Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor

Molecular Endocrinology

Volumn 10, Issue 2, 1996, Pages 132-139

  Turner, Paul R ^b   Bambino, Tom ^b   Nissenson, Robert A ^a  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; PROTEINS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, PARATHYROID HORMONE; SIGNAL TRANSDUCTION;

EID: 0030052971     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.2.132     Document Type: Article

References (24)

1. Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski Jr LF, Hock J, Potts Jr JT, Kronenberg HM, Segre GV 1991 A G-protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026
2. Segre GV, Goldring SR 1993 Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol Metab 4:309-314
3. Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC 1992 Sequence alignment of the G-protein coupled receptor super-family. DNA Cell Biol 11:1-20
4. Jüppner H, Schipani E, Bringhurst FR, McClure I, Keutmann HT, Potts Jr JT, Kronenberg HM, Abou-Samra AB, Segre GV, Gardella TJ 1994 The extracellular aminoterminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34). Endocrinology 134:879-884
5. Trummp-Kallmeyer S, Hoflack J, Bruinvels A, Hibert M 1992 Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors. J Med Chem 35:3448-3462
6. Suryanarayana S, von Zastrow M, Kobilka BK 1992 Identification of intramolecular interactions in adrenergic receptors. J Biol Chem 267:21991-21994
7. 296. Biochemistry 31:12593-12601
8. Fraser CM, Chung F-Z, Wang C-D, Venter JC 1988 Site directed mutagenesis of human β-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase. Proc Natl Acad Sci USA 85:5478-5482
9. Bihoreau C, Monnot C, Davies E, Teutsch B, Bernstein KE, Corvol P, Clauser E 1993 Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling. Proc Natl Acad Sci USA 90:5133-5137
10. Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S 1991 Molecular cloning and expression of a cDNA encoding the secretin receptor. EMBO J 7:1635-1641
11. Kaufmann M, Muff R, Born W, Fischer JA 1994 Functional expression of a stably transfected parathyroid hormone/parathyroid hormone related protein receptor complementary DNA in CHO cells. Mol Cell Endocrinol 104:21-27
12. Blind E, Bambino T, Nissenson RA 1995 Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein. Endocrinology 136:4271-4277
13. Robbins LS, Nadeau JH, Johnson KR, Kelly MA, Roselli-Rehfuss L, Baack E, Mountjoy KG, Cone RD 1993 Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72:827-834
14. Shenker A, Laue L, Kosugi S, Merendino Jr JJ, Minegishi T, Cutler Jr GB 1993 A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 365:652-654
15. 383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production. J Biol Chem 266:14953-14957
16. 2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor. Endocrinology 135:1186-1194
17. Fathi Z, Benya RV, Shapira H, Jensen RT, Battey JF 1993 The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. J Biol Chem 268:14622-14626
18. Krystek Jr SR, Patel PS, Rose PM, Fisher SM, Kienzle BK, Lach DA, Liu EC-K, Lynch JS, Novotny J, Webb ML 1994 Mutation of peptide binding site in transmembrane region of a G protein-coupled receptor accounts for endothelin receptor subtype selectivity. J Biol Chem 269: 12383-12386
19. Siciliano SJ, Rollins TE, DeMartino J, Konteatis Z, Malkowitz L, Van Riper G, Bondy S, Rosen H, Springer MS 1994 Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors. Proc Natl Acad Sci USA 91:1214-1218
20. 1). J Biol Chem 270:14024-14030
21. Schipani E, Kruse K, Jüppner H 1995 A constitutively active mutant PTH/PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268:98-100
22. Lopata MA, Cleveland DW, Sollner-Webb B 1984 High-level expression of a chloramphenicol acetyltransferase gene by DEAE-dextran-mediated DNA transfection coupled with a dimethylsulfoxide or glycerol shock treatment. Nucleic Acid Res 12:5707-5714
23. Nissenson RA, Diep D, Strewler GJ 1988 Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem 263:12866-12871
24. Nissenson RA, Strewler GJ, Williams RD, Leung SC 1985 Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor. Cancer Res 45:5358-5363