Tissues use resident dendritic cells and macrophages to maintain homeostasis and to regain homeostasis upon tissue injury: The immunoregulatory role of changing tissue environments

Mediators of Inflammation

Volumn 2012, Issue , 2012, Pages

  Lech, MacIej ^a   Gröbmayr, Regina ^a   Weidenbusch, Marc ^a   Anders, Hans Joachim ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 4; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 23; INTERLEUKIN 4 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; REACTIVE OXYGEN METABOLITE; STAT6 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL HETEROGENEITY; CYTOKINE RELEASE; DENDRITIC CELL; EXTRACELLULAR MATRIX; FIBROGENESIS; HOMEOSTASIS; HOST RESISTANCE; HUMAN; INNATE IMMUNITY; LEUKOCYTE MIGRATION; MACROPHAGE; MICROENVIRONMENT; MOLECULAR RECOGNITION; PARENCHYMA; PATHOGEN CLEARANCE; PHAGOCYTE; PHAGOCYTOSIS; PHENOTYPE; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TISSUE INJURY; TISSUE REGENERATION; ANIMAL; PHYSIOLOGY; REVIEW; WOUND HEALING;

ANIMALS; DENDRITIC CELLS; HOMEOSTASIS; HUMANS; MACROPHAGES; WOUND HEALING;

EID: 84871669887     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2012/951390     Document Type: Article

References (204)

1. Geissmann F., Manz M. G., Jung S., Sieweke M. H., Merad M., Ley K., Development of monocytes, macrophages, and dendritic cells. Science 2010 327 5966 656 661 2-s2.0-76249095169 10.1126/science.1178331
2. Medzhitov R., Origin and physiological roles of inflammation. Nature 2008 454 7203 428 435 2-s2.0-47949099098 10.1038/nature07201
3. Ricardo S. D., van Goor H., Eddy A. A., Macrophage diversity in renal injury and repair. The Journal of Clinical Investigation 2008 118 11 3522 3530 2-s2.0-55849103960 10.1172/JCI36150
4. Matzinger P., Friendly and dangerous signals: is the tissue in control? Nature Immunology 2007 8 1 11 13 2-s2.0-33846990935 10.1038/ni0107-11
5. Matzinger P., Kamala T., Tissue-based class control: the other side of tolerance. Nature Reviews Immunology 2011 11 3 221 230 2-s2.0-79952126441 10.1038/nri2940
6. van Furth R., Cohn Z. A., The origin and kinetics of mononuclear phagocytes. Journal of Experimental Medicine 1968 128 3 415 435 2-s2.0-0014325451
7. Nelson P. J., Rees A. J., Griffin M. D., Hughes J., Kurts C., Duffield J., The renal mononuclear phagocytic system. Journal of the American Society of Nephrology 2012 23 2 194 203
8. Yoshida H., Kawane K., Koike M., Mori Y., Uchiyama Y., Nagata S., Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature 2005 437 7059 754 758 2-s2.0-26944463126 10.1038/nature03964
9. Steinman R. M., Cohn Z. A., Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. The Journal of Experimental Medicine 1973 137 1142 1162 2-s2.0-39049185232
10. Gordon S., Taylor P. R., Monocyte and macrophage heterogeneity. Nature Reviews Immunology 2005 5 12 953 964 2-s2.0-28544446111 10.1038/nri1733
11. Ehninger A., Trumpp A., The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. Journal of Experimental Medicine 2011 208 3 421 428 2-s2.0-79952724283 10.1084/jem.20110132
12. Yang Z., Kong B., Mosser D. M., Zhang X., TLRs, macrophages, and NK cells: our understandings of their functions in uterus and ovary. International Immunopharmacology 2011 11 1442 1450 2-s2.0-79957476721 10.1016/j.intimp.2011. 04.024
13. John R., Nelson P. J., Dendritic cells in the kidney. Journal of the American Society of Nephrology 2007 18 10 2628 2635 2-s2.0-34948849039 10.1681/ASN.2007030273
14. Welzen-Coppens J. M., van Helden-Meeuwsen C. G., Drexhage H. A., Versnel M. A., Abnormalities of dendritic cell precursors in the pancreas of the nod mouse model of diabetes. European Journal of Immunology 2012 42 1 186 194
15. Sathe P., Shortman K., The steady-state development of splenic dendritic cells. Mucosal Immunology 2008 1 6 425 431 2-s2.0-54449086214 10.1038/mi.2008.56
16. Crispe I. N., Liver antigen-presenting cells. Journal of Hepatology 2011 54 2 357 365 2-s2.0-78751576088 10.1016/j.jhep.2010.10.005
17. Mowat A. M., Bain C. C., Mucosal macrophages in intestinal homeostasis and inflammation. Journal of Innate Immunity 2011 3 550 564
18. Anders H. J., Four danger response programs determine glomerular and tubulointerstitial kidney pathology: clotting, inflammation, epithelial and mesenchymal healing. Organogenesis 2012 8 29 40
19. Rock K. L., Latz E., Ontiveros F., Kono H., The sterile inflammatory response. Annual Review of Immunology 2010 28 321 342 2-s2.0-77952294609 10.1146/annurev-immunol-030409-101311
20. Takeuchi O., Akira S., Pattern recognition receptors and inflammation. Cell 2010 140 6 805 820 2-s2.0-77950343791 10.1016/j.cell.2010.01.022
21. Anders H. J., Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases. Kidney International 2007 72 9 1051 1056 2-s2.0-35349005817 10.1038/sj.ki.5002436
22. Allam R., Scherbaum C. R., Darisipudi M. N., Histones from dying renal cells aggravate kidney injury via tlr2 and tlr4. Journal of the American Society of Nephrology 2012 23 1375 1388
23. Scaffidi P., Misteli T., Bianchi M. E., Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002 418 191 195 2-s2.0-77957373826 10.1038/nature09475
24. 7R. Nature Medicine 2010 16 12 1434 1438 2-s2.0-78649993400 10.1038/nm.2242
25. Kono H., Chen C. J., Ontiveros F., Rock K. L., Uric acid promotes an acute inflammatory response to sterile cell death in mice. The Journal of Clinical Investigation 2010 120 6 1939 1949 2-s2.0-77953187290 10.1172/JCI40124
26. Sorokin L., The impact of the extracellular matrix on inflammation. Nature Reviews Immunology 2010 10 10 712 723 2-s2.0-77957221743 10.1038/nri2852
27. Säemann M. D., Weichhart T., Zeyda M., Staffler G., Schunn M., Stuhlmeier K. M., Sobanov Y., Stulnig T. M., Akira S., Von Gabain A., Von Ahsen U., Hörl W. H., Zlabinger G. J., Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. The Journal of Clinical Investigation 2005 115 2 468 475 2-s2.0-20144373629 10.1172/JCI200522720
28. Darisipudi M. N., Thomasova D., Mulay S. R., Brech D., Noessner E., Liapis H., Anders H. J., Uromodulin trigegrs il-1ß-dependent innate immunity via the nlrp3 inflammasome. Journal of the American Society of Nephrology 2012 23 11 1783 1789
29. Kawai T., Akira S., Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011 34 5 637 650 2-s2.0-79956300649 10.1016/j.immuni.2011.05.006
30. Patole P. S., Schubert S., Hildinger K., Khandoga S., Khandoga A., Segerer S., Henger A., Kretzler M., Werner M., Krombach F., Schlöndorff D., Anders H. J., Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney International 2005 68 6 2582 2587 2-s2.0-32844466826 10.1111/j.1523-1755.2005.00729.x
31. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M., The chemokine system in diverse forms of macrophage activation and polarization. Trends in Immunology 2004 25 12 677 686 2-s2.0-7644231561 10.1016/j.it.2004.09. 015
32. Lech M., Avila-Ferrufino A., Skuginna V., Susanti H. E., Anders H. J., Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice. International Immunology 2010 22 9 717 728 2-s2.0-77956103055 10.1093/intimm/dxq058
33. Lech M., Susanti H. E., Rommele C., Grobmayr R., Gunthner R., Anders H. J., Quantitative expression of c-type lectin receptors in humans and mice. International Journal of Molecular Sciences 2012 13 10113 10131
34. Krausgruber T., Blazek K., Smallie T., Alzabin S., Lockstone H., Sahgal N., Hussell T., Feldmann M., Udalova I. A., IRF5 promotes inflammatory macrophage polarization and T H1-TH17 responses. Nature Immunology 2011 12 3 231 238 2-s2.0-79951671510 10.1038/ni.1990
35. Galli S. J., Borregaard N., Wynn T. A., Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nature Immunology 2011 12 1035 1044
36. Anders H. J., Toll-like receptors and danger signaling in kidney injury. Journal of the American Society of Nephrology 2010 21 8 1270 1274 2-s2.0-77955597328 10.1681/ASN.2010030233
37. Benoit M., Desnues B., Mege J. L., Macrophage polarization in bacterial infections. Journal of Immunology 2008 181 6 3733 3739 2-s2.0-56149103896
38. Kono H., Rock K. L., How dying cells alert the immune system to danger. Nature Reviews Immunology 2008 8 4 279 289 2-s2.0-41149118513 10.1038/nri2215
39. Rock K. L., Lai J. J., Kono H., Innate and adaptive immune responses to cell death. Immunological Reviews 2011 243 191 205
40. Swaminathan S., Griffin M. D., First responders: understanding monocyte-lineage traffic in the acutely injured kidney. Kidney International 2008 74 12 1509 1511 2-s2.0-57049125060 10.1038/ki.2008.555
41. Tarnawski A. S., Ahluwalia A., Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Current Medicinal Chemistry 2012 19 16 27
42. Cowin A. J., Brosnan M. P., Holmes T. M., Ferguson M. W., Endogenous inflammatory response to dermal wound healing in the fetal and adult mouse. Developmental Dynamics 1998 212 385 393
43. Lucas T., Waisman A., Ranjan R., Roes J., Krieg T., Müller W., Roers A., Eming S. A., Differential roles of macrophages in diverse phases of skin repair. Journal of Immunology 2010 184 7 3964 3977 2-s2.0-77951631929 10.4049/jimmunol.0903356
44. Gurtner G. C., Werner S., Barrandon Y., Longaker M. T., Wound repair and regeneration. Nature 2008 453 7193 314 321 2-s2.0-43749088730 10.1038/nature07039
45. Sindrilaru A., Peters T., Wieschalka S., Baican C., Baican A., Peter H., Hainzl A., Schatz S., Qi Y., Schlecht A., Weiss J. M., Wlaschek M., Sunderkötter C., Scharffetter-Kochanek K., An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. The Journal of Clinical Investigation 2011 121 3 985 997 2-s2.0-79952135247 10.1172/JCI44490
46. Recalcati S., Locati M., Gammella E., Invernizzi P., Cairo G., Iron levels in polarized macrophages: regulation of immunity and autoimmunity. Autoimmunity Reviews 2012 11 12 883 889
47. Ikezumi Y., Atkins R. C., Nikolic-Paterson D. J., Interferon- γ augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism. Journal of the American Society of Nephrology 2003 14 4 888 898 2-s2.0-0037378759 10.1097/01.ASN.0000056604.13964.62
48. Anders H. J., Vielhauer V., Eis V., Linde Y., Kretzler M., Perez de Lema G., Strutz F., Bauer S., Rutz M., Wagner H., Gröne H. J., Schlöndorff D., Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. The FASEB Journal 2004 18 3 534 536 2-s2.0-1642396952
49. Allam R., Pawar R. D., Kulkarni O. P., Hornung V., Hartmann G., Segerer S., Akira S., Endres S., Anders H. J., Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinctTLR- independent immune responses. European Journal of Immunology 2008 38 12 3487 3498 2-s2.0-59749101255 10.1002/eji.200838604
50. Patole P. S., Gröne H. J., Segerer S., Ciubar R., Belemezova E., Henger A., Kretzler M., Schlöndorff D., Anders H. J., Viral double-stranded RNA aggravates lupus nephritis through toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. Journal of the American Society of Nephrology 2005 16 5 1326 1338 2-s2.0-23944497673 10.1681/ASN.2004100820
51. Patole P. S., Pawar R. D., Lichtnekert J., Lech M., Kulkarni O. P., Ramanjaneyulu A., Segerer S., Anders H. J., Coactivation of toll-like receptor-3 and -7 in immune complex glomerulonephritis. Journal of Autoimmunity 2007 29 1 52 59 2-s2.0-34347332422 10.1016/j.jaut.2007.04.004
52. Pawar R. D., Patole P. S., Ellwart A., Lech M., Segerer S., Schlondorff D., Anders H. J., Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritis. Journal of the American Society of Nephrology 2006 17 12 3365 3373 2-s2.0-33845236216 10.1681/ASN.2006030263
53. Pawar R. D., Patole P. S., Zecher D., Segerer S., Kretzler M., Schlöndorff D., Anders H. J., Toll-like receptor-7 modulates immune complex glomerulonephritis. Journal of the American Society of Nephrology 2006 17 1 141 149 2-s2.0-33644515263 10.1681/ASN.2005070714
54. Anders H. J., Banas B., Linde Y., Weller L., Cohen C. D., Kretzler M., Martin S., Vielhauer V., Schlöndorff D., Gröne H. J., Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. Journal of the American Society of Nephrology 2003 14 2 317 326 2-s2.0-0037307507 10.1097/01.ASN. 0000042169.23931.73
55. Jose M. D., Ikezumi Y., van Rooijen N., Atkins R. C., Chadban S. J., Macrophages act as effectors of tissue damage in acute renal allograft rejection. Transplantation 2003 76 7 1015 1022 2-s2.0-0142103680 10.1097/01.TP.0000083507.67995.13
56. Bonventre J. V., Zuk A., Ischemic acute renal failure: an inflammatory disease? Kidney International 2004 66 2 480 485 2-s2.0-3242772187 10.1111/j.1523-1755.2004.761-2.x
57. Lee S., Huen S., Nishio H., Nishio S., Lee H. K., Choi B. S., Ruhrberg C., Cantley L. G., Distinct macrophage phenotypes contribute to kidney injury and repair. Journal of the American Society of Nephrology 2011 22 2 317 326 2-s2.0-79551654684 10.1681/ASN.2009060615
58. Lech M., Avila-Ferrufino A., Allam R., Segerer S., Khandoga A., Krombach F., Garlanda C., Mantovani A., Anders H. J., Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein. Journal of Immunology 2009 183 6 4109 4118 2-s2.0-70349320167 10.4049/jimmunol.0900118
59. Wang Y., Wang Y., Cai Q., Zheng G., Lee V. W. S., Zheng D., Li X., Thian K. T., Harris D. C. H., By homing to the kidney, activated macrophages potently exacerbate renal injury. American Journal of Pathology 2008 172 6 1491 1499 2-s2.0-44849125120 10.2353/ajpath.2008.070825
60. Anders H. J., Ryu M., Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis. Kidney International 2011 80 915 925 2-s2.0-79960892354 10.1038/ki.2011.217
61. Kulkarni O., Eulberg D., Selve N., Zöllner S., Allam R., Pawar R. D., Pfeiffer S., Segerer S., Klussmann S., Anders H. J., Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice. Journal of Pharmacology and Experimental Therapeutics 2009 328 2 371 377 2-s2.0-59649089797 10.1124/jpet.108.142711
62. Kulkarni O., Pawar R. D., Purschke W., Eulberg D., Selve N., Buchner K., Ninichuk V., Segerer S., Vielhauer V., Klussmann S., Anders H. J., Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice. Journal of the American Society of Nephrology 2007 18 8 2350 2358 2-s2.0-34547645572 10.1681/ASN.2006121348
63. King I. L., Dickendesher T. L., Segal B. M., Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. Blood 2009 113 14 3190 3197 2-s2.0-65149093082 10.1182/blood-2008-07-168575
64. Mildner A., MacK M., Schmidt H., Brück W., Djukic M., Zabel M. D., Hille A., Priller J., Prinz M., CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 2009 132 9 2487 2500 2-s2.0-71549167047 10.1093/brain/awp144
65. Chervonsky A. V., Influence of microbial environment on autoimmunity. Nature Immunology 2010 11 1 28 35 2-s2.0-74049161267 10.1038/ni.1801
66. Allam R., Anders H. J., The role of innate immunity in autoimmune tissue injury. Current Opinion in Rheumatology 2008 20 5 538 544 2-s2.0-55249100762 10.1097/BOR.0b013e3283025ed4
67. Ryu M., Kulkarni O. P., Radomska E., Miosge N., Gross O., Anders H. J., Bacterial CpG-DNA accelerates Alport glomerulosclerosis by inducing an M1 macrophage phenotype and tumor necrosis factor- α -mediated podocyte loss. Kidney International 2011 79 2 189 198 2-s2.0-78650880591 10.1038/ki.2010.373
68. Anders H. J., Zecher D., Pawar R. D., Patole P. S., Molecular mechanisms of autoimmunity triggered by microbial infection. Arthritis Research and Therapy 2005 7 5 215 224 2-s2.0-25144502472 10.1186/ar1818
69. Pawar R. D., Castrezana-Lopez L., Allam R., Kulkarni O. P., Segerer S., Radomska E., Meyer T. N., Schwesinger C. M., Akis N., Gröne H. J., Anders H. J., Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating toll-like receptor 2 at the glomerular filtration barrier. Immunology 2009 128 1 e206 e221 2-s2.0-68249147524 10.1111/j.1365-2567. 2008.02948.x
70. Stearns-Kurosawa D. J., Osuchowski M. F., Valentine C., Kurosawa S., Remick D. G., The pathogenesis of sepsis. Annual Review of Pathology 2011 6 19 48 2-s2.0-79751504193 10.1146/annurev-pathol-011110-130327
71. Han J., Ulevitch R. J., Limiting inflammatory responses during activation of innate immunity. Nature Immunology 2005 6 12 1198 1205 2-s2.0-30044441094 10.1038/ni1274
72. Serhan C. N., Savill J., Resolution of inflammation: the beginning programs the end. Nature Immunology 2005 6 12 1191 1197 2-s2.0-30044449982 10.1038/ni1276
73. Anders H. J., Vielhauer V., Schlöndorff D., Chemokines and chemokine receptors are involved in the resolution or progression of renal disease. Kidney International 2003 63 2 401 415 2-s2.0-0037252248 10.1046/j.1523-1755. 2003.00750.x
74. Savill J., Apoptosis in resolution of inflammation. Journal of Leukocyte Biology 1997 61 4 375 380 2-s2.0-0031004487
75. Savill J., Gregory C., Haslett C., Eat me or die. Science 2003 302 5650 1516 1517 2-s2.0-0642282284 10.1126/science.1092533
76. Lucas M., Stuart L. M., Savill J., Lacy-Hulbert A., Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion. Journal of Immunology 2003 171 5 2610 2615 2-s2.0-0041427760
77. Duffield J. S., Macrophages and immunologic inflammation of the kidney. Seminars in Nephrology 2010 30 3 234 254 2-s2.0-77953881058 10.1016/j. semnephrol.2010.03.003
78. Liu G., Ma H., Qiu L., Li L., Cao Y., Ma J., Zhao Y., Phenotypic and functional switch of macrophages induced by regulatory CD4 CD25 T cells in mice. Immunology and Cell Biology 2011 89 1 130 142 2-s2.0-78651062856 10.1038/icb.2010.70
79. Negishi H., Ohba Y., Yanai H., Takaoka A., Honma K., Yui K., Matsuyama T., Taniguchi T., Honda K., Negative regulation of Toll-like-receptor signaling by IRF-4. Proceedings of the National Academy of Sciences of the United States of America 2005 102 44 15989 15994 2-s2.0-27644548945 10.1073/pnas.0508327102
80. Satoh T., Takeuchi O., Vandenbon A., Yasuda K., Tanaka Y., Kumagai Y., Miyake T., Matsushita K., Okazaki T., Saitoh T., Honma K., Matsuyama T., Yui K., Tsujimura T., Standley D. M., Nakanishi K., Nakai K., Akira S., The jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nature Immunology 2010 11 10 936 944 2-s2.0-77956954197 10.1038/ni.1920
81. El Chartouni C., Schwarzfischer L., Rehli M., Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming. Immunobiology 2010 215 9-10 821 825 2-s2.0-77955426821 10.1016/j.imbio.2010.05.031
82. Ishii M., Wen H., Corsa C. A. S., Liu T., Coelho A. L., Allen R. M., Carson W. F., Cavassani K. A., Li X., Lukacs N. W., Hogaboam C. M., Dou Y., Kunkel S. L., Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 2009 114 15 3244 3254 2-s2.0-70350435962 10.1182/blood-2009-04- 217620
83. Lassen S., Lech M., Römmele C., Mittruecker H. W., Mak T. W., Anders H. J., Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure. Journal of Immunology 2010 185 3 1976 1983 2-s2.0-77956399102 10.4049/jimmunol.0904207
84. Bottazzi B., Doni A., Garlanda C., Mantovani A., An integrated view of humoral innate immunity: pentraxins as a paradigm. Annual Review of Immunology 2010 28 157 183 2-s2.0-77952316540 10.1146/annurev-immunol-030409-101305
85. Deban L., Russo R. C., Sironi M., Moalli F., Scanziani M., Zambelli V., Cuccovillo I., Bastone A., Gobbi M., Valentino S., Doni A., Garlanda C., Danese S., Salvatori G., Sassano M., Evangelista V., Rossi B., Zenaro E., Constantin G., Laudanna C., Bottazzi B., Mantovani A., Regulation of leukocyte recruitment by the long pentraxin PTX3. Nature Immunology 2010 11 4 328 334 2-s2.0-77949782407 10.1038/ni.1854
86. Lech M., Römmele C., Kulkarni O. P., Susanti H. E., Migliorini A., Garlanda C., Mantovani A., Anders H. J., Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. PLoS One 2011 6 5 2-s2.0-79957626356 10.1371/journal.pone. 0020118 e20118
87. Cao Q., Wang Y., Zheng D., Sun Y., Wang Y., Lee V. W. S., Zheng G., Tan T. K., Ince J., Alexander S. I., Harris D. C. H., IL-10/TGF- β -modified macrophages induce regulatory T cells and protect against adriamycin nephrosis. Journal of the American Society of Nephrology 2010 21 6 933 942 2-s2.0-77952998952 10.1681/ASN.2009060592
88. Kluth D. C., Ainslie C. V., Pearce W. P., Finlay S., Clarke D., Anegon I., Rees A. J., Macrophages transfected with adenovirus to express IL-4 reduce inflammation in experimental glomerulonephritis. Journal of Immunology 2001 166 7 4728 4736 2-s2.0-0035313470
89. Wang Y., Wang Y. P., Zheng G., Lee V. W. S., Ouyang L., Chang D. H. H., Mahajan D., Coombs J., Wang Y. M., Alexander S. I., Harris D. C. H., Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney International 2007 72 3 290 299 2-s2.0-34547461118 10.1038/sj.ki.5002275
90. Zheng D., Wang Y., Cao Q., Lee V. W. S., Zheng G., Sun Y., Tan T. K., Wang Y., Alexander S. I., Harris D. C. H., Transfused macrophages ameliorate pancreatic and renal injury in murine diabetes mellitus. Nephron 2011 118 4 e87 e99 2-s2.0-79751527661 10.1159/000321034
91. Barczyk K., Ehrchen J., Tenbrock K., Ahlmann M., Kneidl J., Viemann D., Roth J., Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3. Blood 2010 116 3 446 455 2-s2.0-77955900726 10.1182/blood-2009-10-247106
92. Bertalan R., Patocs A., Vasarhelyi B., Treszl A., Varga I., Szabo E., Tamas J., Toke J., Boyle B., Nobilis A., Rigo J., Racz K., Association between birth weight in preterm neonates and the BclI polymorphism of the glucocorticoid receptor gene. Journal of Steroid Biochemistry and Molecular Biology 2008 111 1-2 91 94 2-s2.0-48049083534 10.1016/j.jsbmb.2008.05.002
93. Mosser D. M., Edwards J. P., Exploring the full spectrum of macrophage activation. Nature Reviews Immunology 2008 8 12 958 969 2-s2.0-56749174940 10.1038/nri2448
94. Singer A. J., Clark R. A. F., Cutaneous wound healing. The New England Journal of Medicine 1999 341 10 738 746 2-s2.0-0033517356 10.1056/ NEJM199909023411006
95. Filardy A. A., Pires D. R., Nunes M. P., Takiya C. M., Freire-de-Lima C. G., Ribeiro-Gomes F. L., DosReis G. A., Proinflammatory clearance of apoptotic neutrophils induces an IL-12 lowIL-10high regulatory phenotype in macrophages. Journal of Immunology 2010 185 4 2044 2050 2-s2.0-77956919603 10.4049/jimmunol.1000017
96. Noris M., Cassis P., Azzollini N., Cavinato R., Cugini D., Casiraghi F., Aiello S., Solini S., Cassis L., Mister M., Todeschini M., Abbate M., Benigni A., Trionfini P., Tomasoni S., Mele C., Garlanda C., Polentarutti N., Mantovani A., Remuzzi G., The toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts. Journal of Immunology 2009 183 7 4249 4260 2-s2.0-70449709584 10.4049/jimmunol.0803549
97. Lech M., Kantner C., Kulkarni O. P., Interleukin-1 receptor-associated kinase-m suppresses systemic lupus erythematosus. Annals of the Rheumatic Diseases 2011 70 2207 2217
98. Lech M., Weidenbusch M., Kulkarni O. P., Ryu M., Darisipudi M. N., Susanti H. E., Mittruecker H. W., Mak T. W., Anders H. J., IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production. Journal of the American Society of Nephrology 2011 22 8 1443 1452 2-s2.0-79960943876 10.1681/ASN.2010121260
99. Huang X. R., Kitching A. R., Tipping P. G., Holdsworth S. R., Interleukin-10 inhibits macrophage-induced glomerular injury. Journal of the American Society of Nephrology 2000 11 2 262 269 2-s2.0-0343066696
100. Morimoto H., Takahashi M., Shiba Y., Izawa A., Ise H., Hongo M., Hatake K., Motoyoshi K., Ikeda U., Bone marrow-derived CXCR4+ cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice. American Journal of Pathology 2007 171 3 755 766 2-s2.0-34548829653 10.2353/ajpath.2007.061276
101. Ikezumi Y., Suzuki T., Karasawa T., Hasegawa H., Kawachi H., Nikolic-Paterson D. J., Uchiyama M., Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat Thy-1 mesangial proliferative glomerulonephritis. American Journal of Nephrology 2010 31 3 273 282 2-s2.0-75149192714 10.1159/000279163
102. Ghielli M., Verstrepen W. A., Nouwen E. J., De Broe M. E., Inflammatory cells in renal regeneration. Renal Failure 1996 18 3 355 375 2-s2.0-0029955590
103. Arnold L., Henry A., Poron F., Baba-Amer Y., Van Rooijen N., Plonquet A., Gherardi R. K., Chazaud B., Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. Journal of Experimental Medicine 2007 204 5 1057 1069 2-s2.0-34248997759 10.1084/jem.20070075
104. Shi J., Aisaki K., Ikawa Y., Wake K., Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride. American Journal of Pathology 1998 153 2 515 525 2-s2.0-0031876158
105. Ren F., Duan Z., Cheng Q., Shen X., Gao F., Bai L., Liu J., Busuttil R. W., Kupiec-Weglinski J. W., Zhai Y., Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology 2011 54 2 687 696 2-s2.0-79960718373 10.1002/hep.24419
106. Herbert D. R., Hölscher C., Mohrs M., Arendse B., Schwegmann A., Radwanska M., Leeto M., Kirsch R., Hall P., Mossmann H., Claussen B., Förster I., Brombacher F., Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 2004 20 5 623 635 2-s2.0-2442717844 10.1016/S1074-7613(04)00107-4
107. Barron L., Wynn T. A., Macrophage activation governs schistosomiasis- induced inflammation and fibrosis. European Journal of Immunology 2011 41 2509 2514
108. Shechter R., London A., Varol C., Raposo C., Cusimano M., Yovel G., Rolls A., Mack M., Pluchino S., Martino G., Jung S., Schwartz M., Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Medicine 2009 6 7 2-s2.0-68049143269 10.1371/journal.pmed.1000113 e1000113
109. Mantovani A., Germano G., Marchesi F., Locatelli M., Biswas S. K., Cancer-promoting tumor-associated macrophages: new vistas and open questions. European Journal of Immunology 2011 41 2522 2525
110. Schrimpf C., Xin C., Campanholle G., Pericyte timp3 and adamts1 modulate vascular stability after kidney injury. Journal of the American Society of Nephrology 2012 23 868 883
111. Lu T. T., Dendritic cells: novel players in fibrosis and scleroderma. Current Rheumatology Reports 2012 14 1 30 38
112. Zeisberg M., Neilson E. G., Mechanisms of tubulointerstitial fibrosis. Journal of the American Society of Nephrology 2010 21 11 1819 1834 2-s2.0-78149298226 10.1681/ASN.2010080793
113. Duffield J. S., Humphreys B. D., Origin of new cells in the adult kidney: results from genetic labeling techniques. Kidney International 2011 79 5 494 501 2-s2.0-79951678325 10.1038/ki.2010.338
114. Humphreys B. D., Valerius M. T., Kobayashi A., Mugford J. W., Soeung S., Duffield J. S., McMahon A. P., Bonventre J. V., Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008 2 3 284 291 2-s2.0-39749172401 10.1016/j.stem.2008.01.014
115. Humphreys B. D., Bonventre J. V., Mesenchymal stem cells in acute kidney injury. Annual Review of Medicine 2008 59 311 325 2-s2.0-39649113771 10.1146/annurev.med.59.061506.154239
116. Langworthy M., Zhou B., de Caestecker M., Moeckel G., Baldwin H. S., NFATc1 identifies a population of proximal tubule cell progenitors. Journal of the American Society of Nephrology 2009 20 2 311 321 2-s2.0-59949085566 10.1681/ASN.2008010094
117. Blanpain C., Horsley V., Fuchs E., Epithelial stem cells: turning over new leaves. Cell 2007 128 3 445 458 2-s2.0-33846705750 10.1016/j.cell.2007.01. 014
118. Romagnani P., Toward the identification of a "renopoietic system"? Stem Cells 2009 27 9 2247 2253 2-s2.0-70349868343 10.1002/stem.140
119. Coskun V., Wu H., Blanchi B., Tsao S., Kim K., Zhao J., Biancotti J. C., Hutnick L., Krueger R. C., Fan G., De Vellis J., Sun Y. E., CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proceedings of the National Academy of Sciences of the United States of America 2008 105 3 1026 1031 2-s2.0-38949145077 10.1073/pnas.0710000105
120. Angelotti M. L., Ronconi E., Ballerini L., Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. Stem Cells 2012 30 1714 1725
121. Yang L., Besschetnova T. Y., Brooks C. R., Shah J. V., Bonventre J. V., Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nature Medicine 2010 16 5 535 543 2-s2.0-77952174830 10.1038/nm.2144
122. Quan T. E., Cowper S. E., Bucala R., The role of circulating fibrocytes in fibrosis. Current Rheumatology Reports 2006 8 2 145 150 2-s2.0-33646914221 10.1007/s11926-006-0055-x
123. Pilling D., Fan T., Huang D., Kaul B., Gomer R. H., Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS One 2009 4 10 2-s2.0-70449372660 10.1371/journal.pone.0007475 e7475
124. Schmidt M., Sun G., Stacey M. A., Mori L., Mattoli S., Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. Journal of Immunology 2003 171 1 380 389 2-s2.0-0038544594
125. Niedermeier M., Reich B., Gomez M. R., Denzel A., Schmidbauer K., Göbel N., Talke Y., Schweda F., Mack M., CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proceedings of the National Academy of Sciences of the United States of America 2009 106 42 17892 17897 2-s2.0-70449555951 10.1073/pnas.0906070106
126. Sakai N., Furuichi K., Shinozaki Y., Yamauchi H., Toyama T., Kitajima S., Okumura T., Kokubo S., Kobayashi M., Takasawa K., Takeda S. I., Yoshimura M., Kaneko S., Wada T., Fibrocytes are involved in the pathogenesis of human chronic kidney disease. Human Pathology 2010 41 5 672 678 2-s2.0-77950594447 10.1016/j.humpath.2009.10.008
127. Forbes S. J., Russo F. P., Rey V., Burra P., Rugge M., Wright N. A., Alison M. R., A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 2004 126 4 955 963 2-s2.0-1842531265 10.1053/j.gastro.2004.02.025
128. Andersson-Sjöland A., de Alba C. G., Nihlberg K., Becerril C., Ramírez R., Pardo A., Westergren-Thorsson G., Selman M., Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. International Journal of Biochemistry and Cell Biology 2008 40 10 2129 2140 2-s2.0-48949117344 10.1016/j.biocel.2008.02.012
129. van Amerongen M. J., Bou-Gharios G., Popa E. R., Van Ark J., Petersen A. H., Van Dam G. M., Van Luyn M. J. A., Harmsen M. C., Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction. Journal of Pathology 2008 214 3 377 386 2-s2.0-38949214016 10.1002/path.2281
130. Grgic I., Duffield J. S., Humphreys B. D., The origin of interstitial myofibroblasts in chronic kidney disease. Pediatric Nephrology 2012 27 2 183 193 2-s2.0-79651473409 10.1007/s00467-011-1772-6
131. Lin S. L., Kisseleva T., Brenner D. A., Duffield J. S., Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. American Journal of Pathology 2008 173 6 1617 1627 2-s2.0-57149113728 10.2353/ajpath.2008.080433
132. Vielhauer V., Anders H. J., Mack M., Cihak J., Strutz F., Stangassinger
133. Anders H. J., Vielhauer V., Kretzler M., Cohen C. D., Segerer S., Luckow B., Weller L., Gröne H. J., Schlöndorff D., Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. Journal of the American Society of Nephrology 2001 12 5 919 931 2-s2.0-0035028406
134. Anders H. J., Vielhauer V., Frink M., Linde Y., Cohen C. D., Blattner S. M., Kretzler M., Strutz F., Mack M., Gröne H. J., Onuffer J., Horuk R., Nelson P. J., Schlöndorff D., A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. The Journal of Clinical Investigation 2002 109 2 251 259 2-s2.0-0036150991 10.1172/JCI200214040
135. Bedke J., Kiss E., Schaefer L., Behnes C. L., Bonrouhi M., Gretz N., Horuk R., Diedrichs-Moehring M., Wildner G., Nelson P. J., Gröne H. J., Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage. American Journal of Transplantation 2007 7 3 527 537 2-s2.0-33847701747 10.1111/j.1600-6143.2006.01654.x
136. Blease K., Mehrad B., Standiford T. J., Lukacs N. W., Kunkel S. L., Chensue S. W., Lu B., Gerard C. J., Hogaboam C. M., Airway remodeling is absent in CCR1(-/-) mice during chronic fungal allergic airway disease. Journal of Immunology 2000 165 3 1564 1572 2-s2.0-0034254180
137. Eis V., Luckow B., Vielhauer V., Siveke J. T., Linde Y., Segerer S., De Lema G. P., Cohen C. D., Kretzler M., Mack M., Horuk R., Murphy P. M., Gao J. L., Hudkins K. L., Alpers C. E., Gröne H. J., Schlöndorff D., Anders H. J., Chemokine receptor ccr1 but not ccr5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. Journal of the American Society of Nephrology 2004 15 2 337 347 2-s2.0-0942298031 10.1097/01.ASN.0000111246.87175.32
138. Ninichuk V., Anders H. J., Chemokine receptor CCR1: a new target for progressive kidney disease. American Journal of Nephrology 2005 25 4 365 372 2-s2.0-23844496123 10.1159/000087185
139. Scholten D., Reichart D., Paik Y. H., Lindert J., Bhattacharya J., Glass C. K., Brenner D. A., Kisseleva T., Migration of fibrocytes in fibrogenic liver injury. The American Journal of Pathology 2011 179 189 198
140. Seki E., de Minicis S., Inokuchi S., Taura K., Miyai K., Van Rooijen N., Schwabe R. F., Brenner D. A., CCR2 promotes hepatic fibrosis in mice. Hepatology 2009 50 1 185 197 2-s2.0-67651156353 10.1002/hep.22952
141. Tokuda A., Itakura M., Onai N., Kimura H., Kuriyama T., Matsushima K., Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice. Journal of Immunology 2000 164 5 2745 2751 2-s2.0-0034161676
142. Vielhauer V., Berning E., Eis V., Kretzler M., Segerer S., Strutz F., Horuk R., Gröne H. J., Schlöndorff D., Anders H. J., CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome. Kidney International 2004 66 6 2264 2278 2-s2.0-21544463993 10.1111/j.1523-1755.2004.66038.x
143. Anders H. J., Belemezova E., Eis V., Segerer S., Vielhauer V., De Lema G. P., Kretzler M., Cohen C. D., Frink M., Horuk R., Hudkins K. L., Alpers C. E., Mampaso F., Schlöndorff D., Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. Journal of the American Society of Nephrology 2004 15 6 1504 1513 2-s2.0-2542502538 10.1097/01.ASN.0000130082.67775.60
144. Ninichuk V., Gross O., Reichel C., Khandoga A., Pawar R. D., Ciubar R., Segerer S., Belemezova E., Radomska E., Luckow B., Perez De Lema G., Murphy P. M., Gao J. L., Henger A., Kretzler M., Horuk R., Weber M., Krombach F., Anders H. J., Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with alport disease. Journal of the American Society of Nephrology 2005 16 4 977 985 2-s2.0-23844552355 10.1681/ASN.2004100871
145. Ishida Y., Gao J. L., Murphy P. M., Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. Journal of Immunology 2008 180 1 569 579 2-s2.0-40449127195
146. Fang Y., Shen J., Yao M., Beagley K. W., Hambly B. D., Bao S., Granulocyte-macrophage colony-stimulating factor enhances wound healing in diabetes via upregulation of proinflammatory cytokines. British Journal of Dermatology 2010 162 3 478 486 2-s2.0-76949084796 10.1111/j.1365-2133.2009. 09528.x
147. Imamura M., Ogawa T., Sasaguri Y., Chayama K., Ueno H., Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology 2005 128 1 138 146 2-s2.0-11144281835 10.1053/j.gastro.2004.10.005
148. Karlmark K. R., Weiskirchen R., Zimmermann H. W., Gassler N., Ginhoux F., Weber C., Merad M., Luedde T., Trautwein C., Tacke F., Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 2009 50 1 261 274 2-s2.0-67651174837 10.1002/hep.22950
149. Kitagawa K., Wada T., Furuichi K., Hashimoto H., Ishiwata Y., Asano M., Takeya M., Kuziel W. A., Matsushima K., Mukaida N., Yokoyama H., Blockade of CCR2 ameliorates progressive fibrosis in kidney. American Journal of Pathology 2004 165 1 237 246 2-s2.0-3042692326
150. Wada T., Furuichi K., Sakai N., Iwata Y., Kitagawa K., Ishida Y., Kondo T., Hashimoto H., Ishiwata Y., Mukaida N., Tomosugi N., Matsushima K., Egashira K., Yokoyama H., Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. Journal of the American Society of Nephrology 2004 15 4 940 948 2-s2.0-12144286102 10.1097/01.ASN.0000120371.09769.80
151. Ninichuk V., Clauss S., Kulkarni O., Schmid H., Segerer S., Radomska E., Eulberg D., Buchner K., Selve N., Klussmann S., Anders H. J., Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3′PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. American Journal of Pathology 2008 172 3 628 637 2-s2.0-40449140901 10.2353/ajpath.2008.070601
152. Okuma T., Terasaki Y., Kaikita K., Kobayashi H., Kuziel W. A., Kawasuji M., Takeya M., C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metalloproteinases. Journal of Pathology 2004 204 5 594 604 2-s2.0-9744262517 10.1002/path.1667
153. Fichtner-Feigl S., Strober W., Kawakami K., Puri R. K., Kitani A., IL-13 signaling through the IL-13 α 2 receptor is involved in induction of TGF- β 1 production and fibrosis. Nature Medicine 2006 12 1 99 106 2-s2.0-30044449492 10.1038/nm1332
154. Ninichuk V., Gross O., Segerer S., Hoffmann R., Radomska E., Buchstaller A., Huss R., Akis N., Schlöndorff D., Anders H. J., Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney International 2006 70 1 121 129 2-s2.0-33745697880 10.1038/sj.ki.5001521
155. Leibovich S. J., Ross R., The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. American Journal of Pathology 1975 78 1 71 100 2-s2.0-0016428338
156. Occleston N. L., O'Kane S., Laverty H. G., Cooper M., Fairlamb D., Mason T., Bush J. A., Ferguson M. W. J., Discovery and development of avotermin (recombinant human transforming growth factor beta 3): a new class of prophylactic therapeutic for the improvement of scarring. Wound Repair and Regeneration 2011 19 supplement 1 S38 S48 2-s2.0-79960969401 10.1111/j.1524-475X.2011.00711.x
157. Duffield J. S., Forbes S. J., Constandinou C. M., Clay S., Partolina M., Vuthoori S., Wu S., Lang R., Iredale J. P., Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. The Journal of Clinical Investigation 2005 115 1 56 65 2-s2.0-13744255589 10.1172/JCI200522675
158. Fallowfield J. A., Mizuno M., Kendall T. J., Constandinou C. M., Benyon R. C., Duffield J. S., Iredale J. P., Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. Journal of Immunology 2007 178 8 5288 5295 2-s2.0-34247149014
159. Harty M. W., Papa E. F., Huddleston H. M., Young E., Nazareth S., Riley C. A., Ramm G. A., Gregory S. H., Tracy T. F., Hepatic macrophages promote the neutrophil-dependent resolution of fibrosis in repairing cholestatic rat livers. Surgery 2008 143 5 667 678 2-s2.0-43049114996 10.1016/j.surg.2008.01.008
160. Jiang D., Liang J., Campanella G. S., Guo R., Yu S., Xie T., Liu N., Jung Y., Homer R., Meltzer E. B., Li Y., Tager A. M., Goetinck P. F., Luster A. D., Noble P. W., Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. The Journal of Clinical Investigation 2010 120 6 2049 2057 2-s2.0-77953175936 10.1172/JCI38644
161. Tian D. S., Dong Q., Pan D. J., He Y., Yu Z. Y., Xie M. J., Wang W., Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Brain Research 2007 1154 1 206 214 2-s2.0-34249811755 10.1016/j.brainres.2007.04.005
162. Leonardo C. C., Eakin A. K., Ajmo J. M., Collier L. A., Pennypacker K. R., Strongin A. Y., Gottschall P. E., Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat. Journal of Neuroinflammation 2008 5, article 34 2-s2.0-51249109893 10.1186/1742-2094-5-34
163. Raivich G., Moreno-Flores M. T., Moller J. C., Kreutzberg G. W., Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse. European Journal of Neuroscience 1994 6 10 1615 1618 2-s2.0-0028050415 10.1111/j.1460-9568.1994. tb00552.x
164. Cardenas H., Bolin L. M., Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice. Brain Research 2003 985 1 89 97 2-s2.0-0142090539 10.1016/S0006-8993(03)03172-X
165. Tian D. S., Xie M. J., Yu Z. Y., Zhang Q., Wang Y. H., Chen B., Chen C., Wang W., Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Research 2007 1135 1 177 185 2-s2.0-33846590145 10.1016/j.brainres.2006. 11.085
166. Raghavendra V., Tanga F., Deleo J. A., Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. Journal of Pharmacology and Experimental Therapeutics 2003 306 2 624 630 2-s2.0-0037622717 10.1124/jpet.103.052407
167. Spataro L., Dilgen J., Retterer S., Spence A. J., Isaacson M., Turner J. N., Shain W., Dexamethasone treatment reduces astroglia responses to inserted neuroprosthetic devices in rat neocortex. Experimental Neurology 2005 194 2 289 300 2-s2.0-22044446807 10.1016/j.expneurol.2004.08.037
168. Rapalino O., Lazarov-Spiegler O., Agranov E., Velan G. J., Yoles E., Fraidakis M., Solomon A., Gepstein R., Katz A., Belkin M., Hadani M., Schwartz M., Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nature Medicine 1998 4 7 814 821 2-s2.0-0031849511 10.1038/nm0798-814
169. Ziv Y., Avidan H., Pluchino S., Martino G., Schwartz M., Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proceedings of the National Academy of Sciences of the United States of America 2006 103 35 13174 13179 2-s2.0-33748358798 10.1073/pnas.0603747103
170. Mori R., Shaw T. J., Martin P., Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. Journal of Experimental Medicine 2008 205 1 43 51 2-s2.0-38749106966 10.1084/jem.20071412
171. Mirza R., DiPietro L. A., Koh T. J., Selective and specific macrophage ablation is detrimental to wound healing in mice. American Journal of Pathology 2009 175 6 2454 2462 2-s2.0-73549118560 10.2353/ajpath.2009.090248
172. Mori L., Bellini A., Stacey M. A., Schmidt M., Mattoli S., Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Experimental Cell Research 2005 304 1 81 90 2-s2.0-13544263380 10.1016/j.yexcr.2004.11.011
173. Yang L., Scott P. G., Dodd C., Medina A., Jiao H., Shankowsky H. A., Ghahary A., Tredget E. E., Identification of fibrocytes in postburn hypertrophic scar. Wound Repair and Regeneration 2005 13 4 398 404 2-s2.0-23044459992 10.1111/j.1067-1927.2005.130407.x
174. Nahrendorf M., Swirski F. K., Aikawa E., Stangenberg L., Wurdinger T., Figueiredo J. L., Libby P., Weissleder R., Pittet M. J., The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. Journal of Experimental Medicine 2007 204 12 3037 3047 2-s2.0-36549033197 10.1084/jem.20070885
175. Hayashidani S., Tsutsui H., Shiomi T., Ikeuchi M., Matsusaka H., Suematsu N., Wen J., Egashira K., Takeshita A., Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2003 108 17 2134 2140 2-s2.0-0242286636 10.1161/01.CIR.0000092890.29552.22
176. Hayasaki T., Kaikita K., Okuma T., Yamamoto E., Kuziel W. A., Ogawa H., Takeya M., CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemia-reperfusion in mice. Circulation Journal 2006 70 3 342 351 2-s2.0-33644588726 10.1253/circj.70.342
177. Leor J., Rozen L., Zuloff-Shani A., Feinberg M. S., Amsalem Y., Barbash I. M., Kachel E., Holbova R., Mardor Y., Daniels D., Ocherashvilli A., Orenstein A., Danon D., Ex vivo activated human macrophages improve healing, remodeling, and function of the infarcted heart. Circulation 2006 114 1 I94 I100 2-s2.0-33747154155 10.1161/CIRCULATIONAHA.105.000331
178. van Amerongen M. J., Harmsen M. C., van Rooijen N., Petersen A. H., Van Luyn M. J. A., Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. American Journal of Pathology 2007 170 3 818 829 2-s2.0-34247849521 10.2353/ajpath.2007.060547
179. Haudek S. B., Xia Y., Huebener P., Lee J. M., Carlson S., Crawford J. R., Pilling D., Gomer R. H., Trial J., Frangogiannis N. G., Entman M. L., Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proceedings of the National Academy of Sciences of the United States of America 2006 103 48 18284 18289 2-s2.0-33845342873 10.1073/pnas.0608799103
180. Hayashidani S., Tsutsui H., Ikeuchi M., Shiomi T., Matsusaka H., Kubota T., Imanaka-Yoshida K., Itoh T., Takeshita A., Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction. American Journal of Physiology 2003 285 3 H1229 H1235 2-s2.0-0041858010
181. Belperio J. A., Keane M. P., Burdick M. D., Lynch J. P., Ying Ying Xue, Berlin A., Ross D. J., Kunkel S. L., Charo I. F., Strieter R. M., Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. The Journal of Clinical Investigation 2001 108 4 547 556 2-s2.0-17944364488 10.1172/JCI200112214
182. Belperio J. A., Keane M. P., Burdick M. D., Lynch J. P., Xue Y. Y., Li K., Ross D. J., Strieter R. M., Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Journal of Immunology 2002 169 2 1037 1049 2-s2.0-0037100505
183. Xing Z., Tremblay G. M., Sime P. J., Gauldie J., Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor- β 1 and myofibroblast accumulation. American Journal of Pathology 1997 150 1 59 66 2-s2.0-0031022618
184. Atabai K., Jame S., Azhar N., Kuo A., Lam M., McKleroy W., DeHart G., Rahman S., Xia D. D., Melton A. C., Wolters P., Emson C. L., Turner S. M., Werb Z., Sheppard D., Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. The Journal of Clinical Investigation 2009 119 12 3713 3722 2-s2.0-72849117761 10.1172/JCI40053
185. Burdick M. D., Murray L. A., Keane M. P., Xue Y. Y., Zisman D. A., Belperio J. A., Strieter R. M., CXCCL11 attenuates bleomycin-induced pulmonary fibrosis via inhibition of vascular remodeling. American Journal of Respiratory and Critical Care Medicine 2005 171 3 261 268 2-s2.0-12744262853 10.1164/rccm.200409-1164OC
186. Marra F., DeFranco R., Grappone C., Parola M., Milani S., Leonarduzzi G., Pastacaldi S., Wenzel U. O., Pinzani M., Diazani M. U., Laffi G., Gentilini P., Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E. Journal of Investigative Medicine 1999 47 1 66 75 2-s2.0-0032602367
187. Otogawa K., Kinoshita K., Fujii H., Sakabe M., Shiga R., Nakatani K., Ikeda K., Nakajima Y., Ikura Y., Ueda M., Arakawa T., Hato F., Kawada N., Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. American Journal of Pathology 2007 170 3 967 980 2-s2.0-34247844680 10.2353/ajpath.2007.060441
188. Jiang W., Sun R., Wei H., Tian Z., Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proceedings of the National Academy of Sciences of the United States of America 2005 102 47 17077 17082 2-s2.0-28044463780 10.1073/pnas.0504570102
189. Iredale J. P., Benyon R. C., Pickering J., McCullen M., Northrop M., Pawley S., Hovell C., Arthur M. J. P., Mechanisms of spontaneous resolution of rat liver fibrosis: hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. The Journal of Clinical Investigation 1998 102 3 538 549 2-s2.0-0032146551
190. Mitchell C., Couton D., Couty J. P., Anson M., Crain A. M., Bizet V., Rénia L., Pol S., Mallet V., Gilgenkrantz H., Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. American Journal of Pathology 2009 174 5 1766 1775 2-s2.0-65649094468 10.2353/ajpath.2009.080632
191. Ide M., Kuwamura M., Kotani T., Sawamoto O., Yamate J., Effects of gadolinium chloride (GdCl3) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions. Journal of Comparative Pathology 2005 133 2-3 92 102 2-s2.0-23844531047 10.1016/j.jcpa.2005.01.011
192. Kisseleva T., Uchinami H., Feirt N., Quintana-Bustamante O., Segovia J. C., Schwabe R. F., Brenner D. A., Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Journal of Hepatology 2006 45 3 429 438 2-s2.0-33746494050 10.1016/j.jhep.2006.04.014
193. Pesce J. T., Ramalingam T. R., Mentink-Kane M. M., Wilson M. S., Kasmi K. C. E., Smith A. M., Thompson R. W., Cheever A. W., Murray P. J., Wynn T. A., Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathogens 2009 5 4 e1000371 2-s2.0-66349084135 10.1371/journal.ppat.1000371
194. Thomas J. A., Pope C., Wojtacha D., Robson A. J., Gordon-Walker T. T., Hartland S., Ramachandran P., Van Deemter M., Hume D. A., Iredale J. P., Forbes S. J., Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology 2011 53 6 2003 2015 2-s2.0-79957465441 10.1002/hep.24315
195. Popov Y., Sverdlov D. Y., Bhaskar K. R., Sharma A. K., Millonig G., Patsenker E., Krahenbuhl S., Krahenbuhl L., Schuppan D., Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. American Journal of Physiology 2010 298 3 G323 G334 2-s2.0-77249139206 10.1152/ajpgi.00394.2009
196. Anders H. J., Frink M., Linde Y., Banas B., Wörnle M., Cohen C. D., Vielhauer V., Nelson P. J., Gröne H. J., Schlöndorff D., CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration. Journal of Immunology 2003 170 11 5658 5666 2-s2.0-0037514185
197. Castaño A. P., Lin S. L., Surowy T., Nowlin B. T., Turlapati S. A., Patel T., Singh A., Li S., Lupher M. L., Duffield J. S., Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Science Translational Medicine 2009 1 5 5ra13 2-s2.0-77749319814 10.1126/scitranslmed.3000111
198. Ninichuk V., Khandoga A. G., Segerer S., Loetscher P., Schlapbach A., Revesz L., Feifel R., Khandoga A., Krombach F., Nelson P. J., Schlöndorff D., Anders H. J., The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice. American Journal of Pathology 2007 170 4 1267 1276 2-s2.0-34247892356 10.2353/ajpath.2007.060937
199. Dehmel S., Wang S., Schmidt C., Kiss E., Loewe R. P., Chilla S., Schlöndorff D., Gröne H. J., Luckow B., Chemokine receptor Ccr5 deficiency induces alternative macrophage activation and improves long-term renal allograft outcome. European Journal of Immunology 2010 40 1 267 278 2-s2.0-74249121961 10.1002/eji.200939652
200. Wada T., Sakai N., Sakai Y., Matsushima K., Kaneko S., Furuichi K., Involvement of bone-marrow-derived cells in kidney fibrosis. Clinical and Experimental Nephrology 2011 15 1 8 13 2-s2.0-79952189082 10.1007/s10157-010- 0372-2
201. Broekema M., Harmsen M. C., van Luyn M. J. A., Koerts J. A., Petersen A. H., Van Kooten T. G., Van Goor H., Navis G., Popa E. R., Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. Journal of the American Society of Nephrology 2007 18 1 165 175 2-s2.0-33845973760 10.1681/ASN.2005070730
202. Zeisberg M., Hanai J. I., Sugimoto H., Mammoto T., Charytan D., Strutz F., Kalluri R., BMP-7 counteracts TGF- β 1-induced epithelial-to- mesenchymal transition and reverses chronic renal injury. Nature Medicine 2003 9 7 964 968 2-s2.0-0038717407 10.1038/nm888
203. Zeisberg M., Khurana M., Rao V. H., Cosgrove D., Rougier J. P., Werner M. C., Shield C. F., Werb Z., Kalluri R., Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Medicine 2006 3 4, article e100 2-s2.0-33646266237 10.1371/journal.pmed.0030100
204. Nishida M., Okumura Y., Fujimoto S. I., Shiraishi I., Itoi T., Hamaoka K., Adoptive transfer of macrophages ameliorates renal fibrosis in mice. Biochemical and Biophysical Research Communications 2005 332 1 11 16 2-s2.0-19344374996 10.1016/j.bbrc.2005.04.083