(2011)
Cell Stem Cell
, vol.8
, pp. 228-240
-
-
Kattman, S.J.1
Witty, A.D.2
Gagliardi, M.3
Dubois, N.C.4
Niapour, M.5
Hotta, A.6
Ellis, J.7
Keller, G.8
-
160
-
-
79551580013
-
Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
-
M.C. Nostro, F. Sarangi, S. Ogawa, A. Holtzinger, B. Corneo, X. Li, S.J. Micallef, I.H. Park, C. Basford, M.B. Wheeler, G.Q. Daley, A.G. Elefanty, E.G. Stanley, and G. Keller Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells Development 138 2011 861 871
-
(2011)
Development
, vol.138
, pp. 861-871
-
-
Nostro, M.C.1
Sarangi, F.2
Ogawa, S.3
Holtzinger, A.4
Corneo, B.5
Li, X.6
Micallef, S.J.7
Park, I.H.8
Basford, C.9
Wheeler, M.B.10
Daley, G.Q.11
Elefanty, A.G.12
Stanley, E.G.13
Keller, G.14
-
161
-
-
79952161362
-
FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation
-
P. Yu, G. Pan, J. Yu, and J.A. Thomson FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation Cell Stem Cell 8 2011 326 334
-
(2011)
Cell Stem Cell
, vol.8
, pp. 326-334
-
-
Yu, P.1
Pan, G.2
Yu, J.3
Thomson, J.A.4
|