메뉴 건너뛰기




Volumn 8, Issue 3, 2012, Pages

How cells integrate complex stimuli: The effect of feedback from phosphoinositides and cell shape on cell polarization and motility

Author keywords

[No Author keywords available]

Indexed keywords

CELL SIGNALING; COMPLEX NETWORKS; POLARIZATION; PROTEINS;

EID: 84861146594     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002402     Document Type: Article
Times cited : (120)

References (103)
  • 1
    • 0033574722 scopus 로고    scopus 로고
    • The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
    • Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, et al. (1999) The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97: 221-231.
    • (1999) Cell , vol.97 , pp. 221-231
    • Rohatgi, R.1    Ma, L.2    Miki, H.3    Lopez, M.4    Kirchhausen, T.5
  • 2
    • 0034683671 scopus 로고    scopus 로고
    • Activation by Cdc42 and PIP2 of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
    • Higgs HN, Pollard TD, (2000) Activation by Cdc42 and PIP2 of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J Cell Biol 150: 1311-1320.
    • (2000) J Cell Biol , vol.150 , pp. 1311-1320
    • Higgs, H.N.1    Pollard, T.D.2
  • 3
    • 0035854732 scopus 로고    scopus 로고
    • Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the NWASP-Arp2/3 pathway
    • doi: 10.1074/jbc.M103856200
    • Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ, (2001) Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the NWASP-Arp2/3 pathway. J Biol Chem 276: 26448-26452 doi:10.1074/jbc.M103856200.
    • (2001) J Biol Chem , vol.276 , pp. 26448-26452
    • Rohatgi, R.1    Nollau, P.2    Ho, H.Y.3    Kirschner, M.W.4    Mayer, B.J.5
  • 4
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • Raftopoulou M, Hall A, (2004) Cell migration: Rho GTPases lead the way. Dev Biol 265: 23-32.
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 5
    • 9444242736 scopus 로고    scopus 로고
    • Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    • Kimura K, Ito M, Amano M, Chihara K, Fukata Y, et al. (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273: 245-248.
    • (1996) Science , vol.273 , pp. 245-248
    • Kimura, K.1    Ito, M.2    Amano, M.3    Chihara, K.4    Fukata, Y.5
  • 6
    • 24944513184 scopus 로고    scopus 로고
    • Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and spontaneous migration of Walker 256 carcinosarcoma cells
    • doi: 10.1016/j.yexcr.2005.05.001
    • Gutjahr MC, Rossy J, Niggli V, (2005) Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and spontaneous migration of Walker 256 carcinosarcoma cells. Exp Cell Res 308: 422-438 doi:10.1016/j.yexcr.2005.05.001.
    • (2005) Exp Cell Res , vol.308 , pp. 422-438
    • Gutjahr, M.C.1    Rossy, J.2    Niggli, V.3
  • 7
    • 33750610850 scopus 로고    scopus 로고
    • Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis
    • doi: 10.1182/blood-2006-01-010363
    • Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, et al. (2006) Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood 108: 2814-2820 doi:10.1182/blood-2006-01-010363.
    • (2006) Blood , vol.108 , pp. 2814-2820
    • Pestonjamasp, K.N.1    Forster, C.2    Sun, C.3    Gardiner, E.M.4    Bohl, B.5
  • 8
    • 76249109093 scopus 로고    scopus 로고
    • Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish
    • doi: 10.1016/j.devcel.2009.11.015
    • Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, et al. (2010) Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell 18: 226-236 doi:10.1016/j.devcel.2009.11.015.
    • (2010) Dev Cell , vol.18 , pp. 226-236
    • Yoo, S.K.1    Deng, Q.2    Cavnar, P.J.3    Wu, Y.I.4    Hahn, K.M.5
  • 9
    • 0037205265 scopus 로고    scopus 로고
    • Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
    • Funamoto S, Meili R, Lee S, Parry L, Firtel RA, (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109: 611-623.
    • (2002) Cell , vol.109 , pp. 611-623
    • Funamoto, S.1    Meili, R.2    Lee, S.3    Parry, L.4    Firtel, R.A.5
  • 10
    • 0037205230 scopus 로고    scopus 로고
    • Tumor suppressor PTEN mediates sensing of chemoattractant gradients
    • Iijima M, Devreotes P, (2002) Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109: 599-610.
    • (2002) Cell , vol.109 , pp. 599-610
    • Iijima, M.1    Devreotes, P.2
  • 11
    • 0038247883 scopus 로고    scopus 로고
    • Receptormediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells
    • doi: 10.1091/mbc.E02-10-0703
    • Huang YE, Iijima M, Parent CA, Funamoto S, Firtel RA, et al. (2003) Receptormediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell 14: 1913-1922 doi:10.1091/mbc.E02-10-0703.
    • (2003) Mol Biol Cell , vol.14 , pp. 1913-1922
    • Huang, Y.E.1    Iijima, M.2    Parent, C.A.3    Funamoto, S.4    Firtel, R.A.5
  • 12
    • 0033605541 scopus 로고    scopus 로고
    • Crosstalk between Rac and Rho
    • Burridge K, (1999) Crosstalk between Rac and Rho. Science 283: 2028-2029.
    • (1999) Science , vol.283 , pp. 2028-2029
    • Burridge, K.1
  • 13
    • 0036781979 scopus 로고    scopus 로고
    • How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics
    • Giniger E, (2002) How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics. Differentiation 70: 385-396.
    • (2002) Differentiation , vol.70 , pp. 385-396
    • Giniger, E.1
  • 14
    • 13444311711 scopus 로고    scopus 로고
    • Concentric zones of active RhoA and Cdc42 around single cell wounds
    • doi: 10.1083/jcb.200411109
    • Benink HA, Bement WM, (2005) Concentric zones of active RhoA and Cdc42 around single cell wounds. J Cell Biol 168: 429-439 doi:10.1083/jcb.200411109.
    • (2005) J Cell Biol , vol.168 , pp. 429-439
    • Benink, H.A.1    Bement, W.M.2
  • 15
    • 0034628109 scopus 로고    scopus 로고
    • Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
    • Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, et al. (2000) Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol 10: 153-156.
    • (2000) Curr Biol , vol.10 , pp. 153-156
    • Tolias, K.F.1    Hartwig, J.H.2    Ishihara, H.3    Shibasaki, Y.4    Cantley, L.C.5
  • 16
    • 0141866654 scopus 로고    scopus 로고
    • The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity
    • doi: 10.1074/jbc.M307001200
    • Van Hennik PB, Ten Klooster JP, Halstead JR, Voermans C, Anthony EC, et al. (2003) The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem 278: 39166-39175 doi:10.1074/jbc.M307001200.
    • (2003) J Biol Chem , vol.278 , pp. 39166-39175
    • Van Hennik, P.B.1    Ten Klooster, J.P.2    Halstead, J.R.3    Voermans, C.4    Anthony, E.C.5
  • 17
    • 0036308972 scopus 로고    scopus 로고
    • A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
    • doi: 10.1038/ncb811
    • Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, et al. (2002) A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4: 509-513 doi:10.1038/ncb811.
    • (2002) Nat Cell Biol , vol.4 , pp. 509-513
    • Weiner, O.D.1    Neilsen, P.O.2    Prestwich, G.D.3    Kirschner, M.W.4    Cantley, L.C.5
  • 19
    • 33745308103 scopus 로고    scopus 로고
    • PI3K and RAC signalling in leukocyte and cancer cell migration
    • Barber MA, Welch HC, (2006) PI3K and RAC signalling in leukocyte and cancer cell migration. Bull Cancer 93: E44-E52.
    • (2006) Bull Cancer , vol.93
    • Barber, M.A.1    Welch, H.C.2
  • 20
    • 0028338545 scopus 로고
    • Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
    • Zheng Y, Bagrodia S, Cerione RA, (1994) Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem 269: 18727-18730.
    • (1994) J Biol Chem , vol.269 , pp. 18727-18730
    • Zheng, Y.1    Bagrodia, S.2    Cerione, R.A.3
  • 21
    • 0037155727 scopus 로고    scopus 로고
    • PRex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac
    • Welch HCE, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, et al. (2002) PRex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac. Cell 108: 809-821.
    • (2002) Cell , vol.108 , pp. 809-821
    • Welch, H.C.E.1    Coadwell, W.J.2    Ellson, C.D.3    Ferguson, G.J.4    Andrews, S.R.5
  • 22
    • 0037415640 scopus 로고    scopus 로고
    • Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
    • doi: 10.1083/jcb.200208179
    • Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, et al. (2003) Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160: 375-385 doi:10.1083/jcb.200208179.
    • (2003) J Cell Biol , vol.160 , pp. 375-385
    • Srinivasan, S.1    Wang, F.2    Glavas, S.3    Ott, A.4    Hofmann, F.5
  • 23
    • 18244392909 scopus 로고    scopus 로고
    • Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells
    • doi: 10.1091/mbc.E04-10-0904
    • Aoki K, Nakamura T, Fujikawa K, Matsuda M, (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell 16: 2207-2217 doi:10.1091/mbc.E04-10-0904.
    • (2005) Mol Biol Cell , vol.16 , pp. 2207-2217
    • Aoki, K.1    Nakamura, T.2    Fujikawa, K.3    Matsuda, M.4
  • 24
    • 20244379418 scopus 로고    scopus 로고
    • Regulation of PTEN by Rho small GTPases
    • doi: 10.1038/ncb1236
    • Li Z, Dong X, Wang Z, Liu W, Deng N, et al. (2005) Regulation of PTEN by Rho small GTPases. Nat Cell Biol 7: 399-404 doi:10.1038/ncb1236.
    • (2005) Nat Cell Biol , vol.7 , pp. 399-404
    • Li, Z.1    Dong, X.2    Wang, Z.3    Liu, W.4    Deng, N.5
  • 25
    • 33846781374 scopus 로고    scopus 로고
    • Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell
    • doi: 10.1529/biophysj.106.090514
    • Dawes AT, Edelstein-Keshet L, (2007) Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J 92: 744-768 doi:10.1529/biophysj.106.090514.
    • (2007) Biophys J , vol.92 , pp. 744-768
    • Dawes, A.T.1    Edelstein-Keshet, L.2
  • 26
    • 0033617576 scopus 로고    scopus 로고
    • A cell's sense of direction
    • Parent CA, Devreotes PN, (1999) A cell's sense of direction. Science 284: 765-770.
    • (1999) Science , vol.284 , pp. 765-770
    • Parent, C.A.1    Devreotes, P.N.2
  • 27
    • 0034676001 scopus 로고    scopus 로고
    • Role of the PI3K regulatory subunit in the control of actin organization and cell migration
    • Jiménez C, Portela RA, Mellado M, Rodríguez-Frade JM, Collard J, et al. (2000) Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol 151: 249-262.
    • (2000) J Cell Biol , vol.151 , pp. 249-262
    • Jiménez, C.1    Portela, R.A.2    Mellado, M.3    Rodríguez-Frade, J.M.4    Collard, J.5
  • 29
    • 0036308458 scopus 로고    scopus 로고
    • Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
    • doi: 10.1038/ncb810
    • Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, et al. (2002) Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol 4: 513-518 doi:10.1038/ncb810.
    • (2002) Nat Cell Biol , vol.4 , pp. 513-518
    • Wang, F.1    Herzmark, P.2    Weiner, O.D.3    Srinivasan, S.4    Servant, G.5
  • 30
    • 33745384269 scopus 로고    scopus 로고
    • Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase
    • doi: 10.1091/mbc.E05-09-0825
    • Loovers HM, Postma M, Keizer-Gunnink I, Huang YE, Devreotes PN, et al. (2006) Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell 17: 1503-1513 doi:10.1091/mbc.E05-09-0825.
    • (2006) Mol Biol Cell , vol.17 , pp. 1503-1513
    • Loovers, H.M.1    Postma, M.2    Keizer-Gunnink, I.3    Huang, Y.E.4    Devreotes, P.N.5
  • 31
    • 34247361650 scopus 로고    scopus 로고
    • Chemotaxis in the absence of PIP3 gradients
    • doi: 10.1016/j.cub.2007.04.004
    • Hoeller O, Kay RR, (2007) Chemotaxis in the absence of PIP3 gradients. Curr Biol 17: 813-817 doi:10.1016/j.cub.2007.04.004.
    • (2007) Curr Biol , vol.17 , pp. 813-817
    • Hoeller, O.1    Kay, R.R.2
  • 32
    • 34548459788 scopus 로고    scopus 로고
    • Chemotaxis: navigating by multiple signaling pathways
    • doi: 10.1126/stke.3962007pe40
    • Van Haastert PJ, Veltman DM, (2007) Chemotaxis: navigating by multiple signaling pathways. Sci STKE 2007: pe40 doi:10.1126/stke.3962007pe40.
    • (2007) Sci STKE , vol.2007
    • Van Haastert, P.J.1    Veltman, D.M.2
  • 33
    • 44349180298 scopus 로고    scopus 로고
    • Moving towards a better understanding of chemotaxis
    • doi: 10.1016/j.cub.2008.04.048
    • Stephens L, Milne L, Hawkins P, (2008) Moving towards a better understanding of chemotaxis. Curr Biol 18: R485-R494 doi:10.1016/j.cub.2008.04.048.
    • (2008) Curr Biol , vol.18
    • Stephens, L.1    Milne, L.2    Hawkins, P.3
  • 34
    • 34547699211 scopus 로고    scopus 로고
    • Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk
    • doi: 10.1007/s11538-007-9200-6
    • Jilkine A, Marée AFM, Edelstein-Keshet L, (2007) Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk. Bull Math Biol 69: 1943-1978 doi:10.1007/s11538-007-9200-6.
    • (2007) Bull Math Biol , vol.69 , pp. 1943-1978
    • Jilkine, A.1    Marée, A.F.M.2    Edelstein-Keshet, L.3
  • 35
    • 43649095122 scopus 로고    scopus 로고
    • Wave-pinning and cell polarity from a bistable reaction-diffusion system
    • doi: 10.1529/biophysj.107.120824
    • Mori Y, Jilkine A, Edelstein-Keshet L, (2008) Wave-pinning and cell polarity from a bistable reaction-diffusion system. Biophys J 94: 3684-3697 doi:10.1529/biophysj.107.120824.
    • (2008) Biophys J , vol.94 , pp. 3684-3697
    • Mori, Y.1    Jilkine, A.2    Edelstein-Keshet, L.3
  • 36
    • 33745608331 scopus 로고    scopus 로고
    • Polarization and movement of keratocytes: a multiscale modelling approach
    • doi: 10.1007/s11538-006-9131-7
    • Marée AFM, Jilkine A, Dawes A, Grieneisen VA, Edelstein-Keshet L, (2006) Polarization and movement of keratocytes: a multiscale modelling approach. Bull Math Biol 68: 1169-1211 doi:10.1007/s11538-006-9131-7.
    • (2006) Bull Math Biol , vol.68 , pp. 1169-1211
    • Marée, A.F.M.1    Jilkine, A.2    Dawes, A.3    Grieneisen, V.A.4    Edelstein-Keshet, L.5
  • 37
    • 0029775654 scopus 로고    scopus 로고
    • Cell motility driven by actin polymerization
    • Mogilner A, Oster G, (1996) Cell motility driven by actin polymerization. Biophys J 71: 3030-3045.
    • (1996) Biophys J , vol.71 , pp. 3030-3045
    • Mogilner, A.1    Oster, G.2
  • 38
    • 0029907075 scopus 로고    scopus 로고
    • The physics of lamellipodial protrusion
    • Mogilner A, Oster G, (1996) The physics of lamellipodial protrusion. Eur Biophys J 25: 47-53.
    • (1996) Eur Biophys J , vol.25 , pp. 47-53
    • Mogilner, A.1    Oster, G.2
  • 39
    • 0037339268 scopus 로고    scopus 로고
    • Force generation by actin polymerization II: the elastic ratchet and tethered filaments
    • Mogilner A, Oster G, (2003) Force generation by actin polymerization II: the elastic ratchet and tethered filaments. Biophys J 84: 1591-1605.
    • (2003) Biophys J , vol.84 , pp. 1591-1605
    • Mogilner, A.1    Oster, G.2
  • 40
    • 0000825469 scopus 로고
    • Simulation of the differential adhesion driven rearrangement of biological cells
    • Glazier JA, Graner F, (1993) Simulation of the differential adhesion driven rearrangement of biological cells. Phys Rev E 47: 2128-2154.
    • (1993) Phys Rev E , vol.47 , pp. 2128-2154
    • Glazier, J.A.1    Graner, F.2
  • 41
    • 36749017820 scopus 로고    scopus 로고
    • The Cellular Potts Model and biophysical properties of cells, tissues and morphogenesis
    • In: Anderson ARA, Chaplain MAJ, Rejniak KA, editors, Basel, Birkhäuser Verlag
    • Marée AFM, Grieneisen VA, Hogeweg P, (2007) The Cellular Potts Model and biophysical properties of cells, tissues and morphogenesis. In: Anderson ARA, Chaplain MAJ, Rejniak KA, editors. Single-Cell-Based Models in Biology and Medicine Basel Birkhäuser Verlag pp. 107-136.
    • (2007) Single-Cell-Based Models in Biology and Medicine , pp. 107-136
    • Marée, A.F.M.1    Grieneisen, V.A.2    Hogeweg, P.3
  • 42
    • 77958411749 scopus 로고
    • Nonlocal reaction-diffusion equations and nucleation
    • Rubinstein J, Sternberg P, (1992) Nonlocal reaction-diffusion equations and nucleation. IMA J Appl Math 48: 249-264.
    • (1992) IMA J Appl Math , vol.48 , pp. 249-264
    • Rubinstein, J.1    Sternberg, P.2
  • 43
    • 21844498456 scopus 로고
    • Motion by curvature in generalized Cahn-Allen models
    • Fife PC, Lacey AA, (1994) Motion by curvature in generalized Cahn-Allen models. J Stat Phys 77: 173-181.
    • (1994) J Stat Phys , vol.77 , pp. 173-181
    • Fife, P.C.1    Lacey, A.A.2
  • 44
    • 0030269055 scopus 로고    scopus 로고
    • Metastable bubble solutions for the Allen-Cahn equation with mass conservation
    • Ward MJ, (1996) Metastable bubble solutions for the Allen-Cahn equation with mass conservation. SIAM J Appl Math 56: 1247-1279.
    • (1996) SIAM J Appl Math , vol.56 , pp. 1247-1279
    • Ward, M.J.1
  • 45
    • 2942687012 scopus 로고    scopus 로고
    • Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
    • doi: 10.1073/pnas.0402152101
    • Janetopoulos C, Ma L, Devreotes PN, Iglesias PA, (2004) Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci USA 101: 8951-8956 doi:10.1073/pnas.0402152101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8951-8956
    • Janetopoulos, C.1    Ma, L.2    Devreotes, P.N.3    Iglesias, P.A.4
  • 46
  • 48
    • 33751193244 scopus 로고    scopus 로고
    • Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification
    • doi: 10.1088/1478-3975/3/3/004
    • Onsum MD, Wong K, Herzmark P, Bourne HR, Arkin AP, (2006) Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification. Phys Biol 3: 190-199 doi:10.1088/1478-3975/3/3/004.
    • (2006) Phys Biol , vol.3 , pp. 190-199
    • Onsum, M.D.1    Wong, K.2    Herzmark, P.3    Bourne, H.R.4    Arkin, A.P.5
  • 49
    • 33644524741 scopus 로고    scopus 로고
    • Cell-signalling dynamics in time and space
    • doi: 10.1038/nrm1838
    • Kholodenko BN, (2006) Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol 7: 165-176 doi:10.1038/nrm1838.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 165-176
    • Kholodenko, B.N.1
  • 50
    • 43049156015 scopus 로고    scopus 로고
    • Cell shape and negative links in regulatory motifs together control spatial information ow in signaling networks
    • doi: 10.1016/j.cell.2008.04.025
    • Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, et al. (2008) Cell shape and negative links in regulatory motifs together control spatial information ow in signaling networks. Cell 133: 666-680 doi:10.1016/j.cell.2008.04.025.
    • (2008) Cell , vol.133 , pp. 666-680
    • Neves, S.R.1    Tsokas, P.2    Sarkar, A.3    Grace, E.A.4    Rangamani, P.5
  • 51
    • 26844552092 scopus 로고    scopus 로고
    • Directional cell expansion - turning toward actin
    • doi: 10.1016/j.pbi.2005.09.002
    • Bannigan A, Baskin TI, (2005) Directional cell expansion- turning toward actin. Curr Opin Plant Biol 8: 619-624 doi:10.1016/j.pbi.2005.09.002.
    • (2005) Curr Opin Plant Biol , vol.8 , pp. 619-624
    • Bannigan, A.1    Baskin, T.I.2
  • 52
    • 26844464353 scopus 로고    scopus 로고
    • Cell polarity: ROPing the ends together
    • doi: 10.1016/j.pbi.2005.09.003
    • Xu J, Scheres B, (2005) Cell polarity: ROPing the ends together. Curr Opin Plant Biol 8: 613-618 doi:10.1016/j.pbi.2005.09.003.
    • (2005) Curr Opin Plant Biol , vol.8 , pp. 613-618
    • Xu, J.1    Scheres, B.2
  • 53
    • 33745040523 scopus 로고    scopus 로고
    • RAC/ROP GTPases: 'hubs' for signal integration and diversification in plants
    • doi: 10.1016/j.tplants.2006.04.003
    • Nibau C, Wu HM, Cheung AY, (2006) RAC/ROP GTPases: 'hubs' for signal integration and diversification in plants. Trends Plant Sci 11: 309-315 doi:10.1016/j.tplants.2006.04.003.
    • (2006) Trends Plant Sci , vol.11 , pp. 309-315
    • Nibau, C.1    Wu, H.M.2    Cheung, A.Y.3
  • 54
    • 33745584806 scopus 로고    scopus 로고
    • A RHOse by any other name: a comparative analysis of animal and plant Rho GTPases
    • doi: 10.1038/sj.cr.7310055
    • Brembu T, Winge P, Bones AM, Yang Z, (2006) A RHOse by any other name: a comparative analysis of animal and plant Rho GTPases. Cell Res 16: 435-445 doi:10.1038/sj.cr.7310055.
    • (2006) Cell Res , vol.16 , pp. 435-445
    • Brembu, T.1    Winge, P.2    Bones, A.M.3    Yang, Z.4
  • 55
    • 40849133915 scopus 로고    scopus 로고
    • Structure and function of Rho-type molecular switches in plants
    • doi: 10.1016/j.plaphy.2007.12.008
    • Berken A, Wittinghofer A, (2008) Structure and function of Rho-type molecular switches in plants. Plant Physiol Biochem 46: 380-393 doi:10.1016/j.plaphy.2007.12.008.
    • (2008) Plant Physiol Biochem , vol.46 , pp. 380-393
    • Berken, A.1    Wittinghofer, A.2
  • 56
    • 32544447023 scopus 로고    scopus 로고
    • Turning ON the switch - RhoGEFs in plants
    • doi: 10.1016/j.tplants.2005.12.001
    • Shichrur K, Yalovsky S, (2006) Turning ON the switch - RhoGEFs in plants. Trends Plant Sci 11: 57-59 doi:10.1016/j.tplants.2005.12.001.
    • (2006) Trends Plant Sci , vol.11 , pp. 57-59
    • Shichrur, K.1    Yalovsky, S.2
  • 57
    • 69949185998 scopus 로고    scopus 로고
    • Coordination of Rho GTPase activities during cell protrusion
    • doi: 10.1038/nature08242
    • Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, et al. (2009) Coordination of Rho GTPase activities during cell protrusion. Nature 461: 99-103 doi:10.1038/nature08242.
    • (2009) Nature , vol.461 , pp. 99-103
    • Machacek, M.1    Hodgson, L.2    Welch, C.3    Elliott, H.4    Pertz, O.5
  • 58
    • 30744462559 scopus 로고    scopus 로고
    • A RhoGDP dissociation inhibitor spatially regulates growth in root hair cells
    • doi: 10.1038/nature04198
    • Carol RJ, Takeda S, Linstead P, Durrant MC, Kakesova H, et al. (2005) A RhoGDP dissociation inhibitor spatially regulates growth in root hair cells. Nature 438: 1013-1016 doi:10.1038/nature04198.
    • (2005) Nature , vol.438 , pp. 1013-1016
    • Carol, R.J.1    Takeda, S.2    Linstead, P.3    Durrant, M.C.4    Kakesova, H.5
  • 59
    • 20344366927 scopus 로고    scopus 로고
    • Uncovering directional sensing: where are we headed?
    • Krishnan J, Iglesias PA, (2004) Uncovering directional sensing: where are we headed? Syst Biol (Stevenage) 1: 54-61.
    • (2004) Syst Biol (Stevenage) , vol.1 , pp. 54-61
    • Krishnan, J.1    Iglesias, P.A.2
  • 60
    • 33748272313 scopus 로고    scopus 로고
    • Moving toward understanding eukaryotic chemotaxis
    • doi: 10.1016/j.ejcb.2006.04.008
    • Jin T, Hereld D, (2006) Moving toward understanding eukaryotic chemotaxis. Eur J Cell Biol 85: 905-913 doi:10.1016/j.ejcb.2006.04.008.
    • (2006) Eur J Cell Biol , vol.85 , pp. 905-913
    • Jin, T.1    Hereld, D.2
  • 61
    • 36549007483 scopus 로고    scopus 로고
    • Chemotaxis in Dictyostelium: how to walk straight using parallel pathways
    • doi: 10.1016/j.mib.2007.10.004
    • Insall R, Andrew N, (2007) Chemotaxis in Dictyostelium: how to walk straight using parallel pathways. Curr Opin Microbiol 10: 578-581 doi:10.1016/j.mib.2007.10.004.
    • (2007) Curr Opin Microbiol , vol.10 , pp. 578-581
    • Insall, R.1    Andrew, N.2
  • 62
    • 0034866573 scopus 로고    scopus 로고
    • A diffusion-translocation model for gradient sensing by chemotactic cells
    • Postma M, Van Haastert PJM, (2001) A diffusion-translocation model for gradient sensing by chemotactic cells. Biophys J 81: 1314-1323.
    • (2001) Biophys J , vol.81 , pp. 1314-1323
    • Postma, M.1    Van Haastert, P.J.M.2
  • 63
    • 28044473385 scopus 로고    scopus 로고
    • Diffusionlimited phase separation in eukaryotic chemotaxis
    • doi: 10.1073/pnas.0503974102
    • Gamba A, De Candia A, Di Talia S, Coniglio A, Bussolino F, et al. (2005) Diffusionlimited phase separation in eukaryotic chemotaxis. Proc Natl Acad Sci U S A 102: 16927-16932 doi:10.1073/pnas.0503974102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16927-16932
    • Gamba, A.1    De Candia, A.2    Di Talia, S.3    Coniglio, A.4    Bussolino, F.5
  • 64
    • 21844452715 scopus 로고    scopus 로고
    • Distinguishing modes of eukaryotic gradient sensing
    • doi: 10.1529/biophysj.105.061564
    • Skupsky R, Losert W, Nossal RJ, (2005) Distinguishing modes of eukaryotic gradient sensing. Biophys J 89: 2806-2823 doi:10.1529/biophysj.105.061564.
    • (2005) Biophys J , vol.89 , pp. 2806-2823
    • Skupsky, R.1    Losert, W.2    Nossal, R.J.3
  • 65
    • 34347352254 scopus 로고    scopus 로고
    • A mass conserved reaction-diffusion system captures properties of cell polarity
    • doi: 10.1371/journal.pcbi.0030108
    • Otsuji M, Ishihara S, Co C, Kaibuchi K, Mochizuki A, et al. (2007) A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol 3: e108 doi:10.1371/journal.pcbi.0030108.
    • (2007) PLoS Comput Biol , vol.3
    • Otsuji, M.1    Ishihara, S.2    Co, C.3    Kaibuchi, K.4    Mochizuki, A.5
  • 66
    • 42049115235 scopus 로고    scopus 로고
    • Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity
    • doi: 10.1016/j.febslet.2008.03.029
    • Goryachev AB, Pokhilko AV, (2008) Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Lett 582: 1437-1443 doi:10.1016/j.febslet.2008.03.029.
    • (2008) FEBS Lett , vol.582 , pp. 1437-1443
    • Goryachev, A.B.1    Pokhilko, A.V.2
  • 67
    • 49649089500 scopus 로고    scopus 로고
    • On the spontaneous emergence of cell polarity
    • doi: 10.1038/nature07119
    • Altschuler SJ, Angenent SB, Wang Y, Wu LF, (2008) On the spontaneous emergence of cell polarity. Nature 454: 886-889 doi:10.1038/nature07119.
    • (2008) Nature , vol.454 , pp. 886-889
    • Altschuler, S.J.1    Angenent, S.B.2    Wang, Y.3    Wu, L.F.4
  • 68
    • 0032823984 scopus 로고    scopus 로고
    • Orientation of chemotactic cells and growth cones: models and mechanisms
    • Meinhardt H, (1999) Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci 112: 2867-2874.
    • (1999) J Cell Sci , vol.112 , pp. 2867-2874
    • Meinhardt, H.1
  • 69
    • 33646764616 scopus 로고    scopus 로고
    • Spontaneous polarization in eukaryotic gradient sensing: A mathematical model based on mutual inhibition of frontness and backness pathways
    • doi: 10.1016/j.jtbi.2005.10.022
    • Narang A, (2006) Spontaneous polarization in eukaryotic gradient sensing: A mathematical model based on mutual inhibition of frontness and backness pathways. J Theor Biol 240: 538-553 doi:10.1016/j.jtbi.2005.10.022.
    • (2006) J Theor Biol , vol.240 , pp. 538-553
    • Narang, A.1
  • 70
    • 0036219106 scopus 로고    scopus 로고
    • Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils
    • Levchenko A, Iglesias PA, (2002) Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils. Biophys J 82: 50-63.
    • (2002) Biophys J , vol.82 , pp. 50-63
    • Levchenko, A.1    Iglesias, P.A.2
  • 71
    • 10044250005 scopus 로고    scopus 로고
    • Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in Dictyostelium cells
    • doi: 10.1529/biophysj.104.045484
    • Ma L, Janetopoulos C, Yang L, Devreotes PN, Iglesias PA, (2004) Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in Dictyostelium cells. Biophys J 87: 3764-3774 doi:10.1529/biophysj.104.045484.
    • (2004) Biophys J , vol.87 , pp. 3764-3774
    • Ma, L.1    Janetopoulos, C.2    Yang, L.3    Devreotes, P.N.4    Iglesias, P.A.5
  • 72
    • 0242390532 scopus 로고    scopus 로고
    • Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia
    • doi: 10.1007/s00249-003-0300-4
    • Grimm HP, Verkhovsky AB, Mogilner A, Meister JJ, (2003) Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia. Eur Biophys J 32: 563-577 doi:10.1007/s00249-003-0300-4.
    • (2003) Eur Biophys J , vol.32 , pp. 563-577
    • Grimm, H.P.1    Verkhovsky, A.B.2    Mogilner, A.3    Meister, J.J.4
  • 73
    • 34548475260 scopus 로고    scopus 로고
    • Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
    • doi: 10.1371/journal.pbio.0050233
    • Lacayo CI, Pincus Z, VanDuijn MM, Wilson CA, Fletcher DA, et al. (2007) Emergence of large-scale cell morphology and movement from local actin filament growth dynamics. PLoS Biol 5: e233 doi:10.1371/journal.pbio.0050233.
    • (2007) PLoS Biol , vol.5
    • Lacayo, C.I.1    Pincus, Z.2    VanDuijn, M.M.3    Wilson, C.A.4    Fletcher, D.A.5
  • 74
    • 44349186015 scopus 로고    scopus 로고
    • Mechanism of shape determination in motile cells
    • doi: 10.1038/nature06952
    • Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, et al. (2008) Mechanism of shape determination in motile cells. Nature 453: 475-480 doi:10.1038/nature06952.
    • (2008) Nature , vol.453 , pp. 475-480
    • Keren, K.1    Pincus, Z.2    Allen, G.M.3    Barnhart, E.L.4    Marriott, G.5
  • 76
    • 21844458415 scopus 로고    scopus 로고
    • Multiscale two-dimensional modeling of a motile simple-shaped cell
    • Rubinstein B, Jacobson K, Mogilner A, (2005) Multiscale two-dimensional modeling of a motile simple-shaped cell. SIAM Multiscale Model Simul 3: 413-439.
    • (2005) SIAM Multiscale Model Simul , vol.3 , pp. 413-439
    • Rubinstein, B.1    Jacobson, K.2    Mogilner, A.3
  • 77
    • 52049116961 scopus 로고    scopus 로고
    • Modeling cellular deformations using the level set formalism
    • doi: 10.1186/1752-0509-2-68
    • Yang L, Effler JC, Kutscher BL, Sullivan SE, Robinson DN, et al. (2008) Modeling cellular deformations using the level set formalism. BMC Syst Biol 2: 68 doi:10.1186/1752-0509-2-68.
    • (2008) BMC Syst Biol , vol.2 , pp. 68
    • Yang, L.1    Effler, J.C.2    Kutscher, B.L.3    Sullivan, S.E.4    Robinson, D.N.5
  • 78
    • 77955267573 scopus 로고    scopus 로고
    • The Moving Boundary Node Method: A level setbased, finite volume algorithm with applications to cell motility
    • doi: 10.1016/j.jcp.2010.06.014
    • Wolgemuth CW, Zajac M, (2010) The Moving Boundary Node Method: A level setbased, finite volume algorithm with applications to cell motility. J Comput Phys 229: 7287-7308 doi:10.1016/j.jcp.2010.06.014.
    • (2010) J Comput Phys , vol.229 , pp. 7287-7308
    • Wolgemuth, C.W.1    Zajac, M.2
  • 79
    • 78149334276 scopus 로고    scopus 로고
    • Simulating biochemical signaling networks in complex moving geometries
    • Strychalski W, Adalsteinsson D, Elston T, (2010) Simulating biochemical signaling networks in complex moving geometries. SIAM J Sci Comput 32: 3039-3070.
    • (2010) SIAM J Sci Comput , vol.32 , pp. 3039-3070
    • Strychalski, W.1    Adalsteinsson, D.2    Elston, T.3
  • 80
    • 77956336109 scopus 로고    scopus 로고
    • Computational model for cell morphodynamics
    • Shao D, Rappel WJ, Levine H, (2010) Computational model for cell morphodynamics. Phys Rev Lett 105: 108104.
    • (2010) Phys Rev Lett , vol.105 , pp. 108104
    • Shao, D.1    Rappel, W.J.2    Levine, H.3
  • 81
    • 43649107536 scopus 로고    scopus 로고
    • Exploring the control circuit of cell migration by mathematical modeling
    • doi: 10.1529/biophysj.107.117002
    • Satulovsky J, Lui R, Wang YL, (2008) Exploring the control circuit of cell migration by mathematical modeling. Biophys J 94: 3671-3683 doi:10.1529/biophysj.107.117002.
    • (2008) Biophys J , vol.94 , pp. 3671-3683
    • Satulovsky, J.1    Lui, R.2    Wang, Y.L.3
  • 82
    • 39149130598 scopus 로고    scopus 로고
    • The inuence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing
    • doi: 10.1016/j.cub.2007.11.049
    • Farhadifar R, Roper JC, Aigouy B, Eaton S, Julicher F, (2007) The inuence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing. Curr Biol 17: 2095-2104 doi:10.1016/j.cub.2007.11.049.
    • (2007) Curr Biol , vol.17 , pp. 2095-2104
    • Farhadifar, R.1    Roper, J.C.2    Aigouy, B.3    Eaton, S.4    Julicher, F.5
  • 83
    • 34547191723 scopus 로고    scopus 로고
    • Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
    • doi: 10.1038/nrm2222
    • Lecuit T, Lenne PF, (2007) Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol 8: 633-644 doi:10.1038/nrm2222.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 633-644
    • Lecuit, T.1    Lenne, P.F.2
  • 84
    • 38949170737 scopus 로고    scopus 로고
    • Physical modeling of cell geometric order in an epithelial tissue
    • doi: 10.1073/pnas.0711077105
    • Hilgenfeldt S, Erisken S, Carthew RW, (2008) Physical modeling of cell geometric order in an epithelial tissue. Proc Natl Acad Sci U S A 105: 907-911 doi:10.1073/pnas.0711077105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 907-911
    • Hilgenfeldt, S.1    Erisken, S.2    Carthew, R.W.3
  • 85
    • 33750619877 scopus 로고    scopus 로고
    • Potential for control of signaling pathways via cell size and shape
    • doi: 10.1016/j.cub.2006.07.056
    • Meyers J, Craig J, Odde DJ, (2006) Potential for control of signaling pathways via cell size and shape. Curr Biol 16: 1685-1693 doi:10.1016/j.cub.2006.07.056.
    • (2006) Curr Biol , vol.16 , pp. 1685-1693
    • Meyers, J.1    Craig, J.2    Odde, D.J.3
  • 86
    • 0000135489 scopus 로고
    • Simulation of biological cell sorting using a twodimensional extended Potts model
    • Graner F, Glazier JA, (1992) Simulation of biological cell sorting using a twodimensional extended Potts model. Phys Rev Lett 69: 2013-2016.
    • (1992) Phys Rev Lett , vol.69 , pp. 2013-2016
    • Graner, F.1    Glazier, J.A.2
  • 87
    • 0000313998 scopus 로고
    • Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of uctuations
    • Mombach JCM, Glazier JA, Raphael RC, Zajac M, (1995) Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of uctuations. Phys Rev Lett 75: 2244-2247.
    • (1995) Phys Rev Lett , vol.75 , pp. 2244-2247
    • Mombach, J.C.M.1    Glazier, J.A.2    Raphael, R.C.3    Zajac, M.4
  • 88
    • 0036708436 scopus 로고    scopus 로고
    • Regulation of actin dynamics in rapidly moving cells: a quantitative analysis
    • Mogilner A, Edelstein-Keshet L, (2002) Regulation of actin dynamics in rapidly moving cells: a quantitative analysis. Biophys J 83: 1237-1258.
    • (2002) Biophys J , vol.83 , pp. 1237-1258
    • Mogilner, A.1    Edelstein-Keshet, L.2
  • 89
    • 0032819362 scopus 로고    scopus 로고
    • The actin-based nanomachine at the leading edge of migrating cells
    • Abraham VC, Krishnamurthi V, Taylor DL, Lanni F, (1999) The actin-based nanomachine at the leading edge of migrating cells. Biophys J 77: 1721-1732.
    • (1999) Biophys J , vol.77 , pp. 1721-1732
    • Abraham, V.C.1    Krishnamurthi, V.2    Taylor, D.L.3    Lanni, F.4
  • 90
    • 0002058827 scopus 로고
    • The numerical solution of parabolic and elliptic differential equations
    • Peaceman DW, Rachford HH Jr, (1955) The numerical solution of parabolic and elliptic differential equations. J Soc Indust Appl Math 3: 28-41.
    • (1955) J Soc Indust Appl Math , vol.3 , pp. 28-41
    • Peaceman, D.W.1    Rachford Jr., H.H.2
  • 93
    • 33747167610 scopus 로고    scopus 로고
    • Actin filament branching and protrusion velocity in a simple 1D model of a motile cell
    • doi: 10.1016/j.jtbi.2006.02.017
    • Dawes AT, Bard Ermentrout G, Cytrynbaum EN, Edelstein-Keshet L, (2006) Actin filament branching and protrusion velocity in a simple 1D model of a motile cell. J Theor Biol 242: 265-279 doi:10.1016/j.jtbi.2006.02.017.
    • (2006) J Theor Biol , vol.242 , pp. 265-279
    • Dawes, A.T.1    Bard Ermentrout, G.2    Cytrynbaum, E.N.3    Edelstein-Keshet, L.4
  • 94
    • 0029737609 scopus 로고    scopus 로고
    • Novel form of actinbased motility transports bacteria on the surfaces of infected cells
    • Sanger JM, Chang R, Ashton F, Kaper JB, Sanger JW, (1996) Novel form of actinbased motility transports bacteria on the surfaces of infected cells. Cell Motil Cytoskeleton 34: 279-287.
    • (1996) Cell Motil Cytoskeleton , vol.34 , pp. 279-287
    • Sanger, J.M.1    Chang, R.2    Ashton, F.3    Kaper, J.B.4    Sanger, J.W.5
  • 95
    • 0033895234 scopus 로고    scopus 로고
    • Molecular mechanisms controlling actin filament dynamics in nonmuscle cells
    • doi: 10.1146/annurev.biophys.29.1.545
    • Pollard TD, Blanchoin L, Mullins RD, (2000) Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct 29: 545-576 doi:10.1146/annurev.biophys.29.1.545.
    • (2000) Annu Rev Biophys Biomol Struct , vol.29 , pp. 545-576
    • Pollard, T.D.1    Blanchoin, L.2    Mullins, R.D.3
  • 96
    • 0037459075 scopus 로고    scopus 로고
    • Cellular motility driven by assembly and disassembly of actin filaments
    • Pollard TD, Borisy GG, (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112: 453-465.
    • (2003) Cell , vol.112 , pp. 453-465
    • Pollard, T.D.1    Borisy, G.G.2
  • 97
    • 0029795850 scopus 로고    scopus 로고
    • Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides
    • Schafer DA, Jennings PB, Cooper JA, (1996) Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J Cell Biol 135: 169-179.
    • (1996) J Cell Biol , vol.135 , pp. 169-179
    • Schafer, D.A.1    Jennings, P.B.2    Cooper, J.A.3
  • 98
    • 0035825193 scopus 로고    scopus 로고
    • Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding
    • Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, et al. (2001) Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J Cell Biol 152: 111-126.
    • (2001) J Cell Biol , vol.152 , pp. 111-126
    • Michaelson, D.1    Silletti, J.2    Murphy, G.3    D'Eustachio, P.4    Rush, M.5
  • 99
    • 0032515909 scopus 로고    scopus 로고
    • Regulation of RhoA GTP hydrolysis by the GTPaseactivating proteins p190, p50RhoGAP, Bcr, and 3BP-1
    • doi: 10.1021/bi9718447
    • Zhang B, Zheng Y, (1998) Regulation of RhoA GTP hydrolysis by the GTPaseactivating proteins p190, p50RhoGAP, Bcr, and 3BP-1. Biochemistry 37: 5249-5257 doi:10.1021/bi9718447.
    • (1998) Biochemistry , vol.37 , pp. 5249-5257
    • Zhang, B.1    Zheng, Y.2
  • 100
    • 1542607794 scopus 로고    scopus 로고
    • Single-molecule imaging of signaling molecules in living cells
    • Sako Y, Hibino K, Miyauchi T, Miyamoto Y, Ueda M, et al. (2000) Single-molecule imaging of signaling molecules in living cells. Single Mol 1: 159-163.
    • (2000) Single Mol , vol.1 , pp. 159-163
    • Sako, Y.1    Hibino, K.2    Miyauchi, T.3    Miyamoto, Y.4    Ueda, M.5
  • 101
    • 1242298534 scopus 로고    scopus 로고
    • Chemotaxis: signalling modules join hands at front and tail
    • doi: 10.1038/sj.embor.7400051
    • Postma M, Bosgraaf L, Loovers HM, Van Haastert PJM, (2004) Chemotaxis: signalling modules join hands at front and tail. EMBO Rep 5: 35-40 doi:10.1038/sj.embor.7400051.
    • (2004) EMBO Rep , vol.5 , pp. 35-40
    • Postma, M.1    Bosgraaf, L.2    Loovers, H.M.3    Van Haastert, P.J.M.4
  • 102
    • 0347319166 scopus 로고    scopus 로고
    • Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments
    • Schneider IC, Haugh JM, (2004) Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments. Biophys J 86: 599-608.
    • (2004) Biophys J , vol.86 , pp. 599-608
    • Schneider, I.C.1    Haugh, J.M.2
  • 103
    • 84861177547 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and membrane trafficking
    • In: Cockcroft S, editors, Oxford, Oxford University Press
    • Stenmark H, (2000) Phosphatidylinositol 3-kinase and membrane trafficking. In: Cockcroft S, editors. Biology of Phosphoinositides, volume 27 of Frontiers in Molecular Biology Oxford Oxford University Press pp. 239-267.
    • (2000) Biology of Phosphoinositides, Volume 27 of Frontiers in Molecular Biology , pp. 239-267
    • Stenmark, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.