Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4385-4396

  Santos, Rita C ^a   Salvador, Jorge A R ^a   Marín, Silvia ^b   Cascante, Marta ^b   Moreira, João N ^a,c   Dinis, Teresa C P ^a,c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

2 Methylimidazole; Betulinic acid; Cytotoxicity; Triazole; Triterpenoids

Indexed keywords

2 (2' METHYL 1H IMIDAZOLE 1 CARBONYLOXY) 3 OXOLUP 1,20(29) DIEN 28 OIC ACID; 2 HYDROXY 28 (1H TRIAZOL 1 YL) LUP 1,20(29) DIEN 3,28 DIONE; 28 (1H TRIAZOL 1 YL) 28 OXO LUP 20(29) EN 3 BETA YL 1H TRIAZOLE 1 CARBOXYLIC ACID; 28 (2' METHYL 1H IMIDAZOL 1 YL) 28 OXO LUP 20(29) EN 3BETA YL 20 METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID; 28 (2' METHYL 1H IMIDAZOL 1 YL) LUP 1,20(29) DIEN 3,28 DIONE; 28 (2' METHYL 1H IMIDAZOL 1 YL) LUP 20(29) EN 3,28 DIONE; 28 ACETOXY LUP 20(29) EN 3 BETA YL 1H TRIAZOLE 1 CARBOXYLIC ACID; 28 ACETOXY LUP 20(29) EN 3 BETA YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID; 28 HYDROXY LUP 20(29) EN 3 BETA YL 1H TRIAZOLE 1 CARBOXYLIC ACID; 3 BETA (2' METHYL 1H IMIDAZOLE 1 CARBONYLOXY) LUP 20(29) EN 28 OIC ACID (23) AND 28 (20 METHYL 1H IMIDAZOL 1 YL) 28 OXOLUP 20(29) EN 3BETA YL 20 METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID; 3 BETA ACETOXY LUP 20(29) EN 28 YL 1H TRIAZOLE 1 CARBOXYLIC ACID; 3 BETA ACETOXY LUP 20(29) EN 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID; 3 BETA HYDROXY 30 METHOXYLUP 20(29) EN 28 YL 1H TRIAZOLE 1 CARBOXYLIC ACID; 3 BETA HYDROXY 30 METHOXYLUP 20(29) EN 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID; 3 BETA HYDROXY LUP 20(29) EN 28 YL 1H TRIAZOLE 1 CARBOXYLIC ACID; 3 BETA HYDROXY LUP 20(29) EN 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID; 3 BETA HYDROXY LUPAN 29 OXO 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID; 30 METHOXYLUP 20(29) EN 3BETA,28 DI YL (1H TRIAZOLE 1 CARBOXYLIC ACID); 30 METHOXYLUP 20(29) EN 3BETA,28 DI YL (2' METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID); ANTINEOPLASTIC AGENT; BETULIC ACID; BETULIN; CARBAMIC ACID; LUP 20(29) EN 3BETA,28 DI YL (1H TRIAZOLE 1 CARBOXYLIC ACID); LUP 20(29) EN 3BETA,28 DI YL (2' METHYL 1H IMIDAZOLE 1 CARBOXYLIC ACID); METHYL 3 BETA (2' METHYL 1H IMIDAZOLE 1 CARBONYLOXY) LUP 20(29) EN 28 OIC ACID; UNCLASSIFIED DRUG; 2-HYDROXY-28-(1H-TRIAZOL-1-YL)-LUP-1,20(29)-DIEN-3,28-DIONE; 28-(1H-TRIAZOL-1-YL)-28-OXO-LUP-20(29)-EN-3-YL-1H-TRIAZOLE-1-CARBOXYLATE; CARBAMIC ACID DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; HETEROCYCLIC COMPOUND; TRIAZOLE DERIVATIVE; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG SCREENING; METABOLISM; SYNTHESIS; TOXICITY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARBAMATES; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TRITERPENES; TOPOISOMERASE I INHIBITORS;

EID: 77953321890     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.085     Document Type: Article

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