Assessing the (a)symmetry of concentration-effect curves: Empirical versus mechanistic models

Pharmacology and Therapeutics

Volumn 95, Issue 1, 2002, Pages 21-45

  Giraldo, Jesús ^a   Vivas, Nuria M ^a   Vila, Elisabet ^a   Badia, Albert ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Asymmetry; Curve fitting; G protein coupled receptors; Ionic channels; Receptor reserve; Slope parameter

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; NORADRENALIN; PHENYLEPHRINE;

ANIMAL BEHAVIOR; BINDING SITE; CONCENTRATION RESPONSE; EMPIRICISM; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; STOICHIOMETRY; ANIMAL; ARTICLE; COMPARATIVE STUDY; COMPUTER PROGRAM; DOSE RESPONSE; EMPIRICAL RESEARCH; METHODOLOGY; PHARMACOLOGY; RAT; STATISTICAL MODEL; THEORETICAL MODEL; WISTAR KYOTO RAT;

ANIMAL; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; EMPIRICAL RESEARCH; LOGISTIC MODELS; MODELS, THEORETICAL; NOREPINEPHRINE; PHARMACOLOGY; PHENYLEPHRINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SOFTWARE; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0035993439     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00223-1     Document Type: Review

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