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Volumn 43, Issue 5, 2011, Pages 470-476

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; NUCLEOPHOSMIN;

EID: 79955469651     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.796     Document Type: Article
Times cited : (173)

References (40)
  • 3
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • DOI 10.1038/nature03691
    • Dupuy, A.J., Akagi, K., Largaespada, D.A., Copeland, N.G. & Jenkins, N.A. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436, 221-226 (2005). (Pubitemid 41021267)
    • (2005) Nature , vol.436 , Issue.7048 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3    Copeland, N.G.4    Jenkins, N.A.5
  • 4
    • 22444444402 scopus 로고    scopus 로고
    • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
    • DOI 10.1038/nature03681
    • Collier, L.S., Carlson, C.M., Ravimohan, S., Dupuy, A.J. & Largaespada, D.A. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436, 272-276 (2005). (Pubitemid 41021279)
    • (2005) Nature , vol.436 , Issue.7048 , pp. 272-276
    • Collier, L.S.1    Carlson, C.M.2    Ravimohan, S.3    Dupuy, A.J.4    Largaespada, D.A.5
  • 5
    • 41349111453 scopus 로고    scopus 로고
    • The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein
    • DOI 10.1093/jb/mvm222
    • Okuwaki, M. The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein. J. Biochem. 143, 441-448 (2008). (Pubitemid 351451762)
    • (2008) Journal of Biochemistry , vol.143 , Issue.4 , pp. 441-448
    • Okuwaki, M.1
  • 7
    • 0034637578 scopus 로고    scopus 로고
    • Mapping the functional domains of nucleolar protein B23
    • DOI 10.1074/jbc.M003278200
    • Hingorani, K., Szebeni, A. & Olson, M.O. Mapping the functional domains of nucleolar protein B23. J. Biol. Chem. 275, 24451-24457 (2000). (Pubitemid 30626537)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.32 , pp. 24451-24457
    • Hingorani, K.1    Szebeni, A.2    Olson, M.O.J.3
  • 8
    • 70350724838 scopus 로고    scopus 로고
    • Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: Molecular basis and clinical implications
    • Falini, B. et al. Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications. Leukemia 23, 1731-1743 (2009).
    • (2009) Leukemia , vol.23 , pp. 1731-1743
    • Falini, B.1
  • 10
    • 77955081371 scopus 로고    scopus 로고
    • Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias
    • Rocquain, J. et al. Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. BMC Cancer 10, 401 (2010).
    • (2010) BMC Cancer , vol.10 , pp. 401
    • Rocquain, J.1
  • 11
    • 77951443641 scopus 로고    scopus 로고
    • The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model
    • Cheng, K. et al. The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model. Blood 115, 3341-3345 (2010).
    • (2010) Blood , vol.115 , pp. 3341-3345
    • Cheng, K.1
  • 12
    • 43549116415 scopus 로고    scopus 로고
    • Npm1 is a haploinsuffcient suppressor of myeloid and lymphoid malignancies in the mouse
    • Sportoletti, P. et al. Npm1 is a haploinsuffcient suppressor of myeloid and lymphoid malignancies in the mouse. Blood 111, 3859-3862 (2008).
    • (2008) Blood , vol.111 , pp. 3859-3862
    • Sportoletti, P.1
  • 13
    • 0030791974 scopus 로고    scopus 로고
    • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
    • DOI 10.1093/emboj/16.14.4226
    • Lavau, C., Szilvassy, S.J., Slany, R. & Cleary, M.L. Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J. 16, 4226-4237 (1997). (Pubitemid 27298175)
    • (1997) EMBO Journal , vol.16 , Issue.14 , pp. 4226-4237
    • Lavau, C.1    Szilvassy, S.J.2    Slany, R.3    Cleary, M.L.4
  • 15
    • 0015788469 scopus 로고
    • Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids
    • Smith, G.S., Walford, R.L. & Mickey, M.R. Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids. J. Natl. Cancer Inst. 50, 1195-1213 (1973).
    • (1973) J. Natl. Cancer Inst. , vol.50 , pp. 1195-1213
    • Smith, G.S.1    Walford, R.L.2    Mickey, M.R.3
  • 16
    • 78449294626 scopus 로고    scopus 로고
    • PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice
    • Rad, R. et al. PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science 330, 1104-1107 (2010).
    • (2010) Science , vol.330 , pp. 1104-1107
    • Rad, R.1
  • 17
    • 33645754991 scopus 로고    scopus 로고
    • Novel insights into the pathogenesis of the Graff murine leukemia retrovirus
    • Voisin, V., Barat, C., Hoang, T. & Rassart, E. Novel insights into the pathogenesis of the Graff murine leukemia retrovirus. J. Virol. 80, 4026-4037 (2006).
    • (2006) J. Virol. , vol.80 , pp. 4026-4037
    • Voisin, V.1    Barat, C.2    Hoang, T.3    Rassart, E.4
  • 18
    • 33846025793 scopus 로고    scopus 로고
    • Detecting statistically signifcant common insertion sites in retroviral insertional mutagenesis screens
    • de Ridder, J., Uren, A., Kool, J., Reinders, M. & Wessels, L Detecting statistically signifcant common insertion sites in retroviral insertional mutagenesis screens. PLOS Comput. Biol. 2, e166 (2006).
    • (2006) PLOS Comput. Biol. , vol.2
    • De Ridder, J.1    Uren, A.2    Kool, J.3    Reinders, M.4    Wessels, L.5
  • 19
    • 0025373481 scopus 로고
    • In vivo transformation of factor-dependent hemopoietic cells: Role of intracisternal A-particle transposition for growth factor gene activation
    • Dührsen, U., Stahl, J. & Gough, N.M. In vivo transformation of factor-dependent hemopoietic cells: role of intracisternal A-particle transposition for growth factor gene activation. EMBO J. 9, 1087-1096 (1990).
    • (1990) EMBO J. , vol.9 , pp. 1087-1096
    • Dührsen, U.1    Stahl, J.2    Gough, N.M.3
  • 20
    • 0027983682 scopus 로고
    • Evidence for internal autocrine regulation of growth in acute myeloblastic leukemia cells
    • Rogers, S.Y., Bradbury, D., Kozlowski, R. & Russell, N.H. Evidence for internal autocrine regulation of growth in acute myeloblastic leukemia cells. Exp. Hematol. 22, 593-598 (1994). (Pubitemid 24300494)
    • (1994) Experimental Hematology , vol.22 , Issue.7 , pp. 593-598
    • Rogers, S.Y.1    Bradbury, D.2    Kozlowski, R.3    Russell, N.H.4
  • 21
    • 0022811277 scopus 로고
    • Autocrine secretion of GM-CSF in acute myeloblastic leukemia
    • Young, D.C. & Griffn, J.D. Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood 68, 1178-1181 (1986). (Pubitemid 17186399)
    • (1986) Blood , vol.86 , Issue.5 , pp. 1178-1181
    • Young, D.C.1    Griffin, J.D.2
  • 22
    • 77952377310 scopus 로고    scopus 로고
    • Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins
    • Takeda, A., Sarma, N.J., Abdul-Nabi, A.M. & Yaseen, N.R. Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins. J. Biol. Chem. 285, 16248-16257 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 16248-16257
    • Takeda, A.1    Sarma, N.J.2    Abdul-Nabi, A.M.3    Yaseen, N.R.4
  • 23
    • 0037301370 scopus 로고    scopus 로고
    • Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas
    • DOI 10.1128/JVI.77.3.2056-2062.2003
    • Kim, R. et al. Genome-based identifcation of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas. J. Virol. 77, 2056-2062 (2003). (Pubitemid 36110018)
    • (2003) Journal of Virology , vol.77 , Issue.3 , pp. 2056-2062
    • Kim, R.1    Trubetskoy, A.2    Suzuki, T.3    Jenkins, N.A.4    Copeland, N.G.5    Lenz, J.6
  • 24
    • 70349273655 scopus 로고    scopus 로고
    • Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
    • Lauchle, J.O. et al. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature 461, 411-414 (2009).
    • (2009) Nature , vol.461 , pp. 411-414
    • Lauchle, J.O.1
  • 25
    • 0030034673 scopus 로고    scopus 로고
    • Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias
    • DOI 10.1038/ng0296-149
    • Nakamura, T., Largaespada, D.A., Shaughnessy, J.D. Jr., Jenkins, N.A. & Copeland, N.G. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukemias. Nat Genet. 12, 149-153 (1996). (Pubitemid 26051294)
    • (1996) Nature Genetics , vol.12 , Issue.2 , pp. 149-153
    • Nakamura, T.1    Largaespada, D.A.2    Shaughnessy Jr., J.D.3    Jenkins, N.A.4    Copeland, N.G.5
  • 26
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    • DOI 10.1101/gad.1111603
    • Ayton, P.M. & Cleary, M.L. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 17, 2298-2307 (2003). (Pubitemid 37128644)
    • (2003) Genes and Development , vol.17 , Issue.18 , pp. 2298-2307
    • Ayton, P.M.1    Cleary, M.L.2
  • 27
    • 0030942488 scopus 로고    scopus 로고
    • Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis
    • Lawrence, H.J. et al. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood 89, 1922-1930 (1997). (Pubitemid 27132106)
    • (1997) Blood , vol.89 , Issue.6 , pp. 1922-1930
    • Lawrence, H.J.1    Helgason, C.D.2    Sauvageau, G.3    Fong, S.4    Izon, D.J.5    Humphries, R.K.6    Largman, C.7
  • 29
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley, T.J. et al. DNMT3A mutations in acute myeloid leukemia. N. Engl. J. Med. 363, 2424-2433 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2424-2433
    • Ley, T.J.1
  • 30
    • 0037352031 scopus 로고    scopus 로고
    • A highly efficient recombineering-based method for generating conditional knockout mutations
    • DOI 10.1101/gr.749203
    • Liu, P., Jenkins, N.A. & Copeland, N.G. A highly effcient recombineering-based method for generating conditional knockout mutations. Genome Res. 13, 476-484 (2003). (Pubitemid 36395405)
    • (2003) Genome Research , vol.13 , Issue.3 , pp. 476-484
    • Liu, P.1    Jenkins, N.A.2    Copeland, N.G.3
  • 31
    • 0033762448 scopus 로고    scopus 로고
    • A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells
    • Chen, Y.T. & Bradley, A. A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells. Genesis 28, 31-35 (2000).
    • (2000) Genesis , vol.28 , pp. 31-35
    • Chen, Y.T.1    Bradley, A.2
  • 32
  • 33
    • 77956578342 scopus 로고    scopus 로고
    • JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia
    • Li, J. et al. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood 116, 1528-1538 (2010).
    • (2010) Blood , vol.116 , pp. 1528-1538
    • Li, J.1
  • 34
    • 1342294092 scopus 로고    scopus 로고
    • Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation
    • Yang, Y.H. et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30, e15 (2002).
    • (2002) Nucleic Acids Res. , vol.30
    • Yang, Y.H.1
  • 35
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Smyth, G.K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet Mol. Biol. 3, Article3 (2004).
    • (2004) Stat. Appl. Genet Mol. Biol. , vol.3
    • Smyth, G.K.1
  • 36
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc., B 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 37
    • 69849091995 scopus 로고    scopus 로고
    • A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites
    • Uren, A.G. et al. A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat. Protoc. 4, 789-798 (2009).
    • (2009) Nat. Protoc. , vol.4 , pp. 789-798
    • Uren, A.G.1
  • 39
    • 70350537021 scopus 로고    scopus 로고
    • Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality
    • Collier, L.S. et al. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res. 69, 8429-8437 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8429-8437
    • Collier, L.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.