Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor

Journal of Molecular Endocrinology

Volumn 34, Issue 2, 2005, Pages 405-414

  Langer, Ingrid ^a   Langlet, Christelle ^a   Robberecht, Patrick ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; AEQUORIN; ALANINE; CALCIUM ION; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LEUCINE; LYSINE; VASOACTIVE INTESTINAL POLYPEPTIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC CONSERVATION; GENETIC TRANSFECTION; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; CYCLIC AMP; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE, TYPE II; VASOACTIVE INTESTINAL PEPTIDE;

EID: 17844389615     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01717     Document Type: Article

References (28)

1. Blanpain C, Doranz BJ, Vakili J, Rucker J, Govaerts C, Baik SS, Lorthioir O, Migeotte I, Libert F, Baleux F, Vassart G, Doms RW & Parmentier M 1999 Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein. Journal of Biological Chemistry 274 34719-34727.
2. Blom N, Gammeltoft S & Brunak S 1999 Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. Journal of Molecular Biology 294 1351-1362.
3. Brini M, Marsault R, Bastianutto C, Alvarez J, Pozzan T & Rizzuto R 1995 Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation. Journal of Biological Chemistry 270 9896-9903.
4. Chan KY, Pang RT & Chow BK 2001 Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor. Endocrinology 142 3926-3934.
5. Couvineau A, Lacapere JJ, Tan YV, Rouyer-Fessard C, Nicole P & Laburthe M 2003 Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors. Journal of Biological Chemistry 278 24759-24766.
6. Detheux M, Standker L, Vakili J, Munch J, Forssmann U, Adermann K, Pohlmann S, Vassart G, Kirchhoff F, Parmentier M & Forssmann WG 2000 Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-hiv properties. Journal of Experimental Medicine 192 1501-1508.
7. Fahrenkrug J 1993 Transmitter role of vasoactive intestinal peptide. Pharmacology and Toxicology 72 354-363.
8. Ferguson SS 2001 Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacological Reiews 53 1-24.
9. Gomariz RP, Martinez C, Abad C, Leceta J & Delgado M 2001 Immunology of VIP: a review and therapeutical perspectives. Current Pharmaceutical Design 7 89-111.
10. 2 receptor subclass. Peptides 18 403-408.
11. Greasley PJ, Fanelli F, Scheer A, Abuin L, Nenniger-Tosato M, DeBenedetti PG & Cotecchia S 2001 Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein-coupling. Journal of Biological Chemistry 276 46485-46494.
12. Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, Rawlings SR, Robberecht P, Said SI, Sreedharan SP, Wank SA & Waschek JA 1998 International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase- activating polypeptide. Pharmacological Reviews 50 265-270.
13. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Nissenson RA & Shoback DM 1996 The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways. Journal of Biological Chemistry 271 33382-33389.
14. Kohout TA & Lefkowitz RJ 2003 Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Molecular Pharmacology 63 9-18.
15. Kostenis E, Gomeza J, Lerche C & Wess J 1997 Genetic analysis of receptor-Galphaq coupling selectivity. Journal of Biological Chemistry 272 23675-23681.
16. Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A & Kohn LD 1992 Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies. Journal of Biological Chemistry 267 24153-24156.
17. i and cyclic AMP in CHO cells expressing Galpha16. Cell Calcium 30 229-234.
18. Langer I, Vertongen P, Perret J, Waelbroeck M & Robberecht P 2002 A small sequence in the third intracellular loop of the VPAC(1) receptor is responsible for its efficient coupling to the calcium effector. Molecular Endocrinology 16 1089-1096.
19. McDonald TP, Dinnis DM, Morrison CF & Harmar AJ 1998 Desensitization of the human vasoactive intestinal peptide receptor (hVIP2/PACAP R): evidence for agonist-induced receptor phosphorylation and internalization. Annals of the New York Academy of Sciences 865 64-72.
20. Mhaouty-Kodja S, Barak LS, Scheer A, Abuin L, Diviani D, Caron MG & Cotecchia S 1999 Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features. Molecular Pharmacology 55 339-347.
21. Min L & Ascoli M 2000 Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor. Molecular Endocrinology 14 1797-1810.
22. Moreno D, Gourlet P, De Neef P, Cnudde J, Waelbroeck M & Robberecht P 2000 Development of selective agonists and antagonists for the human vasoactive intestinal polypeptide VPAC(2) receptor. Peptides 21 1543-1549.
23. O'Donnell M, Garippa RJ, Rinaldi N, Selig WM, Simko B, Renzetti L, Tannu SA, Wasserman MA, Welton A & Bolin DR 2004 Ro 25-1553: a novel, long-acting vasoactive intestinal peptide agonist. Part I: In vitro and in vivo bronchodilator studies. Journal of Pharmacology and Experimental Therapeutics 279 1282-1288.
24. Perry SJ & Lefkowitz RJ 2002 Arresting developments in heptahelical receptor signaling and regulation. Trends in Cell Biology 12 130-138.
25. Salomon Y, Londos C & Rodbell M 1974 A highly sensitive adenylate cyclase assay. Analytical Biochemistry 58 541-548.
26. Stables J, Green A, Marshall F, Fraser N, Knight E, Sautel M, Milligan G, Lee M & Rees S 1997 A bioluminescent assay for agonist activity at potentially any G- protein-coupled receptor. Analytical Biochemistry 252 115-126.
27. Takhar S, Gyomorey S, Su RC, Mathi SK, Li X & Wheeler MB 1996 The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system. Endocrinology 137 2175-2178.
28. Wess J 1997 G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB Journal 11 346-354.