Chemical rescue of a mutant enzyme in living cells

Science

Volumn 311, Issue 5765, 2006, Pages 1293-1297

  Qiao, Yingfeng ^a   Molina, Henrik ^a   Pandey, Akhilesh ^a   Zhang, Jin ^a   Cole, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; ONCOLOGY; PROTEINS; SPECTROMETRY;

CATALYTIC ACTIVITY; CHEMICAL RESCUE; KINASE PATHWAY; MUTANT ENZYMES; R388A; RAPID AND REVERSIBLE; SMALL MOLECULES; VIRAL SRC HOMOLOG;

CELLS;

ALANINE; ARGININE; ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT ENZYME; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ENZYME; MUTATION;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOPHOSPHORYLATION; CARCINOGENICITY; EMBRYO; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; IN VITRO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HUMANS; IMIDAZOLES; KINETICS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RECOMBINANT PROTEINS; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 33644684486     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1122224     Document Type: Article

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