Protection by transfected rat or human class 3 aldehyde dehydrogenases against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines: Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme

Journal of Biological Chemistry

Volumn 271, Issue 20, 1996, Pages 11891-11896

  Bunting, Kevin D ^a,b   Townsend, Alan J ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; MINK CELL FOCUS-FORMING VIRUS;

4 HYDROPEROXYCYCLOPHOSPHAMIDE; 4 HYDROPEROXYIFOSFAMIDE; ACROLEIN; ALDEHYDE DEHYDROGENASE; ALDOPHOSPHAMIDE; IFOSFAMIDE; MELPHALAN; OXAZAPHOSPHORINE; PHOSPHORAMIDE MUSTARD;

ANIMAL CELL; ARTICLE; CHO CELL; CONFORMATIONAL TRANSITION; CYTOTOXICITY; DNA CROSS LINKING; DRUG RESISTANCE; GENE EXPRESSION; GENETIC TRANSFECTION; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL LINE; CRICETINAE; CRICETULUS; CYTOSOL; ENZYME INHIBITORS; HUMANS; ISOENZYMES; PHOSPHORAMIDE MUSTARDS; RATS; TRANSFECTION;

EID: 0029936167     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.20.11891     Document Type: Article

References (28)

1. Hilton, J. (1984) Cancer Res. 44, 5156-5160
2. Koelling, T. M., Yeager, A. M., Hilton, J., Haynie, D. T., and Wiley, J. M. (1990) Blood 76, 1209-1213
3. Sreerama, L., and Sladek, N. E. (1993) Biochem. Pharmacol. 45, 2487-2505
4. Rekha, G. K., Sreerama, L., and Sladek, N. E. (1994) Biochem. Pharmacol. 48, 1943-1952
5. Sreerama, L., and Sladek, N. E. (1993) Adv. Exp. Med. Biol. 328, 99-113
6. Sreerama, L., Rekha, G. K., and Sladek, N. E. (1995) Biochem. Pharmacol. 49, 669-675
7. Sladek, N. E. (1988) Pharmacol. Ther. 37, 301-355
8. Hill, D. L., Laster, W. R. J., and Struck, R. F. (1972) Cancer Res. 32, 658-665
9. Husso, J. E., and Hilton, J. (1988) Cancer Res. 48, 2963-2968
10. Manthey, C. L., and Sladek, N. E. (1988) Biochem. Pharmacol. 37, 2781-2790
11. Sladek, N. E., Dockham, P. A., and Lee, M. O. (1991) Adv. Exp. Med. Biol. 284, 97-104
12. Lee, M. O., Manthey, C. L., and Sladek, N. E. (1991) Biochem. Pharmacol. 42, 1279-1285
13. Dockham, P. A., Lee, M. O., and Sladek, N. E. (1992) Biochem. Pharmacol. 43, 2453-2469
14. Sreerama, L., and Sladek, N. E. (1994) Cancer Res. 54, 2176-2185
15. Sreerama, L., and Sladek, N. E. (1994) Biochem. Pharmacol. 48, 617-620
16. Von, E. U., Meier, T. D., Agarwal, D. P., and Goedde, H. W. (1994) Cancer Lett. 76, 45-49
17. Bunting, K. D., Lindahl, R., and Townsend, A. J. (1994) J. Biol. Chem. 269, 23197-23203
18. Kozak, M. (1991) J. Biol. Chem. 266, 19867-19870
19. Shine, J., and Dalgarno, L. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 1342-1346
20. Hsu, L. C., Chang, W.-C., Shibuya, A., and Yoshida, A. (1992) J. Biol. Chem. 267, 3030-3037
21. Doehmer, J., Dogra, S., Friedberg, T., Monier, S., Adesnik, M., Glatt, H., and Oesch, F. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 5769-5773
22. Townsend, A. J., Tu, C. P., and Cowan, K. H. (1992) Mol. Pharmacol. 41, 230-236
23. Hadidi, A.-H., and Idle, J. R. (1988) J. Chromatogr. 427, 121-130
24. Hilton, J. (1984) Biochem. Pharmacol. 33, 1867-1872
25. Lindahl, R., and Feinstein, R. N. (1976) Biochim. Biophys. Acta 452, 345-55
26. Lin, K. H., Leach, M. F., Winters, A. L., and Lindahl, R. (1986) In Vitro Cell. Dev. Biol. 22, 263-272
27. Sladek, N., and Sreerama, L. (1995) Proc. Am. Assoc. Cancer Res. 36, 325
28. Bunting, K. D., and Townsend, A. J. (1996) J. Biol. Chem. 271, 11884-11890