Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 23888-23899

  Dong, Maoqing ^a   Lam, Polo C H ^b   Pinon, Delia I ^a   Hosohata, Keiko ^a   Orry, Andrew ^b   Sexton, Patrick M ^c   Abagyan, Ruben ^b,d   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b MOLSOFT LLC   (United States)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINUS; AMINO-TERMINAL DOMAIN; AMINO-TERMINAL REGION; CARBOXYL TERMINUS; EMPIRICAL DATA; EXTRACELLULAR LOOPS; G PROTEIN COUPLED RECEPTORS; HELICAL BUNDLE; LIGAND BINDING; MOLECULAR BASIS; MOLECULAR MECHANISM; PEPTIDE LIGAND; PEPTIDE MAPPING; PEPTIDE-BINDING; PHARMACOPHORES; PHOTOLABILE MOIETIES; RECEPTOR COMPLEX; STRUCTURAL MOTIFS; WILD TYPES;

CRYSTAL STRUCTURE; LIGANDS; PEPTIDES;

PROBES;

G PROTEIN COUPLED RECEPTOR; SECRETIN; SECRETIN DERIVATIVE; SECRETIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR PROBE; MUTANT; NONHUMAN; PEPTIDE MAPPING; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; WILD TYPE;

ANIMALS; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; LIGANDS; MOLECULAR PROBES; PEPTIDE MAPPING; PEPTIDES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; SECRETIN;

EID: 79959872463     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.245969     Document Type: Article

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