Aldehyde dehydrogenases in cellular responses to oxidative/ electrophilicstress

Free Radical Biology and Medicine

Volumn 56, Issue , 2013, Pages 89-101

  Singh, Surendra ^a   Brocker, Chad ^a   Koppaka, Vindhya ^a   Chen, Ying ^a   Jackson, Brian C ^a   Matsumoto, Akiko ^b   Thompson, David C ^a   Vasiliou, Vasilis ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Aldehyde dehydrogenase; Cancer stem cells; Chemical stress; Dehydration; Electrophilic stress; Oxidative stress

Indexed keywords

ALCOHOL; ALDEHYDE; ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC METAL COMPLEX; MEMBRANE LIPID; OXAZAPHOSPHORINE; TAXANE DERIVATIVE;

CAENORHABDITIS ELEGANS; CANCER RESISTANCE; CANCER STEM CELL; CHEMICAL STRESS; ELECTROPHILIC STRESS; ENVIRONMENTAL STRESS; ENZYME ACTIVITY; EUKARYOTE; LIPID PEROXIDATION; MEMBRANE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROKARYOTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SACCHAROMYCES CEREVISIAE; SALT STRESS; TOXICITY; ULTRAVIOLET RADIATION; UPREGULATION;

ALDEHYDE DEHYDROGENASE; ANIMALS; BACTERIA; CAENORHABDITIS ELEGANS; HUMANS; NEOPLASTIC STEM CELLS; OXIDATIVE STRESS; PLANTS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE;

CAENORHABDITIS ELEGANS; EUKARYOTA; MAMMALIA; PROKARYOTA;

EID: 84872117242     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.11.010     Document Type: Review

References (218)

1. V. Vasiliou, A. Pappa, and T. Estey Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism Drug Metab. Rev. 36 2004 279 299
2. Y. Chen, G. Mehta, and V. Vasiliou Antioxidant defenses in the ocular surface Ocul. Surf. 7 2009 176 185
3. C.-x. Wu, S.-c. Su, and Y Peng -l. Molecular cloning and differential expression of an aldehyde dehydrogenase gene in rice leaves in response to infection by blast fungus Biologia 62 2007 523 528
4. E. Cabiscol, J. Tamarit, and J. Ros Oxidative stress in bacteria and protein damage by reactive oxygen species Int. Microbiol. 3 2000 3 8
5. P. Mydel, Y. Takahashi, H. Yumoto, M. Sztukowska, M. Kubica, F.C. Gibson 3rd, D.M. Kurtz Jr.; J. Travis, L.V. Collins, K.A. Nguyen, C.A. Genco, and J. Potempa Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection PLoS Pathog. 2 2006 e76
6. J.P. Navarro-Avino, R. Prasad, V.J. Miralles, R.M. Benito, and R. Serrano A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes Yeast 15 1999 829 842
7. S.P. Singh, M. Niemczyk, L. Zimniak, and P. Zimniak Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE) Aging (Albany NY) 1 2009 68 80
8. B. Jackson, C. Brocker, D.C. Thompson, W. Black, K. Vasiliou, D.W. Nebert, and V. Vasiliou Update on the aldehyde dehydrogenase gene (ALDH) superfamily Hum. Genomics 5 2011 283 303
9. A.T. Jacobs, and L.J. Marnett Systems analysis of protein modification and cellular responses induced by electrophile stress Acc. Chem. Res. 43 2010 673 683
10. D.V. Nadkarni, and L.M. Sayre Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal Chem. Res. Toxicol. 8 1995 284 291
11. P.J. Brooks, and J.A. Theruvathu DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis Alcohol 35 2005 187 193
12. H. Yin, L. Xu, and N.A. Porter Free radical lipid peroxidation: mechanisms and analysis Chem. Rev. 111 2011 5944 5972
13. G.P. Voulgaridou, I. Anestopoulos, R. Franco, M.I. Panayiotidis, and A. Pappa DNA damage induced by endogenous aldehydes: current state of knowledge Mutat. Res. 711 2011 13 27
14. S.A. Marchitti, C. Brocker, D. Stagos, and V. Vasiliou Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily Expert Opin. Drug Metab. Toxicol 4 2008 697 720
15. N.E. Sladek Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact J. Biochem. Mol. Toxicol. 17 2003 7 23
16. W.J. Black, D. Stagos, S.A. Marchitti, D.W. Nebert, K.F. Tipton, A. Bairoch, and V. Vasiliou Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature Pharmacogenet. Genomics 19 2009 893 902
17. B.J. Song, M.A. Abdelmegeed, S.H. Yoo, B.J. Kim, S.A. Jo, I. Jo, and K.H. Moon Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications J. Proteomics 74 2011 2691 2702
18. V. Vasiliou, and A. Pappa Polymorphisms of human aldehyde dehydrogenases: consequences for drug metabolism and disease Pharmacology 61 2000 192 198
19. W.B. Rizzo, and G. Carney Sjogren-Larsson syndrome: diversity of mutations and polymorphisms in the fatty aldehyde dehydrogenase gene (ALDH3A2) Hum. Mutat. 26 2005 1 10
20. Onenli-Mungan, N.; Yuksel, B.; Elkay, M.; Topaloglu, A. K.; Baykal, T.; Ozer, G. Type II hyperprolinemia: a case report. Turk. J. Pediatr. 46:167-169; 2004.
21. S. Akaboshi, B.M. Hogema, A. Novelletto, P. Malaspina, G.S. Salomons, G.D. Maropoulos, C. Jakobs, M. Grompe, and K.M. Gibson Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency Hum. Mutat. 22 2003 442 450
22. P.B. Mills, E. Struys, C. Jakobs, B. Plecko, P. Baxter, M. Baumgartner, M.A. Willemsen, H. Omran, U. Tacke, B. Uhlenberg, B. Weschke, and P.T. Clayton Mutations in antiquitin in individuals with pyridoxine-dependent seizures Nat. Med 12 2006 307 309
23. M.R. Baumgartner, C.A. Hu, S. Almashanu, G. Steel, C. Obie, B. Aral, D. Rabier, P. Kamoun, J.M. Saudubray, and D. Valle Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase Hum. Mol. Genet. 9 2000 2853 2858
24. N. Enomoto, S. Takase, N. Takada, and A. Takada Alcoholic liver disease in heterozygotes of mutant and normal aldehyde dehydrogenase-2 genes Hepatology 13 1991 1071 1075
25. A. Yokoyama, T. Muramatsu, T. Omori, T. Yokoyama, S. Matsushita, S. Higuchi, K. Maruyama, and H. Ishii Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics Carcinogenesis 22 2001 433 439
26. K. Kamino, K. Nagasaka, M. Imagawa, H. Yamamoto, H. Yoneda, A. Ueki, S. Kitamura, K. Namekata, T. Miki, and S. Ohta Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population Biochem. Biophys. Res. Commun. 273 2000 192 196
27. A. Pappa, C. Chen, Y. Koutalos, A.J. Townsend, and V. Vasiliou Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage Free Radic. Biol. Med. 34 2003 1178 1189
28. N. Lassen, A. Pappa, W.J. Black, J.V. Jester, B.J. Day, E. Min, and V. Vasiliou Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts Free Radic. Biol. Med. 41 2006 1459 1469
29. T. Estey, M. Cantore, P.A. Weston, J.F. Carpenter, J.M. Petrash, and V. Vasiliou Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1 J. Biol. Chem. 282 2007 4382 4392
30. N. Lassen, J.B. Bateman, T. Estey, J.R. Kuszak, D.W. Nees, J. Piatigorsky, G. Duester, B.J. Day, J. Huang, L.M. Hines, and V. Vasiliou Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice J. Biol. Chem. 282 2007 25668 25676
31. L. Uma, J. Hariharan, Y. Sharma, and D. Balasubramanian Corneal aldehyde dehydrogenase displays antioxidant properties Exp. Eye Res. 63 1996 117 120
32. S.A. Marchitti, R.A. Deitrich, and V. Vasiliou Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase Pharmacol. Rev. 59 2007 125 150
33. D.J. Conklin, A. Bhatnagar, H.R. Cowley, G.H. Johnson, R.J. Wiechmann, L.M. Sayre, M.B. Trent, and P.J. Boor Acrolein generation stimulates hypercontraction in isolated human blood vessels Toxicol. Appl. Pharmacol. 217 2006 277 288
34. R. Ishitani, A. Miyakawa, and T. Iwamoto Elemental analyses of autoradiographic grains by X-ray microanalysis Experientia 33 1977 440 441
35. P. Zimniak Relationship of electrophilic stress to aging Free Radic. Biol. Med. 51 2011 1087 1105
36. G. Duester Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid Eur. J. Biochem 267 2000 4315 4324
37. S.A. Krupenko FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism Chem. Biol. Interact. 178 2009 84 93
38. H. Esterbauer, R.J. Schaur, and H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic. Biol. Med. 11 1991 81 128
39. D.R. Petersen, and J.A. Doorn Reactions of 4-hydroxynonenal with proteins and cellular targets Free Radic. Biol. Med. 37 2004 937 945
40. K.L. Chambliss, and K.M. Gibson Succinic semialdehyde dehydrogenase from mammalian brain: subunit analysis using polyclonal antiserum Int. J. Biochem. 24 1992 1493 1499
41. W. Ambroziak, and R. Pietruszko Human aldehyde dehydrogenase: metabolism of putrescine and histamine Alcohol. Clin. Exp. Res. 11 1987 528 532
42. N.E. Sladek, R. Kollander, L. Sreerama, and D.T. Kiang Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens Cancer Chemother. Pharmacol 49 2002 309 321
43. N.E. Sladek Aldehyde dehydrogenase-mediated cellular relative insensitivity to the oxazaphosphorines Curr. Pharm. Des 5 1999 607 625
44. 2 against formaldehyde and other aldehyde compounds Mutat. Res 255 1991 265 271
45. S. Jozefczuk, S. Klie, G. Catchpole, J. Szymanski, A. Cuadros-Inostroza, D. Steinhauser, J. Selbig, and L. Willmitzer Metabolomic and transcriptomic stress response of Escherichia coli Mol. Syst. Biol. 6 2010 364
46. K. Parvatiyar, E.M. Alsabbagh, U.A. Ochsner, M.A. Stegemeyer, A.G. Smulian, S.H. Hwang, C.R. Jackson, T.R. McDermott, and D.J. Hassett Global analysis of cellular factors and responses involved in Pseudomonas aeruginosa resistance to arsenite J. Bacteriol. 187 2005 4853 4864
47. L.F. Ferraz, L.C. Verde, R. Vicentini, A.P. Felicio, M.L. Ribeiro, F. Alexandrino, M.T. Novo, O. Garcia Jr, D.J. Rigden, and L.M. Ottoboni Ferric iron uptake genes are differentially expressed in the presence of copper sulfides in Acidithiobacillus ferrooxidans strain LR Antonie Van Leeuwenhoek 99 2011 609 617
48. V. Yildirim, S. Ozcan, D. Becher, K. Buttner, M. Hecker, and G. Ozcengiz Characterization of proteome alterations in Phanerochaete chrysosporium in response to lead exposure Proteome Sci. 9 2011 12
49. R. Singh, R.J. Mailloux, S. Puiseux-Dao, and V.D. Appanna Oxidative stress evokes a metabolic adaptation that favors increased NADPH synthesis and decreased NADH production in Pseudomonas fluorescens J. Bacteriol. 189 2007 6665 6675
50. V.J. Zaldivar-Machorro, M. Lopez-Ortiz, P. Demare, I. Regla, and R.A. Munoz-Clares The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial growth Biochimie 93 2011 286 295
51. J.O. Sass, M. Walter, J.P. Shield, A.M. Atherton, U. Garg, D. Scott, C.G. Woods, and L.D. Smith 3-Hydroxyisobutyrate aciduria and mutations in the ALDH6A1 gene coding for methylmalonate semialdehyde dehydrogenase J. Inherit. Metab. Dis. 35 2012 437 442
52. H.H. Kirch, D. Bartels, Y. Wei, P.S. Schnable, and A.J. Wood The ALDH gene superfamily of Arabidopsis Trends Plant Sci. 9 2004 371 377
53. Y. Zhang, L. Mao, H. Wang, C. Brocker, X. Yin, V. Vasiliou, Z. Fei, and X. Wang Genome-wide identification and analysis of grape aldehyde dehydrogenase (ALDH) gene superfamily PLoS One 7 2012 e32153 2012
54. H.H. Kirch, S. Schlingensiepen, S. Kotchoni, R. Sunkar, and D. Bartels Detailed expression analysis of selected genes of the aldehyde dehydrogenase (ALDH) gene superfamily in Arabidopsis thaliana Plant Mol. Biol. 57 2005 315 332
55. Y. Li, M. Nakazono, N. Tsutsumi, and A. Hirai Molecular and cellular characterizations of a cDNA clone encoding a novel isozyme of aldehyde dehydrogenase from rice Gene 249 2000 67 74
56. T.D. Missihoun, J. Schmitz, R. Klug, H.H. Kirch, and D. Bartels Betaine aldehyde dehydrogenase genes from Arabidopsis with different sub-cellular localization affect stress responses Planta 233 2011 369 382
57. R.B. Nair, K.L. Bastress, M.O. Ruegger, J.W. Denault, and C. Chapple The Arabidopsis thaliana reduced epidermal fluorescence1 gene encodes an aldehyde dehydrogenase involved in ferulic acid and sinapic acid biosynthesis Plant Cell 16 2004 544 554
58. J.H. Grabber, J. Ralph, and R.D. Hatfield Cross-linking of maize walls by ferulate dimerization and incorporation into lignin J. Agric. Food Chem. 48 2000 6106 6113
59. + antiporter gene SeNHX1 Biotechnol. Lett 30 2008 369 376
60. S.O. Kotchoni, J.C. Jimenez-Lopez, A.P. Kayode, E.W. Gachomo, and L. Baba-Moussa The soybean aldehyde dehydrogenase (ALDH) protein superfamily Gene 495 2012 128 133
61. S.M. Rodrigues, M.O. Andrade, A.P. Gomes, F.M. Damatta, M.C. Baracat-Pereira, and E.P. Fontes Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought, salinity, and oxidative stress J. Exp. Bot. 57 2006 1909 1918
62. M. Vojtechova, A.D. Hanson, and R.A. Munoz-Clares Betaine-aldehyde dehydrogenase from amaranth leaves efficiently catalyzes the NAD-dependent oxidation of dimethylsulfoniopropionaldehyde to dimethylsulfoniopropionate Arch. Biochem. Biophys. 337 1997 81 88
63. N. Smirnoff Hydroxyl radical scavenging activity of compatible solutes Phytochemistry 28 1989
64. R. Sunkar, D. Bartels, and H.H. Kirch Overexpression of a stress-inducible aldehyde dehydrogenase gene from Arabidopsis thaliana in transgenic plants improves stress tolerance Plant J. 35 2003 452 464
65. H. Yang, D. Zhang, J. Wang, A.J. Wood, and Y. Zhang Molecular cloning of a stress-responsive aldehyde dehydrogenase gene ScALDH21 from the desiccation-tolerant moss Syntrichia caninervis and its responses to different stresses Mol. Biol. Rep 39 2012 2645 2652
66. C. Inostroza-Blancheteau, M. Reyes-Diaz, F. Aquea, A. Nunes-Nesi, M. Alberdi, and P. Arce-Johnson Biochemical and molecular changes in response to aluminium-stress in highbush blueberry (Vaccinium corymbosum L.) Plant Physiol. Biochem. 49 2011 1005 1012
67. V.M. Achary, S. Jena, K.K. Panda, and B.B. Panda Aluminium induced oxidative stress and DNA damage in root cells of Allium cepa L Ecotoxicol. Environ. Saf 70 2008 300 310
68. R.G. op den Camp, and C. Kuhlemeier Aldehyde dehydrogenase in tobacco pollen Plant Mol. Biol. 35 1997 355 365
69. J.C. Jimenez-Lopez, E.W. Gachomo, M.J. Seufferheld, and S.O. Kotchoni The maize ALDH protein superfamily: linking structural features to functional specificities BMC Struct. Biol 10 2010 43
70. M. Nakazono, H. Tsuji, Y. Li, D. Saisho, S. Arimura, N. Tsutsumi, and A. Hirai Expression of a gene encoding mitochondrial aldehyde dehydrogenase in rice increases under submerged conditions Plant Physiol. 124 2000 587 598
71. F. Liu, X. Cui, H.T. Horner, H. Weiner, and P.S. Schnable Mitochondrial aldehyde dehydrogenase activity is required for male fertility in maize Plant Cell 13 2001 1063 1078
72. K.B. Busch, and H. Fromm Plant succinic semialdehyde dehydrogenase: cloning, purification, localization in mitochondria, and regulation by adenine nucleotides Plant Physiol. 121 1999 589 597
73. N. Bouche, A. Fait, D. Bouchez, S.G. Moller, and H. Fromm Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants Proc. Natl. Acad. Sci. USA 100 2003 6843 6848
74. J.H. Shin, S.R. Kim, and G. An Rice aldehyde dehydrogenase7 is needed for seed maturation and viability Plant Physiol. 149 2009 905 915
75. F.M. Hulett, C. Bookstein, and K. Jensen Evidence for two structural genes for alkaline phosphatase in Bacillus subtilis J. Bacteriol. 172 1990 735 740
76. B. Rathinasabapathi, M. Burnet, B.L. Russell, D.A. Gage, P.C. Liao, G.J. Nye, P. Scott, J.H. Golbeck, and A.D. Hanson Choline monooxygenase, an unusual iron-sulfur enzyme catalyzing the first step of glycine betaine synthesis in plants: prosthetic group characterization and cDNA cloning Proc. Natl. Acad. Sci. USA 94 1997 3454 3458
77. R.A. Munoz-Clares, A.G. Diaz-Sanchez, L. Gonzalez-Segura, and C. Montiel Kinetic and structural features of betaine aldehyde dehydrogenases: mechanistic and regulatory implications Arch. Biochem. Biophys. 493 2010 71 81
78. T. Nakamura, S. Yokota, Y. Muramoto, K. Tsutsui, Y. Oguri, K. Fukui, and T. Takabe Expression of a betaine aldehyde dehydrogenase gene in rice, a glycinebetaine nonaccumulator, and possible localization of its protein in peroxisomes Plant J. 11 1997 1115 1120
79. D.M. Morgan Oxidized polyamines and the growth of human vascular endothelial cells: prevention of cytotoxic effects by selective acetylation Biochem. J. 242 1987 347 352
80. Z. Yu, W. Li, and U.T. Brunk 3-Aminopropanal is a lysosomotropic aldehyde that causes oxidative stress and apoptosis by rupturing lysosomes APMIS 111 2003 643 652
81. Z. Yu, W. Li, J. Hillman, and U.T. Brunk Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal Brain Res. 1016 2004 163 169
82. Z. Gao, and W.H. Loescher NADPH supply and mannitol biosynthesis: characterization, cloning, and regulation of the non-reversible glyceraldehyde-3-phosphate dehydrogenase in celery leaves Plant Physiol 124 2000 321 330
83. K. Gallardo, C. Job, S.P. Groot, M. Puype, H. Demol, J. Vandekerckhove, and D. Job Proteomic analysis of Arabidopsis seed germination and priming Plant Physiol. 126 2001 835 848
84. D. Bartels, and F. Salamini Desiccation tolerance in the resurrection plant Craterostigma plantagineum: a contribution to the study of drought tolerance at the molecular level Plant Physiol 127 2001 1346 1353
85. G. Miller, A. Honig, H. Stein, N. Suzuki, R. Mittler, and A. Zilberstein Unraveling delta1-pyrroline-5-carboxylate-proline cycle in plants by uncoupled expression of proline oxidation enzymes J. Biol. Chem. 284 2009 26482 26492
86. K.A. Yoon, Y. Nakamura, and H. Arakawa Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses J. Hum. Genet. 49 2004 134 140
87. W.T. Lv, B. Lin, M. Zhang, and X.J. Hua Proline accumulation is inhibitory to Arabidopsis seedlings during heat stress Plant Physiol. 156 2011 1921 1933
88. X. Chen, Q. Zeng i. n.; and A.J. Wood The stress-responsive Tortula ruralis gene ALDH21A1 describes a novel eukaryotic aldehyde dehydrogenase protein family J. Plant Physiol. 159 2002 677 684
89. W. Huang, X. Ma, Q. Wang, Y. Gao, Y. Xue, X. Niu, G. Yu, and Y. Liu Significant improvement of stress tolerance in tobacco plants by overexpressing a stress-responsive aldehyde dehydrogenase gene from maize (Zea mays) Plant Mol. Biol. 68 2008 451 463
90. A. Aranda, and M.M. del Olmo Response to acetaldehyde stress in the yeast Saccharomyces cerevisiae involves a strain-dependent regulation of several ALD genes and is mediated by the general stress response pathway Yeast 20 2003 747 759
91. S. Izawa, and Y. Inoue Post-transcriptional regulation of gene expression in yeast under ethanol stress Biotechnol. Appl. Biochem. 53 2009 93 99
92. N.P. Mira, M. Palma, J.F. Guerreiro, and I. Sa-Correia Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid Microb. Cell Fact. 9 2010 79
93. A.M. Torres, M.L. Maceiras, E.R. Belmonte, L.N. Naveira, M.B. Calvo, and M.E. Cerdan KlRox1p contributes to yeast resistance to metals and is necessary for KlYCF1 expression in the presence of cadmium Gene 497 2012 27 37
94. F.M. Klis, A. Boorsma, and P.W. De Groot Cell wall construction in Saccharomyces cerevisiae Yeast 23 2006 185 202
95. C.K. Hu, F.W. Bai, and L.J. An Protein amino acid composition of plasma membranes affects membrane fluidity and thereby ethanol tolerance in a self-flocculating fusant of Schizosaccharomyces pombe and Saccharomyces cerevisiae Sheng Wu Gong Cheng Xue Bao 21 2005 809 813
96. A. Aranda, A. Querol, and M. del Olmo Correlation between acetaldehyde and ethanol resistance and expression of HSP genes in yeast strains isolated during the biological aging of sherry wines Arch. Microbiol 177 2002 304 312
97. J. Ding, X. Huang, L. Zhang, N. Zhao, D. Yang, and K. Zhang Tolerance and stress response to ethanol in the yeast Saccharomyces cerevisiae Appl. Microbiol. Biotechnol. 85 2009 253 263
98. T. Modig, K. Granath, L. Adler, and G. Liden Anaerobic glycerol production by Saccharomyces cerevisiae strains under hyperosmotic stress Appl. Microbiol. Biotechnol. 75 2007 289 296
99. W.H. Mager, and M. Siderius Novel insights into the osmotic stress response of yeast FEMS Yeast Res. 2 2002 251 257
100. D. Shenton, and C.M. Grant Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae Biochem. J. 374 2003 513 519
101. Saccharomyces Genome Database. URL: 〈http://www.yeastgenome.org/ 〉.
102. J.H. Parmar, S. Bhartiya, and K.V. Venkatesh Characterization of the adaptive response and growth upon hyperosmotic shock in Saccharomyces cerevisiae Mol. Biosyst. 7 2011 1138 1148
103. B. Cambon, V. Monteil, F. Remize, C. Camarasa, and S. Dequin Effects of GPD1 overexpression in Saccharomyces cerevisiae commercial wine yeast strains lacking ALD6 genes Appl. Environ. Microbiol. 72 2006 4688 4694
104. D. Grabowska, and A. Chelstowska The ALD6 gene product is indispensable for providing NADPH in yeast cells lacking glucose-6-phosphate dehydrogenase activity J. Biol. Chem 278 2003 13984 13988
105. J.W. Golden, and D.L. Riddle The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature Dev. Biol. 102 1984 368 378
106. B. Lant, and K.B. Storey An overview of stress response and hypometabolic strategies in Caenorhabditis elegans: conserved and contrasting signals with the mammalian system Int. J. Biol. Sci 6 2010 9 50
107. A. Madi, S. Mikkat, C. Koy, B. Ringel, H.J. Thiesen, and M.O. Glocker Mass spectrometric proteome analysis suggests anaerobic shift in metabolism of Dauer larvae of Caenorhabditis elegans Biochim. Biophys. Acta 1784 2008 1763 1770
108. Y. Tabuse, T. Nabetani, and A. Tsugita Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis Proteomics 5 2005 2876 2891
109. J.Y. Kwon, M. Hong, M.S. Choi, S. Kang, K. Duke, S. Kim, S. Lee, and J. Lee Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans Genomics 83 2004 600 614
110. A. Dey, and A.I. Cederbaum Alcohol and oxidative liver injury Hepatology (Baltimore, MD) 43 2006 S63 74
111. L. Jing, C.M. Jin, S.S. Li, F.M. Zhang, L. Yuan, W.M. Li, Y. Sang, S. Li, and L.J. Zhou Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy Mol. Cell. Biochem. 359 2012 283 292
112. J.S. Pan, S.Z. He, H.Z. Xu, X.J. Zhan, X.N. Yang, H.M. Xiao, H.X. Shi, and J.L. Ren Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury World J. Gastroenterol. 14 2008 5857 5867
113. C.C. Cunningham, W.B. Coleman, and P.I. Spach The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism Alcohol Alcohol. 25 1990 127 136
114. H. Huang, and K.G. Manton The role of oxidative damage in mitochondria during aging: a review Front. Biosci. 9 2004 1100 1117
115. C. Garcia-Ruiz, and J.C. Fernandez-Checa Mitochondrial glutathione: hepatocellular survival-death switch J. Gastroenterol. Hepatol. 21 Suppl. 3 2006 S3 6
116. P. Zhao, T.F. Kalhorn, and J.T. Slattery Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver Hepatology (Baltimore, MD) 36 2002 326 335
117. M.D. Wheeler, M. Nakagami, B.U. Bradford, T. Uesugi, R.P. Mason, H.D. Connor, A. Dikalova, M. Kadiiska, and R.G. Thurman Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat J. Biol. Chem. 276 2001 36664 36672
118. A. Colell, C. Garcia-Ruiz, A. Morales, A. Ballesta, M. Ookhtens, J. Rodes, N. Kaplowitz, and J.C. Fernandez-Checa Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine Hepatology (Baltimore, MD) 26 1997 699 708
119. Y. Lu, and A.I. Cederbaum CYP2E1 and oxidative liver injury by alcohol Free Radic. Biol. Med. 44 2008 723 738
120. R.W. Chapman, M.Y. Morgan, R. Bell, and S. Sherlock Hepatic iron uptake in alcoholic liver disease Gastroenterology 84 1983 143 147
121. J.B. Whitfield, G. Zhu, A.C. Heath, L.W. Powell, and N.G. Martin Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers Alcohol. Clin. Exp. Res. 25 2001 1037 1045
122. D.Y. Mitchell, and D.R. Petersen The oxidation of alpha-beta unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases. Toxicol Appl. Pharmacol 87 1987 403 410
123. D.P. Hartley, J.A. Ruth, and D.R. Petersen The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase Arch. Biochem. Biophys. 316 1995 197 205
124. S. Ohta, and I. Ohsawa Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification J. Alzheimers Dis 9 2006 155 166
125. R. Manzer, L. Qamar, T. Estey, A. Pappa, D.R. Petersen, and V. Vasiliou Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA DNA Cell Biol 22 2003 329 338
126. Mahreen, R.; Mohsin, M.; Nasreen, Z.; Siraj, M.; Ishaq, M. Significantly increased levels of serum malonaldehyde in type 2diabetics with myocardial infarction. Int. J. Diabetes Dev. Countries 30:49-51.
127. G.M. Siu, and H.H. Draper Metabolism of malonaldehyde in vivo and in vitro Lipids 17 1982 349 355
128. Y.M. Tseng, Y.R. Jin, I.J. Chen, F.D. Huang, S.H. Wu, H. Ma, S.Y. Chen, L.Y. Tsai, S.M. Tsai, and J.H. Lee Roles of the genetic variation of alcohol-metabolizing enzymes on biomarkers in trauma patients with excessive alcohol intake at emergency department Clin. Chim. Acta 389 2008 14 18
129. D. Stagos, Y. Chen, C. Brocker, E. Donald, B.C. Jackson, D.J. Orlicky, D.C. Thompson, and V. Vasiliou Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme Drug Metab. Dispos. 38 2010 1679 1687
130. J.P. Bergmanson, and P.G. Soderberg The significance of ultraviolet radiation for eye diseases: a review with comments on the efficacy of UV-blocking contact lenses Ophthalmic Physiol. Opt 15 1995 83 91
131. H. Esterbauer Cytotoxicity and genotoxicity of lipid-oxidation products Am. J. Clin. Nutr. 57 779S-785S 1993 785S 786S discussion
132. C.X. Cai, D.E. Birk, and T.F. Linsenmayer Nuclear ferritin protects DNA from UV damage in corneal epithelial cells Mol. Biol. Cell 9 1998 1037 1051
133. Z.G. Liu, R. Baskaran, E.T. Lea-Chou, L.D. Wood, Y. Chen, M. Karin, and J.Y. Wang Three distinct signalling responses by murine fibroblasts to genotoxic stress Nature 384 1996 273 276
134. S.C. Sacca, C. Bolognesi, A. Battistella, A. Bagnis, and A. Izzotti Gene-environment interactions in ocular diseases Mutat. Res. 667 2009 98 117
135. D. Stagos, Y. Chen, M. Cantore, J.V. Jester, and V. Vasiliou Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization Brain Res. Bull. 81 2010 211 218
136. C. Verhagen, R. Hoekzema, G.M. Verjans, and A. Kijlstra Identification of bovine corneal protein 54 (BCP 54) as an aldehyde dehydrogenase Exp. Eye Res. 53 1991 283 284
137. J.V. Jester, A. Budge, S. Fisher, and J. Huang Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering Invest. Ophthalmol. Visual Sci. 46 2005 2369 2378
138. A. Pappa, N.A. Sophos, and V. Vasiliou Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals Chem. Biol. Interact. 130-132 2001 181 191
139. C. Graham, J. Hodin, and G. Wistow A retinaldehyde dehydrogenase as a structural protein in a mammalian eye lens: gene recruitment of eta-crystallin J. Biol. Chem. 271 1996 15623 15628
140. R.T. Dean, S. Fu, R. Stocker, and M.J. Davies Biochemistry and pathology of radical-mediated protein oxidation Biochem. J. 324 1997 1 18
141. H. Bloemendal, W. de Jong, R. Jaenicke, N.H. Lubsen, C. Slingsby, and A. Tardieu Ageing and vision: structure, stability and function of lens crystallins Prog. Biophys. Mol. Biol. 86 2004 407 485
142. T. Estey, Y. Chen, J.F. Carpenter, and V. Vasiliou Structural and functional modifications of corneal crystallin ALDH3A1 by UVB light PLoS One 5 2010 e15218
143. A. Pappa, T. Estey, R. Manzer, D. Brown, and V. Vasiliou Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea Biochem. J. 376 2003 615 623
144. K.C. Bhuyan, D.K. Bhuyan, O. Santos, and S.M. Podos Antioxidant and anticataractogenic effects of topical captopril in diquat-induced cataract in rabbits Free Radic. Biol. Med. 12 1992 251 261
145. R. Buddi, B. Lin, S.R. Atilano, N.C. Zorapapel, M.C. Kenney, and D.J. Brown Evidence of oxidative stress in human corneal diseases J. Histochem. Cytochem. 50 2002 341 351
146. C. Verdejo, P. Marco, J. Renau-Piqueras, and M.D. Pinazo-Duran Lipid peroxidation in proliferative vitreoretinopathies Eye (London) 13 1999 183 188
147. W. Black, Y. Chen, A. Matsumoto, D.C. Thompson, N. Lassen, A. Pappa, and V. Vasiliou Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal Free Radic. Biol. Med. 52 2012 1937 1944
148. D.A. Dickinson, and H.J. Forman Glutathione in defense and signaling: lessons from a small thiol Ann. N. Y. Acad. Sci 973 2002 488 504
149. S.J. Atherton, C. Lambert, J. Schultz, N. Williams, and S. Zigman Fluorescence studies of lens epithelial cells and their constituents Photochem. Photobiol. 70 1999 823 828
150. C. Ginestier, M.H. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, M. Brown, J. Jacquemier, P. Viens, C.G. Kleer, S. Liu, A. Schott, D. Hayes, D. Birnbaum, M.S. Wicha, and G. Dontu ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome Cell Stem Cell 1 2007 555 567
151. G. Muzio, M. Maggiora, E. Paiuzzi, M. Oraldi, and R.A. Canuto Aldehyde dehydrogenases and cell proliferation Free Radic. Biol. Med. 52 2012 735 746
152. Y. Chen, D.J. Orlicky, A. Matsumoto, S. Singh, D.C. Thompson, and V. Vasiliou Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer Biochem. Biophys. Res. Commun. 405 2011 173 179
153. J.S. Moreb Aldehyde dehydrogenase as a marker for stem cells Curr. Stem Cell Res. Ther 3 2008 237 246
154. A. Emadi, R.J. Jones, and R.A. Brodsky Cyclophosphamide and cancer: golden anniversary Nat. Rev. Clin. Oncol. 6 2009 638 647
155. C.N. Landen Jr, B. Goodman, A.A. Katre, A.D. Steg, A.M. Nick, R.L. Stone, L.D. Miller, P.V. Mejia, N.B. Jennings, D.M. Gershenson, R.C. Bast Jr, R.L. Coleman, G. Lopez-Berestein, and A.K. Sood Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer Mol. Cancer Ther. 9 2010 3186 3199
156. E.H. Huang, M.J. Hynes, T. Zhang, C. Ginestier, G. Dontu, H. Appelman, J.Z. Fields, M.S. Wicha, and B.M. Boman Aldehyde dehydrogenase 1is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis Cancer Res. 69 2009 3382 3389
157. Y. Ueshima, Y. Matsuda, M. Tsutsumi, and A. Takada Role of the aldehyde dehydrogenase-1 isozyme in the metabolism of acetaldehyde Alcohol Alcohol. Suppl. 1B 1993 15 19
158. R.J. Ward, A.J. McPherson, C. Chow, J. Ealing, D.I. Sherman, A. Yoshida, and T.J. Peters Identification and characterisation of alcohol-induced flushing in Caucasian subjects Alcohol Alcohol. 29 1994 433 438
159. A. Yoshida, V. Dave, R.J. Ward, and T.J. Peters Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers Ann. Hum. Genet. 53 1989 1 7
160. D. Galter, S. Buervenich, A. Carmine, M. Anvret, and L. Olson ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia Neurobiol. Dis 14 2003 637 647
161. L.M. De Luca Retinoids and their receptors in differentiation,
162. H. Kim, J. Lapointe, G. Kaygusuz, D.E. Ong, C. Li, M. van de Rijn, J.D. Brooks, and J.R. Pollack The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer Cancer Res. 65 2005 8118 8124
163. K. Niederreither, V. Subbarayan, P. Dolle, and P. Chambon Embryonic retinoic acid synthesis is essential for early mouse post-implantation development Nat. Genet. 21 1999 444 448
164. V. Dupe, N. Matt, J.M. Garnier, P. Chambon, M. Mark, and N.B. Ghyselinck A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3is prevented by maternal retinoic acid treatment Proc. Natl. Acad. Sci. USA 100 2003 14036 14041
165. Y. Ogino, K. Suzuki, R. Haraguchi, Y. Satoh, P. Dolle, and G. Yamada External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium Ann. N. Y. Acad. Sci 948 2001 13 31
166. Y. Xiaojun, Q. Cheng, Z. Yuxing, and H. Zhiqian Microarray analysis of differentially expressed background genes in rats following hemorrhagic shock Mol. Biol. Rep. 39 2012 2045 2053
167. A. Linneberg, A. Gonzalez-Quintela, C. Vidal, T. Jorgensen, M. Fenger, T. Hansen, O. Pedersen, and L.L. Husemoen Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians Clin. Exp. Allergy 40 2010 123 130
168. L.L. Husemoen, M. Fenger, N. Friedrich, J.S. Tolstrup, S. Beenfeldt Fredriksen, and A. Linneberg The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors Alcohol. Clin. Exp. Res. 32 2008 1984 1991
169. S.A. Krupenko, and N.V. Oleinik 10-Formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells Cell Growth Differ 13 2002 227 236
170. N.V. Oleinik, and S.A. Krupenko Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis Mol. Cancer Res 1 2003 577 588
171. F.C. Johlin, E. Swain, C. Smith, and T.R. Tephly Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase Mol. Pharmacol. 35 1989 745 750
172. T.E. Anthony, and N. Heintz The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects J. Comp. Neurol 500 2007 368 383
173. E.A. Mazzio, N. Boukli, N. Rivera, and K.F. Soliman Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells Cancer Sci 103 2012 422 432
174. K.C. Strickland, N.I. Krupenko, M.E. Dubard, C.J. Hu, Y. Tsybovsky, and S.A. Krupenko Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase Chem. Biol. Interact. 191 2011 129 136
175. A.A. Klyosov, L.G. Rashkovetsky, M.K. Tahir, and W.M. Keung Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism Biochemistry 35 1996 4445 4456
176. T.L. Wall, M.L. Johnson, S.M. Horn, L.G. Carr, T.L. Smith, and M.A. Schuckit Evaluation of the self-rating of the effects of alcohol form in Asian Americans with aldehyde dehydrogenase polymorphisms J. Stud. Alcohol 60 1999 784 789
177. G.S. Peng, Y.C. Chen, T.P. Tsao, M.F. Wang, and S.J. Yin Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele Pharmacogenet. Genomics 17 2007 845 855
178. M. Muto, Y. Hitomi, A. Ohtsu, S. Ebihara, S. Yoshida, and H. Esumi Association of aldehyde dehydrogenase 2gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients Gut 47 2000 256 261
179. Y. Li, D. Zhang, W. Jin, C. Shao, P. Yan, C. Xu, H. Sheng, Y. Liu, J. Yu, Y. Xie, Y. Zhao, D. Lu, D.W. Nebert, D.C. Harrison, W. Huang, and L. Jin Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin J. Clin. Invest. 116 2006 506 511
180. S.A. Jo, E.K. Kim, M.H. Park, C. Han, H.Y. Park, Y. Jang, B.J. Song, and I.A Jo Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2is associated with myocardial infarction in elderly Korean men Clin. Chim. Acta 382 2007 43 47
181. P. Hui, T. Nakayama, A. Morita, N. Sato, M. Hishiki, K. Saito, Y. Yoshikawa, M. Tamura, I. Sato, T. Takahashi, M. Soma, Y. Izumi, Y. Ozawa, and Z. Cheng Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2gene as a risk factor independent of alcohol consumption Hypertens. Res. 30 2007 585 592
182. L. Sreerama, and N.E. Sladek Identification and characterization of a novel class 3aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance Biochem. Pharmacol 45 1993 2487 2505
183. C.L. Manthey, G.J. Landkamer, and N.E. Sladek Identification of the mouse aldehyde dehydrogenases important in aldophosphamide detoxification Cancer Res. 50 1990 4991 5002
184. J.S. Wang, Q. Fang, D.J. Sun, J. Chen, X.L. Zhou, G.W. Lin, H.Z. Lu, and J. Fei Genetic modification of hematopoietic progenitor cells for combined resistance to 4-hydroperoxycyclophosphamide, vincristine, and daunorubicin Acta Pharmacol. Sin. 22 2001 949 955
185. Q. Xu, Y.B. Jia, B.Y. Zhang, K. Zou, Y.B. Tao, Y.P. Wang, B.Q. Qiang, G.Y. Wu, Y. Shen, H.K. Ji, Y. Huang, X.Q. Sun, L. Ji, Y.D. Li, Y.B. Yuan, L. Shu, X. Yu, Y.C. Shen, Y.Q. Yu, and G.Z. Ju Association study of an SNP combination pattern in the dopaminergic pathway in paranoid schizophrenia: a novel strategy for complex disorders Mol. Psychiatry 9 2004 510 521
186. X. Sun, Y. Jia, X. Zhang, Q. Xu, Y. Shen, and Y. Li Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method Sci. China C Life Sci. 48 2005 263 269
187. M.R. Haslett, D. Pink, B. Walters, and M.E. Brosnan Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liver Biochim. Biophys. Acta 1675 2004 81 86
188. M.T. Geraghty, D. Vaughn, A.J. Nicholson, W.W. Lin, G. Jimenez-Sanchez, C. Obie, M.P. Flynn, D. Valle, and C.A. Hu Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia Hum. Mol. Genet. 7 1998 1411 1415
189. J.H. Kang, Y.B. Park, T.L. Huh, W.H. Lee, M.S. Choi, and O.S. Kwon High-level expression and characterization of the recombinant enzyme, and tissue distribution of human succinic semialdehyde dehydrogenase Protein Expression Purif 44 2005 16 22
190. G.W. Goodwin, P.M. Rougraff, E.J. Davis, and R.A. Harris Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver: identity to malonate-semialdehyde dehydrogenase J. Biol. Chem. 264 1989 14965 14971
191. C. Brocker, M. Cantore, P. Failli, and V. Vasiliou Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity Chem. Biol. Interact. 191 2011 269 277
192. P. Lheureux, A. Penaloza, and M. Gris Pyridoxine in clinical toxicology: a review Eur. J. Emerg. Med. 12 2005 78 85
193. Y.F. Chang, P. Ghosh, and V.V. Rao L-Pipecolic acid metabolism in human liver: L-alpha-aminoadipate delta-semialdehyde oxidoreductase Biochim. Biophys. Acta 1038 1990 300 305
194. M. Lin, and J.L. Napoli cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12 J. Biol. Chem 275 2000 40106 40112
195. G. Kurys, W. Ambroziak, and R. Pietruszko Human aldehyde dehydrogenase: purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde J. Biol. Chem. 264 1989 4715 4721
196. W. Sato, Y. Horie, E. Kataoka, S. Ohshima, T. Dohmen, M. Iizuka, J. Sasaki, T. Sasaki, K. Hamada, H. Kishimoto, A. Suzuki, and S. Watanabe Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge Hepatol. Res. 34 2006 256 265
197. P. Sulem, D.F. Gudbjartsson, G.B. Walters, H.T. Helgadottir, A. Helgason, S.A. Gudjonsson, C. Zanon, S. Besenbacher, G. Bjornsdottir, O.T. Magnusson, G. Magnusson, E. Hjartarson, J. Saemundsdottir, A. Gylfason, A. Jonasdottir, H. Holm, A. Karason, T. Rafnar, H. Stefansson, O.A. Andreassen, J.H. Pedersen, A.I. Pack, M.C. de Visser, L.A. Kiemeney, A.J. Geirsson, G.I. Eyjolfsson, I. Olafsson, A. Kong, G. Masson, H. Jonsson, U. Thorsteinsdottir, I. Jonsdottir, and K. Stefansson Identification of low-frequency variants associated with gout and serum uric acid levels Nat. Genet. 43 2011 1127 1130
198. M.C. Hanna, and C. Blackstone Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1 Neurogenetics 10 2009 217 228
199. P. Kamoun, B. Aral, and J.M. Saudubray [A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency] Bull. Acad. Natl. Med. 182 131-137 1998 138 139 discussion
200. M.R. Baumgartner, D. Rabier, M.C. Nassogne, J.L. Dufier, J.P. Padovani, P. Kamoun, D. Valle, and J.M. Saudubray Delta1-pyrroline-5-carboxylate synthase deficiency: neurodegeneration, cataracts and connective tissue manifestations combined with hyperammonaemia and reduced ornithine, citrulline, arginine and proline Eur. J. Pediatr. 164 2005 31 36
201. G.K. Rekha, L. Sreerama, and N.E. Sladek Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class-3 aldehyde dehydrogenase Biochem. Pharmacol 48 1994 1943 1952
202. F.R. Kohn, and N.E. Sladek Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines Biochem. Pharmacol 34 1985 3465 3471
203. N.E. Sladek, J.E. Low, and G.J. Landkamer Collateral sensitivity to cross-linking agents exhibited by cultured L1210 cells resistant to oxazaphosphorines Cancer Res. 45 1985 625 629
204. J.E. Russo, and J. Hilton Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells Cancer Res. 48 1988 2963 2968
205. H.S. Friedman, O.M. Colvin, S.H. Kaufmann, S.M. Ludeman, N. Bullock, D.D. Bigner, and O.W. Griffith Cyclophosphamide resistance in medulloblastoma Cancer Res. 52 1992 5373 5378
206. M.D. Bacolod, S.M. Lin, S.P. Johnson, N.S. Bullock, M. Colvin, D.D. Bigner, and H.S. Friedman The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide Curr. Cancer Drug Targets 8 2008 172 179
207. T.M. Koelling, A.M. Yeager, J. Hilton, D.T. Haynie, and J.M. Wiley Development and characterization of a cyclophosphamide-resistant subline of acute myeloid leukemia in the Lewis × Brown Norway hybrid rat Blood 76 1990 1209 1213
208. M. Magni, S. Shammah, R. Schiro, W. Mellado, R. Dalla-Favera, and A.M. Gianni Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer Blood 87 1996 1097 1103
209. J.S. Moreb, M. Schweder, B. Gray, J. Zucali, and R. Zori In vitro selection for K562 cells with higher retrovirally mediated copy number of aldehyde dehydrogenase class-1 and higher resistance to 4- hydroperoxycyclophosphamide Hum. Gene Ther 9 1998 611 619
210. X.W. Yang, W. Wang, J.X. Fu, J.N. Cen, F. Guo, X.M. Xia, and Z.X. Chen Aldehyde-dehydrogenase gene-transduced hematopoietic cell line K562 overcomes the cytotoxicity of cyclophosphamide in vitro Zhongguo Shi Yan Xue Ye Xue Za Zhi 10 2002 205 208
211. J. Moreb, M. Schweder, A. Suresh, and J.R. Zucali Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide Cancer Gene Ther 3 1996 24 30
212. K.D. Bunting, R. Lindahl, and A.J. Townsend Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3aldehyde dehydrogenase J. Biol. Chem 269 1994 23197 23203
213. J.S. Moreb, C. Maccow, M. Schweder, and J. Hecomovich Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro J. Pharmacol. Exp. Ther. 293 2000 390 396
214. K.D. Bunting, and A.J. Townsend De novo expression of transfected human class 1aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines: elevated class 1ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality J. Biol. Chem 271 1996 11884 11890
215. K.D. Bunting, and A.J. Townsend Protection by transfected rat or human class 3aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines: demonstration of aldophosphamide metabolism by the human cytosolic class 3isozyme J. Biol. Chem 271 1996 11891 11896
216. A.J. Townsend, S. Leone-Kabler, R.L. Haynes, Y. Wu, L. Szweda, and K.D. Bunting Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells Chem. Biol. Interact. 130-132 2001 261 273
217. + cells to improve combination chemotherapy tolerance Chin. Med. J. (English) 114 2001 25 29
218. N. Takebe, S.C. Zhao, D. Adhikari, S. Mineishi, M. Sadelain, J. Hilton, M. Colvin, D. Banerjee, and J.R. Bertino Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1gene and a mutated dihydrofolate reductase gene Mol. Ther. 3 2001 88 96