Synthesis and biological evaluation of antitumor-active γ-butyrolactone substituted betulin derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2549-2558

  Csuk, René ^a   Barthel, Alexander ^a   Schwarz, Stefan ^a   Kommera, Harish ^b   Paschke, Reinhard ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b BioSolution GmbH   (Germany)

Author keywords

Butyrolactone; Antitumor activity; Apoptosis; Betulin; Betulinic acid

Indexed keywords

ANTINEOPLASTIC AGENT; BETULIC ACID; BETULIN; GAMMA BUTYROLACTONE; TRITERPENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IC 50; SWERN OXIDATION;

4-BUTYROLACTONE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; COLORING AGENTS; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; OXIDATION-REDUCTION; RHODAMINES; STEREOISOMERISM; TRITERPENES;

EID: 77950061495     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.042     Document Type: Article

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