Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5164-5169

  Vasilevsky, Sergey F ^a   Govdi, Anastasiya I ^a   Shults, El'vira E ^b   Shakirov, Makhmut M ^b   Sorokina, Irina V ^b   Tolstikova, Tatyana G ^b   Baev, Dmitry S ^b   Tolstikov, Genrikh A ^b   Alabugin, Igor V ^c  

^a INSTITUTE OF CHEMICAL KINETICS AND COMBUSTION   (Russian Federation)

^b N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^c FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Anti inflammatory activity; Arylacetylenes; Betulonic acid; Cross coupling; Hepatoprotection; Triterpenoids

Indexed keywords

ACETYLENE DERIVATIVE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALKENE; ANTIINFLAMMATORY AGENT; ASPARTATE AMINOTRANSFERASE; BETULONIC ACID DERIVATIVE; CARBON TETRACHLORIDE; CARRAGEENAN; INDOMETACIN; LIVER PROTECTIVE AGENT; N [3 OXOLUP 20(29)EN 28 OYL] 4 (N MORPHOLINOPROPARGYL 1)ANILINE; N [3 OXOLUP 20(29)EN 28 OYL] 4 (N PIPERIDINEPROPARGYL 1)ANILINE; N [3 OXOLUP 20(29)EN 28 OYL] 4 IODOANILINE; TAXIFOLIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRITERPENOID; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG SYNTHESIS; EDEMA; LIVER FUNCTION TEST; LIVER PROTECTION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SONOGASHIRA REACTION; TOXIC HEPATITIS;

ACETYLENE; ANIMALS; ANTI-INFLAMMATORY AGENTS; EDEMA; ENZYMES; HEPATITIS, TOXIC; INFLAMMATION; MALE; MICE; OLEANOLIC ACID;

EID: 67650178255     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.059     Document Type: Article

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