MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast

Nature

Volumn 446, Issue 7131, 2007, Pages 46-51

  Paliwal, Saurabh ^a   Iglesias, Pablo A ^a,b   Campbell, Kyle ^c   Hilioti, Zoe ^a   Groisman, Alex ^c   Levchenko, Andre ^a  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHEROMONE; STE 12 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; GENE; GENE EXPRESSION; MATING BEHAVIOR; PHENOTYPE; SEX PHEROMONE; YEAST;

ARTICLE; CELL GROWTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEEDBACK SYSTEM; GENE EXPRESSION; MATING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STOCHASTIC MODEL; WILD TYPE; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 33847394655     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05561     Document Type: Article

References (30)

1. Roberts, C. J. et al. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287, 873-880 (2000).
2. Poritz, M. A., Malmstrom, S., Kim, M. K., Rossmeissl, P. J. & Kamb, A. Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis. Yeast 18, 1331-1338 (2001).
3. Ferrell, J. E. Jr & Machleder, E. M. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280, 895-898 (1998).
4. Jeon, N. L. et al. Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nature Biotechnol. 20, 826-830 (2002).
5. Moore, S. A. Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action. J. Biol. Chem. 258, 13849-13856 (1983).
6. Lee, T. I. et al. Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 298, 799-804 (2002).
7. Angeli, D., Ferrell, J. E. Jr & Sontag, E. D. Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc. Natl Acad. Sci. USA 101, 1822-1827 (2004).
8. Becskei, A., Seraphin, B. & Serrano, L. Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J. 20, 2528-2535 (2001).
9. Biggar, S. R. & Crabtree, G. R. Cell signaling can direct either binary or graded transcriptional responses. EMBO J. 20, 3167-3176 (2001).
10. Ferrell, J. E. Jr. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr. Opin. Cell Biol. 14, 140-148 (2002).
11. Gardner, T. S., Cantor, C. R. & Collins, J. J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342 (2000).
12. Ninfa, A. J. & Mayo, A. E. Hysteresis vs. graded responses: the connections make all the difference. Sci. STKE 232, pe20 (2004).
13. Pomerening, J. R., Sontag, E. D. & Ferrell, J. E. Jr. Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nature Cell Biol. 5, 346-351 (2003).
14. Sha, W. et al. From the cover: hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts. Proc. Natl Acad. Sci. USA 100, 975-980 (2003).
15. Ozbudak, E. M., Thattai, M., Lim, H. N., Shraiman, B. I. & Van Oudenaarden, A. Multistability in the lactose utilization network of Escherichia coli. Nature 427, 737-740 (2004).
16. Bardwell, L., Cook, J. G., Zhu-Shimoni, J. X., Voora, D. & Thorner, J. Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc. Natl Acad. Sci. USA 95, 15400-15405 (1998).
17. Cook, J. G., Bardwell, L. & Thorner, J. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature 390, 85-88 (1997).
18. Madhani, H. D., Styles, C. A. & Fink, G. R. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91, 673-684 (1997).
19. Colman-Lerner, A. et al. Regulated cell-to-cell variation in a cell-fate decision system. Nature 437, 699-706 (2005); erratum Nature 439, 502 (2006).
20. Elion, E. A., Satterberg, B. & Kranz, J. E. FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol. Biol. Cell 4, 495-510 (1993).
21. Farley, F. W., Satterberg, B., Goldsmith, E. J. & Elion, E. A. Relative dependence of different outputs of the Saccharomyces cerevisiae pheromone response pathway on the MAP kinase Fus3p. Genetics 151, 1425-1444 (1999).
22. Matheos, D., Metodiev, M., Muller, E., Stone, D. & Rose, M. D. Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p. J. Cell Biol. 165, 99-109 (2004).
23. Roberts, R. L. & Fink, G. R. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev. 8, 2974-2985 (1994).
24. Bardwell, L. et al. Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev. 12, 2887-2898 (1998).
25. Ma, D., Cook, J. G. & Thorner, J. Phosphorylation and localization of Kss1, a MAP kinase of the Saccharomyces cerevisiae pheromone response pathway. Mol. Biol. Cell 6, 889-909 (1995).
26. Segall, J. E. Polarization of yeast cells in spatial gradients of alpha mating factor. Proc. Natl Acad. Sci. USA 90, 8332-8336 (1993).
27. Janetopoulos, C., Ma, L., Devreotes, P. N. & Iglesias, P. A. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc. Natl Acad. Sci. USA 101, 8951-8956 (2004).
28. Isbister, C. M., Mackenzie, P. J., To, K. C. W. & O'Connor, T. P. Gradient steepness influences the pathfinding decisions of neuronal growth cones in vivo. J. Neurosci. 23, 193-202 (2003).
29. Guthrie, C. & Fink, G. R. (eds) Methods in Enzymology. Guide to Yeast Genetics and Molecular Biology (Academic, San Diego, 1991).
30. Unger, M. A., Chou, H. P., Thorsen, T., Scherer, A. & Quake, S. R. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288, 113-116 (2000).