Secretin occupies a single protomer of the homodimeric secretin receptor complex: Insights from photoaffinity labeling studies using dual sites of covalent attachment

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9919-9931

  Dong, Maoqing ^a   Lam, Polo C H ^b,c   Pinon, Delia I ^a   Orry, Andrew ^b,c   Sexton, Patrick M ^d,e   Abagyan, Ruben ^b,c   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c MOLSOFT LLC   (United States)

^d MONASH UNIVERSITY   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO-TERMINAL DOMAIN; BIFUNCTIONAL; COOPERATIVITY; COVALENT ATTACHMENT; CYANOGEN BROMIDE; DUAL SITES; ELECTROPHORETIC MIGRATION; G PROTEIN COUPLED RECEPTORS; HIGH-RESOLUTION STRUCTURES; HOMODIMERIC COMPLEXES; HOMODIMERS; MOLECULAR MODELS; PHOTOAFFINITY LABELING; PROTOMERS; RECEPTOR COMPLEX; SINGLE PROBE; SUB-DOMAINS;

LABELING;

PROBES;

AMINO ACID; BENZOYLPHENYLALANINE; HORMONE RECEPTOR; SECRETIN; SECRETIN RECEPTOR; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; HORMONE; LIGAND; PEPTIDE; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; ELECTROPHORETIC MOBILITY; FEMALE; ISOTOPE LABELING; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR PROBE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CRICETULUS; DIMERIZATION; GENETICS; HAMSTER; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PEPTIDE MAPPING; PROTEIN BINDING; RAT; SEQUENCE HOMOLOGY;

RUMEX;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; HORMONES; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PEPTIDES; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; SECRETIN; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 77951245644     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.089730     Document Type: Article

References (46)

1. Harikumar, K. G., Morfis, M. M., Lisenbee, C. S., Sexton, P. M., and Miller, L. J. (2006) Mol. Pharmacol. 69, 363-373
2. Gao, F., Harikumar, K. G., Dong, M., Lam, P. C., Sexton, P. M., Christopoulos, A., Bordner, A., Abagyan, R., and Miller, L. J. (2009) Mol. Pharmacol. 76, 264-274
3. Harikumar, K. G., Pinon, D. I., and Miller, L. J. (2007) J. Biol. Chem. 282, 30363-30372
4. Harikumar, K. G., Happs, R. M., and Miller, L. J. (2008) Biochim. Biophys. Acta 1778, 2555-2563
5. De Meyts, P. (2008) Trends Biochem. Sci. 33, 376-384
6. De Meyts, P., Gauguin, L., Svendsen, A. M., Sarhan, M., Knudsen, L., Nøhr, J., and Kiselyov, V. V. (2009) Ann. N.Y. Acad. Sci. 1160, 45-53
7. Harikumar, K. G., Morfis, M. M., Sexton, P. M., and Miller, L. J. (2008) J. Mol. Neurosci. 36, 279-285
8. Seck, T., Baron, R., and Horne, W. C. (2003) J. Biol. Chem. 278, 23085-23093
9. Dong, M., Lam, P. C., Pinon, D. I., Sexton, P. M., Abagyan, R., and Miller, L. J. (2008) Mol. Pharmacol. 74, 413-422
10. Dong, M., Lam, P. C., Gao, F., Hosohata, K., Pinon, D. I., Sexton, P. M., Abagyan, R., and Miller, L. J. (2007) Mol. Pharmacol. 72, 280-290
11. Harikumar, K. G., Lam, P. C., Dong, M., Sexton, P. M., Abagyan, R., and Miller, L. J. (2007) J. Biol. Chem. 282, 32834-32843
12. Hadac, E. M., Ghanekar, D. V., Holicky, E. L., Pinon, D. I., Dougherty, R. W., and Miller, L. J. (1996) Pancreas 13, 130-139
13. Dong, M., Li, Z., Pinon, D. I., Lybrand, T. P., and Miller, L. J. (2004) J. Biol. Chem. 279, 2894-2903
14. Dong, M., Asmann, Y. W., Zang, M., Pinon, D. I., and Miller, L. J. (2000) J. Biol. Chem. 275, 26032-26039
15. Dong, M., Wang, Y., Pinon, D. I., Hadac, E. M., and Miller, L. J. (1999) J. Biol. Chem. 274, 903-909
16. Gardner, J. D., Conlon, T. P., Beyerman, H. C., and Van Zon, A. (1977) Gastroenterology 73, 52-56
17. Kofod, H. (1991) Int. J. Pept. Protein Res. 37, 185-190
18. Powers, S. P., Pinon, D. I., and Miller, L. J. (1988) Int. J. Pept. Protein Res. 31, 429-434
19. Ulrich, C. D., 2nd, Pinon, D. I., Hadac, E. M., Holicky, E. L., Chang-Miller, A., Gates, L. K., and Miller, L. J. (1993) Gastroenterology 105, 1534-1543
20. Holtmann, M. H., Hadac, E. M., and Miller, L. J. (1995) J. Biol. Chem. 270, 14394-14398
21. Ji, Z., Hadac, E. M., Henne, R. M., Patel, S. A., Lybrand, T. P., and Miller, L. J. (1997) J. Biol. Chem. 272, 24393-24401
22. Abagyan, R., Totrov, M., and Kuznetsov, D. (1994) J. Comput. Chem. 15, 488-506
23. Abagyan, R., and Totrov, M. (1994) J. Mol. Biol. 235, 983-1002
24. Metropolis, N., Rosenbluth, A. W., Rosenbluth, M. N., Teller, A. H., and Teller, E. (1953) J. Chem. Phys. 21, 1087-1092
25. Parthier, C., Kleinschmidt, M., Neumann, P., Rudolph, R., Manhart, S., Schlenzig, D., Fanghänel, J., Rahfeld, J. U., Demuth, H. U., and Stubbs, M. T. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 13942-13947
26. Hooft, R. W., Vriend, G., Sander, C., and Abola, E. E. (1996) Nature 381, 272-272
27. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
28. Munson, P. J., and Rodbard, D. (1980) Anal. Biochem. 107, 220-239
29. Zang, M., Dong, M., Pinon, D. I., Ding, X. Q., Hadac, E. M., Li, Z., Lybrand, T. P., and Miller, L. J. (2003) Mol. Pharmacol. 63, 993-1001
30. Chang, C. P., Pearse, R. V., 2nd, O'Connell, S., and Rosenfeld, M. G. (1993) Neuron 11, 1187-1195
31. Ishihara, T., Nakamura, S., Kaziro, Y., Takahashi, T., Takahashi, K., and Nagata, S. (1991) EMBO J. 10, 1635-1641
32. Lin, H. Y., Harris, T. L., Flannery, M. S., Aruffo, A., Kaji, E. H., Gorn, A., Kolakowski, L. F., Jr., Lodish, H. F., and Goldring, S. R. (1991) Science 254, 1022-1024
33. Thorens, B. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 8641-8645
34. Cao, Y. J., Gimpl, G., and Fahrenholz, F. (1995) Biochem. Biophys. Res. Commun. 212, 673-680
35. Gourlet, P., Vilardaga, J. P., De Neef, P., Waelbroeck, M., Vandermeers, A., and Robberecht, P. (1996) Peptides 17, 825-829
36. Jüppner, H., Schipani, E., Bringhurst, F. R., McClure, I., Keutmann, H. T., Potts, J. T., Jr., Kronenberg, H. M., Abou-Samra, A. B., Segre, G. V., and Gardella, T. J. (1994) Endocrinology 134, 879-884
37. Stroop, S. D., Kuestner, R. E., Serwold, T. F., Chen, L., and Moore, E. E. (1995) Biochemistry 34, 1050-1057
38. Grace, C. R., Perrin, M. H., DiGruccio, M. R., Miller, C. L., Rivier, J. E., Vale, W. W., and Riek, R. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 12836-12841
39. Grace, C. R., Perrin, M. H., Gulyas, J., Digruccio, M. R., Cantle, J. P., Rivier, J. E., Vale, W. W., and Riek, R. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 4858-4863
40. Pioszak, A. A., Parker, N. R., Suino-Powell, K., and Xu, H. E. (2008) J. Biol. Chem. 283, 32900-32912
41. Pioszak, A. A., and Xu, H. E. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 5034-5039
42. Runge, S., Thøgersen, H., Madsen, K., Lau, J., and Rudolph, R. (2008) J. Biol. Chem. 283, 11340-11347
43. Sun, C., Song, D., Davis-Taber, R. A., Barrett, L. W., Scott, V. E., Richardson, P. L., Pereda-Lopez, A., Uchic, M. E., Solomon, L. R., Lake, M. R., Walter, K. A., Hajduk, P. J., and Olejniczak, E. T. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 7875-7880
44. Hadac, E. M., Ji, Z., Pinon, D. I., Henne, R. M., Lybrand, T. P., and Miller, L. J. (1999) J. Med. Chem. 42, 2105-2111
45. Dong, M., Pinon, D. I., Asmann, Y. W., and Miller, L. J. (2006) Mol. Pharmacol. 70, 206-213
46. Dong, M., Cox, R. F., and Miller, L. J. (2009) J. Biol. Chem. 284, 21839-21847