The role of oxidative damage in mitochondria during aging: A review

Frontiers in Bioscience

Volumn 9, Issue , 2004, Pages 1100-1117

  Huang, Hai ^a   Manton, Kenneth G ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Aging; Free radicals; Mitochondrial DNA; mtDNA; Oxidative damage; Reactive oxygen species; Review; ROS

Indexed keywords

DNA; HYDROGEN PEROXIDE; HYDROXYL RADICAL; HYPOCHLOROUS ACID; PEROXY RADICAL; PEROXYNITRITE; PROTEIN; REACTIVE OXYGEN METABOLITE; RNA; SINGLET OXYGEN; SUPEROXIDE;

AGING; ALZHEIMER DISEASE; APOPTOSIS; CELL DAMAGE; CELL ORGANELLE; DEGENERATIVE DISEASE; DNA DAMAGE; ELECTRON TRANSPORT; ENERGY YIELD; GERIATRIC DISORDER; HUMAN; MITOCHONDRION; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; REVIEW; TELOMERE; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY;

AGING; ANIMALS; HUMANS; MICE; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 2442685843     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1298     Document Type: Review

References (243)

1. Harman D: Aging: a theory based on free radical and radiation chemistry. J gerontol 11, 298-300 (1956)
2. Stadtman E R: Protein oxidation and ageing. Science 257, 1220-1224 (1992)
3. Martin GM, Austad SN, Johnson TE: Genetic analysis of ageing: role of oxidative damage and environmental stresses. Review. Nat Genet 13 (1), 25-34 (1996)
4. Sohal RS, Weindruch R: Oxidative stress, caloric restriction, and aging: a review. Science 273 (5271), 59-63 (1996)
5. Wallace DC: Mitochondrial diseases in man and mouse: a review. Science 283 (5407), 1482-8 (1999)
6. Finkel T, Holbrook NJ: Oxidants, oxidative stress and the biology of ageing. Review. Nature 408 (6809), 239-47 (2000)
7. Sun J, Folk D, Bradley TJ, Tower J: Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics, 161 (2), 661-72 (2002)
8. Huang WC, Juang SW, Liu IM, Chi TC, Cheng JT: Changes of superoxide dismutase gene expression and activity in the brain of streptozotocin-induced diabetic rats. Neurosci Lett 275(1), 25-8 (1999)
9. Robert E Huie and P Neta: Chemistry of Reactive oxygen Species. In: Reactive Oxygen Species in biological systems. Eds: Daniel L Gilbert and Carol A Colton, Kluker, Academic/Plenum Publishers, New York, Boston, Dordrecht, London, Moscow 33-73 (1999)
10. Gutteridge JM, Halliwell B: Iron toxicity and oxygen radicals. Review. Baillieres Clin Haematol 2 (2), 195-256 (1989)
11. Halliwell B, Cross CE: Oxygen-derived species: their relation to human disease and environmental stress. Review. Environ Health Perspect 102, Suppl 10, 5-12 (1994)
12. Allen RC: Role of oxygen in phagocyte microbicidal action. Review. Environ Health Perspect 102, Suppl 10, 201-8 (1994)
13. Babior BM: Activation of the respiratory burst oxidase. Review. Environ Health Perspect 102, Suppl 10, 53-6 (1994)
14. Robert E. Huie and P Neta: Chemistry of reactive oxygen species. In: Reactive oxygen species in biological systems. Eds: Daniel L. Gilbert and Carol A.Colton, Kluwer Academic Publishers, Hingham, MA 02018-0358 U.S.A.; AZ Dordrecht, The Netherlands 33-63 (1999)
15. Kim JM, Araki S, Kim DJ, Park CB, Takasuka N, Baba-Toriyama H, Ota T, Nir Z, Khachik F, Shimidzu N, Tanaka Y, Osawa T, Uraji T, Murakoshi M, Nishino H, Tsuda H: Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation. Carcinogenesis 19 (1), 81-5 (1998)
16. Kondo K, Matsumoto A, Kurata H, Tanahashi H, Koda H, Amachi T, Itakura H: Inhibition of oxidation of low-density lipoprotein with red wine. Lancet 344 (8930), 1152 (1994)
17. Yokozawa T, Liu ZW, Dong E: A study of ginsenoside-Rd in a renal ischemia-reperfusion model. Nephron 78 (2), 201-6 (1998)
18. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ: A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 336 (17), 1216-22 (1997)
19. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames, BN: Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci USA 99 (4), 2356-61 (2002)
20. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334 (18), 1150-5 (1996)
21. Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers and asbestos. N Engl J Med 334, 1145-9 (1994)
22. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R: Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334 (18), 1145-9 (1996)
23. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY,Yu Y, Liu BQ, Tangrea J, Sun YH, Liu FS, Fraumeni JF Jr., Zhang YH, Li B: Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 85 (18), 1483-92 (1993)
24. Boveris A and LE Costa: The mitochondrial production of oxygen Radicals and Cellular Aging. In: Understanding the process of aging: The roles of mitochondria, free radicals, and antioxidants. Eds: E Cadenas and L Packer Press, Marcel Dekker, Inc. NY. Basel 1-16 (1999)
25. Patel RP, T Cornwell, and VM Darley-Usmar: The biochemistry of nitric oxide and peroxynitrite: implications for Mitochonchondrial function. In: Understanding the process of aging: The roles of mitochondria, free radicals, and antioxidants. Eds: E Cadenas and L Packer, Marcel Dekker, Inc. NY. Basel 39-55 (1999)
26. Hei TK, Piao CQ, He ZY, Vannais D, Waldren CA: Chrysotile fiber is a strong mutagen in mammalian cells. Cancer Res 52 (22), 6305-9 (1992)
27. Gerschman R, Gilbert D, Nye SW, Dwyer P, Fenn WO: Oxygen poisoning and X-irradiation: a mechanism in common. Science 119, 623-26 (1954)
28. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, and Ames BN: Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid. PNAS 99 (4), 2356-2361 (2002a)
29. Liu J, Killilea DW, and Ames BN: Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-α-lipoic acid. PNAS 99 (4), 1876-1881 (2002b)
30. Linnane AW, Degli Esposti M, Generowicz M, Luff AR, Nagley P: The universality of bioenergetic disease and amelioration with redox therapy. Biochem Biophys Acta 1271, 191-194 (1995)
31. Yakes FM, Van Houten B: Mitochondria DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 94, 514-519 (1997)
32. Yan LJ, Sohal RS: Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci USA 95, 12896-12901 (1998)
33. Cortopassi GA and Wong A: Mitochondrial in organismal aging and degeneration. Biochem Biophys Acta 1410, 183-193 (1999)
34. Goodell S, Cortopassi G: Analysis of oxygen consumption and mitochondrial permeability with age in mice. Mech Ageing Dev 101 (3), 245-56 (1998)
35. Klimek J, Schaap AP, Kimura T: The relationship between NADPH-dependent lipid peroxidation and degradation of cytochrome P-450 in adrenal cortex mitochondria. Biochem Biophys Res Commun 110 (2), 559-66 (1983)
36. Rouach H, Clement M, Orfanelli MT, Janvier B, Nordmann J, Nordmann R: Hepatic lipid peroxidation and mitochondrial susceptibility to peroxidative attacks during ethanol inhalation and withdrawal. Biochim Biophys Acta 753 (3), 439-44 (1983)
37. Marcillat O, Zhang Y, and Davies KJ: Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin. Biochem J 259 (1), 181-9 (1989)
38. Musci G, Bonaccorsi di Patti MC, Fagiolo U, Calabrese L: Age-related changes in human ceruloplasmin. Evidence for oxidative modifications. J Biol Chem 268 (18), 13388-95 (1993)
39. Carney J M, Starke-Reed P E, and Oliver C N: Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N- tert -butyl-a-phenylnitrone. Proc Natl Acad Sci USA 88, 3633-3636 (1991)
40. Forster M J, Dubey A, and Dawson K M: Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci USA 93, 4765-4769 (1996)
41. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW: Oxidative damage increases with age in a canine model of human brain aging. J Neurochem 82 (2), 375-81 (2002)
42. Khalil A., Jay-Gerin J. P. and Fulop T., Jr: Age-related increased susceptibility of high-density lipoproteins (HDL) to in vitro oxidation induced by c-radiolysis of water. FEBS Lett 435, 153-158 (1998)
43. Lowseth L.A., Gillett N. A., Gerlach R. F. and Muggenburg B. A.: The effects of aging on hematology and serum chemistry values in the beagle dog. Vet Clin Pathol 19, 13-19 (1990)
44. Ramsey J. J., Harper M. E. and Weindruch R.: Restriction of energy intake, energy expenditure, and aging. Free Radic Bio. Med 29, 946-968 (2000)
45. Packer L and Fuehr K: Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature 267, 423-425 (1977)
46. Fraga CG, Shigenaga MK, Park JW, Degan P, and Ames BN: Oxidative damage to DNA during aging: 8-Hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87, 4533-4537 (1990)
47. Di Leonardo A, Linke SP, Clarkin K, Wahl GM. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 8, 2540-2551 (1994)
48. Shay JW, Wright WE, Werbin H: Toward a molecular understanding of human breast cancer: A hypothesis. Breast Cancer Res Treat 25, 83-94 (1993)
49. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51, 6304-6311 (1991)
50. Hayflick, L. & Moorhead, PS.: The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961)
51. Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37, 614-636 (1965)
52. Balin AK, Goodman DB, Rasmussen H, Cristofalo VJ: The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro. J Ceil. Biol 74, 58-67 (1977)
53. Petersen S, Saretzki G, von Zglinicki T: Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res 239, 152-160 (1998)
54. Sohal RS, Weindruch R: Oxidative stress, caloric restriction, and aging: a review. Science 273 (5271), 59-63 (1996)
55. Gille J.J., Joeje H: Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxia. Review. Mutat Res 275 (3-6), 405-14 (1992)
56. Stadtman ER, Levine RL: Protein oxidation. Ann N Y Acad Sci 899, 191 -208 (2000)
57. Brunk UT, Terman A. Lipofuscin: Mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 33, 611-619 (2002)
58. Sohal RS, Lass A, Yan LJ Kwong L: Mitochondrial generation of reactive oxygen species and oxidative damage during aging: roles of coenzyme Q and tocopherol. In: Understanding the process of aging, L. Packer, Editor, Marcel Dekker, Inc., New York 119-142 (1999)
59. Yan LJ, Sohal RS: Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damage to specific mitochondrial proteins. Free Radic. Biol. Med 29, 1143-1150 (2000)
60. Van Remmen H, Richardson A.: Oxidative damage to mitochondria and aging. Review. Exp Gerontol 36 (7), 957-68 (2001)
61. Harman D: The biologic clock: the mitochondria? J Am Geriatr Soc 20 (4), 145-7 (1972)
62. Miquel J, Economos AC, Fleming J, Johnson JE Jr.: Mitochondrial role in cell aging. Exp Gerontol 15 (6), 575-91 (1980)
63. Sohal RS: Mitochondrial changes in the heart of Drosophila repleta, Wollaston with age. Exp Gerontol 5 (3), 213-6 (1970)
64. Wei YH, Ma YS, Lee HC, Lee CF, and Lu CY: Mitochondrial theory of aging matures-roles of mtDNA mutation and oxidative stress in human aging: a review. Zhonghua Yi Xue Za Zhi (Taipei) 64 (5), 259-70 (2001)
65. Liu J, Atamna H, Kuratsune H, Ames BN: Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci 959, 133-66 (2002c)
66. Anderson S, Bankier AT, Barrell BG, De Bruijn, MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG: Sequence and organization of the human mitochondrial genome. Nature 290, 457-465 (1981)
67. Toescu EC, Myronova N, Verkhratsky A: Age-related structural and functional changes of brain mitochondria: a review. Cell Calcium 28 (5-6), 329-38 (2000)
68. Nicholls DG, Ferguson S: Bioenergetics 2. Academic Press, London (1992)
69. Van Remmen H, Richardson A. Oxidative damage to mitochondria and aging. Review. Exp Gerontol 36 (7), 957-68 (2001)
70. Tyler D: The mitochondrion in health and disease. Cambridge, England, VCH Publishers (1992)
71. Chance B, Sies H, Boveris A: Hydroperoxide metabolism in mammalian organs. Physiol Rev 59 (3), 527-605 (1979)
72. Shigenaga MK, Hagen TM, and Ames BN: Oxidative damage and mitochondrial decay in aging: a review. Proc Natl Acad Sci USA 91 (23), 10771-8 (1994)
73. Beckman KB, Ames BN: The free radical theory of aging matures: a review. Physiol Rev, 78 (2), 547-81 (1998)
74. Ozawa T: Oxidative damage and fragmentation of mitochondrial DNA in cellular apoptosis: a review. Biosci Rep 17 (3), 237-50 (1997)
75. Clayton DA: Transcription of the mammalian mitochondrial genome: a review. Annu Rev Biochem 53, 573-94 (1984)
76. Croteau DL, Bohr VA: Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells: a review. J Biol Chem 272 (41), 25409-12 (1997)
77. Dizdaroglu M: Chemical determination of free radical-induced damage to DNA: a review. Free Radic Biol Med 10 (3-4), 225-42 (1991)
78. Bibb MJ, Van Etten RA, Wright CT, Walberg MW, and Clayton DA: Sequence and gene organization of mouse mitochondrial DNA. Cell 26 (2 Pt 2), 167-80 (1981)
79. DiMauro S, Andreu AL: Mutations in mtDNA: Are we scraping the bottom of the barrel?: a review. Brain Pathol 10 (3), 431-41 (2000)
80. Cortopassi GA, Arnheim N: Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucl Acid Res 18, 6927-6933 (1990)
81. Ozawa T, Tanaka M, Ikebe S, Ohno K, Kondo T, Mizuno Y: Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis. Biochem Biophys Res Commun 172, 483-489 (1990)
82. Corral-Debrinski M, Stepien G, Shoffner JM, Lott MT, Kanter K, Wallace DC: Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease. JAMA 266, 1812-1816 (1991)
83. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, and Wallace DC: Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genet 2, 324-329 (1992)
84. Zhang C, Baumer A, Maxwell RJ, Linnane AW, Nagley P: Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett 297, 34-38 (1992)
85. Simonetti S, Chen X, DiMauro S, Schon EA: Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. Biochim Biophys Acta 1180, 113-122 (1992)
86. Cooper JM, Mann VM, Schapira AH: Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J Neurol Sci 113, 91-98 (1992)
87. Baumer A, Zhang C, Linnane AW, Nagley P: Age-related human mtDNA deletions: a heterogeneous set of deletions arising at a single pair of directly repeated sequences. Am J Hum Genet 54, 618-630 (1994)
88. Melov S, Shoffner JM, Kaufman A, Wallace DC: Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acid Res 23, 4122-4126 (1995)
89. Munscher C, Rieger T, Muller-Hocker J, and Kadenbach B: The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett 317, 27-30 (1993)
90. Khrapko K, Coller HA, Andre PC, Li XC, Hanekamp JS, Thilly WG: Mitochondrial mutational spectra in human cells and tissues. Proc Natl Acad Sci U S A 94 (25), 13798-803 (1997)
91. Wang Y, Michikawa Y, Mallidis C, Bai Y, Woodhouse L, Yarasheski KE, Miller CA, Askanas V, Engel WK, Bhasin S, Attardi G: Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci U S A 98 (7), 4022-7 (2001)
92. Hayakawa M, Sugiyama S, Hattori K, Takasawa M, and Ozawa T: Age-associated damage in mitochondrial DNA in human hearts. Mol Cell Biochem 119, 95-103 (1993)
93. Muscari C, Giaccari A, Stefanelli C, Viticchi C, Giordano E, Guarnieri C, Caldarera CM: Presence of a DNA-4236 bp deletion and 8-hydroxy-deoxyguanosine in mouse cardiac mitochondrial DNA during aging. Aging (Milano) 8 (6), 429-33 (1996)
94. Kaneko T, Tahara S, Matsuo M: Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging. Mutat Res 316 (5-6), 277-85 (1996)
95. Souza-Pinto NC, Croteau DL, Hudson EK, Hansford RG, Bohr VA: Age-associated increase in 8-oxodeoxyguanosine glycosylase/AP lyase activity in rat mitochondria. Nucleic Acids Res 27 (8), 1935-42 (1999)
96. Wei YH, Lu CY, Lee HC, Pang CY, Ma YS: Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Ann N Y Acad Sci. 854, 155-70 (1998)
97. Muller-Hocker J: Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J Neurol Sci 100, 14-21 (1990)
98. Brierley EJ, Johnson MA, James OFW, Turnbull DM: Effects of physical activity and age on mitochondrial function. Q J Med 89, 251-258 (1996)
99. Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G: Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286 (5440), 774-9 (1999)
100. Jazin EE, Cavelier L, Eriksson I, and Oreland L, Gyllensten U: Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA. Proc Natl Acad Sci USA 93 (22), 12382-7 (1996)
101. Bendall KE, Macaulay VA, and Sykes BC: Variable levels of a heteroplasmic point mutation in individual hair roots. Am J Hum Genet 61 (6), 1303-8 (1997)
102. Polyak K, Li Y, Zhu H, Lengauer C, Willson JK, Markowitz SD, Trush MA, Kinzler KW, Vogelstein B: Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 20 (3), 291-3 (1998)
103. Fliss MS, Usadel H, Caballero OL, Wu L, Buta MR, Eleff SM, Jen J, Sidransky D: Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 287 (5460), 2017-9 (2000)
104. Trounce I., Byrne E., and Marzuki S: Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1, 637-639 (1989)
105. Boffoli D., Scacco S.C., Vergari R., Solarino G., Santacroce G., and Papa S: Decline with age of the respiratory chain activity in human skeletal muscle. Biochimica et Biophysica Acta 1226 (1) 73-82 (1994)
106. Yen T.C., Chen Y.S., King K.L., Yeh S.H., and Wei Y.H: Liver mitochondrial respiratory functions decline with age. Biochemical and Biophysical Research Communications 165, 944-1003 (1989)
107. Bowling A.C., Mutisya E.M., Walker L.C., Price D.L., Cork L.C., and Beal M.F: Age-dependent impairment of mitochondrial function in primate brain. Journal of Neurochemistry 60 (5) 1964-1967 (1993)
108. Muller-Hocker J., Schneiderbanger K., Stefani F.H., and Kadenbach B: Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing - a cytochemical-immunohistochmeical study. Mutation Research 275, 115-124 (1992)
109. Muller-Hocker J., Seibel P., Schneiderbanger K., and Kadenbach B: Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch A, Pathological Anatomy and Histopathology 422, 7-15 (1993)
110. Piko L., Hougham A.J., and Bullpitt K.J.: Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging. Mechanisms of Ageing and Development 43, 279-293 (1988)
111. Linnane A.W., Marzuki S., Ozawa T., and Tanaka M.: Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1 (8639), 642-645 (1989)
112. Linnane A.W., Baumer A., Maxwell R.J., Preston H., Zhang C., and Marzuki S.: Mitochondrial gene mutation: the aging process and degenerative diseases. Biochemistry International 22 (6) 1067-1076 (1990)
113. Yen T.C., Pang C.Y., Hsieh R.H., Su C.H., King K.L., and Wei Y.H.: Age-dependent 6kb deletion in human liver mitochondrial DNA. Biochemistry International 26, 457-468 (1992)
114. Yen, T.C., King K.L., Lee H.C., Yeh S.H., and Wei Y.H.: Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria. Free Radical Biology and Medicine 16 (2), 207-214 (1994)
115. Arnheim N. and Cortopassi GL: Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutation Research 275, 157-167 (1992)
116. Cortopassi G. and Arnheim N.: Accumulation of mitochondrial DNA mutation in normal aging brain and muscle. In: Mitochondrial DNA in Human Pathology. Editors: DiMauro S. and Wallace D.C. Raven Press, N.Y, 125-136 (1992a)
117. Cortopassi G.A., Shibata D., Soong N.W., and Arnheim N.: A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proceedings of the National Academy of Sciences of the United States of America 89 (16), 7370-7374 (1992b)
118. Mann V.M., Cooper J.M., and Schapira A.H.V.: Quantitation of a mitochondrial DNA deletion in Parkinson's disease. FEBS Letters 299 (3), 218-222 (1992)
119. Soong N.W., Hinton D.R., Cortopassi G., and Arnheim N.: Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature Genetics 2, 318-323 (1992)
120. Sugiyama S., Hattori K., Hayakawa M., and Ozawa T.: Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts. Biochemical and Biophysical Research Communications 180, 894-899 (1992)
121. Wei, Y.H.: Mitochondrial DNA alterations as ageing-associated molecular events. Mutation Research 275, 145-155 (1992)
122. Hamblet N.S. and Castora FJ.: Mitochondrial DNA deletion analysis: a comparison of PCR quantitative methods. Biochemical and Biophysical Research Communications 207 (2), 839-847 (1995)
123. Munscher C., Muller-Hocker J., and Kadenbach B.: Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA. Biological Chemistry Hoppe Seyler 374, 1099-1104 (1993a)
124. Munscher C., Rieger T., Muller-Hocker J., and Kadenbach B.: The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Letters 317, 27-30 (1993b)
125. Rieger T., Munscher C., Seibel P., Muller-Hocker J., and Kadenbach B.: Detection of small amounts of mutated mitochondrial DNA by allele-specific PCR (AS-PCR) Methods Mol. Cell Biol 4, 121-127 (1993)
126. Zhang C., Linnane A.W., and Nagley P.: Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochemical and Biophysical Research Communications 195 (2), 1104-1110 (1993)
127. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, and Wallace DC: Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genet 2, 324-329 (1992)
128. Wallace D.C.: Diseases of the mitochondrial DNA. Annual Review of Biochemistry 61, 1175-1212 (1992a)
129. Wallace D.C.: Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256, 628-632 (1992b)
130. Mroczek-Tonska K, Ratajska D, Guillot C, Sasiadek M, Ambroziak A, Lubos L, Bartnik E.: Heteroplasmy analysis in the Polish patients with 11778A mutation responsible for Leber hereditary optic neuropathy. Acta Biochim Pol 49 (1), 257-62 (2002)
131. Volz-Lingenhohl A, Solignac M, Sperlich D: Stable heteroplasmy for a large-scale deletion in the coding region of Drosophila subobscura mitochondrial DNA. Proc Natl Acad Sci USA 89 (23), 1152832 (1992)
132. Shoubridge EA: Mitochondrial DNA diseases: histological and cellular studies: a review. J Bioenerg Biomembr 26 (3), 301-10 (1994)
133. Tokunaga M, Mita S, Murakami T, Kumamoto T, Uchino M, Nonaka I, Ando M: Single muscle fiber analysis of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Ann Neurol 35 (4), 413-9 (1994)
134. Macmillan C, Lach B, Shoubridge EA: Variable distribution of mutant mitochondrial DNAs (tRNA(Leu[3243])) in tissues of symptomatic relatives with MELAS: the role of mitotic segregation. Neurology 43 (8) 1586-90 (1993)
135. Manfredi G, Vu T, Bonilla E, Schon EA, DiMauro S, Arnaudo E, Zhang L, Rowland LP, and Hirano M: Association of myopathy with large-scale mitochondrial DNA duplications and deletions: which is pathogenic? Ann Neurol 42 (2), 180-8 (1997)
136. Nakamura N, Hattori N, Tanaka M, Mizuno Y: Specific detection of deleted mitochondrial DNA by in situ hybridization using a chimera probe. Biochim Biophys Acta 1308 (3), 215-21 (1996)
137. Vu TH, Tanji K, Pallotti F, Golzi V, Hirano M, DiMauro S, Bonilla E: Analysis of mtDNA deletions in muscle by in situ hybridization. Muscle Nerve 23 (1), 80-5 (2000)
138. Engelhardt M, Martens UM: The implication of telomerase activity and telomere stability for replicative aging and cellular immortality (Review). Oncol Rep 5 (5), 1043-52 (1998)
139. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB: Telomere end-replication problem and cell aging. J Mol Biol 225 (4), 951-60 (1992)
140. Blackburn EH: Telomere states and cell fates. Nature 408 (6808), 53-6 (2000)
141. Proctor CJ, Kirkwood TB: Modelling telomere shortening and the role of oxidative stress. Mech Ageing Dev Feb 123 (4), 351-63 (2002)
142. Petersen S, Saretzki G, von Zglinicki T: Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res 239 (1), 152-60 (1998)
143. von Zglinicki T. Telomeres and replicative senescence: Is it only length that counts? Review. Cancer Lett 168 (2), 111-6 (2001)
144. von Zglinicki T: Oxidative stress shortens telomeres. Trends Biochem Sci 27 (7), 339-44 (2002)
145. Lemasters JJ, DiGuiseppi J, Nieminen AL, Herman B. Blebbing: free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes. Nature 325 (6099), 78-81 (1987)
146. Hockenbery DM, Nunfez, G, Milliman, C, Schreiber, RD and Korsmeyer, SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334-336 (1990)
147. Pastorino JG, Snyder JW, Serroni A, Hoek JB and Farber JL: Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J. Biol. Chem 268, 13791-13798 (1993)
148. Imberti R., Nieminen A.-L., Herman B. and Lemasters J.J.: Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine. J Pharmacol Exp Ther 265, 392-400 (1993)
149. Ankarcrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A. and Nicotera P: Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961-973 (1995)
150. Zamzami N., Marchetti P., Castedo M., Decaudin D., Macho A., Hirsch T., Susin S.A., Petit P.X., Mignotte B. and Kroemer G: Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182, 367-377 (1995)
151. Liu X., Kim C.N., Yang J., Jemmerson R. and Wang X: Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147-157 (1996)
152. Zou H., Henzel W.J., Liu X., Lutschg A., and Wang X.: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413 (1997)
153. Troen BR: The biology of aging: a review. Mt Sinai J Med 70 (1), 3-22 (2003)
154. Kroemer G, Dallaporta B, Resche-Rigon M: The mitochondrial death/life regulator in apoptosis and necrosis: a review. Annu Rev Physiol 60, 619-42 (1998)
155. Esteve JM, Mompo J, Garcia de la Asuncion J, Sastre J, Asensi M, Boix J, Vina JR, Vina J, Pallardo FV: Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro. FASEB J 13 (9), 1055-64 (1999)
156. Kroemer G, Petit P, Zamzami N, Vayssiere JL, Mignotte B: The biochemistry of programmed cell death: a review. FASEB J 9 (13), 1277-87 (1995)
157. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75 (2), 241-51 (1993)
158. Zamzami N, Susin SA, Marchetti P, Hirsch T, Gomez-Monterrey I, Castedo M, Kroemer G: Mitochondrial control of nuclear apoptosis. J Exp Med 183 (4), 1533-44 (1996)
159. Skulachev VP. The programmed death phenomena, aging, and the Samurai law of biology. Exp Gerontol 36 (7), 995-1024. Review (2001)
160. Juan Sastre, Federico V. Pallardo, Jose Garcia de la Asuncion, Miguel A. Asensi, Juan M. Esteve, and Jose Vinaribes: Role of mitochondria in oxidative stress associated with aging and apoptosis: studies in intact cells. In: Understanding the process of aging, the role of mitochondria, free radicals, and antioxidants. Eds: E Cadenas and L Packer, Marcel Dekker Press, Inc. NY. Basel 181-202 (1999)
161. Jacobson MD, Burne JF, King MP, Miyashita T, Reed JC, Raff MC: Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361 (6410), 365-9 (1993)
162. Jiang S, Cai J, Wallace DC, Jones DP: Cytochrome c-mediated apoptosis in cells lacking mitochondrial DNA. Signaling pathway involving release and caspase 3 activation is conserved. J Biol Chem 274 (42), 29905-11 (1999)
163. Chomyn A, Attardi G: MtDNA mutations in aging and apoptosis. Review. Biochem Biophys Res Commun 304 (3), 519-29 (2003)
164. Ames BN, Shigenaga MK, Hagen TM: Mitochondrial decay in aging. Biochem Biophys Acta 1271, 165-170 (1995)
165. Kim SH, Fountoulakis M, Cairns N, Lubec G.: Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. J Neurol Transm Suppl (61), 223-35 (2001)
166. de la Asuncion JG, Millan A, Pla R, Bruseghini L, Esteras A, Pallardo FV, Sastre J, Vina J: Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J 10 (2), 333 (1996)
167. Sohal RS: Role of oxidative stress and protein oxidation in the aging process: a review. Free Radic Biol Med 33 (1), 37-44 (2002)
168. Agarwal S and Sohal R.S.: DNA oxidative damage and life expectancy in houseflies. Proc. Natl. Acad. Sci. USA 91, 12332-12335 (1994)
169. Agarwal S and Sohal R.S.: Aging and protein oxidative damage. Mech. Aging Develop. 75, 11-19 (1994)
170. Sohal RS, Agarwal S, Dubey A, Orr WC: Protein oxidative damage is associated with life expectancy of houseflies. Proc Natl Acad Sci USA 90 (15), 7255-9 (1993)
171. Sohal RS: The free radical hypothesis of aging: an appraisal of the current status: a review. Aging (Milano) 5 (1), 3-17 (1993)
172. Weindruch R. and Sohal R.S.: Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N. Engl. J. Med. 337, 986-994 (1997)
173. Stadtman E.R: Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences [published erratum appears in Free Radic Biol Med 10 (3-4), 249 (1991)]. Free Radic. Biol. Med. 9, 315-325 (1990)
174. Sohal RS, Mockett RJ, Orr WC: Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Review. Free Radic Biol Med 33 (5), 575-86 (2002)
175. Wallace DC: Mitochondrial defects in neurodegenerative disease. Review. Ment Retard Dev Disabil Res Rev 1 (3), 158-66 (2001)
176. Butterfield D.A. and Stadtman E.R.: Protein oxidation processes in aging brain. Adv. Cell Aging Gerontol 2, 161-191 (1997)
177. Butterfield DA, Howard BJ, Yatin S, Allen KL, Carney JM: Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone. Proc Natl Acad Sci USA 94 (2), 674-8 (1997)
178. Dean RT, Fu S, Stocker R, and Davies MJ: Biochemistry and pathology of radical-mediated protein oxidation: a review. Biochem J 324 Pt 1, 1-18 (1997)
179. Butterfield DA and Kanski J: Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins: a review. Mech Ageing Dev 122 (9), 945-62 (2001)
180. Markesbery W.R: Oxidative stress hypothesis in Alzheimer's disease: a review. Free Radic Biol Med 23 (1), 134-47 (1997)
181. Friede RI: Enzyme histochemical studies of senile plaques. J Neuropathol Exp Neurol 24, 477-491 (1965)
182. Mecocci P, MacGarvey U, and Beal MF: Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36 (5), 747-51 (1994)
183. Lyras L, Cairns NJ, Jenner A, Jenner P, Halliwell B: An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J Neurochem 68 (5), 2061-9 (1997)
184. Gabbita SP, Lovell MA, Markesbery WR: Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J Neurochem 71 (5), 2034-40 (1998)
185. Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, and Smith MA: RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci 19 (6), 1959-64 (1999)
186. de la Monte SM, Luong T, Neely TR, Robinson D, Wands JR.: Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab Invest 80 (8), 1323-35 (2000)
187. Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA: Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21 (9), 3017-23 (2001)
188. Smith C. D., Carney J. M., Starke-Reed P. E., Oliver C. N., Stadtman E.R., Floyd R. A. and Markesbery W.R.: Excess brainprotein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci USA 88, 10540-10543 (1991)
189. Markesbery W. R. and Lovell M. A.: Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease. Neurobiol Aging 19, 33-36 (1998)
190. Mirra S. S., Heyman A., McKeel D., Sumi S. M., Grain B. J., Brownlee L. M., Vogel F. S., Hughes J. P., van Belle G., and Berg L: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II, Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486 (1991)
191. Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K. H., Multhaup G., Beyreuther K. and Muller-Hill B.: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736 (1987)
192. Gabuzda D., Busciglio J., Chen L. B., Matsudaira P. and Yankner B, A.: Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 269, 13623-13628 (1994)
193. Multhaup G.: Amyloid precursor protein, copper and Alzheimer's disease. Biomed Pharmacother 51, 105-111 (1997)
194. in t' Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, Breteler MM, Stricker BH.: Nonsteroidal Antiinflammatory Drugs and the risk of Alzheimer's Disease. The New England Journal of Medicine 245 (21), 1515-1521 (2001)
195. Hoozemans JJ, Veerhuis R, Rozemuller AJ, Eikelenboom P.: Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. Curr Drug Targets 4 (6), 461-8 (2003)
196. Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ.: Chronic parkinsonism secondary to intravenous injection of meperidine analogues. Psych Res 1, 249-254 (1979)
197. Langsten JW, Ballard PA, Tetrud JW, Irwin I: Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980 (1983)
198. Chiba K, Trevor A, Castagnoli N Jr.: Metabolism of the neurotoxic tertiaryamine, MPTP by brain monoamine oxidase. Biochem Biophys Res Conim 120, 574-578 (1984)
199. Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH: Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metaboliteN-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82, 2173-2177 (1985)
200. Ramsay RR, Salach JI, Singer TP. Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP1) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD1 linked substrates by MPP1. Biochem Biophys Res Comm 134, 743-748 (1986)
201. Nicklas WJ, Vyas I, Heikkila RE: Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci 36, 2503-2508 (1985)
202. Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ.: A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine. Proc Natl Acad Sci USA 80, 4546-4550 (1983)
203. Forno LS, Langston JW, DeLanney LE, Irwin I, Ricuarte GA: Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 20, 449-455 (1986)
204. Swerdlow RH, Parks JK, Pattee G, Parker WD Jr. Role of mitochondria in amyotrophic lateral sclerosis. Review. Amyotroph Lateral Scler Other Motor Neuron Disord 1 (3), 185-90 (2000)
205. Blin O, Desnuelle C, Rascol O, Borg M, Peyro Saint Paul H, Azulay JP, Bille F, Figarella D, Coulom F, Pellissier JF, Montastruc JL, Chatel M, Sterratrice G.: Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy. J Neurol Sci 125, 95-101 (1993)
206. Di Monte DA, Harati Y, Jankovic J, Sandy MS, Jewell SA, Langsten JW.: Muscle mitochondrial ATP production in progressive supranuclear palsy. J Neurochem 62, 1631-1634 (1994)
207. Albers DS, Augood SJ, Martin DM, Standaert DG, Vonsattel JP, Beal MF.: Evidence for oxidative stress in subthalamic nucleus in progressive supranuclear palsy. J Neurochem 73, 881-884 (1999)
208. Albers DS, Augood SJ, Park LC, Browne SE, Martin DM, Adamson J, Hutton M, Standaert DG, Vonsattel JP, Gibson GE, Beal MF.: Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. J Neurochem 74, 878-881 (2000)
209. Smith RA, Porteous CM, Gane AM, Murphy MP: Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci USA 11 (9), 5407-5412 (2003)
210. Seibel P, Trappe J, Villani G, Klopstock T, Papa S, Reichmann H: Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases. Nucleic Acids Res 23 (1), 10-7 (1995)
211. Chrzanowska-Lightowlers ZM, Lightowlers RN, and Turnbull DM: Gene therapy for mitochondrial DNA defects: is it possible? a review. Gene Ther 2 (5), 311-6 (1995)
212. Vestweber D, Schatz G: DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature 338 (6211), 170-2 (1989)
213. Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ: Extension of life-span with superoxide dismutase/catalase mimetics. Science 289 (5484), 1567-9 (2000)
214. Keaney M, Gems D: No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free Radic Biol Med 34 (2), 277-82 (2003)
215. Tower J., Aging mechanisms in fruit flies. Bioessays 18, 799-807 (1996)
216. Tatar M: Transgenes in the analysis of life span and fitness. Am Nat 154 Suppl, S67-S81 (1999)
217. Sohal R.S., Mockett, R.J. and Orr, W.C.: Current issues concerning the role of oxidative stress in aging: a perspective. In: Results and Problems in Cell Differentiation. Editor: Hekimi, Springer, Berlin (2000)
218. Tower J., Transgenic methods for increasing Drosophila life span. Review. Mech Ageing Dev 118 (1-2), 1-14 (2000)
219. Orr WC, Sohal RS: Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster? Exp Gerontol 38 (3), 227-30 (2003)
220. Orr WC, Sohal RS: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263 (5150), 1128-30 (1994)
221. Orr WC, Sohal RS: Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys 301 (1), 34-40 (1993)
222. Orr WC, Sohal RS: The effects of catala2se gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys 297 (1), 35-41 (1992)
223. Sun J, Tower J: FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 19 (1), 216-28 (1999)
224. Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL: Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nature Genet 10, 171-175 (1998)
225. Amstad P, Peskin A, Shah G, Mirault ME, Moret R, Zbinden I, Cerutti P: The balance between Cu, Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress. Biochemistry 30, 9305-9313 (1991)
226. Riddle, D. L. & Alberts, P. S.: Genetic and environmental regulation of dauer larva development. In C. elegans II (eds Riddle, D. L., Blumenthal T., Meyer, B. J. & Priess, J. R.) 739-768 (Cold Spring Harbor Press, New York, (1997)
227. Kenyon, C: Environmental factors and gene activities that influence life span. In C. elegans II. Eds: Riddle, D. L., Blumenthal, T., Meyer, B. J. & Priess, J. R. Cold Spring Harbor Press, New York 791-814 (1997)
228. Taub J, Lau JF, Ma C, Hahn JH, Hoque R, Rothblatt J, Chalfie M: A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature 399 (6732), 162-6 (1999). Taub J, Lau JF, Ma C, Hahn JH, Hoque R, Rothblatt J, Chalfie M. Retraction. Nature 421 (6924), 764 (2003)
229. Taub J, Lau JF, Ma C, Hahn JH, Hoque R, Rothblatt J, Chalfie M: A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature 399 (6732), 162-6 (1999). Taub J, Lau JF, Ma C, Hahn JH, Hoque R, Rothblatt J, Chalfie M. Retraction. Nature 421 (6924), 764 (2003)
230. Lakowski B, Hekimi S: The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95 (22), 13091-6 (1998)
231. Lakowski B, Hekimi S: Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272 (5264), 1010-3 (1996)
232. Ahmed A, Tollefsbol T: Telomeres and telomerase: basic science implications for aging. Review. J Am Geriatr Soc 49 (8), 1105-9 (2001)
233. Lim CS, Mian IS, Dernburg AF, Campisi J: C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr Biol 11 (21), 1706-10 (2001)
234. Benard C, McCright B, Zhang Y, Felkai S, Lakowski B, Hekimi S: The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 128 (20), 4045-55 (2001)
235. Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33 (1), 40-8 (2003)
236. Van Remmen H, Williams MD, Guo Z, Estlack L, Yang H, Carlson EJ, Epstein CJ, Huang TT, Richardson A: Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am J Physiol Heart Circ Physiol 281 (3), H1422-32 (2001)
237. Walter PB, Knutson, MD, Paler-Martinez A, Lee S, Xu, Y, Viteri FE, and Ames BN: Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. PNAS 99 (4), 2264-2269 (2002)
238. Hagen, T.M., Liu, J., Lykkesfeldt, J., Wehr, C.M., Ingersoll, R.T., Vinarsky, V., Bartholomew, J.C., and Ames, B.N.: Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA 99 (4), 1870-1875 (2002)
239. Bluher M, Kahn BB, Kahn CR: Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 (5606), 572-4 (2003)
240. Tatar M, Bartke A, Antebi A: The endocrine regulation of aging by insulin-like signals. Review. Science 299 (5611), 1346-51 (2003)
241. Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D, Metter EJ: Biomarkers of caloric restriction may predict longevity in humans. Science 297 (5582), 811 (2002)
242. Wrutniak-Cabello, C., Casas F., and Cabello G: Thyroid hormone action in mitochondria. J Mol Endocrinol 26, 67-77 (2001)
243. Manton KG: Aging and Longevity of Human Population. Encyclopaedia of Endocrine Diseases Submitted (2003)