G-protein-coupled receptor dynamics: Dimerization and activation models compared with experiment

Biochemical Society Transactions

Volumn 40, Issue 2, 2012, Pages 394-399

  Taddese, Bruck ^a   Simpson, Lisa M ^a   Wall, Ian D ^b   Blaney, Frank E ^c   Kidley, Nathan J ^a   Clark, Henry S X ^a   Smith, Richard E ^a   Upton, Graham J G ^a   Gouldson, Paul R ^a   Psaroudakis, George ^a   Bywater, Robert P ^a   Reynolds, Christopher A ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Memprot Consulting   (United Kingdom)

Author keywords

2 adrenergic receptor ( 2 AR); Activation model; G protein; G protein coupled receptor dimerization (GPCR dimerization); Homology modelling; Rotamer toggle switch

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; DIMER; G PROTEIN COUPLED RECEPTOR; RHODOPSIN;

BINDING SITE; DIMERIZATION; MOLECULAR DYNAMICS; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE; REVIEW; SIMULATION; TRANSMEMBRANE HELIX 4;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; HUMANS; MODELS, BIOLOGICAL; MOLECULAR DYNAMICS SIMULATION; PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84859325952     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20110755     Document Type: Review

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