메뉴 건너뛰기




Volumn 27, Issue 1, 2013, Pages 13-22

Mutational landscape of AML with normal cytogenetics: Biological and clinical implications

Author keywords

Acute myeloid leukemia; Mutations; Normal karyotype; Whole exome sequencing

Indexed keywords

AZACITIDINE; CCAAT ENHANCER BINDING PROTEIN ALPHA; COREPRESSOR PROTEIN; CYTARABINE; DNA METHYLTRANSFERASE 3A; FLT3 LIGAND; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; LESTAURTINIB; MIDOSTAURIN; NUCLEOPHOSMIN; PROTEIN BCL 6; QUIZARTINIB; RETINOIC ACID; SORAFENIB; SUNITINIB; TRANSCRIPTION FACTOR RUNX1; WT1 PROTEIN;

EID: 84872165619     PISSN: 0268960X     EISSN: 15321681     Source Type: Journal    
DOI: 10.1016/j.blre.2012.11.001     Document Type: Article
Times cited : (88)

References (148)
  • 1
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D., Walker H., Oliver F., Wheatley K., Harrison C., Harrison G., et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998, 92:2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3    Wheatley, K.4    Harrison, C.5    Harrison, G.6
  • 2
    • 62249168182 scopus 로고    scopus 로고
    • Acute myeloid leukaemia with recurrent genetic abnormalities
    • International Agency for Research on Cancer (IARC), Lyon, France, S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein (Eds.)
    • Arber D.A., Brunning R.D., Le Beau M.M., Falini B., Vardiman J.W., Porwit A., et al. Acute myeloid leukaemia with recurrent genetic abnormalities. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 2008, 110-123. International Agency for Research on Cancer (IARC), Lyon, France. S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein (Eds.).
    • (2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues , pp. 110-123
    • Arber, D.A.1    Brunning, R.D.2    Le Beau, M.M.3    Falini, B.4    Vardiman, J.W.5    Porwit, A.6
  • 3
    • 0028170817 scopus 로고
    • Receptor protein-tyrosine kinases and their signal transduction pathways
    • van der Geer P., Hunter T., Lindberg R.A. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 1994, 10:251-337.
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 251-337
    • van der Geer, P.1    Hunter, T.2    Lindberg, R.A.3
  • 4
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M., Yokota S., Iwai T., Kaneko H., Horiike S., Kashima K., et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996, 10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3    Kaneko, H.4    Horiike, S.5    Kashima, K.6
  • 5
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt D.L., Radich J.P. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003, 3:650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 7
    • 40849084180 scopus 로고    scopus 로고
    • NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia
    • Falini B., Mecucci C., Saglio G., Lo Coco F., Diverio D., Brown P., et al. NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia. Haematologica 2008, 93:439-442.
    • (2008) Haematologica , vol.93 , pp. 439-442
    • Falini, B.1    Mecucci, C.2    Saglio, G.3    Lo Coco, F.4    Diverio, D.5    Brown, P.6
  • 8
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C., Steudel C., Mohr B., Schaich M., Schakel U., Platzbecker U., et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002, 99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schakel, U.5    Platzbecker, U.6
  • 9
    • 33745184051 scopus 로고    scopus 로고
    • A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies
    • Slovak M.L., Gundacker H., Bloomfield C.D., Dewald G., Appelbaum F.R., Larson R.A., et al. A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies. Leukemia 2006, 20:1295-1297.
    • (2006) Leukemia , vol.20 , pp. 1295-1297
    • Slovak, M.L.1    Gundacker, H.2    Bloomfield, C.D.3    Dewald, G.4    Appelbaum, F.R.5    Larson, R.A.6
  • 10
    • 41949087055 scopus 로고    scopus 로고
    • Prognostic relevance of FLT3-TKD mutations in AML: the combination matters-an analysis of 3082 patients
    • Bacher U., Haferlach C., Kern W., Haferlach T., Schnittger S. Prognostic relevance of FLT3-TKD mutations in AML: the combination matters-an analysis of 3082 patients. Blood 2008, 111:2527-2537.
    • (2008) Blood , vol.111 , pp. 2527-2537
    • Bacher, U.1    Haferlach, C.2    Kern, W.3    Haferlach, T.4    Schnittger, S.5
  • 11
    • 34548029756 scopus 로고    scopus 로고
    • FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia
    • Mead A.J., Linch D.C., Hills R.K., Wheatley K., Burnett A.K., Gale R.E. FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia. Blood 2007, 110:1262-1270.
    • (2007) Blood , vol.110 , pp. 1262-1270
    • Mead, A.J.1    Linch, D.C.2    Hills, R.K.3    Wheatley, K.4    Burnett, A.K.5    Gale, R.E.6
  • 12
    • 20444402664 scopus 로고    scopus 로고
    • FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model
    • Grundler R., Miething C., Thiede C., Peschel C., Duyster J. FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. Blood 2005, 105:4792-4799.
    • (2005) Blood , vol.105 , pp. 4792-4799
    • Grundler, R.1    Miething, C.2    Thiede, C.3    Peschel, C.4    Duyster, J.5
  • 13
    • 22044448746 scopus 로고    scopus 로고
    • AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
    • Choudhary C., Schwable J., Brandts C., Tickenbrock L., Sargin B., Kindler T., et al. AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood 2005, 106:265-273.
    • (2005) Blood , vol.106 , pp. 265-273
    • Choudhary, C.1    Schwable, J.2    Brandts, C.3    Tickenbrock, L.4    Sargin, B.5    Kindler, T.6
  • 14
    • 79251556241 scopus 로고    scopus 로고
    • Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
    • Falini B., Martelli M.P., Bolli N., Sportoletti P., Liso A., Tiacci E., et al. Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?. Blood 2011, 117:1109-1120.
    • (2011) Blood , vol.117 , pp. 1109-1120
    • Falini, B.1    Martelli, M.P.2    Bolli, N.3    Sportoletti, P.4    Liso, A.5    Tiacci, E.6
  • 16
    • 84864775100 scopus 로고    scopus 로고
    • Diversity of the juxtamembrane and TKD1 mutations (Exons 13-15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data
    • Schnittger S., Bacher U., Haferlach C., Alpermann T., Kern W., Haferlach T. Diversity of the juxtamembrane and TKD1 mutations (Exons 13-15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data. Genes Chromosomes Cancer 2012, 51:910-924.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 910-924
    • Schnittger, S.1    Bacher, U.2    Haferlach, C.3    Alpermann, T.4    Kern, W.5    Haferlach, T.6
  • 17
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale R.E., Green C., Allen C., Mead A.J., Burnett A.K., Hills R.K., et al. The impact of FLT3 internal tandem duplication mutant level, number, size and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008, 111:2776-2784.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3    Mead, A.J.4    Burnett, A.K.5    Hills, R.K.6
  • 18
    • 84870720777 scopus 로고    scopus 로고
    • Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia
    • [Epub ahead of print]
    • How J., Sykes J., Gupta V., Yee K.W., Schimmer A.D., Schuh A.C., et al. Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia. Cancer 2012, [Epub ahead of print]. 10.1002/cncr.27683.
    • (2012) Cancer
    • How, J.1    Sykes, J.2    Gupta, V.3    Yee, K.W.4    Schimmer, A.D.5    Schuh, A.C.6
  • 20
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study
    • Whitman S.P., Archer K.J., Feng L., Baldus C., Becknell B., Carlson B.D., et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res 2001, 61:7233-7239.
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3    Baldus, C.4    Becknell, B.5    Carlson, B.D.6
  • 21
    • 80855133514 scopus 로고    scopus 로고
    • Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knock in mice
    • Li L., Bailey E., Greenblatt S., Huso D., Small D. Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knock in mice. Blood 2011, 118:4935-4945.
    • (2011) Blood , vol.118 , pp. 4935-4945
    • Li, L.1    Bailey, E.2    Greenblatt, S.3    Huso, D.4    Small, D.5
  • 22
    • 70350504884 scopus 로고    scopus 로고
    • Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
    • Kayser S., Schlenk R.F., Londono M.C., Breitenbuecher F., Wittke K., Du J., et al. Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome. Blood 2009, 114:2386-2392.
    • (2009) Blood , vol.114 , pp. 2386-2392
    • Kayser, S.1    Schlenk, R.F.2    Londono, M.C.3    Breitenbuecher, F.4    Wittke, K.5    Du, J.6
  • 23
    • 84855190284 scopus 로고    scopus 로고
    • Meta-analysis for the potential application of FLT3-TKD mutations as prognostic indicator in non-promyelocytic AML
    • Li W., Zhang L., Huang L., Mi Y., Wang J. Meta-analysis for the potential application of FLT3-TKD mutations as prognostic indicator in non-promyelocytic AML. Leuk Res 2012, 36:186-191.
    • (2012) Leuk Res , vol.36 , pp. 186-191
    • Li, W.1    Zhang, L.2    Huang, L.3    Mi, Y.4    Wang, J.5
  • 24
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H., Estey E.H., Amadori S., Appelbaum F.R., Buchner T., Burnett A.K., et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010, 115:453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Buchner, T.5    Burnett, A.K.6
  • 25
    • 80051670412 scopus 로고    scopus 로고
    • Role of allogeneic transplantation for FLT3/ITD acute myeloid leukemia: outcomes from 133 consecutive newly diagnosed patients from a single institution
    • DeZern A.E., Sung A., Kim S., Smith B.D., Karp J.E., Gore S.D., et al. Role of allogeneic transplantation for FLT3/ITD acute myeloid leukemia: outcomes from 133 consecutive newly diagnosed patients from a single institution. Biol Blood Marrow Transplant 2011, 17:1404-1409.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 1404-1409
    • DeZern, A.E.1    Sung, A.2    Kim, S.3    Smith, B.D.4    Karp, J.E.5    Gore, S.D.6
  • 26
    • 84869092568 scopus 로고    scopus 로고
    • Potent graft-versus-leukemia effect after reduced-intensity allogeneic SCT for intermediate risk AML with FLT3-ITD or wild-type NPM1 and CEBPA without FLT3-ITD
    • Laboure G., Dulucq S., Labopin M., Tabrizi R., Guerin E., Pigneux A., et al. Potent graft-versus-leukemia effect after reduced-intensity allogeneic SCT for intermediate risk AML with FLT3-ITD or wild-type NPM1 and CEBPA without FLT3-ITD. Biol Blood Marrow Transplant 2012, 18:1845-1850.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 1845-1850
    • Laboure, G.1    Dulucq, S.2    Labopin, M.3    Tabrizi, R.4    Guerin, E.5    Pigneux, A.6
  • 27
    • 84857058777 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first complete remission: have the indications changed?
    • Paun O., Lazarus H.M. Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first complete remission: have the indications changed?. Curr Opin Hematol 2012, 19:95-101.
    • (2012) Curr Opin Hematol , vol.19 , pp. 95-101
    • Paun, O.1    Lazarus, H.M.2
  • 28
    • 84870844659 scopus 로고    scopus 로고
    • Allo-SCT for high-risk AML-CR1 in the molecular era: impact of FLT3/ITD outweighs the conventional markers
    • [Epub ahead of print]
    • Sengsayadeth S.M., Jagasia M., Engelhardt B.G., Kassim A., Strickland S.A., Goodman S., et al. Allo-SCT for high-risk AML-CR1 in the molecular era: impact of FLT3/ITD outweighs the conventional markers. Bone Marrow Transplant 2012, [Epub ahead of print]. 10.1038/bmt.2012.88.
    • (2012) Bone Marrow Transplant
    • Sengsayadeth, S.M.1    Jagasia, M.2    Engelhardt, B.G.3    Kassim, A.4    Strickland, S.A.5    Goodman, S.6
  • 29
    • 79952043438 scopus 로고    scopus 로고
    • FLT3 inhibitors: a story of the old and the new
    • Fathi A., Levis M. FLT3 inhibitors: a story of the old and the new. Curr Opin Hematol 2011, 18:71-76.
    • (2011) Curr Opin Hematol , vol.18 , pp. 71-76
    • Fathi, A.1    Levis, M.2
  • 30
    • 70449475105 scopus 로고    scopus 로고
    • AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
    • Zarrinkar P.P., Gunawardane R.N., Cramer M.D., Gardner M.F., Brigham D., Belli B., et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 2009, 114:2984-2992.
    • (2009) Blood , vol.114 , pp. 2984-2992
    • Zarrinkar, P.P.1    Gunawardane, R.N.2    Cramer, M.D.3    Gardner, M.F.4    Brigham, D.5    Belli, B.6
  • 31
    • 79953073247 scopus 로고    scopus 로고
    • FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo
    • Sato T., Yang X., Knapper S., White P., Smith B.D., Galkin S., et al. FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo. Blood 2011, 117:3286-3293.
    • (2011) Blood , vol.117 , pp. 3286-3293
    • Sato, T.1    Yang, X.2    Knapper, S.3    White, P.4    Smith, B.D.5    Galkin, S.6
  • 32
    • 84860747223 scopus 로고    scopus 로고
    • Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia
    • Smith C.C., Wang Q., Chin C.S., Salerno S., Damon L.E., Levis M.J., et al. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature 2012, 485:260-263.
    • (2012) Nature , vol.485 , pp. 260-263
    • Smith, C.C.1    Wang, Q.2    Chin, C.S.3    Salerno, S.4    Damon, L.E.5    Levis, M.J.6
  • 33
    • 77949887020 scopus 로고    scopus 로고
    • FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML
    • Pratz K.W., Sato T., Murphy K.M., Stine A., Rajkhowa T., Levis M. FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood 2010, 115:1425-1432.
    • (2010) Blood , vol.115 , pp. 1425-1432
    • Pratz, K.W.1    Sato, T.2    Murphy, K.M.3    Stine, A.4    Rajkhowa, T.5    Levis, M.6
  • 34
    • 34547676848 scopus 로고    scopus 로고
    • Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias
    • Falini B., Nicoletti I., Bolli N., Martelli M.P., Liso A., Gorello P., et al. Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. Haematologica 2007, 92:519-532.
    • (2007) Haematologica , vol.92 , pp. 519-532
    • Falini, B.1    Nicoletti, I.2    Bolli, N.3    Martelli, M.P.4    Liso, A.5    Gorello, P.6
  • 35
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B., Mecucci C., Tiacci E., Alcalay M., Rosati R., Pasqualucci L., et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005, 352:254-266.
    • (2005) N Engl J Med , vol.352 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3    Alcalay, M.4    Rosati, R.5    Pasqualucci, L.6
  • 36
    • 34247596501 scopus 로고    scopus 로고
    • Identification and functional characterization of a cytoplasmic nucleophosmin leukaemic mutant generated by a novel exon-11 NPM1 mutation
    • Albiero E., Madeo D., Bolli N., Giaretta I., Bona E.D., Martelli M.F., et al. Identification and functional characterization of a cytoplasmic nucleophosmin leukaemic mutant generated by a novel exon-11 NPM1 mutation. Leukemia 2007, 21:1099-1103.
    • (2007) Leukemia , vol.21 , pp. 1099-1103
    • Albiero, E.1    Madeo, D.2    Bolli, N.3    Giaretta, I.4    Bona, E.D.5    Martelli, M.F.6
  • 37
    • 33645802652 scopus 로고    scopus 로고
    • Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML
    • Falini B., Bolli N., Shan J., Martelli M.P., Liso A., Pucciarini A., et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood 2006, 107:4514-4523.
    • (2006) Blood , vol.107 , pp. 4514-4523
    • Falini, B.1    Bolli, N.2    Shan, J.3    Martelli, M.P.4    Liso, A.5    Pucciarini, A.6
  • 38
    • 70350724838 scopus 로고    scopus 로고
    • Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications
    • Falini B., Bolli N., Liso A., Martelli M.P., Mannucci R., Pileri S., et al. Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications. Leukemia 2009, 23:1731-1743.
    • (2009) Leukemia , vol.23 , pp. 1731-1743
    • Falini, B.1    Bolli, N.2    Liso, A.3    Martelli, M.P.4    Mannucci, R.5    Pileri, S.6
  • 39
    • 33748703838 scopus 로고    scopus 로고
    • Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia
    • Falini B., Martelli M.P., Bolli N., Bonasso R., Ghia E., Pallotta M.T., et al. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia. Blood 2006, 108:1999-2005.
    • (2006) Blood , vol.108 , pp. 1999-2005
    • Falini, B.1    Martelli, M.P.2    Bolli, N.3    Bonasso, R.4    Ghia, E.5    Pallotta, M.T.6
  • 40
    • 34250721029 scopus 로고    scopus 로고
    • Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas
    • Falini B., Lenze D., Hasserjian R., Coupland S., Jaehne D., Soupir C., et al. Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas. Leukemia 2007, 21:1566-1570.
    • (2007) Leukemia , vol.21 , pp. 1566-1570
    • Falini, B.1    Lenze, D.2    Hasserjian, R.3    Coupland, S.4    Jaehne, D.5    Soupir, C.6
  • 41
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications
    • Marcucci G., Haferlach T., Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011, 29:475-486.
    • (2011) J Clin Oncol , vol.29 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Dohner, H.3
  • 42
    • 84857413092 scopus 로고    scopus 로고
    • Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML)
    • Schneider F., Hoster E., Schneider S., Dufour A., Benthaus T., Kakadia P.M., et al. Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML). Ann Hematol 2012, 91:9-18.
    • (2012) Ann Hematol , vol.91 , pp. 9-18
    • Schneider, F.1    Hoster, E.2    Schneider, S.3    Dufour, A.4    Benthaus, T.5    Kakadia, P.M.6
  • 43
    • 45149130870 scopus 로고    scopus 로고
    • In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML
    • Liso A., Bogliolo A., Freschi V., Martelli M.P., Pileri S.A., Santodirocco M., et al. In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML. Leukemia 2008, 22:1285-1289.
    • (2008) Leukemia , vol.22 , pp. 1285-1289
    • Liso, A.1    Bogliolo, A.2    Freschi, V.3    Martelli, M.P.4    Pileri, S.A.5    Santodirocco, M.6
  • 44
    • 43749116866 scopus 로고    scopus 로고
    • Therapy-related acute myeloid leukaemia with mutated NPM1: treatment induced or de novo in origin?
    • Falini B. Therapy-related acute myeloid leukaemia with mutated NPM1: treatment induced or de novo in origin?. Leukemia 2008, 22:891-892.
    • (2008) Leukemia , vol.22 , pp. 891-892
    • Falini, B.1
  • 45
    • 23044459136 scopus 로고    scopus 로고
    • Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
    • Alcalay M., Tiacci E., Bergomas R., Bigerna B., Venturini E., Minardi S.P., et al. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood 2005, 106:899-902.
    • (2005) Blood , vol.106 , pp. 899-902
    • Alcalay, M.1    Tiacci, E.2    Bergomas, R.3    Bigerna, B.4    Venturini, E.5    Minardi, S.P.6
  • 47
    • 70350637903 scopus 로고    scopus 로고
    • AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features
    • Haferlach C., Mecucci C., Schnittger S., Kohlmann A., Mancini M., Cuneo A., et al. AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features. Blood 2009, 114:3024-3032.
    • (2009) Blood , vol.114 , pp. 3024-3032
    • Haferlach, C.1    Mecucci, C.2    Schnittger, S.3    Kohlmann, A.4    Mancini, M.5    Cuneo, A.6
  • 48
    • 77952578145 scopus 로고    scopus 로고
    • Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)
    • Falini B., Macijewski K., Weiss T., Bacher U., Schnittger S., Kern W., et al. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1). Blood 2010, 115:3776-3786.
    • (2010) Blood , vol.115 , pp. 3776-3786
    • Falini, B.1    Macijewski, K.2    Weiss, T.3    Bacher, U.4    Schnittger, S.5    Kern, W.6
  • 49
    • 77957995156 scopus 로고    scopus 로고
    • CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
    • Martelli M.P., Pettirossi V., Thiede C., Bonifacio E., Mezzasoma F., Cecchini D., et al. CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice. Blood 2010, 116:3907-3922.
    • (2010) Blood , vol.116 , pp. 3907-3922
    • Martelli, M.P.1    Pettirossi, V.2    Thiede, C.3    Bonifacio, E.4    Mezzasoma, F.5    Cecchini, D.6
  • 52
    • 78549273715 scopus 로고    scopus 로고
    • Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA
    • Federici L., Arcovito A., Scaglione G.L., Scaloni F., Lo Sterzo C., Di Matteo A., et al. Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA. J Biol Chem 2010, 285:37138-37149.
    • (2010) J Biol Chem , vol.285 , pp. 37138-37149
    • Federici, L.1    Arcovito, A.2    Scaglione, G.L.3    Scaloni, F.4    Lo Sterzo, C.5    Di Matteo, A.6
  • 53
    • 78049368857 scopus 로고    scopus 로고
    • Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition
    • Leong S.M., Tan B.X., Bte Ahmad B., Yan T., Chee L.Y., Ang S.T., et al. Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition. Blood 2010, 116:3286-3296.
    • (2010) Blood , vol.116 , pp. 3286-3296
    • Leong, S.M.1    Tan, B.X.2    Bte Ahmad, B.3    Yan, T.4    Chee, L.Y.5    Ang, S.T.6
  • 54
    • 34447134905 scopus 로고    scopus 로고
    • Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants
    • Bolli N., Nicoletti I., De Marco M.F., Bigerna B., Pucciarini A., Mannucci R., et al. Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants. Cancer Res 2007, 67:6230-6237.
    • (2007) Cancer Res , vol.67 , pp. 6230-6237
    • Bolli, N.1    Nicoletti, I.2    De Marco, M.F.3    Bigerna, B.4    Pucciarini, A.5    Mannucci, R.6
  • 55
    • 79955469651 scopus 로고    scopus 로고
    • Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
    • Vassiliou G.S., Cooper J.L., Rad R., Li J., Rice S., Uren A., et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet 2011, 43:470-475.
    • (2011) Nat Genet , vol.43 , pp. 470-475
    • Vassiliou, G.S.1    Cooper, J.L.2    Rad, R.3    Li, J.4    Rice, S.5    Uren, A.6
  • 56
    • 33846876123 scopus 로고    scopus 로고
    • Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features
    • Falini B., Nicoletti I., Martelli M.F., Mecucci C. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood 2007, 109:874-885.
    • (2007) Blood , vol.109 , pp. 874-885
    • Falini, B.1    Nicoletti, I.2    Martelli, M.F.3    Mecucci, C.4
  • 57
    • 67149084950 scopus 로고    scopus 로고
    • NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS)
    • Schneider F., Hoster E., Unterhalt M., Schneider S., Dufour A., Benthaus T., et al. NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS). Blood 2009, 113:5250-5253.
    • (2009) Blood , vol.113 , pp. 5250-5253
    • Schneider, F.1    Hoster, E.2    Unterhalt, M.3    Schneider, S.4    Dufour, A.5    Benthaus, T.6
  • 59
    • 39149085355 scopus 로고    scopus 로고
    • Nucleophosmin leukaemic mutants contain C-terminus peptides that bind HLA class I molecules
    • Liso A., Colau D., Benmaamar R., De Groot A., Martin W., Benedetti R., et al. Nucleophosmin leukaemic mutants contain C-terminus peptides that bind HLA class I molecules. Leukemia 2008, 22:424-426.
    • (2008) Leukemia , vol.22 , pp. 424-426
    • Liso, A.1    Colau, D.2    Benmaamar, R.3    De Groot, A.4    Martin, W.5    Benedetti, R.6
  • 60
    • 84865180738 scopus 로고    scopus 로고
    • Mutated regions of nucleophosmin 1 (NPM1) elicit both CD4+ and CD8+ T cell responses in patients with acute myeloid leukemia
    • Greiner J., Ono Y., Hofmann S., Schmitt A., Mehring E., Gotz M., et al. Mutated regions of nucleophosmin 1 (NPM1) elicit both CD4+ and CD8+ T cell responses in patients with acute myeloid leukemia. Blood 2012, 120:1282-1289.
    • (2012) Blood , vol.120 , pp. 1282-1289
    • Greiner, J.1    Ono, Y.2    Hofmann, S.3    Schmitt, A.4    Mehring, E.5    Gotz, M.6
  • 61
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede C., Koch S., Creutzig E., Steudel C., Illmer T., Schaich M., et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 2006, 107:4011-4020.
    • (2006) Blood , vol.107 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3    Steudel, C.4    Illmer, T.5    Schaich, M.6
  • 62
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
    • Mrozek K., Marcucci G., Paschka P., Whitman S.P., Bloomfield C.D. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?. Blood 2007, 109:431-448.
    • (2007) Blood , vol.109 , pp. 431-448
    • Mrozek, K.1    Marcucci, G.2    Paschka, P.3    Whitman, S.P.4    Bloomfield, C.D.5
  • 63
    • 77953612369 scopus 로고    scopus 로고
    • Favorable outcome in patients with acute myelogenous leukemia with the nucleophosmin gene mutation autografted after conditioning with high-dose continuous infusion of idarubicin and busulfan
    • Ferrara F., Izzo T., Criscuolo C., Riccardi C., Muccioli G., Viola A., et al. Favorable outcome in patients with acute myelogenous leukemia with the nucleophosmin gene mutation autografted after conditioning with high-dose continuous infusion of idarubicin and busulfan. Biol Blood Marrow Transplant 2010, 16:1018-1024.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 1018-1024
    • Ferrara, F.1    Izzo, T.2    Criscuolo, C.3    Riccardi, C.4    Muccioli, G.5    Viola, A.6
  • 64
    • 84872159562 scopus 로고    scopus 로고
    • Allogenic stem cell transplantation confers a favorable outcome in patients with NPM1 positive acute myeloid leukemia: results from a donor vs. no-donor analysis of 309 patients treated in the SAL AML-2003 trial
    • [ASH Annual Meeting Abstracts]
    • Röllig C., Bornhauser M., Thiede C., Kramer M., Ho A., Wandt H., et al. Allogenic stem cell transplantation confers a favorable outcome in patients with NPM1 positive acute myeloid leukemia: results from a donor vs. no-donor analysis of 309 patients treated in the SAL AML-2003 trial. Blood 2011, 493. [ASH Annual Meeting Abstracts].
    • (2011) Blood , pp. 493
    • Röllig, C.1    Bornhauser, M.2    Thiede, C.3    Kramer, M.4    Ho, A.5    Wandt, H.6
  • 65
    • 79952129510 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia: myths, controversies, and unknowns
    • Gupta V., Tallman M.S., Weisdorf D.J. Allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia: myths, controversies, and unknowns. Blood 2011, 117:2307-2318.
    • (2011) Blood , vol.117 , pp. 2307-2318
    • Gupta, V.1    Tallman, M.S.2    Weisdorf, D.J.3
  • 66
    • 77449140390 scopus 로고    scopus 로고
    • Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study
    • Becker H., Marcucci G., Maharry K., Radmacher M.D., Mrozek K., Margeson D., et al. Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28:596-604.
    • (2010) J Clin Oncol , vol.28 , pp. 596-604
    • Becker, H.1    Marcucci, G.2    Maharry, K.3    Radmacher, M.D.4    Mrozek, K.5    Margeson, D.6
  • 67
    • 58149388069 scopus 로고    scopus 로고
    • Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group
    • Buchner T., Berdel W.E., Haferlach C., Haferlach T., Schnittger S., Muller-Tidow C., et al. Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group. J Clin Oncol 2009, 27:61-69.
    • (2009) J Clin Oncol , vol.27 , pp. 61-69
    • Buchner, T.1    Berdel, W.E.2    Haferlach, C.3    Haferlach, T.4    Schnittger, S.5    Muller-Tidow, C.6
  • 68
    • 84872143922 scopus 로고    scopus 로고
    • Prognostic value of immunophenotyping and gene mutations in elderly patients with acute myeloid leukemia with normal karyotype
    • [Electronic pub ahead of print] A 28
    • Dang H., Jiang A., Kamel-Reid S., Brandwein J., Chang H. Prognostic value of immunophenotyping and gene mutations in elderly patients with acute myeloid leukemia with normal karyotype. Hum Pathol Aug 28 2012, [Electronic pub ahead of print].
    • (2012) Hum Pathol
    • Dang, H.1    Jiang, A.2    Kamel-Reid, S.3    Brandwein, J.4    Chang, H.5
  • 69
    • 84872162012 scopus 로고    scopus 로고
    • Prognostic significance of karyotype in octogenarian patients (Pts) with Acute Myeloid Leukemia (AML)-an international study
    • [ASH Annual Meeting Abstracts]
    • Wetzler M., Kohlschmidt J., Mrozek K., Dombret H., Dohner H., Pilorge S., et al. Prognostic significance of karyotype in octogenarian patients (Pts) with Acute Myeloid Leukemia (AML)-an international study. Blood 2011, 2521. [ASH Annual Meeting Abstracts].
    • (2011) Blood , pp. 2521
    • Wetzler, M.1    Kohlschmidt, J.2    Mrozek, K.3    Dombret, H.4    Dohner, H.5    Pilorge, S.6
  • 70
    • 77956553248 scopus 로고    scopus 로고
    • A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
    • Röllig C., Thiede C., Gramatzki M., Aulitzky W., Bodenstein H., Bornhauser M., et al. A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial. Blood 2010, 116:971-978.
    • (2010) Blood , vol.116 , pp. 971-978
    • Röllig, C.1    Thiede, C.2    Gramatzki, M.3    Aulitzky, W.4    Bodenstein, H.5    Bornhauser, M.6
  • 71
    • 84872130405 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 and NPM1 mutations in adults of age 18-60 with De Novo Acute Myeloid Leukemia (AML) on SWOG S0106 study: a study by FHCRC and SWOG
    • [ASH Annual Meeting Abstracts]
    • Pogosova-Agadjanyan E., Kopecky K., Petersdorf S., Erba H.P., Stone R., Meshinchi S., et al. Prognostic significance of FLT3 and NPM1 mutations in adults of age 18-60 with De Novo Acute Myeloid Leukemia (AML) on SWOG S0106 study: a study by FHCRC and SWOG. Blood 2011, 2520. [ASH Annual Meeting Abstracts].
    • (2011) Blood , pp. 2520
    • Pogosova-Agadjanyan, E.1    Kopecky, K.2    Petersdorf, S.3    Erba, H.P.4    Stone, R.5    Meshinchi, S.6
  • 72
    • 58149240890 scopus 로고    scopus 로고
    • Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B
    • Schlenk R.F., Dohner K., Kneba M., Gotze K., Hartmann F., Del Valle F., et al. Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B. Haematologica 2009, 94:54-60.
    • (2009) Haematologica , vol.94 , pp. 54-60
    • Schlenk, R.F.1    Dohner, K.2    Kneba, M.3    Gotze, K.4    Hartmann, F.5    Del Valle, F.6
  • 73
    • 77649211990 scopus 로고    scopus 로고
    • The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA
    • Burnett A.K., Hills R.K., Green C., Jenkinson S., Koo K., Patel Y., et al. The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA. Blood 2010, 115:948-956.
    • (2010) Blood , vol.115 , pp. 948-956
    • Burnett, A.K.1    Hills, R.K.2    Green, C.3    Jenkinson, S.4    Koo, K.5    Patel, Y.6
  • 74
    • 84872128183 scopus 로고    scopus 로고
    • All-Trans retinoic Acid improves outcome in younger adult patients with nucleophosmin-1 mutated acute myeloid leukemia - results of the AMLSG 07-04 randomized treatment trial
    • [ASH Annual Meeting Abstracts]
    • Schlenk R.F., Dohner K., Krauter J., Gaidzik V., Paschka P., Heuser M., et al. All-Trans retinoic Acid improves outcome in younger adult patients with nucleophosmin-1 mutated acute myeloid leukemia - results of the AMLSG 07-04 randomized treatment trial. Blood 2011, 80. [ASH Annual Meeting Abstracts].
    • (2011) Blood , pp. 80
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3    Gaidzik, V.4    Paschka, P.5    Heuser, M.6
  • 75
    • 74249118052 scopus 로고    scopus 로고
    • Successful treatment of molecular relapse in NPM1-positive AML using 5-azacytidine
    • Wermke M., Thiede C., Kiani A., Ehninger G., Bornhauser M., Platzbecker U. Successful treatment of molecular relapse in NPM1-positive AML using 5-azacytidine. Leukemia 2010, 24:236-237.
    • (2010) Leukemia , vol.24 , pp. 236-237
    • Wermke, M.1    Thiede, C.2    Kiani, A.3    Ehninger, G.4    Bornhauser, M.5    Platzbecker, U.6
  • 76
    • 80053649326 scopus 로고    scopus 로고
    • Minimal residual disease-directed preemptive treatment with azacitidine in patients with NPM1-mutant acute myeloid leukemia and molecular relapse
    • Sockel K., Wermke M., Radke J., Kiani A., Schaich M., Bornhauser M., et al. Minimal residual disease-directed preemptive treatment with azacitidine in patients with NPM1-mutant acute myeloid leukemia and molecular relapse. Haematologica 2011, 96:1568-1570.
    • (2011) Haematologica , vol.96 , pp. 1568-1570
    • Sockel, K.1    Wermke, M.2    Radke, J.3    Kiani, A.4    Schaich, M.5    Bornhauser, M.6
  • 77
    • 80052939925 scopus 로고    scopus 로고
    • Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1
    • Balusu R., Fiskus W., Rao R., Chong D.G., Nalluri S., Mudunuru U., et al. Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1. Blood 2011, 118:3096-3106.
    • (2011) Blood , vol.118 , pp. 3096-3106
    • Balusu, R.1    Fiskus, W.2    Rao, R.3    Chong, D.G.4    Nalluri, S.5    Mudunuru, U.6
  • 78
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    • Zhang D.E., Zhang P., Wang N.D., Hetherington C.J., Darlington G.J., Tenen D.G. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A 1997, 94:569-574.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 569-574
    • Zhang, D.E.1    Zhang, P.2    Wang, N.D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 79
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst T., Mueller B.U., Zhang P., Radomska H.S., Narravula S., Schnittger S., et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet 2001, 27:263-270.
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3    Radomska, H.S.4    Narravula, S.5    Schnittger, S.6
  • 80
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters B.J., Lowenberg B., Erpelinck-Verschueren C.A., van Putten W.L., Valk P.J., Delwel R. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood 2009, 113:3088-3091.
    • (2009) Blood , vol.113 , pp. 3088-3091
    • Wouters, B.J.1    Lowenberg, B.2    Erpelinck-Verschueren, C.A.3    van Putten, W.L.4    Valk, P.J.5    Delwel, R.6
  • 81
    • 79952254129 scopus 로고    scopus 로고
    • Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology
    • Grossmann V., Schnittger S., Schindela S., Klein H.U., Eder C., Dugas M., et al. Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology. J Mol Diagn 2011, 13:129-136.
    • (2011) J Mol Diagn , vol.13 , pp. 129-136
    • Grossmann, V.1    Schnittger, S.2    Schindela, S.3    Klein, H.U.4    Eder, C.5    Dugas, M.6
  • 82
    • 70350497395 scopus 로고    scopus 로고
    • Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML
    • Bereshchenko O., Mancini E., Moore S., Bilbao D., Mansson R., Luc S., et al. Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML. Cancer Cell 2009, 16:390-400.
    • (2009) Cancer Cell , vol.16 , pp. 390-400
    • Bereshchenko, O.1    Mancini, E.2    Moore, S.3    Bilbao, D.4    Mansson, R.5    Luc, S.6
  • 83
    • 84864054209 scopus 로고    scopus 로고
    • GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia
    • Greif P.A., Dufour A., Konstandin N.P., Ksienzyk B., Zellmeier E., Tizazu B., et al. GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia. Blood 2012, 120:395-403.
    • (2012) Blood , vol.120 , pp. 395-403
    • Greif, P.A.1    Dufour, A.2    Konstandin, N.P.3    Ksienzyk, B.4    Zellmeier, E.5    Tizazu, B.6
  • 84
    • 84873569964 scopus 로고    scopus 로고
    • GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis
    • [Epub ahead of print]
    • Fasan A., Eder C., Haferlach C., Grossmann V., Kohlmann A., Dicker F., et al. GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis. Leukemia 2012, [Epub ahead of print]. 10.1038/leu.2012.174.
    • (2012) Leukemia
    • Fasan, A.1    Eder, C.2    Haferlach, C.3    Grossmann, V.4    Kohlmann, A.5    Dicker, F.6
  • 85
    • 77449146413 scopus 로고    scopus 로고
    • Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome
    • Dufour A., Schneider F., Metzeler K.H., Hoster E., Schneider S., Zellmeier E., et al. Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome. J Clin Oncol 2010, 28:570-577.
    • (2010) J Clin Oncol , vol.28 , pp. 570-577
    • Dufour, A.1    Schneider, F.2    Metzeler, K.H.3    Hoster, E.4    Schneider, S.5    Zellmeier, E.6
  • 86
    • 64949122396 scopus 로고    scopus 로고
    • Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
    • Pabst T., Eyholzer M., Fos J., Mueller B.U. Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis. Br J Cancer 2009, 100:1343-1346.
    • (2009) Br J Cancer , vol.100 , pp. 1343-1346
    • Pabst, T.1    Eyholzer, M.2    Fos, J.3    Mueller, B.U.4
  • 87
    • 77954921625 scopus 로고    scopus 로고
    • Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations
    • Green C.L., Koo K.K., Hills R.K., Burnett A.K., Linch D.C., Gale R.E. Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations. J Clin Oncol 2010, 28:2739-2747.
    • (2010) J Clin Oncol , vol.28 , pp. 2739-2747
    • Green, C.L.1    Koo, K.K.2    Hills, R.K.3    Burnett, A.K.4    Linch, D.C.5    Gale, R.E.6
  • 88
    • 79952122978 scopus 로고    scopus 로고
    • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity
    • Taskesen E., Bullinger L., Corbacioglu A., Sanders M.A., Erpelinck C.A., Wouters B.J., et al. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood 2011, 117:2469-2475.
    • (2011) Blood , vol.117 , pp. 2469-2475
    • Taskesen, E.1    Bullinger, L.2    Corbacioglu, A.3    Sanders, M.A.4    Erpelinck, C.A.5    Wouters, B.J.6
  • 89
    • 84861214425 scopus 로고    scopus 로고
    • Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity
    • Bacher U., Schnittger S., Macijewski K., Grossmann V., Kohlmann A., Alpermann T., et al. Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity. Blood 2012, 119:4719-4722.
    • (2012) Blood , vol.119 , pp. 4719-4722
    • Bacher, U.1    Schnittger, S.2    Macijewski, K.3    Grossmann, V.4    Kohlmann, A.5    Alpermann, T.6
  • 90
    • 77954697566 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism
    • Reitman Z.J., Yan H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst 2010, 102:932-941.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 932-941
    • Reitman, Z.J.1    Yan, H.2
  • 92
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P., Schlenk R.F., Gaidzik V.I., Habdank M., Kronke J., Bullinger L., et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010, 28:3636-3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Kronke, J.5    Bullinger, L.6
  • 93
    • 0031741379 scopus 로고    scopus 로고
    • Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family
    • Nekrutenko A., Hillis D.M., Patton J.C., Bradley R.D., Baker R.J. Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family. Mol Biol Evol 1998, 15:1674-1684.
    • (1998) Mol Biol Evol , vol.15 , pp. 1674-1684
    • Nekrutenko, A.1    Hillis, D.M.2    Patton, J.C.3    Bradley, R.D.4    Baker, R.J.5
  • 94
    • 4043105583 scopus 로고    scopus 로고
    • Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
    • Xu X., Zhao J., Xu Z., Peng B., Huang Q., Arnold E., et al. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem 2004, 279:33946-33957.
    • (2004) J Biol Chem , vol.279 , pp. 33946-33957
    • Xu, X.1    Zhao, J.2    Xu, Z.3    Peng, B.4    Huang, Q.5    Arnold, E.6
  • 95
    • 77957771067 scopus 로고    scopus 로고
    • IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
    • Schnittger S., Haferlach C., Ulke M., Alpermann T., Kern W., Haferlach T. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 2010, 116:5486-5496.
    • (2010) Blood , vol.116 , pp. 5486-5496
    • Schnittger, S.1    Haferlach, C.2    Ulke, M.3    Alpermann, T.4    Kern, W.5    Haferlach, T.6
  • 96
    • 77957192661 scopus 로고    scopus 로고
    • Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia (AML): prevalence and prognostic value
    • Abbas S., Lugthart S., Kavelaars F.G., Schelen A., Koenders J., Zeilemaker A., et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia (AML): prevalence and prognostic value. Blood 2010, 116:2122-2126.
    • (2010) Blood , vol.116 , pp. 2122-2126
    • Abbas, S.1    Lugthart, S.2    Kavelaars, F.G.3    Schelen, A.4    Koenders, J.5    Zeilemaker, A.6
  • 97
    • 79251510890 scopus 로고    scopus 로고
    • Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features
    • Patel K.P., Ravandi F., Ma D., Paladugu A., Barkoh B.A., Medeiros L.J., et al. Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features. Am J Clin Pathol 2011, 135:35-45.
    • (2011) Am J Clin Pathol , vol.135 , pp. 35-45
    • Patel, K.P.1    Ravandi, F.2    Ma, D.3    Paladugu, A.4    Barkoh, B.A.5    Medeiros, L.J.6
  • 98
    • 80755140131 scopus 로고    scopus 로고
    • Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups
    • Damm F., Thol F., Hollink I., Zimmermann M., Reinhardt K., van den Heuvel-Eibrink M.M., et al. Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups. Leukemia 2011, 25:1704-1710.
    • (2011) Leukemia , vol.25 , pp. 1704-1710
    • Damm, F.1    Thol, F.2    Hollink, I.3    Zimmermann, M.4    Reinhardt, K.5    van den Heuvel-Eibrink, M.M.6
  • 99
    • 77957759961 scopus 로고    scopus 로고
    • The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
    • Green C.L., Evans C.M., Hills R.K., Burnett A.K., Linch D.C., Gale R.E. The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. Blood 2010, 116:2779-2782.
    • (2010) Blood , vol.116 , pp. 2779-2782
    • Green, C.L.1    Evans, C.M.2    Hills, R.K.3    Burnett, A.K.4    Linch, D.C.5    Gale, R.E.6
  • 102
    • 84856725273 scopus 로고    scopus 로고
    • Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients
    • Patnaik M.M., Hanson C.A., Hodnefield J.M., Lasho T.L., Finke C.M., Knudson R.A., et al. Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients. Leukemia 2012, 26:101-105.
    • (2012) Leukemia , vol.26 , pp. 101-105
    • Patnaik, M.M.1    Hanson, C.A.2    Hodnefield, J.M.3    Lasho, T.L.4    Finke, C.M.5    Knudson, R.A.6
  • 103
    • 77954658823 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
    • Tefferi A., Lasho T.L., Abdel-Wahab O., Guglielmelli P., Patel J., Caramazza D., et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia 2010, 24:1302-1309.
    • (2010) Leukemia , vol.24 , pp. 1302-1309
    • Tefferi, A.1    Lasho, T.L.2    Abdel-Wahab, O.3    Guglielmelli, P.4    Patel, J.5    Caramazza, D.6
  • 104
    • 84865683059 scopus 로고    scopus 로고
    • Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia
    • Zhang Y., Wei H., Tang K., Lin D., Zhang C., Mi Y., et al. Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia. Genet Test Mol Biomarkers 2012, 16:991-995.
    • (2012) Genet Test Mol Biomarkers , vol.16 , pp. 991-995
    • Zhang, Y.1    Wei, H.2    Tang, K.3    Lin, D.4    Zhang, C.5    Mi, Y.6
  • 105
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward P.S., Patel J., Wise D.R., Abdel-Wahab O., Bennett B.D., Coller H.A., et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010, 17:225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6
  • 106
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa M.E., Abdel-Wahab O., Lu C., Ward P.S., Patel J., Shih A., et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010, 18:553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 107
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W., Yang H., Liu Y., Yang Y., Wang P., Kim S.H., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011, 19:17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6
  • 108
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Marcucci G., Maharry K., Wu Y.Z., Radmacher M.D., Mrozek K., Margeson D., et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28:2348-2355.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3    Radmacher, M.D.4    Mrozek, K.5    Margeson, D.6
  • 109
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group
    • Boissel N., Nibourel O., Renneville A., Gardin C., Reman O., Contentin N., et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol 2010, 28:3717-3723.
    • (2010) J Clin Oncol , vol.28 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3    Gardin, C.4    Reman, O.5    Contentin, N.6
  • 110
    • 79960534917 scopus 로고    scopus 로고
    • The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
    • Green C.L., Evans C.M., Zhao L., Hills R.K., Burnett A.K., Linch D.C., et al. The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood 2011, 118:409-412.
    • (2011) Blood , vol.118 , pp. 409-412
    • Green, C.L.1    Evans, C.M.2    Zhao, L.3    Hills, R.K.4    Burnett, A.K.5    Linch, D.C.6
  • 111
    • 0033753779 scopus 로고    scopus 로고
    • The DNA, methyltransferases of mammals
    • Bestor T.H. The DNA, methyltransferases of mammals. Hum Mol Genet 2000, 9:2395-2402.
    • (2000) Hum Mol Genet , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 112
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M., Bell D.W., Haber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 113
    • 27744547290 scopus 로고    scopus 로고
    • Maintenance and regulation of DNA methylation patterns in mammals
    • Chen Z.X., Riggs A.D. Maintenance and regulation of DNA methylation patterns in mammals. Biochem Cell Biol 2005, 83:438-448.
    • (2005) Biochem Cell Biol , vol.83 , pp. 438-448
    • Chen, Z.X.1    Riggs, A.D.2
  • 114
    • 78751470921 scopus 로고    scopus 로고
    • Structure and function of mammalian DNA methyltransferases
    • Jurkowska R.Z., Jurkowski T.P., Jeltsch A. Structure and function of mammalian DNA methyltransferases. Chembiochem 2011, 12:206-222.
    • (2011) Chembiochem , vol.12 , pp. 206-222
    • Jurkowska, R.Z.1    Jurkowski, T.P.2    Jeltsch, A.3
  • 116
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan X.J., Xu J., Gu Z.H., Pan C.M., Lu G., Shen Y., et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011, 43:309-315.
    • (2011) Nat Genet , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3    Pan, C.M.4    Lu, G.5    Shen, Y.6
  • 117
    • 84862909358 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications
    • Hou H.A., Kuo Y.Y., Liu C.Y., Chou W.C., Lee M.C., Chen C.Y., et al. DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications. Blood 2012, 119:559-568.
    • (2012) Blood , vol.119 , pp. 559-568
    • Hou, H.A.1    Kuo, Y.Y.2    Liu, C.Y.3    Chou, W.C.4    Lee, M.C.5    Chen, C.Y.6
  • 118
    • 84872124813 scopus 로고    scopus 로고
    • DMT3A and IDH1/2 mutations are stable during the progression of acute myeloid leukemia
    • [ASH Annual Meeting Abstracts]
    • Kihara R., Hoshino H., Kiyoi H., Naoe T. DMT3A and IDH1/2 mutations are stable during the progression of acute myeloid leukemia. Blood 2011, 1466. [ASH Annual Meeting Abstracts].
    • (2011) Blood , pp. 1466
    • Kihara, R.1    Hoshino, H.2    Kiyoi, H.3    Naoe, T.4
  • 119
    • 80055118997 scopus 로고    scopus 로고
    • Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
    • Lin J., Yao D.M., Qian J., Chen Q., Qian W., Li Y., et al. Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. PLoS One 2011, 6:e26906.
    • (2011) PLoS One , vol.6
    • Lin, J.1    Yao, D.M.2    Qian, J.3    Chen, Q.4    Qian, W.5    Li, Y.6
  • 120
    • 84867009280 scopus 로고    scopus 로고
    • Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease
    • Li Y., Zhang D.F., Zhang S.W., Zeng Y., Yao Y.G. Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease. Int J Hematol 2012, 96:229-233.
    • (2012) Int J Hematol , vol.96 , pp. 229-233
    • Li, Y.1    Zhang, D.F.2    Zhang, S.W.3    Zeng, Y.4    Yao, Y.G.5
  • 121
    • 84872147611 scopus 로고    scopus 로고
    • DNMT3A mutations predict for inferior outcome in NPM1-wildtype and molecular unfavorable cytogenetically-normal acute myeloid leukemia: a study of the German-Austrian AMLSG
    • [ASH Annual Meeting Abstracts]
    • Gaidzik V.I., Schlenk R.F., Paschka P., Stolzle A., Corbacioglu A., Nachbaur D., et al. DNMT3A mutations predict for inferior outcome in NPM1-wildtype and molecular unfavorable cytogenetically-normal acute myeloid leukemia: a study of the German-Austrian AMLSG. Blood 2011, 415. [ASH Annual Meeting Abstracts].
    • (2011) Blood , pp. 415
    • Gaidzik, V.I.1    Schlenk, R.F.2    Paschka, P.3    Stolzle, A.4    Corbacioglu, A.5    Nachbaur, D.6
  • 122
    • 84866077973 scopus 로고    scopus 로고
    • Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation
    • Holz-Schietinger C., Matje D.M., Reich N.O. Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation. J Biol Chem 2012, 287:30941-30951.
    • (2012) J Biol Chem , vol.287 , pp. 30941-30951
    • Holz-Schietinger, C.1    Matje, D.M.2    Reich, N.O.3
  • 123
    • 82855177869 scopus 로고    scopus 로고
    • Rare occurrence of DNMT3A mutations in myelodysplastic syndromes
    • Thol F., Winschel C., Ludeking A., Yun H., Friesen I., Damm F., et al. Rare occurrence of DNMT3A mutations in myelodysplastic syndromes. Haematologica 2011, 96:1870-1873.
    • (2011) Haematologica , vol.96 , pp. 1870-1873
    • Thol, F.1    Winschel, C.2    Ludeking, A.3    Yun, H.4    Friesen, I.5    Damm, F.6
  • 124
    • 79960255863 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
    • Walter M.J., Ding L., Shen D., Shao J., Grillot M., McLellan M., et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011, 25:1153-1158.
    • (2011) Leukemia , vol.25 , pp. 1153-1158
    • Walter, M.J.1    Ding, L.2    Shen, D.3    Shao, J.4    Grillot, M.5    McLellan, M.6
  • 125
    • 84872168817 scopus 로고    scopus 로고
    • Landmark analyses of DNMT3A mutations in hematological malignancies
    • [ASH Annual Meeting Abstracts]
    • Grossmann V., Kohlmann A., Haferlach C., Alpermann T., Wild M., Weissmann S., et al. Landmark analyses of DNMT3A mutations in hematological malignancies. Blood 2011, 407. [ASH Annual Meeting Abstracts].
    • (2011) Blood , pp. 407
    • Grossmann, V.1    Kohlmann, A.2    Haferlach, C.3    Alpermann, T.4    Wild, M.5    Weissmann, S.6
  • 127
    • 84555207349 scopus 로고    scopus 로고
    • Dnmt3a is essential for hematopoietic stem cell differentiation
    • Challen G.A., Sun D., Jeong M., Luo M., Jelinek J., Berg J.S., et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2011, 44:23-31.
    • (2011) Nat Genet , vol.44 , pp. 23-31
    • Challen, G.A.1    Sun, D.2    Jeong, M.3    Luo, M.4    Jelinek, J.5    Berg, J.S.6
  • 128
    • 79960735923 scopus 로고    scopus 로고
    • Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
    • Thol F., Damm F., Ludeking A., Winschel C., Wagner K., Morgan M., et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol 2011, 29:2889-2896.
    • (2011) J Clin Oncol , vol.29 , pp. 2889-2896
    • Thol, F.1    Damm, F.2    Ludeking, A.3    Winschel, C.4    Wagner, K.5    Morgan, M.6
  • 129
    • 83055161507 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
    • Grossmann V., Tiacci E., Holmes A.B., Kohlmann A., Martelli M.P., Kern W., et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 2011, 118:6153-6163.
    • (2011) Blood , vol.118 , pp. 6153-6163
    • Grossmann, V.1    Tiacci, E.2    Holmes, A.B.3    Kohlmann, A.4    Martelli, M.P.5    Kern, W.6
  • 130
    • 81555228423 scopus 로고    scopus 로고
    • Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
    • Shen Y., Zhu Y.M., Fan X., Shi J.Y., Wang Q.R., Yan X.J., et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011, 118:5593-5603.
    • (2011) Blood , vol.118 , pp. 5593-5603
    • Shen, Y.1    Zhu, Y.M.2    Fan, X.3    Shi, J.Y.4    Wang, Q.R.5    Yan, X.J.6
  • 131
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M., Huang Y., Jankowska A.M., Pape U.J., Tahiliani M., Bandukwala H.S., et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010, 468:839-843.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3    Pape, U.J.4    Tahiliani, M.5    Bandukwala, H.S.6
  • 132
    • 84862266735 scopus 로고    scopus 로고
    • TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group
    • Gaidzik V.I., Paschka P., Spath D., Habdank M., Kohne C.H., Germing U., et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin Oncol 2012, 30:1350-1357.
    • (2012) J Clin Oncol , vol.30 , pp. 1350-1357
    • Gaidzik, V.I.1    Paschka, P.2    Spath, D.3    Habdank, M.4    Kohne, C.H.5    Germing, U.6
  • 133
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Metzeler K.H., Maharry K., Radmacher M.D., Mrozek K., Margeson D., Becker H., et al. TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2011, 29:1373-1381.
    • (2011) J Clin Oncol , vol.29 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3    Mrozek, K.4    Margeson, D.5    Becker, H.6
  • 134
    • 52649089060 scopus 로고    scopus 로고
    • DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication
    • Whitman S.P., Hackanson B., Liyanarachchi S., Liu S., Rush L.J., Maharry K., et al. DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication. Blood 2008, 112:2013-2016.
    • (2008) Blood , vol.112 , pp. 2013-2016
    • Whitman, S.P.1    Hackanson, B.2    Liyanarachchi, S.3    Liu, S.4    Rush, L.J.5    Maharry, K.6
  • 135
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study
    • Paschka P., Marcucci G., Ruppert A.S., Whitman S.P., Mrozek K., Maharry K., et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2008, 26:4595-4602.
    • (2008) J Clin Oncol , vol.26 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3    Whitman, S.P.4    Mrozek, K.5    Maharry, K.6
  • 136
    • 56749098118 scopus 로고    scopus 로고
    • Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party
    • Virappane P., Gale R., Hills R., Kakkas I., Summers K., Stevens J., et al. Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008, 26:5429-5435.
    • (2008) J Clin Oncol , vol.26 , pp. 5429-5435
    • Virappane, P.1    Gale, R.2    Hills, R.3    Kakkas, I.4    Summers, K.5    Stevens, J.6
  • 137
    • 66549116716 scopus 로고    scopus 로고
    • Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group
    • Gaidzik V.I., Schlenk R.F., Moschny S., Becker A., Bullinger L., Corbacioglu A., et al. Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group. Blood 2009, 113:4505-4511.
    • (2009) Blood , vol.113 , pp. 4505-4511
    • Gaidzik, V.I.1    Schlenk, R.F.2    Moschny, S.3    Becker, A.4    Bullinger, L.5    Corbacioglu, A.6
  • 138
    • 79952134550 scopus 로고    scopus 로고
    • RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
    • Schnittger S., Dicker F., Kern W., Wendland N., Sundermann J., Alpermann T., et al. RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis. Blood 2011, 117:2348-2357.
    • (2011) Blood , vol.117 , pp. 2348-2357
    • Schnittger, S.1    Dicker, F.2    Kern, W.3    Wendland, N.4    Sundermann, J.5    Alpermann, T.6
  • 139
    • 79954448043 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group
    • Gaidzik V.I., Bullinger L., Schlenk R.F., Zimmermann A.S., Rock J., Paschka P., et al. RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group. J Clin Oncol 2011, 29:1364-1372.
    • (2011) J Clin Oncol , vol.29 , pp. 1364-1372
    • Gaidzik, V.I.1    Bullinger, L.2    Schlenk, R.F.3    Zimmermann, A.S.4    Rock, J.5    Paschka, P.6
  • 140
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations
    • Tang J.L., Hou H.A., Chen C.Y., Liu C.Y., Chou W.C., Tseng M.H., et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood 2009, 114:5352-5361.
    • (2009) Blood , vol.114 , pp. 5352-5361
    • Tang, J.L.1    Hou, H.A.2    Chen, C.Y.3    Liu, C.Y.4    Chou, W.C.5    Tseng, M.H.6
  • 142
    • 76749084667 scopus 로고    scopus 로고
    • Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
    • Carbuccia N., Trouplin V., Gelsi-Boyer V., Murati A., Rocquain J., Adelaide J., et al. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. Leukemia 2010, 24:469-473.
    • (2010) Leukemia , vol.24 , pp. 469-473
    • Carbuccia, N.1    Trouplin, V.2    Gelsi-Boyer, V.3    Murati, A.4    Rocquain, J.5    Adelaide, J.6
  • 143
    • 0036814971 scopus 로고    scopus 로고
    • Molecular genetics of human leukemias: new insights into therapy
    • Gilliland D.G. Molecular genetics of human leukemias: new insights into therapy. Semin Hematol 2002, 39:6-11.
    • (2002) Semin Hematol , vol.39 , pp. 6-11
    • Gilliland, D.G.1
  • 145
    • 84865029087 scopus 로고    scopus 로고
    • Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics
    • Fernandez-Mercado M., Yip B.H., Pellagatti A., Davies C., Larrayoz M.J., Kondo T., et al. Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics. PLoS One 2012, 7:e42334.
    • (2012) PLoS One , vol.7
    • Fernandez-Mercado, M.1    Yip, B.H.2    Pellagatti, A.3    Davies, C.4    Larrayoz, M.J.5    Kondo, T.6
  • 146
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel J.P., Gonen M., Figueroa M.E., Fernandez H., Sun Z., Racevskis J., et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012, 366:1079-1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3    Fernandez, H.4    Sun, Z.5    Racevskis, J.6
  • 147
    • 84867806184 scopus 로고    scopus 로고
    • A novel hierarchical prognostic model of AML solely based on molecular mutations
    • Grossmann V., Schnittger S., Kohlmann A., Eder C., Roller A., Dicker F., et al. A novel hierarchical prognostic model of AML solely based on molecular mutations. Blood 2012, 120:2963-2972.
    • (2012) Blood , vol.120 , pp. 2963-2972
    • Grossmann, V.1    Schnittger, S.2    Kohlmann, A.3    Eder, C.4    Roller, A.5    Dicker, F.6
  • 148
    • 84859410003 scopus 로고    scopus 로고
    • Novel approaches to the treatment of acute myeloid leukemia
    • Roboz G.J. Novel approaches to the treatment of acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2011, 43-50.
    • (2011) Hematology Am Soc Hematol Educ Program , pp. 43-50
    • Roboz, G.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.