Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration

PLoS ONE

Volumn 3, Issue 8, 2008, Pages

  Inoue, Takanari ^a,b   Meyer, Tobias ^a  

^a STANFORD UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; RAC PROTEIN; ACTIN; BACTERIAL PROTEIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOTOPROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL POLARITY; CELL STRAIN HL 60; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; GATE CONTROL THEORY; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; POSITIVE FEEDBACK; CELL MOTION; CHEMOTAXIS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

DICTYOSTELIUM DISCOIDEUM; MAMMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; BACTERIAL PROTEINS; CELL MOVEMENT; CELL POLARITY; CHEMOTAXIS; ENZYME ACTIVATION; GTP-BINDING PROTEINS; HL-60 CELLS; HUMANS; LUMINESCENT PROTEINS; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 52449120635     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003068     Document Type: Article

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