Synthetic spatially graded Rac activation drives cell polarization and movement

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 52, 2012, Pages

  Lin, Benjamin ^a   Holmes, William R ^b,c   Wang, C Joanne ^a   Ueno, Tasuku ^d   Harwell, Andrew ^a   Edelstein Keshet, Leah ^b   Inoue, Takanari ^d   Levchenko, Andre ^a  

^a Johns Hopkins University   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell signaling; Chemotaxis; Signal transduction; Synthetic biology

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; RAC PROTEIN;

ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL MIGRATION; CELL MOTILITY; CELL MOTION; CELL POLARITY; CELL STRUCTURE; CELLULAR DISTRIBUTION; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

CELL MOVEMENT; CELL POLARITY; ENZYME ACTIVATION; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN MULTIMERIZATION; RAC GTP-BINDING PROTEINS; SIROLIMUS; TIME FACTORS;

EID: 84871832583     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1210295109     Document Type: Article

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