-
1
-
-
20244387299
-
Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
-
Adolfsson J., Mansson R., Buza-Vidas N., Hultquist A., Liuba K., Jensen C.T., Bryder D., Yang L., Borge O.J., Thoren L.A., et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121 (2005) 295-306
-
(2005)
Cell
, vol.121
, pp. 295-306
-
-
Adolfsson, J.1
Mansson, R.2
Buza-Vidas, N.3
Hultquist, A.4
Liuba, K.5
Jensen, C.T.6
Bryder, D.7
Yang, L.8
Borge, O.J.9
Thoren, L.A.10
-
2
-
-
0034624828
-
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
-
Akashi K., Traver D., Miyamoto T., and Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404 (2000) 193-197
-
(2000)
Nature
, vol.404
, pp. 193-197
-
-
Akashi, K.1
Traver, D.2
Miyamoto, T.3
Weissman, I.L.4
-
3
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D., and Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3 (1997) 730-737
-
(1997)
Nat. Med.
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
4
-
-
42949097515
-
Malignant transformation initiated by Mll-AF9: Gene dosage and critical target cells
-
Chen W., Kumar A.R., Hudson W.A., Li Q., Wu B., Staggs R.A., Lund E.A., Sam T.N., and Kersey J.H. Malignant transformation initiated by Mll-AF9: Gene dosage and critical target cells. Cancer Cell 13 (2008) 432-440
-
(2008)
Cancer Cell
, vol.13
, pp. 432-440
-
-
Chen, W.1
Kumar, A.R.2
Hudson, W.A.3
Li, Q.4
Wu, B.5
Staggs, R.A.6
Lund, E.A.7
Sam, T.N.8
Kersey, J.H.9
-
5
-
-
0346100567
-
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
-
Cozzio A., Passegue E., Ayton P.M., Karsunky H., Cleary M.L., and Weissman I.L. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17 (2003) 3029-3035
-
(2003)
Genes Dev.
, vol.17
, pp. 3029-3035
-
-
Cozzio, A.1
Passegue, E.2
Ayton, P.M.3
Karsunky, H.4
Cleary, M.L.5
Weissman, I.L.6
-
6
-
-
43249084218
-
Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen
-
Hasemann M.S., Damgaard I., Schuster M.B., Theilgaard-Monch K., Sorensen A.B., Mrsic A., Krugers T., Ylstra B., Pedersen F.S., Nerlov C., and Porse B.T. Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen. Blood 111 (2008) 4309-4321
-
(2008)
Blood
, vol.111
, pp. 4309-4321
-
-
Hasemann, M.S.1
Damgaard, I.2
Schuster, M.B.3
Theilgaard-Monch, K.4
Sorensen, A.B.5
Mrsic, A.6
Krugers, T.7
Ylstra, B.8
Pedersen, F.S.9
Nerlov, C.10
Porse, B.T.11
-
7
-
-
4444233646
-
C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
-
Heath V., Suh H.C., Holman M., Renn K., Gooya J.M., Parkin S., Klarmann K.D., Ortiz M., Johnson P., and Keller J. C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood 104 (2004) 1639-1647
-
(2004)
Blood
, vol.104
, pp. 1639-1647
-
-
Heath, V.1
Suh, H.C.2
Holman, M.3
Renn, K.4
Gooya, J.M.5
Parkin, S.6
Klarmann, K.D.7
Ortiz, M.8
Johnson, P.9
Keller, J.10
-
8
-
-
0036463950
-
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
-
Higuchi M., O'Brien D., Kumaravelu P., Lenny N., Yeoh E.J., and Downing J.R. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1 (2002) 63-74
-
(2002)
Cancer Cell
, vol.1
, pp. 63-74
-
-
Higuchi, M.1
O'Brien, D.2
Kumaravelu, P.3
Lenny, N.4
Yeoh, E.J.5
Downing, J.R.6
-
9
-
-
0030954167
-
Multilineage gene expression precedes commitment in the hemopoietic system
-
Hu M., Krause D., Greaves M., Sharkis S., Dexter M., Heyworth C., and Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 11 (1997) 774-785
-
(1997)
Genes Dev.
, vol.11
, pp. 774-785
-
-
Hu, M.1
Krause, D.2
Greaves, M.3
Sharkis, S.4
Dexter, M.5
Heyworth, C.6
Enver, T.7
-
10
-
-
19944385935
-
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
-
Huntly B.J., Shigematsu H., Deguchi K., Lee B.H., Mizuno S., Duclos N., Rowan R., Amaral S., Curley D., Williams I.R., et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 6 (2004) 587-596
-
(2004)
Cancer Cell
, vol.6
, pp. 587-596
-
-
Huntly, B.J.1
Shigematsu, H.2
Deguchi, K.3
Lee, B.H.4
Mizuno, S.5
Duclos, N.6
Rowan, R.7
Amaral, S.8
Curley, D.9
Williams, I.R.10
-
11
-
-
0029155610
-
Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation
-
Jordan C.T., Astle C.M., Zawadzki J., Mackarehtschian K., Lemischka I.R., and Harrison D.E. Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation. Exp. Hematol. 23 (1995) 1011-1015
-
(1995)
Exp. Hematol.
, vol.23
, pp. 1011-1015
-
-
Jordan, C.T.1
Astle, C.M.2
Zawadzki, J.3
Mackarehtschian, K.4
Lemischka, I.R.5
Harrison, D.E.6
-
13
-
-
41249103144
-
Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
-
Kirstetter P., Schuster M.B., Bereshchenko O., Moore S., Dvinge H., Kurz E., Theilgaard-Monch K., Mansson R., Pedersen T.A., Pabst T., et al. Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell 13 (2008) 299-310
-
(2008)
Cancer Cell
, vol.13
, pp. 299-310
-
-
Kirstetter, P.1
Schuster, M.B.2
Bereshchenko, O.3
Moore, S.4
Dvinge, H.5
Kurz, E.6
Theilgaard-Monch, K.7
Mansson, R.8
Pedersen, T.A.9
Pabst, T.10
-
14
-
-
0036785393
-
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: Implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
-
Kottaridis P.D., Gale R.E., Langabeer S.E., Frew M.E., Bowen D.T., and Linch D.C. Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: Implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood 100 (2002) 2393-2398
-
(2002)
Blood
, vol.100
, pp. 2393-2398
-
-
Kottaridis, P.D.1
Gale, R.E.2
Langabeer, S.E.3
Frew, M.E.4
Bowen, D.T.5
Linch, D.C.6
-
15
-
-
30344446665
-
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia
-
Kuo Y.H., Landrette S.F., Heilman S.A., Perrat P.N., Garrett L., Liu P.P., Le Beau M.M., Kogan S.C., and Castilla L.H. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell 9 (2006) 57-68
-
(2006)
Cancer Cell
, vol.9
, pp. 57-68
-
-
Kuo, Y.H.1
Landrette, S.F.2
Heilman, S.A.3
Perrat, P.N.4
Garrett, L.5
Liu, P.P.6
Le Beau, M.M.7
Kogan, S.C.8
Castilla, L.H.9
-
16
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T., Sirard C., Vormoor J., Murdoch B., Hoang T., Caceres-Cortes J., Minden M., Paterson B., Caligiuri M.A., and Dick J.E. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367 (1994) 645-648
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
Minden, M.7
Paterson, B.8
Caligiuri, M.A.9
Dick, J.E.10
-
17
-
-
35048848955
-
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
-
Lee B.H., Tothova Z., Levine R.L., Anderson K., Buza-Vidas N., Cullen D.E., McDowell E.P., Adelsperger J., Frohling S., Huntly B.J., et al. FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Cancer Cell 12 (2007) 367-380
-
(2007)
Cancer Cell
, vol.12
, pp. 367-380
-
-
Lee, B.H.1
Tothova, Z.2
Levine, R.L.3
Anderson, K.4
Buza-Vidas, N.5
Cullen, D.E.6
McDowell, E.P.7
Adelsperger, J.8
Frohling, S.9
Huntly, B.J.10
-
18
-
-
15044358998
-
CEBPA point mutations in hematological malignancies
-
Leroy H., Roumier C., Huyghe P., Biggio V., Fenaux P., and Preudhomme C. CEBPA point mutations in hematological malignancies. Leukemia 19 (2005) 329-334
-
(2005)
Leukemia
, vol.19
, pp. 329-334
-
-
Leroy, H.1
Roumier, C.2
Huyghe, P.3
Biggio, V.4
Fenaux, P.5
Preudhomme, C.6
-
19
-
-
34247092922
-
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
-
Mansson R., Hultquist A., Luc S., Yang L., Anderson K., Kharazi S., Al-Hashmi S., Liuba K., Thoren L., Adolfsson J., et al. Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 26 (2007) 407-419
-
(2007)
Immunity
, vol.26
, pp. 407-419
-
-
Mansson, R.1
Hultquist, A.2
Luc, S.3
Yang, L.4
Anderson, K.5
Kharazi, S.6
Al-Hashmi, S.7
Liuba, K.8
Thoren, L.9
Adolfsson, J.10
-
20
-
-
55549103713
-
Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: A Cancer and Leukemia Group B Study
-
Marcucci G., Maharry K., Radmacher M.D., Mrozek K., Vukosavljevic T., Paschka P., Whitman S.P., Langer C., Baldus C.D., Liu C.G., et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: A Cancer and Leukemia Group B Study. J. Clin. Oncol. 26 (2008) 5078-5087
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 5078-5087
-
-
Marcucci, G.1
Maharry, K.2
Radmacher, M.D.3
Mrozek, K.4
Vukosavljevic, T.5
Paschka, P.6
Whitman, S.P.7
Langer, C.8
Baldus, C.D.9
Liu, C.G.10
-
21
-
-
20444503239
-
Converging pathways in leukemogenesis and stem cell self-renewal
-
Moore M.A. Converging pathways in leukemogenesis and stem cell self-renewal. Exp. Hematol. 33 (2005) 719-737
-
(2005)
Exp. Hematol.
, vol.33
, pp. 719-737
-
-
Moore, M.A.1
-
22
-
-
2342544921
-
C/EBPalpha mutations in acute myeloid leukaemias
-
Nerlov C. C/EBPalpha mutations in acute myeloid leukaemias. Nat. Rev. Cancer 4 (2004) 394-400
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 394-400
-
-
Nerlov, C.1
-
23
-
-
34547133494
-
The C/EBP family of transcription factors: A paradigm for interaction between gene expression and proliferation control
-
Nerlov C. The C/EBP family of transcription factors: A paradigm for interaction between gene expression and proliferation control. Trends Cell Biol. 17 (2007) 318-324
-
(2007)
Trends Cell Biol.
, vol.17
, pp. 318-324
-
-
Nerlov, C.1
-
24
-
-
33745322046
-
Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property
-
Nygren J.M., Bryder D., and Jacobsen S.E. Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property. J. Immunol. 177 (2006) 201-208
-
(2006)
J. Immunol.
, vol.177
, pp. 201-208
-
-
Nygren, J.M.1
Bryder, D.2
Jacobsen, S.E.3
-
25
-
-
35348908269
-
Transcriptional dysregulation during myeloid transformation in AML
-
Pabst T., and Mueller B.U. Transcriptional dysregulation during myeloid transformation in AML. Oncogene 26 (2007) 6829-6837
-
(2007)
Oncogene
, vol.26
, pp. 6829-6837
-
-
Pabst, T.1
Mueller, B.U.2
-
26
-
-
22344437854
-
Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
-
Porse B.T., Bryder D., Theilgaard-Monch K., Hasemann M.S., Anderson K., Damgaard I., Jacobsen S.E., and Nerlov C. Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. J. Exp. Med. 202 (2005) 85-96
-
(2005)
J. Exp. Med.
, vol.202
, pp. 85-96
-
-
Porse, B.T.1
Bryder, D.2
Theilgaard-Monch, K.3
Hasemann, M.S.4
Anderson, K.5
Damgaard, I.6
Jacobsen, S.E.7
Nerlov, C.8
-
27
-
-
0035913913
-
E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo
-
Porse B.T., Pedersen T.A., Xu X., Lindberg B., Wewer U.M., Friis-Hansen L., and Nerlov C. E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 107 (2001) 247-258
-
(2001)
Cell
, vol.107
, pp. 247-258
-
-
Porse, B.T.1
Pedersen, T.A.2
Xu, X.3
Lindberg, B.4
Wewer, U.M.5
Friis-Hansen, L.6
Nerlov, C.7
-
28
-
-
34848896359
-
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
-
Pronk C.J., Rossi D.J., Mansson R., Attema J.L., Norddahl G.L., Chan C.K., Sigvardsson M., Weissman I.L., and Bryder D. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell 1 (2007) 428-442
-
(2007)
Cell Stem Cell
, vol.1
, pp. 428-442
-
-
Pronk, C.J.1
Rossi, D.J.2
Mansson, R.3
Attema, J.L.4
Norddahl, G.L.5
Chan, C.K.6
Sigvardsson, M.7
Weissman, I.L.8
Bryder, D.9
-
29
-
-
0036786289
-
Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse
-
Shih L.Y., Huang C.F., Wu J.H., Lin T.L., Dunn P., Wang P.N., Kuo M.C., Lai C.L., and Hsu H.C. Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse. Blood 100 (2002) 2387-2392
-
(2002)
Blood
, vol.100
, pp. 2387-2392
-
-
Shih, L.Y.1
Huang, C.F.2
Wu, J.H.3
Lin, T.L.4
Dunn, P.5
Wang, P.N.6
Kuo, M.C.7
Lai, C.L.8
Hsu, H.C.9
-
30
-
-
1642301466
-
Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: A comparative analysis of 120 paired diagnostic and relapse bone marrow samples
-
Shih L.Y., Huang C.F., Wu J.H., Wang P.N., Lin T.L., Dunn P., Chou M.C., Kuo M.C., and Tang C.C. Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: A comparative analysis of 120 paired diagnostic and relapse bone marrow samples. Clin. Cancer Res. 10 (2004) 1326-1332
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 1326-1332
-
-
Shih, L.Y.1
Huang, C.F.2
Wu, J.H.3
Wang, P.N.4
Lin, T.L.5
Dunn, P.6
Chou, M.C.7
Kuo, M.C.8
Tang, C.C.9
-
31
-
-
33646474281
-
AML patients with CEBPalpha mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: A comparative analysis on paired diagnosis and relapse samples
-
Shih L.Y., Liang D.C., Huang C.F., Wu J.H., Lin T.L., Wang P.N., Dunn P., Kuo M.C., and Tang T.C. AML patients with CEBPalpha mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: A comparative analysis on paired diagnosis and relapse samples. Leukemia 20 (2006) 604-609
-
(2006)
Leukemia
, vol.20
, pp. 604-609
-
-
Shih, L.Y.1
Liang, D.C.2
Huang, C.F.3
Wu, J.H.4
Lin, T.L.5
Wang, P.N.6
Dunn, P.7
Kuo, M.C.8
Tang, T.C.9
-
32
-
-
33749440584
-
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
-
Somervaille T.C., and Cleary M.L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10 (2006) 257-268
-
(2006)
Cancer Cell
, vol.10
, pp. 257-268
-
-
Somervaille, T.C.1
Cleary, M.L.2
-
33
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., and Mesirov J.P. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102 (2005) 15545-15550
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
34
-
-
50949090415
-
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells
-
Taussig D.C., Miraki-Moud F., Anjos-Afonso F., Pearce D.J., Allen K., Ridler C., Lillington D., Oakervee H., Cavenagh J., Agrawal S.G., et al. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood 112 (2008) 568-575
-
(2008)
Blood
, vol.112
, pp. 568-575
-
-
Taussig, D.C.1
Miraki-Moud, F.2
Anjos-Afonso, F.3
Pearce, D.J.4
Allen, K.5
Ridler, C.6
Lillington, D.7
Oakervee, H.8
Cavenagh, J.9
Agrawal, S.G.10
-
35
-
-
8844250116
-
Molecular signatures of proliferation and quiescence in hematopoietic stem cells
-
Venezia T.A., Merchant A.A., Ramos C.A., Whitehouse N.L., Young A.S., Shaw C.A., and Goodell M.A. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2 (2004) e301
-
(2004)
PLoS Biol.
, vol.2
-
-
Venezia, T.A.1
Merchant, A.A.2
Ramos, C.A.3
Whitehouse, N.L.4
Young, A.S.5
Shaw, C.A.6
Goodell, M.A.7
-
36
-
-
10344230611
-
Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha
-
Zhang P., Iwasaki-Arai J., Iwasaki H., Fenyus M.L., Dayaram T., Owens B.M., Shigematsu H., Levantini E., Huettner C.S., Lekstrom-Himes J.A., et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 21 (2004) 853-863
-
(2004)
Immunity
, vol.21
, pp. 853-863
-
-
Zhang, P.1
Iwasaki-Arai, J.2
Iwasaki, H.3
Fenyus, M.L.4
Dayaram, T.5
Owens, B.M.6
Shigematsu, H.7
Levantini, E.8
Huettner, C.S.9
Lekstrom-Himes, J.A.10
|