메뉴 건너뛰기




Volumn 105, Issue 12, 2005, Pages 4792-4799

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; VASCULOTROPIN RECEPTOR 3;

EID: 20444402664     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-11-4430     Document Type: Article
Times cited : (173)

References (42)
  • 1
    • 0025870946 scopus 로고
    • Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family
    • Rosnet O, Marchetto S, deLapeyriere O, Birnbaum D. Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 1991;6:1641-1650.
    • (1991) Oncogene , vol.6 , pp. 1641-1650
    • Rosnet, O.1    Marchetto, S.2    DeLapeyriere, O.3    Birnbaum, D.4
  • 2
    • 0025770646 scopus 로고
    • A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
    • Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell. 1991;65:1143-1152.
    • (1991) Cell , vol.65 , pp. 1143-1152
    • Matthews, W.1    Jordan, C.T.2    Wiegand, G.W.3    Pardoll, D.4    Lemischka, I.R.5
  • 3
    • 0027130517 scopus 로고
    • Hematopoietic receptors of class III receptor-type tyrosine kinases
    • Rosnet O, Birnbaum D. Hematopoietic receptors of class III receptor-type tyrosine kinases. Crit Rev Oncog. 1993;4:595-613.
    • (1993) Crit Rev Oncog , vol.4 , pp. 595-613
    • Rosnet, O.1    Birnbaum, D.2
  • 4
    • 0034649210 scopus 로고    scopus 로고
    • Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
    • Zhang S, Broxmeyer HE. Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. Biochem Biophys Res Commun. 2000;277:195-199.
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 195-199
    • Zhang, S.1    Broxmeyer, H.E.2
  • 5
    • 0034605042 scopus 로고    scopus 로고
    • Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
    • Zhang S, Fukuda S, Lee Y, et al. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J Exp Med. 2000;192:719-728.
    • (2000) J Exp Med , vol.192 , pp. 719-728
    • Zhang, S.1    Fukuda, S.2    Lee, Y.3
  • 6
    • 0031883328 scopus 로고    scopus 로고
    • FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates
    • Lavagna-Sevenier C, Marchetto S, Birnbaum D, Rosnet O. FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates. Leukemia. 1998;12:301-310.
    • (1998) Leukemia , vol.12 , pp. 301-310
    • Lavagna-Sevenier, C.1    Marchetto, S.2    Birnbaum, D.3    Rosnet, O.4
  • 7
    • 0032519768 scopus 로고    scopus 로고
    • c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
    • Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101-1134.
    • (1998) Blood , vol.91 , pp. 1101-1134
    • Lyman, S.D.1    Jacobsen, S.E.2
  • 8
    • 0034210658 scopus 로고    scopus 로고
    • Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    • McKenna HJ, Stocking KL, Miller RE, et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 2000;95:3489-3497.
    • (2000) Blood , vol.95 , pp. 3489-3497
    • McKenna, H.J.1    Stocking, K.L.2    Miller, R.E.3
  • 9
    • 0028928832 scopus 로고
    • FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver
    • Muench MO, Roncarolo MG, Menon S, et al. FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood. 1995;85:963-972.
    • (1995) Blood , vol.85 , pp. 963-972
    • Muench, M.O.1    Roncarolo, M.G.2    Menon, S.3
  • 10
    • 0030948721 scopus 로고    scopus 로고
    • Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential
    • Molineux G, McCrea C, Van XQ, Kerzic P, McNiece I. Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential. Blood. 1997;89:3998-4004.
    • (1997) Blood , vol.89 , pp. 3998-4004
    • Molineux, G.1    McCrea, C.2    Van, X.Q.3    Kerzic, P.4    McNiece, I.5
  • 11
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 12
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia. 1997;11:1605-1609.
    • (1997) Leukemia , vol.11 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3
  • 13
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 14
    • 0037409885 scopus 로고    scopus 로고
    • Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia
    • Kottaridis PD, Gale RE, Linch DC. Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia. Leuk Lymphoma. 2003;44:905-913.
    • (2003) Leuk Lymphoma , vol.44 , pp. 905-913
    • Kottaridis, P.D.1    Gale, R.E.2    Linch, D.C.3
  • 16
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 17
    • 0038156174 scopus 로고    scopus 로고
    • Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor
    • Grundler R, Thiede C, Miething C, Steudel C, Peschel C, Duyster J. Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor. Blood. 2003;102:646-651.
    • (2003) Blood , vol.102 , pp. 646-651
    • Grundler, R.1    Thiede, C.2    Miething, C.3    Steudel, C.4    Peschel, C.5    Duyster, J.6
  • 18
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3
  • 19
    • 4444350364 scopus 로고    scopus 로고
    • Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML
    • Jiang J, Paez JG, Lee JC, et al. Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML. Blood. 2004;104:1855-1858.
    • (2004) Blood , vol.104 , pp. 1855-1858
    • Jiang, J.1    Paez, J.G.2    Lee, J.C.3
  • 20
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood. 2000;96:3907-3914.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3
  • 21
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S, Woods WG, Stirewalt DL, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood. 2001;97:89-94.
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.G.2    Stirewalt, D.L.3
  • 22
    • 0033758958 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group
    • Abu-Duhier FM, Goodeve AC, Wilson GA, et al. FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group. Br J Haematol. 2000;111:190-195.
    • (2000) Br J Haematol , vol.111 , pp. 190-195
    • Abu-Duhier, F.M.1    Goodeve, A.C.2    Wilson, G.A.3
  • 23
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 24
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002;100:59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 25
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
    • Frohling S, Schlenk RF, Breitruck J, et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood. 2002;100:4372-4380.
    • (2002) Blood , vol.100 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3
  • 26
    • 12244282411 scopus 로고    scopus 로고
    • Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia
    • Moreno I, Martin G, Bolufer P, et al. Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia. Haematologica. 2003;88:19-24.
    • (2003) Haematologica , vol.88 , pp. 19-24
    • Moreno, I.1    Martin, G.2    Bolufer, P.3
  • 27
    • 17844365933 scopus 로고    scopus 로고
    • Point mutations of the FLT3-receptor tyrosine kinase in patients with acute myeloid leukemia: Results of an intergroup analysis of the AML CG Study and the AML96 Study of the SHG
    • Abstract 2237
    • Thiede C, Schnittger S, Kern W, et al. Point mutations of the FLT3-receptor tyrosine kinase in patients with acute myeloid leukemia: results of an intergroup analysis of the AML CG Study and the AML96 Study of the SHG [abstract]. Blood. 2003;102:606a. Abstract 2237.
    • (2003) Blood , vol.102
    • Thiede, C.1    Schnittger, S.2    Kern, W.3
  • 28
    • 9144244169 scopus 로고    scopus 로고
    • FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
    • Taketani T, Taki T, Sugita K, et al. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood. 2004;103:1085-1088.
    • (2004) Blood , vol.103 , pp. 1085-1088
    • Taketani, T.1    Taki, T.2    Sugita, K.3
  • 29
    • 1542276560 scopus 로고    scopus 로고
    • FLT3 mutations in childhood acute lymphoblastic leukemia
    • Armstrong SA, Mabon ME, Silverman LB, et al. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood. 2004;103:3544-3546.
    • (2004) Blood , vol.103 , pp. 3544-3546
    • Armstrong, S.A.1    Mabon, M.E.2    Silverman, L.B.3
  • 30
    • 3142512347 scopus 로고    scopus 로고
    • Activating FLT3 mutations in CD117/KIT positive T-cell acute lymphoblastic leukemias
    • Paietta E, Ferrando AA, Neuberg D, et al. Activating FLT3 mutations in CD117/KIT positive T-cell acute lymphoblastic leukemias. Blood. 2004;104:558-560.
    • (2004) Blood , vol.104 , pp. 558-560
    • Paietta, E.1    Ferrando, A.A.2    Neuberg, D.3
  • 31
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 32
    • 85044560453 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene is infrequent in infant acute leukemia: Japan Infant Leukemia Study Group
    • Xu F, Taki T, Eguchi M, et al. Tandem duplication of the FLT3 gene is infrequent in infant acute leukemia: Japan Infant Leukemia Study Group. Leukemia. 2000;14:945-947.
    • (2000) Leukemia , vol.14 , pp. 945-947
    • Xu, F.1    Taki, T.2    Eguchi, M.3
  • 33
    • 0001097136 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children
    • Xu F, Taki T, Yang HW, et al. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol. 1999;105:155-162.
    • (1999) Br J Haematol , vol.105 , pp. 155-162
    • Xu, F.1    Taki, T.2    Yang, H.W.3
  • 34
    • 1542269168 scopus 로고    scopus 로고
    • FLT3 inhibitors: A paradigm for the development of targeted therapeutics for paediatric cancer
    • discussion 722-704
    • Brown P, Small D. FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer. Eur J Cancer. 2004;40:707-721, discussion 722-704.
    • (2004) Eur J Cancer , vol.40 , pp. 707-721
    • Brown, P.1    Small, D.2
  • 35
    • 0036093475 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    • Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood. 2002;99:310-318.
    • (2002) Blood , vol.99 , pp. 310-318
    • Kelly, L.M.1    Liu, Q.2    Kutok, J.L.3    Williams, I.R.4    Boulton, C.L.5    Gilliland, D.G.6
  • 36
    • 20444429845 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model that responds to the FLT3 inhibitor PKC412
    • Abstract 363
    • Gilliland D, Lee B, Williams I, et al. FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model that responds to the FLT3 inhibitor PKC412 [abstract]. Blood. 2003;102:107a. Abstract 363.
    • (2003) Blood , vol.102
    • Gilliland, D.1    Lee, B.2    Williams, I.3
  • 38
    • 0032533257 scopus 로고    scopus 로고
    • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
    • Pear WS, Miller JP, Xu L, et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 1998;92:3780-3792.
    • (1998) Blood , vol.92 , pp. 3780-3792
    • Pear, W.S.1    Miller, J.P.2    Xu, L.3
  • 39
    • 0043091984 scopus 로고    scopus 로고
    • The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model
    • Miething C, Grundler R, Fend F, et al. The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model. Oncogene. 2003;22:4642-4647.
    • (2003) Oncogene , vol.22 , pp. 4642-4647
    • Miething, C.1    Grundler, R.2    Fend, F.3
  • 40
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3:650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 41
    • 0037062350 scopus 로고    scopus 로고
    • PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model
    • Kelly LM, Kutok JL, Williams IR, et al. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci U S A. 2002;99:8283-8288.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8283-8288
    • Kelly, L.M.1    Kutok, J.L.2    Williams, I.R.3
  • 42
    • 0013312329 scopus 로고    scopus 로고
    • Inhibition of FLT3 in MLL: Validation of a therapeutic target identified by gene expression based classification
    • Armstrong SA, Kung AL, Mabon ME, et al. Inhibition of FLT3 in MLL: validation of a therapeutic target identified by gene expression based classification. Cancer Cell. 2003;3:173-183.
    • (2003) Cancer Cell , vol.3 , pp. 173-183
    • Armstrong, S.A.1    Kung, A.L.2    Mabon, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.