Solubilities of betulinic acid in thirteen organic solvents at different temperatures

Journal of Chemical and Engineering Data

Volumn 56, Issue 12, 2011, Pages 4587-4591

  Cheng, Yong ^a   Shao, Yundong ^b   Yan, Weidong ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Skyherb Ingredients   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1-BUTANOL; 1-HEXANOL; 1-PENTANOL; 1-PROPANOL; 2-BUTANOL; 2-PROPANOL; ANALYTICAL METHOD; BETULINIC ACID; BUTYL ACETATE; CRYSTAL HABITS; EMPIRICAL EQUATIONS; ETHYL ACETATES; ETHYL FORMATE; EXPERIMENTAL DATA; TEMPERATURE RANGE; TETRA-HYDROFURAN; UNIQUAC MODELS;

ACETONE; ETHANOL; METHANOL; SOLUBILITY; VOLATILE FATTY ACIDS;

ORGANIC SOLVENTS;

EID: 83455235849     PISSN: 00219568     EISSN: 15205134     Source Type: Journal    
DOI: 10.1021/je200531k     Document Type: Article

References (17)

1. Su, B.; Cuendet, M.; Farnsworth, N.; Fong, H.; Pezzuto, J.; Kinghorn, A. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay Planta Med. 2002, 68 (12) 1125-1127
2. Chang, C.; Wu, T.; Hsieh, Y.; Kuo, S.; Chao, P. Terpenoids of Syzygium formosanum J. Nat. Prod. 1999, 62 (2) 327-328
3. Lin, H.; Ding, H.; Wu, Y. Two novel compounds from Paeonia suffruticosa J. Nat. Prod. 1998, 61 (3) 343-346
4. andola, A. Determination of the triterpenoid, betulinic acid, in Doliocarpus schottianus by HPLC Phytochem. Anal. 2002, 13 (2) 95-98
5. Liu, W.-K.; Ho, J. C. K.; Cheung, F. W. K.; Liu, B. P. L.; Ye, W.-C.; Che, C.-T. Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line Eur. J. Pharmacol. 2004, 498 (1-3) 71-78
6. Kessler, J. H.; Mullauer, F. B.; de Roo, G. M.; Medema, J. P. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types Cancer Lett. 2007, 251 (1) 132-145
7. Honda, T.; Liby, K. T.; Su, X.; Sundararajan, C.; Honda, Y.; Suh, N.; Risingsong, R.; Williams, C. R.; Royce, D. B.; Sporn, M. B.; Gribble, G. W. Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A Bioorg. Med. Chem. Lett. 2006, 16 (24) 6306-6309
8. Kashiwada, Y.; Hashimoto, F.; Cosentino, L.; Chen, C.; Garrett, P.; Lee, K. Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents1 J. Med. Chem. 1996, 39 (5) 1016-1017
9. Krasutsky, P. A. Birch bark research and development Nat. Prod. Rep. 2006, 23 (6) 919-942
10. Cao, D.; Zhao, G. L.; Yan, W. D. Solubilities of betulin in fourteen organic solvents at different temperatures J. Chem. Eng. Data 2007, 52 (4) 1366-1368
11. Zhao, G. L.; Yan, W. D. Solubilities of betulin in chloroform+methanol mixed solvents at T=(278.2, 288.2, 293.2, 298.2, 308.2 and 313.2) K Fluid Phase Equilib. 2008, 267 (1) 79-82
12. Zhao, G. L.; Yan, W. D.; Cao, D. Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC J. Pharm. Biomed. Anal. 2007, 43 (3) 959-962
13. Prausnitz, J. M.; Lichtenthaler, R. N.; de Azevedo, E. G. Molecular thermodynamics of fluid-phase equilibria, 3 rd ed.; Prentice-Hall Inc.: Englewood Cliffs, NJ, 1999.
14. Fredenslund, A.; Jones, R. L.; Prausnitz, J. M. Group contribution estimation of activity coefficients in nonideal liquid mixtures AIChE J. 1975, 21 (6) 1086-1099
15. Yili, A.; Mutalipu; Aisa, H.; Isaev, M. Betulinic acid and sterols from Astragalus altaicus Chem. Nat. Compd. 2009, 45 (4) 592-594
16. Dannenfelser, R. M.; Yalkowsky, S. H. Estimation of entropy of melting from molecular structure: A non-group contribution method Ind. Eng. Chem. Res. 1996, 35 (4) 1483-1486
17. Gavezzotti, A. A solid-state chemist's view of the crystal polymorphism of organic compounds J. Pharm. Sci. 2007, 96 (9) 2232-2241