Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 2, 2013, Pages 425-435

  Csuk, René ^a   Sczepek, Ronny ^a   Siewert, Bianka ^a   Nitsche, Christoph ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Annexin V assay; Antitumor; Apoptosis; Betulin; Cancer; DNA laddering; Hydroxypropargylamines; Mannich reaction; SRB assay

Indexed keywords

28 [3 (DIISOPROPYLAMINO)PROP 1 YN 1 YL]LUP 20 EN 3,28 DIOL; 28 ETHYNYL 28 HYDROXLUP 20(29) EN 3 ON; 28 ETHYNYL BETULIN; 28 HYDROXY 28 (3 PYRROLIDIN 1 YL PROP 1 YN 1 YL)LUP 20(29) EN 3 ON; 28 OXOLUP 20(29)EN 3 YL ACETATE; 3 O ACETYL 28 [(DIALLYLAMINO) 1 YL PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [3 (DICYCLOHEXLAMINO)PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [3 (DIMETHYLAMINO)PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [3 (DIPROPYLAMINO)PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [3 AZEPAN PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [3 MORPHOLIN 4 YL PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [3 PYRROLIDINE 1 YL PROP 1 YN 1 YL] LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [3 THIOMORPHOLIN 4 YL PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [DIBENZYLAMINE 1 YL PROP 1 YN 1 YL] LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 [PIPERIDINE 1 YL PROP 1 YN 1 YL]LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 ETHYNYLLUP 20(29) EN 3,28 DIOL; 3 O ACETYLBETULINIC ALDEHYDE; 3 OXOLUP 20(29)EN 28 AL; ACRIDINE ORANGE; BETULIN; BETULIN HYDROXYPROPARGLYAMINE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MANNICH BASE; PROPIDIUM IODIDE; SULFORHODAMINE B; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; DNA DETERMINATION; DNA LADDERING; DRUG CYTOTOXICITY; DRUG SCREENING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MANNICH REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MICE; NIH 3T3 CELLS; PARGYLINE; PROPYLAMINES; TRITERPENES;

EID: 84871629620     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.016     Document Type: Article

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