Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

Cell Death and Differentiation

Volumn 19, Issue 8, 2012, Pages 1337-1346

  Gonzalez, P ^a   Mader, I ^a   Tchoghandjian, A ^b   Enzenmuller S ^a   Cristofanon, S ^b   Basit, F ^b   Debatin, K M ^a   Fulda, S ^a,b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

apoptosis; autophagy; betulinic acid; lysosomes

Indexed keywords

B10; BETULIC ACID; CA074ME; CASPASE 3; CATHEPSIN B; CATHEPSIN X; PROTEIN BCL 2; PROTEIN INHIBITOR; TRITERPENOID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL MEMBRANE; CELL PERMEABILIZATION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; GLYCOSYLATION; LYSOSOME; PRIORITY JOURNAL; PROTEIN SECRETION; RNA INTERFERENCE; STAINING;

ANIMALS; AUTOPHAGY; CELL DEATH; CELL LINE; DOWN-REGULATION; GLYCOSYLATION; HEK293 CELLS; HUMANS; LYSOSOMES; MICE; TRANSFECTION; TRITERPENES;

EID: 84863726751     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.10     Document Type: Article

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