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Bioorganic and Medicinal Chemistry

Volumn 18, Issue 20, 2010, Pages 7252-7259

Synthesis, cytotoxicity and liposome preparation of 28-acetylenic betulin derivatives

(4) Csuk, René a Barthel, Alexander a Kluge, Ralph a Ströhl, Dieter a

a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG (Germany)

Author keywords

1,3 Dipolar cycloaddition; Antitumor; Betulin; Betulinic acid; Liposomes; SRB assay

Indexed keywords

28 [3 (ETHYLCARBOXY) 4 (METHYLCARBOXY)PYRAZOL 5 YL] 3,28 DIOXO 28 ETHINYLLUP 20(29) ENE; 28 [3 (ETHYLCARBOXY) 5 (METHYLCARBOXY)PYRAZOL 4 YL] 3,28 DIOXO 28 ETHINYLLUP 20(29) ENE; 28 [4 (METHYLCARBOXY) 1H 1,2,3 TRIAZOL 5 YL] 3,28 DIOXO 28 ETHINYLLUP 20(29) ENE; 28 [N METHYL 3 (METHYLCARBOXY)PYRAZOL 4 YL] 3,28 DIOXO 28 ETHINYLLUP 20(29) ENE; 3 (CYCLOPROPYLAMINO) 4 [3BETA HYDROXY 28 NORLUP 20(29) EN 17BETA YL] 2 BUTENOLIDE; 3 (DIMETHYLAMINO) 4 [3BETA HYDROXY 28 NORLUP 20(29) EN 17BETA YL] 2 BUTENOLIDE; 3 (PYRROLIDYL) 4 [3BETA HYDROXY 28 NORLUP 20(29) EN 17BETA YL] 2 BUTENOLIDE; 3 O ACETYL 28 (3 HYDROXYPROP 1 ENYL)LUP 20(29) EN 3,28 DIOL; 3 O ACETYL 28 (3 HYDROXYPROP 1 YNYL)LUP 20(29)EN 3,28 DIOL; 3 O ACETYL 28 (PHENYLETHYNYL)LUP 20(29) EN 3,28 DIOL; ANTINEOPLASTIC AGENT; BETULIC ACID; BETULIN; LIPOSOME; METHYL 3 [3BETA ACETOXY 28 HYDROXY LUP 20(29) EN 28 YL]PROPIOLATE; METHYL 3 [3BETA ACETOXY 28 OXOLUP 20(29) EN 28 YL]PROPIOLATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CYCLOADDITION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENCAPSULATION; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIPOSOMES; TRITERPENES;

EID: 77957603163 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.08.023 Document Type: Article

Times cited : (47)

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