Aldehyde dehydrogenase 1B1: Molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme

Drug Metabolism and Disposition

Volumn 38, Issue 10, 2010, Pages 1679-1687

  Stagos, Dimitrios ^a,c   Chen, Ying ^a   Brocker, Chad ^a   Donald, Elizabeth ^a   Jackson, Brian C ^a   Orlicky, David J ^b   Thompson, David C ^a   Vasiliou, Vasilis ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF THESSALY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE; ALDEHYDE DEHYDROGENASE; DISULFIRAM; MALONALDEHYDE;

AFFINITY CHROMATOGRAPHY; ARTICLE; CHEMICAL ANALYSIS; CLINICAL ASSESSMENT; COLON; DUODENUM; ENZYME ANALYSIS; ENZYME PURIFICATION; HEART; HUMAN; ILEUM; IMMUNOHISTOCHEMISTRY; INSECT CELL; JEJUNUM; LIPID PEROXIDATION; LIVER; LUNG; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE; STOMACH; TESTIS; TISSUE DISTRIBUTION; WESTERN BLOTTING;

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; AMINO ACID SEQUENCE; ANIMALS; BACULOVIRIDAE; BLOTTING, WESTERN; CELL LINE; CLONING, MOLECULAR; ETHANOL; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INSECTS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; NAD; ORGAN SPECIFICITY; OXIDATION-REDUCTION; PLASMIDS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

HEXAPODA; MUS;

EID: 77957134124     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.034678     Document Type: Article

References (43)

1. Bacolod MD, Lin SM, Johnson SP, Bullock NS, Colvin M, Bigner DD, and Friedman HS (2008) The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide. Curr Cancer Drug Targets 8:172-179. (Pubitemid 351666854)
2. Black WJ, Stagos D, Marchitti SA, Nebert DW, Tipton KF, Bairoch A, and Vasiliou V (2009) Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature. Pharmacogenet Genomics 19:893-902.
3. Bond SL and Singh SM (1990) Studies with cDNA probes on the in vivo effect of ethanol on expression of the genes of alcohol metabolism. Alcohol Alcohol 25:385-394.
4. Bond SL, Wigle MR, and Singh SM (1991) Acetaldehyde dehydrogenase (Ahd-2)-associated DNA polymorphisms in mouse strains with variable ethanol preferences. Alcohol Clin Exp Res 15:304-307.
5. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, and Mochly-Rosen D (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321:1493-1495.
6. Crabb DW, Edenberg HJ, Bosron WF, and Li TK (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest 83:314-316.
7. Crabb DW, Matsumoto M, Chang D, and You M (2004) Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 63:49-63. (Pubitemid 38543873)
8. Ding WX and Nam Ong C (2003) Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiol Lett 220:1-7. (Pubitemid 36324313)
9. Duester G (2000) Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 267:4315-4324.
10. Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, et al. (2009) Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res 105:1118-1127.
11. Eriksson CJ (2001) The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 25:15S-32S.
12. Esterbauer H, Schaur RJ, and Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11:81-128. (Pubitemid 121003917)
13. Hsu LC and Chang WC (1991) Cloning and characterization of a new functional human aldehyde dehydrogenase gene. J Biol Chem 266:12257-12265. (Pubitemid 21907086)
14. Husemoen LL, Fenger M, Friedrich N, Tolstrup JS, Beenfeldt Fredriksen S, and Linneberg A (2008) The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. Alcohol Clin Exp Res 32:1984-1991.
15. Klyosov AA, Rashkovetsky LG, Tahir MK, and Keung WM (1996) Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism. Biochemistry 35:4445-4456.
16. Lam JP, Mays DC, and Lipsky JJ (1997) Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram. Biochemistry 36:13748-13754.
17. Larson HN, Weiner H, and Hurley TD (2005) Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant. J Biol Chem 280:30550-30556.
18. Lassen N, Estey T, Tanguay RL, Pappa A, Reimers MJ, and Vasiliou V (2005) Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. Drug Metab Dispos 33:649-656. (Pubitemid 40593879)
19. Linneberg A, Gonzalez-Quintela A, Vidal C, Jørgensen T, Fenger M, Hansen T, Pedersen O, and Husemoen LL (2010) Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. Clin Exp Allergy 40:123-130.
20. Little RG 2nd and Petersen DR (1983) Subcellular distribution and kinetic parameters of HS mouse liver aldehyde dehydrogenase. Comp Biochem Physiol C 74:271-279.
21. Liu F and Schnable PS (2002) Functional specialization of maize mitochondrial aldehyde dehydrogenases. Plant Physiol 130:1657-1674. (Pubitemid 36048809)
22. -ΔΔCT method. Methods 25:402-408.
23. Luo P, Wang A, Payne KJ, Peng H, Wang JG, Parrish YK, Rogerio JW, Triche TJ, He Q, and Wu L (2007) Intrinsic retinoic acid receptor α-cyclin- dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells. Stem Cells 25:2628-2637.
24. Manzer R, Qamar L, Estey T, Pappa A, Petersen DR, and Vasiliou V (2003) Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA. DNA Cell Biol 22:329-338. (Pubitemid 36833295)
25. Masaki R, Yamamoto A, and Tashiro Y (1996) Membrane topology and retention of microsomal aldehyde dehydrogenase in the endoplasmic reticulum. J Biol Chem 271:16939-16944. (Pubitemid 26239065)
26. Meier P and Seitz HK (2008) Age, alcohol metabolism and liver disease. Curr Opin Clin Nutr Metab Care 11:21-26. (Pubitemid 350295221)
27. Moon KH, Lee YM, and Song BJ (2010) Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation. Free Radic Biol Med 48:391-398.
28. Niemelä O (2007) Acetaldehyde adducts in circulation. Novartis Found Symp 285:183-192; discussion 193-197.
29. Pappa A, Estey T, Manzer R, Brown D, and Vasiliou V (2003) Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea. Biochem J 376:615-623. (Pubitemid 38063115)
30. Petersen EN (1992) The pharmacology and toxicology of disulfiram and its metabolites. Acta Psychiatr Scand Suppl 369:7-13.
31. Sheikh S and Weiner H (1997) Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol 53:471-478. (Pubitemid 27149539)
32. Shi Z, Dragin N, Galvez-Peralta M, Jorge-Nebert LF, Miller ML, Wang B, and Nebert DW (2010) Organ-specific roles of CYP1A1 during detoxication of oral benzo[a]pyrene. Mol Pharmacol 78:46-57.
33. Stagos D, Chen Y, Cantore M, Jester JV, and Vasiliou V (2010) Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization. Brain Res Bull 81:211-218.
34. Stewart MJ, Malek K, and Crabb DW (1996) Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 44:42-46. (Pubitemid 126820662)
35. Stewart MJ, Malek K, Xiao Q, Dipple KM, and Crabb DW (1995) The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. Biochem Biophys Res Commun 211:144-151.
36. Stewart SF, Vidali M, Day CP, Albano E, and Jones DE (2004) Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease. Hepatology 39:197-203. (Pubitemid 38461482)
37. Vaglenova J, Martínez SE, Porté S, Duester G, Farrés J, and Parés X (2003) Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract. Eur J Biochem 270:2652-2662. (Pubitemid 36723996)
38. van de Kerkhof EG, de Graaf IA, and Groothuis GM (2007) In vitro methods to study intestinal drug metabolism. Curr Drug Metab 8:658-675. (Pubitemid 47578115)
39. Vasiliou V and Pappa A (2000) Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology 61:192-198.
40. Viitala K, Makkonen K, Israel Y, Lehtimäki T, Jaakkola O, Koivula T, Blake JE, and Niemelä O (2000) Autoimmune responses against oxidant stress and acetaldehyde-derived epitopes in human alcohol consumers. Alcohol Clin Exp Res 24:1103-1109. (Pubitemid 30604332)
41. Wang X and Weiner H (1995) Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde dehydrogenase as probed by site-directed mutagenesis. Biochemistry 34:237-243.
42. Yoshida A, Huang IY, and Ikawa M (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci USA 81:258-261. (Pubitemid 14180868)
43. Yu HS, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TT, and Kawamoto T (2009) Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. Toxicol Mech Methods 19:535-540.