NFATc1 identifies a population of proximal tubule cell progenitors

Journal of the American Society of Nephrology

Volumn 20, Issue 2, 2009, Pages 311-321

  Langworthy, Melissa ^a,b   Zhou, Bin ^b   De Caestecker, Mark ^a,b   Moeckel, Gilbert ^b   Baldwin, H Scott ^a,b,c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c 9435 A Medical Research Building IV   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; CREATININE; CYCLOSPORIN A; MERCURIC CHLORIDE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CELL PROLIFERATION; CELL REGENERATION; CREATININE BLOOD LEVEL; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MORTALITY; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; STEM CELL;

EID: 59949085566     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008010094     Document Type: Article

References (30)

1. Basile DP: Novel approaches in the investigation of acute kidney injury. J Am Soc Nephrol 18: 7-9, 2007
2. Tumlin JA, Someren JT, Swanson CE, Lea JP: Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. Am J Physiol 269: F558-F563, 1995
3. Gooch JL, Barnes JL, Garcia S, Abboud HE: Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation. Am J Physiol Renal Physiol 284: F144-F154, 2003
4. Puri S, Magenheimer BS, Maser RL, Ryan EM, Zien CA, Walker DD, Wallace DP, Hempson SJ, Calvet JP: Polycystin-1 activates the calcineurin/NFAT signaling pathway. J Biol Chem 279: 55455-55464, 2004
5. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH: The transcription factor NF-ATc is essential for cardiac valve formation. Nature 392: 186 -190, 1998
6. de la Pompa JL, Timmerman LA, Takimoto H, Yoshida H, Elia AJ, Samper E, Potter J, Wakeham A, Marengere L, Langille BL, Crabtree GR, Mak TW: Role of NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392: 182-186, 1998
7. Zhou B, Wu B, Tompkins KL, Boyer KL, Grindley JC, Baldwin HS: Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development 132: 1137-1146, 2005
8. Myers BD, Sibley R, Newton L, Tomlanovich SJ, Boshkos C, Stinson E, Luetscher JA, Whitney DJ, Krasny D, Coplon NS, et al.: The long-term course of cyclosporine-associated chronic nephropathy. Kidney Int33: 590-600, 1988
9. Hultman P, Enestrom S: Localization of mercury in the kidney during experimental acute tubular necrosis studied by the cytochemical Silver Amplification method. Br J Exp Pathol 67: 493-503, 1986
10. Ramesh G, Reeves WB: TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 110: 835-842, 2002
11. Chuvpilo S, Jankevics E, Tyrsin D, Akimzhanov A, Moroz D, Jha MK, Schulze-Luehrmann J, Santner-Nanan B, Feoktistova E, Konig T, Avots A, Schmitt E, Berberich-Siebelt F, Schimpl A, Serfling E: Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Immunity 16: 881-895, 2002
12. Zhou B, Cron RQ, Wu B, Genin A, Wang Z, Liu S, Robson P, Baldwin HS: Regulation of the murine NFATc1 gene by NFATc2. J Biol Chem 277: 10704-10711, 2002
13. Diehl S, Krahl T, Rinaldi L, Norton R, Irvin CG, Rincón M: Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation. J Immunol 172: 3597-3603, 2004
14. Wilkins BJ, De Windt LJ, Bueno OF, BrazJC, Glascock BJ, Kimball TF, Molkentin JD: Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol 22: 7603-7613, 2002
15. Ma J, Nishimura H, Fogo A, Kon V, Inagami T, Ichikawa I: Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int 53: 937-944, 1998
16. Justo P, Lorz C, Sanz A, Egido J, Ortiz A: Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis. J Am Soc Nephrol 14: 3072-3080, 2003
17. Roy MK, Takenaka M, Kobori M, Nakahara K, Isobe S, Tsushida T: Apoptosis, necrosis and cell proliferation-inhibition by cyclosporine A in U937 cells (a human monocytic cell line). Pharmacol Res 53: 293302, 2006
18. Eckstein LA, Van Quill KR, Bui SK, Uusitalo MS, O'Brien JM: Cyclosporin a inhibits calcineurin/nuclear factor of activated T-cells signaling and induces apoptosis in retinoblastoma cells. Invest Ophthalmol Vis Sci 46: 782-790, 2005
19. Soriano P: Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71, 1999
20. Andoh TF, Lam TT, Lindsley J, Alpers CE, Bennett WM: Enhancement of chronic cyclosporine nephrotoxicity by sodium depletion in an experimental mouse model. Nephrology 3: 471-478, 1997
21. Neal JW, Clipstone NA: A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J Biol Chem 278: 17246-17254, 2003
22. Morigi M, Benigni A, Remuzzi G, Imberti B: The regen erative potential of stem cells in acute renal failure. Cell Transplant 15[Suppl 1]:S11-S117, 2006
23. Gupta S, Verfaillie C, Chmielewski D, Kren S, Eidman K, Connaire J, Heremans Y, Lund T, Blackstad M, Jiang Y, Luttun A, Rosenberg ME: Isolation and characterization of kidney-derived stem cells. J Am Soc Nephrol 17: 3028 -3040, 2006
24. Sagrinati C, Netti GS, Mazzinghi B, Lazzeri E, Liotta F, Frosali F, Ronconi E, Meini C, Gacci M, Squecco R, Carini M, Gesualdo L, Francini F, Maggi E, Annunziato F, Lasagni L, Serio M, Romagnani S, Romagnani P: Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol 17: 2443-2456, 2006
25. Miyaji T, Hu X, Star RA: Alpha-melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury. Am J Physiol Renal Physiol 282: F795-F801, 2002
26. Dunn SR, Qi Z, Bottinger EP, Breyer MD, Sharma K: Utility of endogenous creatinine clearance as a measure of renal function in mice. Kidney Int 65: 1959-1967, 2004
27. Ma W, Rogers K, Zbar B, Schmidt L: Effects of different fixatives on beta-galactosidase activity. J Histochem Cytochem 50: 1421-1444, 2002
28. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001
29. Vinay P, Gougoux A, Lemieux G: Isolation of a pure suspension of rat proximal tubules. Am J Physiol 241: F403-F411, 1981
30. Xu J, Yao B, Fan X, Langworthy MM, Zhang MZ, Harris RC: Characterization of a putative intrarenal serotonergic system. Am J Physiol Renal Physiol 293: F1468-F1475, 2007