The mechanism of autophagy regulation and the role of autophagy in Alzheimer's disease

Progress in Biochemistry and Biophysics

Volumn 39, Issue 8, 2012, Pages 726-733

  Liu, Zhi Xue ^a   Chen, Jie ^a   Zhang, De Yi ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

A ; Alzheimer's diease; AMPK; Autophagy; MTOR

Indexed keywords

MAMMALIA;

EID: 84870934117     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2012.00363     Document Type: Review

References (81)

1. Crotzer V L, Blum J S. Autophagy and intracellular surveillance: Modulating MHC class II antigen presentation with stress. Proc Natl Acad Sci USA, 2005, 102(22): 7779-7780 (Pubitemid 40781014)
2. Cuervo A M, Dice J F. A receptor for the selective uptake and degradation of proteins by lysosomes. Science, 1996, 273(5274): 501-503 (Pubitemid 26286451)
3. Hosokawa N, Hara T, Kaizuka T, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell, 2009, 20( 7): 1981-1991
4. Itakura E, Kishi C, Inoue K, et al. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atgl4 and UVRAG. Mol Biol Cell, 2008, 19( 12): 5360-5372
5. Sun Q, Fan W, Chen K, et al. Identification of barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA, 2008, 105( 49): 19211-19216
6. Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell, 2005, 122(6): 927-939 (Pubitemid 41345209)
7. Tian S, Lin J, Zhou J, et al. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy, 2010, 6( 8): 1032-1041
8. Fimia G M, Di Bartolomeo S, Piacentini M, et al. Unleashing the ambral-beclin 1 complex from dynein chains: Ulk 1 sets ambra 1 free to induce autophagy. Autophagy, 2011, 7( 1): 115-117
9. He C, Song H, Yorimitsu T, et al. Recruitment of Atg9 to the preautophagosomal structure by Atgl 1 is essential for selective autophagy in budding yeast. J Cell Biol, 2006, 175(6): 925-935 (Pubitemid 44969198)
10. Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol, 2004, 36(12): 2503-2518 (Pubitemid 39119762)
11. Yoshimori T. Autophagy: a regulated bulk degradation process inside cells. Biochem Biophys Res Commun, 2004, 313 (2): 453-458 (Pubitemid 37543608)
12. Mizushima N, Yamamoto A, Hatano M, et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol, 2001, 152( 4): 657-668
13. Arai H, Lee V M, Otvos L, et al. Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques. Proc Natl Acad Sci USA, 1990,( 6): 2249-2253
14. Rubinsztein D C. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature, 2006, 443( 7113): 780-786
15. Rubinsztein D C, DiFiglia M, Heintz N, et al. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy, 2005, 1( 1): 11-22
16. Yu W H, Cuervo A M, Kumar A, et al. Macroautophagy - a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol, 2005, 171( 1): 87-98
17. Brunk U T, Terman A. The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis. European J Biochemistry/FEBS, 2002, 269( 8): 1996-2002
18. Dadakhujaev S, Noh H S, Jung E J, et al. Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells. Neuroscience Letters, 2010, 472( 1): 47-52
19. Dolan P J, Johnson G V. A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J Biol Chemistry, 2010, 285( 29): 21978-21987
20. Duncan C, Papanikolaou T, Ellerby L M. Autophagy: PolyQ toxic fragment turnover. Autophagy, 2010, 6( 2): 312-314
21. Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature, 2006, 441( 7095): 885-889
22. Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature, 2006, 441( 7095): 880-884
23. Larsen K E, Sulzer D. Autophagy in neurons: a review. Histol Histopathol, 2002, 17(3): 897-908 (Pubitemid 34784673)
24. Klafki H, Abramowski D, Swoboda R, et al. The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities. J Biological Chemistry, 1996, 271(45): 28655-28659 (Pubitemid 26374693)
25. Fukutani Y, Cairns N J, Rossor M N, et al. Cerebellar pathology in sporadic and familial Alzheimer's disease including APP 717 (Val>Ile) mutation cases: a morphometric investigation. Journal of the neurological sciences, 1997, 149(2): 177-184 (Pubitemid 27202376)
26. Wegiel J, Wisniewski H M, Kuchna I, et al. Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L). J Neuropathology and Experimental Neurology, 1998, 57(9): 831-838 (Pubitemid 28409398)
27. Reznik-Wolf H, Machado J, Haroutunian V, et al. Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brains. J Neurogenetics, 1998, 12(1): 55-65 (Pubitemid 28234221)
28. Jiang Y, Mullaney K A, Peterhoff C M, et al. Alzheimer's-related endosome dysfunction in down syndrome is abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci USA, 2010, 107( 4): 1630-1635
29. Skovronsky D M, Pijak D S, Doms R W, et al. A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP. Biochemistry, 2000, 39(4): 810-817 (Pubitemid 30065051)
30. Yan R, Han P, Miao H, et al. The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late golgi localization and access to beta -amyloid precursor protein (APP) substrate. J Biological Chemistry, 2001, 276( 39): 36788-36796
31. Tian Y, Bustos V, Flajolet M, et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5dependent autophagy pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, 25( 6): 1934-1942
32. Yu W H, Kumar A, Peterhoff C, et al. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. International J Biochemistry & Cell Biology, 2004, 36(12): 2531-2540 (Pubitemid 39119764)
33. Mawuenyega K G, Sigurdson W, Ovod V, et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science, 2010, 330( 6012): 1774
34. Sahara N, Maeda S, Takashima A. Tau oligomerization: A role for tau aggregation intermediates linked to neurodegeneration. Curr Alzheimer Res, 2008, 5( 6): 591-598
35. Baumann K, Mandelkow E M, Biernat J, et al. Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett, 1993, 336(3): 417-424 (Pubitemid 24036992)
36. Gomez-Ramos A, Dominguez J, Zafra D, et al. Inhibition of GSK3 dependent tau phosphorylation by metals. Curr Alzheimer Res, 2006, 3( 2): 123-127
37. Sawamura N, Gong J S, Garver W S, et al. Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of niemann-pick type C mice. J Biol Chem, 2001, 276 ( 13): 10314-10319
38. Goldbaum O, Richter-Landsberg C. Activation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytes. Glia, 2002, 40(3): 271-282 (Pubitemid 36016722)
39. Wyttenbach A, Hands S, King M A, et al. Amelioration of protein misfolding disease by rapamycin: translation or autophagy?. Autophagy, 2008, 4(4): 542-545 (Pubitemid 351705159)
40. Zhang J Y, Peng C, Shi H, et al. Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. J Alzheimer's Disease: JAD, 2009, 16( 1): 39-47
41. Aplin A, Jasionowski T, Tuttle D L, et al. Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles. J Cell Physiol, 1992, 152( 3): 458-466
42. Pacheco C D, Elrick M J, Lieberman A P. Tau deletion exacerbates the phenotype of niemann-pick type C mice and implicates autophagy in pathogenesis. Human Molecular Genetics, 2009, 18( 5): 956-965
43. Sherrington R, Rogaev E I, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature, 1995, 375( 6534): 754-760
44. Shen J, Kelleher R J 3rd. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci USA, 2007,104(2): 403-409 (Pubitemid 46123039)
45. Wilson C A, Murphy D D, Giasson B I, et al. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol, 2004, 165(3): 335-346 (Pubitemid 38649909)
46. Esselens C, Oorschot V, Baert V, et al. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol, 2004, 166(7): 1041-1054 (Pubitemid 39304767)
47. Lee J H, Yu W H, Kumar A, et al. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer related PS1 mutations. Cell, 2010, 141( 7): 1146-1158
48. Tee A R, Blenis J, Proud C G. Analysis of mTOR signaling by the small G-proteins, rheb and rheb and RhebL1 FEBS Lett, 2005, 579( 21): 4763- 4768
49. Wahl P R, Serra A L, Le Hir M, et al. Inhibition of mTOR with sirolimus slows disease progression in Han: SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol Dial Transplant, 2006, 21(3): 598-604 (Pubitemid 43372904)
50. Jaworski J, Sheng M. The growing role of mTOR in neuronal development and plasticity. Mol Neurobiol, 2006, 34( 3): 205-219
51. Chang R C, Wong A K, Ng H K, et al. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport, 2002, 13(18): 2429-2432 (Pubitemid 36143538)
52. Page G, Rioux Bilan A, Ingrand S, et al Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease. Neuroscience, 2006, 139( 4): 1343-1354
53. Li X, Alafuzoff I, Soininen H, et al. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. FEBS J, 2005, 272(16): 4211-4220 (Pubitemid 41160927)
54. Khurana V, Lu Y, Steinhilb M L, et al. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol, 2006, 16(3): 230-241 (Pubitemid 43190222)
55. Pei J J, An W L, Zhou X W, et al. P70 S6 kinase mediates tau phosphorylation and synthesis. FEBS Lett, 2006, 580( 1): 107-114
56. Virdee K, Yoshida H, Peak-Chew S, et al. Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily. FEBS Lett, 2007, 581(14): 2657-2662 (Pubitemid 46829108)
57. Jung C H, Jun C B, Ro S H, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell, 2009, 20( 7): 1992-2003
58. Thornton C, Bright N J, Sastre M, et al. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure. Biochem J, 2011, 434( 3): 503-512
59. Vingtdeux V, Davies P, Dickson D W, et al. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol, 2011, 121( 3): 337-349
60. Nakano A, Kato H, Watanabe T, et al. AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol, 2010, 12( 6): 583-590
61. Greco S J, Sarkar S, Johnston J M, et al. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochem Biophys Res Commun, 2009, 380( 1): 98-104
62. Won J S, Im Y B, Kim J, et al. Involvement of AMP-activatedprotein-kinase (AMPK) in neuronal amyloidogenesis. Biochem Biophys Res Commun, 2010, 399( 4): 487-491
63. Behrends C, Sowa M E, Gygi S P, et al. Network organization of the human autophagy system. Nature, 2010, 466( 7302): 68-76
64. Lee J W, Park S, Takahashi Y, et al. The association of AMPK with ULK1 regulates autophagy. PLoS One, 2010, 5( 11): el5394
65. Egan D F, Shackelford D B, Mihaylova M M, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science, 2011, 331( 6016): 456-461
66. He C, Bassik M C, Moresi V, et al. Exercise-induced BCL2regulated autophagy is required for muscle glucose homeostasis. Nature, 2012, 481( 7382): 511-515
67. Cong L, Jia J. Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. Neurobiology of Aging, 2011, 32( 1): 54-62
68. Zhou J. Recent progress in neurodegenerative disorder research in China. Science China Life Sciences, 2010, 53( 3): 348-355
69. He R, Lu J, Miao J. Formaldehyde stress. Science China Life Sciences, 2010, 53( 12): 1399-1404
70. Tong Z, Zhang J, Luo W, et al. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiology of Aging, 2011, 32( 1): 31-41
71. Lu J, Miao J Y, Pan R, et al. Prog Biochem Biophys, 2011, 38( 12): 1113-1120
72. Tong Z, Han C, Luo W, et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline. Age, 2012, 2012, DOI: 10.1007/s11357-012-9388-8
73. Liu Y, Qiang M, Wei Y, et al. A novel molecular mechanism for nitrated a-synuclein-induced cell death. J Mol Cell Biology, 2011, 3( 4): 239-249
74. Xu Y J, Qiang M, Liu Y, et al. Reactive carbonyl compounds (RCCs) cause aggregation and dysfunction of fibrinogen. Protein & Cell, 2012, DOI 10.1007/s13238-012-2057-y
75. Lu J, Miao J Y, Pan R, et al. Prog Biochem Biophys, 2011, 38( 12): 1113-1120
76. Zhang X H, Poo M M. Progress in neural plasticity. Science China Life Sciences, 2010, 53( 3): 322-329
77. Luo Z G. Synapse formation and remodeling. Science China Life Sciences, 2010, 53( 3): 315-321
78. Zhang M, Zhao Z M, He L, et al. A meta-analysis of oxidative stress markers in schizophrenia. Science China Life Sciences, 2010, 53( 1): 112-124
79. Wang J W, Su T, Liu Y, et al. Post-operative cognitive dysfunction is an important cause of post-operative morbidity. Neurochem Res, 2012, DOI: 10.1007/s11064-012-0834-X
80. Luo Y F, Zhang J, Liu N Q, et al. Copper ions influence the toxicity of β-amyloid (1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease. Science China Life Sciences, 2011, 54( 6): 527-534
81. Liu L L, Sheng B Y, Gong K, et al. Progress in Biochemistry and Biophysics, 2010, 37( 2): 154-160