New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells

Biochimie

Volumn 93, Issue 6, 2011, Pages 1065-1075

  Santos, Rita C ^a   Salvador, Jorge A R ^a   Cortés, Roldán ^b,c   Pachón, Gisela ^b   Marín, Silvia ^b   Cascante, Marta ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b CSIC   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Apoptosis; Betulinic acid; Cytotoxicity; Imidazole; Triterpenoids

Indexed keywords

28 (1H IMIDAZOL 1 YL)LUP 1,20(29) DIEN 3,28 DIONE; 28 (1H IMIDAZOL 1 YL)LUP 20(29) EN 3,28 DIONE; 28 HYDROXYLUP 20(29) EN 3BETA YL 1H IMIDAZOLE 1 CARBOXYLATE; BETULIC ACID; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG POTENCY; DRUG SELECTIVITY; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CYTOCHROMES C; DNA FRAGMENTATION; HUMANS; S PHASE; TRITERPENES;

EID: 79955054133     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.02.014     Document Type: Article

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