-
1
-
-
13444304163
-
Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: Testing the "accelerator hypothesis" (2)
-
Betts P, Mulligan J, Ward P, Smith B, Wilkin T. Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: Testing the "accelerator hypothesis" (2). Diabet Med. 2005; 22: 144-51.
-
(2005)
Diabet Med
, vol.22
, pp. 144-151
-
-
Betts, P.1
Mulligan, J.2
Ward, P.3
Smith, B.4
Wilkin, T.5
-
2
-
-
0036893522
-
Incidence data of childhood-onset type I diabetes in France during 1988-1997: The case for a shift toward younger age at onset
-
Charkaluk ML, Czernichow P, Levy-Marchal C. Incidence data of childhood-onset type I diabetes in France during 1988-1997: The case for a shift toward younger age at onset. Pediatr Res. 2002; 52: 859-62.
-
(2002)
Pediatr Res
, vol.52
, pp. 859-862
-
-
Charkaluk, M.L.1
Czernichow, P.2
Levy-Marchal, C.3
-
3
-
-
28444458516
-
The "accelerator hypothesis": Relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9248 German and Austrian children with type 1 diabetes mellitus
-
Knerr I, Wolf J, Reinehr T et al. The "accelerator hypothesis": Relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9248 German and Austrian children with type 1 diabetes mellitus. Diabetologia. 2005; 48: 2501-4.
-
(2005)
Diabetologia
, vol.48
, pp. 2501-2504
-
-
Knerr, I.1
Wolf, J.2
Reinehr, T.3
-
4
-
-
80052744510
-
Current state of type 1 diabetes immunotherapy: Incremental advances, huge leaps, or more of the same?
-
Phillips B, Trucco M, Giannoukakis N. Current state of type 1 diabetes immunotherapy: Incremental advances, huge leaps, or more of the same?Clin Dev Immunol. 2011; 2011: 1-18.
-
(2011)
Clin Dev Immunol
, vol.2011
, pp. 1-18
-
-
Phillips, B.1
Trucco, M.2
Giannoukakis, N.3
-
6
-
-
80755148728
-
Artificial pancreas: Past, present, future
-
Cobelli C, Renard E, Kovatchev B. Artificial pancreas: Past, present, future. Diabetes. 2011; 60: 2672-82.
-
(2011)
Diabetes
, vol.60
, pp. 2672-2682
-
-
Cobelli, C.1
Renard, E.2
Kovatchev, B.3
-
8
-
-
0035085643
-
Clinical outcomes and insulin secretion after islet transplantation with the Edmonton Protocol
-
Ryan EA, Lakey JR, Rajotte RV et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton Protocol. Diabetes. 2001; 50: 710-19.
-
(2001)
Diabetes
, vol.50
, pp. 710-719
-
-
Ryan, E.A.1
Lakey, J.R.2
Rajotte, R.V.3
-
9
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000; 343: 230-8.
-
(2000)
N Engl J Med
, vol.343
, pp. 230-238
-
-
Shapiro, A.M.1
Lakey, J.R.2
Ryan, E.A.3
-
10
-
-
41149101209
-
Improved metabolic control and quality of life in seven patients with type 1 diabetes following islet after kidney transplantation
-
Cure P, Pileggi A, Froud T et al. Improved metabolic control and quality of life in seven patients with type 1 diabetes following islet after kidney transplantation. Transplantation. 2008; 85: 801-12.
-
(2008)
Transplantation
, vol.85
, pp. 801-812
-
-
Cure, P.1
Pileggi, A.2
Froud, T.3
-
11
-
-
34247566032
-
The effect of medical therapy and islet cell transplantation on diabetic nephropathy: An interim report
-
Fung MA, Warnock GL, Ao Z et al. The effect of medical therapy and islet cell transplantation on diabetic nephropathy: An interim report. Transplantation. 2007; 84: 17-22.
-
(2007)
Transplantation
, vol.84
, pp. 17-22
-
-
Fung, M.A.1
Warnock, G.L.2
Ao, Z.3
-
12
-
-
79951508861
-
Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy
-
Thompson DM, Meloche M, Ao Z et al. Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy. Transplantation. 2011; 91: 373-8.
-
(2011)
Transplantation
, vol.91
, pp. 373-378
-
-
Thompson, D.M.1
Meloche, M.2
Ao, Z.3
-
13
-
-
0032830997
-
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro
-
Giannoukakis N, Rudert WA, Ghivizzani SC et al. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes. 1999; 48: 1730-6.
-
(1999)
Diabetes
, vol.48
, pp. 1730-1736
-
-
Giannoukakis, N.1
Rudert, W.A.2
Ghivizzani, S.C.3
-
14
-
-
79960983261
-
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
-
Montane J, Bischoff L, Soukhatcheva G et al. Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J Clin Invest. 2011; 121: 3024-8.
-
(2011)
J Clin Invest
, vol.121
, pp. 3024-3028
-
-
Montane, J.1
Bischoff, L.2
Soukhatcheva, G.3
-
15
-
-
79953214408
-
Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes
-
Goudy KS, Johnson MC, Garland A et al. Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes. J Immunol. 2011; 186: 3779-86.
-
(2011)
J Immunol
, vol.186
, pp. 3779-3786
-
-
Goudy, K.S.1
Johnson, M.C.2
Garland, A.3
-
16
-
-
48349087101
-
AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice
-
Rehman KK, Trucco M, Wang Z, Xiao X, Robbins PD. AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther. 2008; 16: 1409-16.
-
(2008)
Mol Ther
, vol.16
, pp. 1409-1416
-
-
Rehman, K.K.1
Trucco, M.2
Wang, Z.3
Xiao, X.4
Robbins, P.D.5
-
17
-
-
66649102397
-
Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model
-
Hecht G, Eventov-Friedman S, Rosen C et al. Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model. Proc Natl Acad Sic USA. 2009; 106: 8659-64.
-
(2009)
Proc Natl Acad Sic USA
, vol.106
, pp. 8659-8664
-
-
Hecht, G.1
Eventov-Friedman, S.2
Rosen, C.3
-
18
-
-
34250613861
-
Differentiation of transplanted microencapsulated fetal pancreatic cells
-
Foster JL, Williams G, Williams LJ, Tuch BE. Differentiation of transplanted microencapsulated fetal pancreatic cells. Transplantation. 2007; 83: 1440-8.
-
(2007)
Transplantation
, vol.83
, pp. 1440-1448
-
-
Foster, J.L.1
Williams, G.2
Williams, L.J.3
Tuch, B.E.4
-
19
-
-
33644829825
-
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
-
Cardona K, Korbutt GS, Milas Z et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med. 2006; 12: 304-6.
-
(2006)
Nat Med
, vol.12
, pp. 304-306
-
-
Cardona, K.1
Korbutt, G.S.2
Milas, Z.3
-
20
-
-
0029990981
-
Large scale isolation, growth, and function of porcine neonatal islet cells
-
Korbutt GS, Elliott JF, Ao Z, Smith DK, Warnock GL, Rajotte RV. Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest. 1996; 97: 2119-29.
-
(1996)
J Clin Invest
, vol.97
, pp. 2119-2129
-
-
Korbutt, G.S.1
Elliott, J.F.2
Ao, Z.3
Smith, D.K.4
Warnock, G.L.5
Rajotte, R.V.6
-
21
-
-
0037222059
-
Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice
-
Omer A, Duvivier-Kali VF, Trivedi N, Wilmot K, Bonner-Weir S, Weir GC. Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes. 2003; 52: 69-75.
-
(2003)
Diabetes
, vol.52
, pp. 69-75
-
-
Omer, A.1
Duvivier-Kali, V.F.2
Trivedi, N.3
Wilmot, K.4
Bonner-Weir, S.5
Weir, G.C.6
-
22
-
-
33644831338
-
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
-
Hering BJ, Wijkstrom M, Graham ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med. 2006; 12: 301-3.
-
(2006)
Nat Med
, vol.12
, pp. 301-303
-
-
Hering, B.J.1
Wijkstrom, M.2
Graham, M.L.3
-
23
-
-
68249087180
-
Long-term metabolic control of autoimmune diabetes in spontaneously diabetic nonobese diabetic mice by nonvascularized microencapsulated adult porcine islets
-
Cui H, Tucker-Burden C, Cauffiel SM et al. Long-term metabolic control of autoimmune diabetes in spontaneously diabetic nonobese diabetic mice by nonvascularized microencapsulated adult porcine islets. Transplantation. 2009; 88: 160-9.
-
(2009)
Transplantation
, vol.88
, pp. 160-169
-
-
Cui, H.1
Tucker-Burden, C.2
Cauffiel, S.M.3
-
24
-
-
33749825574
-
Neonatal porcine islets exhibit natural resistance to hypoxia-induced apoptosis
-
Emamaullee JA, Shapiro AM, Rajotte RV, Korbutt G, Elliott JF. Neonatal porcine islets exhibit natural resistance to hypoxia-induced apoptosis. Transplantation. 2006; 82: 945-52.
-
(2006)
Transplantation
, vol.82
, pp. 945-952
-
-
Emamaullee, J.A.1
Shapiro, A.M.2
Rajotte, R.V.3
Korbutt, G.4
Elliott, J.F.5
-
25
-
-
0035680595
-
In vitro maturation of neonatal porcine islets: a novel model for the study of islet development and xenotransplantation
-
Binette TM, Dufour JM, Korbutt GS. In vitro maturation of neonatal porcine islets: a novel model for the study of islet development and xenotransplantation. Annals N Y Acad Sci. 2001; 944: 47-61.
-
(2001)
Annals N Y Acad Sci
, vol.944
, pp. 47-61
-
-
Binette, T.M.1
Dufour, J.M.2
Korbutt, G.S.3
-
26
-
-
0347367029
-
Production of alpha 1,3-galactosyltransferase-deficient pigs
-
Phelps CJ, Koike C, Vaught TD et al. Production of alpha 1, 3-galactosyltransferase-deficient pigs. Science. 2003; 299: 411-14.
-
(2003)
Science
, vol.299
, pp. 411-414
-
-
Phelps, C.J.1
Koike, C.2
Vaught, T.D.3
-
27
-
-
83755225863
-
Islets transplanted in immunoisolation devices: A review of the progress and the challenges that remain
-
O'Sullivan ES, Vegas A, Anderson DG, Weir GC. Islets transplanted in immunoisolation devices: A review of the progress and the challenges that remain. Endocr Rev. 2011; 32: 827-44.
-
(2011)
Endocr Rev
, vol.32
, pp. 827-844
-
-
O'Sullivan, E.S.1
Vegas, A.2
Anderson, D.G.3
Weir, G.C.4
-
28
-
-
0034719871
-
Microencapsulation of neonatal porcine islets: Protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice
-
Rayat GR, Rajotte RV, Ao Z, Korbutt GS. Microencapsulation of neonatal porcine islets: Protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice. Transplantation. 2000; 69: 1084-90.
-
(2000)
Transplantation
, vol.69
, pp. 1084-1090
-
-
Rayat, G.R.1
Rajotte, R.V.2
Ao, Z.3
Korbutt, G.S.4
-
29
-
-
33947360223
-
Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation
-
Elliott RB, Escobar L, Tan PL, Muzina M, Zwain S, Buchanan C. Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation. Xenotransplantation. 2007; 14: 157-61.
-
(2007)
Xenotransplantation
, vol.14
, pp. 157-161
-
-
Elliott, R.B.1
Escobar, L.2
Tan, P.L.3
Muzina, M.4
Zwain, S.5
Buchanan, C.6
-
30
-
-
0033979603
-
Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
-
Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes. 2000; 49: 157-62.
-
(2000)
Diabetes
, vol.49
, pp. 157-162
-
-
Soria, B.1
Roche, E.2
Berna, G.3
Leon-Quinto, T.4
Reig, J.A.5
Martin, F.6
-
31
-
-
0035906902
-
Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
-
Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 2001; 292: 1389-94.
-
(2001)
Science
, vol.292
, pp. 1389-1394
-
-
Lumelsky, N.1
Blondel, O.2
Laeng, P.3
Velasco, I.4
Ravin, R.5
McKay, R.6
-
32
-
-
0035434048
-
Insulin production by human embryonic stem cells
-
Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M. Insulin production by human embryonic stem cells. Diabetes. 2001; 50: 1691-7.
-
(2001)
Diabetes
, vol.50
, pp. 1691-1697
-
-
Assady, S.1
Maor, G.2
Amit, M.3
Itskovitz-Eldor, J.4
Skorecki, K.L.5
Tzukerman, M.6
-
33
-
-
0037449573
-
Insulin staining of ES cell progeny from insulin uptake
-
Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science. 2003; 299: 363.
-
(2003)
Science
, vol.299
, pp. 363
-
-
Rajagopal, J.1
Anderson, W.J.2
Kume, S.3
Martinez, O.I.4
Melton, D.A.5
-
34
-
-
4644222526
-
Artifactual insulin release from differentiated embryonic stem cells
-
Hansson M, Tonning A, Frandsen U et al. Artifactual insulin release from differentiated embryonic stem cells. Diabetes. 2004; 53: 2603-9.
-
(2004)
Diabetes
, vol.53
, pp. 2603-2609
-
-
Hansson, M.1
Tonning, A.2
Frandsen, U.3
-
35
-
-
0037417958
-
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
-
Blyszczuk P, Czyz J, Kania G et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci USA. 2003; 100: 998-1003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 998-1003
-
-
Blyszczuk, P.1
Czyz, J.2
Kania, G.3
-
36
-
-
1842527497
-
Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells
-
Miyazaki S, Yamato E, Miyazaki J. Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes. 2004; 53: 1030-7.
-
(2004)
Diabetes
, vol.53
, pp. 1030-1037
-
-
Miyazaki, S.1
Yamato, E.2
Miyazaki, J.3
-
37
-
-
33749185455
-
The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells
-
Lavon N, Yanuka O, Benvenisty N. The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells. Stem Cells. 2006; 24: 1923-30.
-
(2006)
Stem Cells
, vol.24
, pp. 1923-1930
-
-
Lavon, N.1
Yanuka, O.2
Benvenisty, N.3
-
38
-
-
62549083921
-
Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells
-
Bernardo AS, Cho CH, Mason S et al. Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells. 2009; 27: 341-51.
-
(2009)
Stem Cells
, vol.27
, pp. 341-351
-
-
Bernardo, A.S.1
Cho, C.H.2
Mason, S.3
-
39
-
-
34248203739
-
Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method
-
Lin HT, Kao CL, Lee KH et al. Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method. World J Gastroenterol. 2007; 13: 1672-9.
-
(2007)
World J Gastroenterol
, vol.13
, pp. 1672-1679
-
-
Lin, H.T.1
Kao, C.L.2
Lee, K.H.3
-
40
-
-
46349111797
-
PAX4 enhances beta-cell differentiation of human embryonic stem cells
-
Liew CG, Shah NN, Briston SJ et al.PAX4 enhances beta-cell differentiation of human embryonic stem cells. PLoS ONE. 2008; 3: e1783.
-
(2008)
PLoS ONE
, vol.3
-
-
Liew, C.G.1
Shah, N.N.2
Briston, S.J.3
-
41
-
-
33750542712
-
Differentiation of embryonic stem cells conditionally expressing neurogenin 3
-
Treff NR, Vincent RK, Budde ML et al. Differentiation of embryonic stem cells conditionally expressing neurogenin 3. Stem Cells. 2006; 24: 2529-37.
-
(2006)
Stem Cells
, vol.24
, pp. 2529-2537
-
-
Treff, N.R.1
Vincent, R.K.2
Budde, M.L.3
-
42
-
-
23144439415
-
Differentiation of embryonic stem cells into insulin-producing cells promoted by Nkx2.2 gene transfer
-
Shiroi A, Ueda S, Ouji Y et al. Differentiation of embryonic stem cells into insulin-producing cells promoted by Nkx2.2 gene transfer. World J Gastroenterol. 2005; 11: 4161-6.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 4161-4166
-
-
Shiroi, A.1
Ueda, S.2
Ouji, Y.3
-
43
-
-
33750846133
-
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
-
D'Amour KA, Bang AG, Eliazer S et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol. 2006; 24: 1392-401.
-
(2006)
Nat Biotechnol
, vol.24
, pp. 1392-1401
-
-
D'Amour, K.A.1
Bang, A.G.2
Eliazer, S.3
-
44
-
-
41849151748
-
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
-
Kroon E, Martinson LA, Kadoya K et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008; 26: 443-52.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 443-452
-
-
Kroon, E.1
Martinson, L.A.2
Kadoya, K.3
-
45
-
-
62649138086
-
A small molecule that directs differentiation of human ESCs into the pancreatic lineage
-
Chen S, Borowiak M, Fox JL et al.A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009; 5: 258-65.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 258-265
-
-
Chen, S.1
Borowiak, M.2
Fox, J.L.3
-
46
-
-
79551580013
-
Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
-
Nostro MC, Sarangi F, Ogawa S et al. Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development. 2011; 138: 861-71.
-
(2011)
Development
, vol.138
, pp. 861-871
-
-
Nostro, M.C.1
Sarangi, F.2
Ogawa, S.3
-
47
-
-
34547857040
-
Generation of insulin-producing islet-like clusters from human embryonic stem cells
-
Jiang J, Au M, Lu K et al. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells. 2007; 25: 1940-53.
-
(2007)
Stem Cells
, vol.25
, pp. 1940-1953
-
-
Jiang, J.1
Au, M.2
Lu, K.3
-
48
-
-
34247353657
-
In vitro derivation of functional insulin-producing cells from human embryonic stem cells
-
Jiang W, Shi Y, Zhao D et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007; 17: 333-44.
-
(2007)
Cell Res
, vol.17
, pp. 333-344
-
-
Jiang, W.1
Shi, Y.2
Zhao, D.3
-
49
-
-
80755187146
-
Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells
-
Xu X, Browning VL, Odorico JS. Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev. 2011; 128: 412-27.
-
(2011)
Mech Dev
, vol.128
, pp. 412-427
-
-
Xu, X.1
Browning, V.L.2
Odorico, J.S.3
-
50
-
-
77952682209
-
Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells
-
Mfopou JK, Chen B, Mateizel I, Sermon K, Bouwens L. Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells. Gastroenterology. 2010; 138: 2233-45.
-
(2010)
Gastroenterology
, vol.138
, pp. 2233-2245
-
-
Mfopou, J.K.1
Chen, B.2
Mateizel, I.3
Sermon, K.4
Bouwens, L.5
-
51
-
-
77950364568
-
Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells
-
Cai J, Yu C, Liu Y et al. Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells. J Mol Cell Biol. 2010; 2: 50-60.
-
(2010)
J Mol Cell Biol
, vol.2
, pp. 50-60
-
-
Cai, J.1
Yu, C.2
Liu, Y.3
-
52
-
-
34247898958
-
Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
-
Shim JH, Kim SE, Woo DH et al. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia. 2007; 50: 1228-38.
-
(2007)
Diabetologia
, vol.50
, pp. 1228-1238
-
-
Shim, J.H.1
Kim, S.E.2
Woo, D.H.3
-
53
-
-
64149118087
-
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells
-
Zhang D, Jiang W, Liu M et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res. 2009; 19: 429-38.
-
(2009)
Cell Res
, vol.19
, pp. 429-438
-
-
Zhang, D.1
Jiang, W.2
Liu, M.3
-
54
-
-
28644448149
-
Efficient differentiation of human embryonic stem cells to definitive endoderm
-
D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol. 2005; 23: 1534-41.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1534-1541
-
-
D'Amour, K.A.1
Agulnick, A.D.2
Eliazer, S.3
Kelly, O.G.4
Kroon, E.5
Baetge, E.E.6
-
55
-
-
78751502673
-
Production of functional glucagon-secreting alpha-cells from human embryonic stem cells
-
Rezania A, Riedel MJ, Wideman RD et al. Production of functional glucagon-secreting alpha-cells from human embryonic stem cells. Diabetes. 2011; 60: 239-47.
-
(2011)
Diabetes
, vol.60
, pp. 239-247
-
-
Rezania, A.1
Riedel, M.J.2
Wideman, R.D.3
-
56
-
-
84856696056
-
The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells
-
Basford CL, Prentice KJ, Hardy AB et al. The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells. Diabetologia. 2012; 55: 358-71.
-
(2012)
Diabetologia
, vol.55
, pp. 358-371
-
-
Basford, C.L.1
Prentice, K.J.2
Hardy, A.B.3
-
57
-
-
79961175124
-
Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells
-
Kelly OG, Chan MY, Martinson LA et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol. 2011; 29: 750-6.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 750-756
-
-
Kelly, O.G.1
Chan, M.Y.2
Martinson, L.A.3
-
58
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126: 663-76.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
59
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131: 861-72.
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
-
60
-
-
57649128308
-
Generation of insulin-secreting islet-like clusters from human skin fibroblasts
-
Tateishi K, He J, Taranova O, Liang G, D'Alessio AC, Zhang Y. Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol Chem. 2008; 283: 31601-7.
-
(2008)
J Biol Chem
, vol.283
, pp. 31601-31607
-
-
Tateishi, K.1
He, J.2
Taranova, O.3
Liang, G.4
D'Alessio, A.C.5
Zhang, Y.6
-
61
-
-
70349437501
-
Generation of pluripotent stem cells from patients with type 1 diabetes
-
Maehr R, Chen S, Snitow M et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci USA. 2009; 106: 15768-73.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 15768-15773
-
-
Maehr, R.1
Chen, S.2
Snitow, M.3
-
62
-
-
79959992876
-
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells
-
Bar-Nur O, Russ HA, Efrat S, Benvenisty N. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell. 2011; 9: 17-23.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 17-23
-
-
Bar-Nur, O.1
Russ, H.A.2
Efrat, S.3
Benvenisty, N.4
-
63
-
-
77955814966
-
Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells
-
Alipio Z, Liao W, Roemer EJ et al. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci USA. 2010; 107: 13426-31.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13426-13431
-
-
Alipio, Z.1
Liao, W.2
Roemer, E.J.3
-
64
-
-
80054689566
-
Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells
-
Zhu FF, Zhang PB, Zhang DH et al. Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells. Diabetologia. 2011; 54: 2325-36.
-
(2011)
Diabetologia
, vol.54
, pp. 2325-2336
-
-
Zhu, F.F.1
Zhang, P.B.2
Zhang, D.H.3
-
65
-
-
40449141341
-
Marked differences in differentiation propensity among human embryonic stem cell lines
-
Osafune K, Caron L, Borowiak M et al. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008; 26: 313-15.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 313-315
-
-
Osafune, K.1
Caron, L.2
Borowiak, M.3
-
68
-
-
78951478823
-
Dedifferentiation, transdifferentiation and reprogramming: Three routes to regeneration
-
Jopling C, Boue S, Izpisua Belmonte JC. Dedifferentiation, transdifferentiation and reprogramming: Three routes to regeneration. Nat Rev Mol Cell Biol. 2011; 12: 79-89.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 79-89
-
-
Jopling, C.1
Boue, S.2
Izpisua Belmonte, J.C.3
-
69
-
-
0017290221
-
The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells
-
Pictet RL, Rall LB, Phelps P, Rutter WJ. The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells. Science. 1976; 191: 191-2.
-
(1976)
Science
, vol.191
, pp. 191-192
-
-
Pictet, R.L.1
Rall, L.B.2
Phelps, P.3
Rutter, W.J.4
-
70
-
-
0029027780
-
Developmental biology of the pancreas
-
Slack JM. Developmental biology of the pancreas. Development. 1995; 121: 1569-80.
-
(1995)
Development
, vol.121
, pp. 1569-1580
-
-
Slack, J.M.1
-
71
-
-
14244266611
-
Minireview: Transcriptional regulation in pancreatic development
-
Habener JF, Kemp DM, Thomas MK. Minireview: Transcriptional regulation in pancreatic development. Endocrinology. 2005; 146: 1025-34.
-
(2005)
Endocrinology
, vol.146
, pp. 1025-1034
-
-
Habener, J.F.1
Kemp, D.M.2
Thomas, M.K.3
-
72
-
-
2542446343
-
Minireview: Development and differentiation of gut endocrine cells
-
Schonhoff SE, Giel-Moloney M, Leiter AB. Minireview: Development and differentiation of gut endocrine cells. Endocrinology. 2004; 145: 2639-44.
-
(2004)
Endocrinology
, vol.145
, pp. 2639-2644
-
-
Schonhoff, S.E.1
Giel-Moloney, M.2
Leiter, A.B.3
-
74
-
-
33745214464
-
Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
-
Fukuda A. Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Investig. 2006; 116: 1484-93.
-
(2006)
J Clin Investig
, vol.116
, pp. 1484-1493
-
-
Fukuda, A.1
-
75
-
-
34047181476
-
Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas
-
Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME. Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev Biol. 2007; 304: 786-99.
-
(2007)
Dev Biol
, vol.304
, pp. 786-799
-
-
Jarikji, Z.H.1
Vanamala, S.2
Beck, C.W.3
Wright, C.V.4
Leach, S.D.5
Horb, M.E.6
-
76
-
-
0036328180
-
PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells
-
Yoshida S, Kajimoto Y, Yasuda T et al.PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Diabetes. 2002; 51: 2505-13.
-
(2002)
Diabetes
, vol.51
, pp. 2505-2513
-
-
Yoshida, S.1
Kajimoto, Y.2
Yasuda, T.3
-
77
-
-
0036312398
-
Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin
-
Kojima H, Nakamura T, Fujita Y et al. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes. 2002; 51: 1398-408.
-
(2002)
Diabetes
, vol.51
, pp. 1398-1408
-
-
Kojima, H.1
Nakamura, T.2
Fujita, Y.3
-
78
-
-
33748286893
-
MafA differentiates rat intestinal cells into insulin-producing cells
-
Nomura S, Nakamura T, Hashimoto T et al. MafA differentiates rat intestinal cells into insulin-producing cells. Biochem Biophys Res Commun. 2006; 349: 136-43.
-
(2006)
Biochem Biophys Res Commun
, vol.349
, pp. 136-143
-
-
Nomura, S.1
Nakamura, T.2
Hashimoto, T.3
-
79
-
-
42349083585
-
Genetic programming of liver and pancreas progenitors: Lessons for stem-cell differentiation
-
Zaret KS. Genetic programming of liver and pancreas progenitors: Lessons for stem-cell differentiation. Nat Rev Genet. 2008; 9: 329-40.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 329-340
-
-
Zaret, K.S.1
-
80
-
-
66349097174
-
Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver
-
Servitja JM, Pignatelli M, Maestro MA et al. Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. Mol Cell Biol. 2009; 29: 2945-59.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2945-2959
-
-
Servitja, J.M.1
Pignatelli, M.2
Maestro, M.A.3
-
81
-
-
10744227070
-
Control of pancreas and liver gene expression by HNF transcription factors
-
Odom DT, Zizlsperger N, Gordon DB et al. Control of pancreas and liver gene expression by HNF transcription factors. Science. 2004; 303: 1378-81.
-
(2004)
Science
, vol.303
, pp. 1378-1381
-
-
Odom, D.T.1
Zizlsperger, N.2
Gordon, D.B.3
-
82
-
-
0034068602
-
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
-
Ferber S, Halkin A, Cohen H et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med. 2000; 6: 568-72.
-
(2000)
Nat Med
, vol.6
, pp. 568-572
-
-
Ferber, S.1
Halkin, A.2
Cohen, H.3
-
83
-
-
0041856137
-
Functional, persistent, and extended liver to pancreas transdifferentiation
-
Ber I, Shternhall K, Perl S et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem. 2003; 278: 31.
-
(2003)
J Biol Chem
, vol.278
, pp. 31
-
-
Ber, I.1
Shternhall, K.2
Perl, S.3
-
84
-
-
9944235761
-
Constitutively active PDX1 induced efficient insulin production in adult murine liver
-
Imai J, Katagiri H, Yamada T et al. Constitutively active PDX1 induced efficient insulin production in adult murine liver. Biochem Biophys Res Commun. 2005; 326: 402-9.
-
(2005)
Biochem Biophys Res Commun
, vol.326
, pp. 402-409
-
-
Imai, J.1
Katagiri, H.2
Yamada, T.3
-
85
-
-
15944417831
-
PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance
-
Kaneto H, Nakatani Y, Miyatsuka T et al.PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes. 2005; 54: 1009-22.
-
(2005)
Diabetes
, vol.54
, pp. 1009-1022
-
-
Kaneto, H.1
Nakatani, Y.2
Miyatsuka, T.3
-
86
-
-
33846316025
-
Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver
-
Wang AY, Ehrhardt A, Xu H, Kay MA. Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Mol Ther. 2007; 15: 255-63.
-
(2007)
Mol Ther
, vol.15
, pp. 255-263
-
-
Wang, A.Y.1
Ehrhardt, A.2
Xu, H.3
Kay, M.A.4
-
87
-
-
0038413922
-
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
-
Kojima H, Fujimiya M, Matsumura K et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med. 2003; 9: 596-603.
-
(2003)
Nat Med
, vol.9
, pp. 596-603
-
-
Kojima, H.1
Fujimiya, M.2
Matsumura, K.3
-
88
-
-
20344394437
-
Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
-
Sapir T, Shternhall K, Meivar-Levy I et al. Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA. 2005; 102: 7964-9.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7964-7969
-
-
Sapir, T.1
Shternhall, K.2
Meivar-Levy, I.3
-
89
-
-
84874979890
-
Human liver cells expressing albumin and mesenchymal characteristics give rise to insulin-producing cells
-
Meivar-Levy I, Sapir T, Berneman D et al. Human liver cells expressing albumin and mesenchymal characteristics give rise to insulin-producing cells. J Transplant. 2011; 2011: 1-12.
-
(2011)
J Transplant
, vol.2011
, pp. 1-12
-
-
Meivar-Levy, I.1
Sapir, T.2
Berneman, D.3
-
90
-
-
78649522751
-
NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming
-
Gefen-Halevi S, Rachmut IH, Molakandov K et al.NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming. Cell Reprogram. 2010; 12: 655-64.
-
(2010)
Cell Reprogram
, vol.12
, pp. 655-664
-
-
Gefen-Halevi, S.1
Rachmut, I.H.2
Molakandov, K.3
-
91
-
-
17644381301
-
A crucial role of MafA as a novel therapeutic target for diabetes
-
Kaneto H, Matsuoka TA, Nakatani Y et al.A crucial role of MafA as a novel therapeutic target for diabetes. J Biol Chem. 2005; 280: 15047-52.
-
(2005)
J Biol Chem
, vol.280
, pp. 15047-15052
-
-
Kaneto, H.1
Matsuoka, T.A.2
Nakatani, Y.3
-
92
-
-
61749094740
-
Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
-
Yechoor V, Liu V, Espiritu C et al. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell. 2009; 16: 358-73.
-
(2009)
Dev Cell
, vol.16
, pp. 358-373
-
-
Yechoor, V.1
Liu, V.2
Espiritu, C.3
-
93
-
-
0030661741
-
Intermediate endocrine-acinar pancreatic cells in duct ligation conditions
-
Bertelli E, Bendayan M. Intermediate endocrine-acinar pancreatic cells in duct ligation conditions. Am J Physiol. 1997; 273: C1641-9.
-
(1997)
Am J Physiol
, vol.273
-
-
Bertelli, E.1
Bendayan, M.2
-
94
-
-
1042288598
-
Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas
-
Lardon J, Huyens N, Rooman I, Bouwens L. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch. 2004; 444: 61-5.
-
(2004)
Virchows Arch
, vol.444
, pp. 61-65
-
-
Lardon, J.1
Huyens, N.2
Rooman, I.3
Bouwens, L.4
-
95
-
-
80051521184
-
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas
-
Houbracken I, De Waele E, Lardon J et al. Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology. 2011; 141: 731-41.
-
(2011)
Gastroenterology
, vol.141
, pp. 731-741
-
-
Houbracken, I.1
De Waele, E.2
Lardon, J.3
-
96
-
-
27244437951
-
Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells
-
Minami K, Okuno M, Miyawaki K et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA. 2005; 102: 15116-21.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15116-15121
-
-
Minami, K.1
Okuno, M.2
Miyawaki, K.3
-
97
-
-
12944327377
-
In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
-
Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I, Bouwens L. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia. 2005; 48: 49-57.
-
(2005)
Diabetologia
, vol.48
, pp. 49-57
-
-
Baeyens, L.1
De Breuck, S.2
Lardon, J.3
Mfopou, J.K.4
Rooman, I.5
Bouwens, L.6
-
98
-
-
0034608816
-
In vitro cultivation of human islets from expanded ductal tissue
-
Bonner-Weir S, Taneja M, Weir GC et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA. 2000; 97: 7999-8004.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7999-8004
-
-
Bonner-Weir, S.1
Taneja, M.2
Weir, G.C.3
-
99
-
-
0037269132
-
β-Cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas
-
Taniguchi H, Yamato E, Tashiro F, Ikegami H, Ogihara T, Miyazaki J. β-Cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas. Gene Ther. 2003; 10: 15-23.
-
(2003)
Gene Ther
, vol.10
, pp. 15-23
-
-
Taniguchi, H.1
Yamato, E.2
Tashiro, F.3
Ikegami, H.4
Ogihara, T.5
Miyazaki, J.6
-
100
-
-
53349178722
-
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
-
Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008; 455: 627-32.
-
(2008)
Nature
, vol.455
, pp. 627-632
-
-
Zhou, Q.1
Brown, J.2
Kanarek, A.3
Rajagopal, J.4
Melton, D.A.5
-
101
-
-
77951611220
-
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
-
Thorel F, Nepote V, Avril I et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 2010; 464: 1149-54.
-
(2010)
Nature
, vol.464
, pp. 1149-1154
-
-
Thorel, F.1
Nepote, V.2
Avril, I.3
-
102
-
-
77958099053
-
Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells
-
Chung CH, Hao E, Piran R, Keinan E, Levine F. Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells. Stem Cells. 2010; 28: 1630-8.
-
(2010)
Stem Cells
, vol.28
, pp. 1630-1638
-
-
Chung, C.H.1
Hao, E.2
Piran, R.3
Keinan, E.4
Levine, F.5
-
103
-
-
68149162957
-
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
-
Collombat P, Xu X, Ravassard P et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell. 2009; 138: 449-62.
-
(2009)
Cell
, vol.138
, pp. 449-462
-
-
Collombat, P.1
Xu, X.2
Ravassard, P.3
-
104
-
-
58749102383
-
Genes controlling pancreas ontogeny
-
Bonal C, Herrera PL. Genes controlling pancreas ontogeny. Int J Dev Biol. 2008; 52: 823-35.
-
(2008)
Int J Dev Biol
, vol.52
, pp. 823-835
-
-
Bonal, C.1
Herrera, P.L.2
-
105
-
-
70449364064
-
Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection
-
Pechhold S, Stouffer M, Walker G et al. Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Nat Biotechnol. 2009; 27: 1038-42.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 1038-1042
-
-
Pechhold, S.1
Stouffer, M.2
Walker, G.3
-
106
-
-
0034091111
-
Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice
-
Li Z, Karlsson FA, Sandler S. Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice. J Endocrinol. 2000; 165: 93-9.
-
(2000)
J Endocrinol
, vol.165
, pp. 93-99
-
-
Li, Z.1
Karlsson, F.A.2
Sandler, S.3
-
107
-
-
0037417984
-
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice
-
Gelling RW. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sic USA. 2003; 100: 1438-43.
-
(2003)
Proc Natl Acad Sic USA
, vol.100
, pp. 1438-1443
-
-
Gelling, R.W.1
-
108
-
-
80755168891
-
Normal glucagon signaling and beta-cell function after near-total alpha-cell ablation in adult mice
-
Thorel F, Damond N, Chera S et al. Normal glucagon signaling and beta-cell function after near-total alpha-cell ablation in adult mice. Diabetes. 2011; 60: 2872-82.
-
(2011)
Diabetes
, vol.60
, pp. 2872-2882
-
-
Thorel, F.1
Damond, N.2
Chera, S.3
-
109
-
-
0035491791
-
Gene and cell-replacement therapy in the treatment of type 1 diabetes: How high must the standards be set?
-
Halban PA, Kahn SE, Lernmark A, Rhodes CJ. Gene and cell-replacement therapy in the treatment of type 1 diabetes: How high must the standards be set?Diabetes. 2001; 50: 2181-91.
-
(2001)
Diabetes
, vol.50
, pp. 2181-2191
-
-
Halban, P.A.1
Kahn, S.E.2
Lernmark, A.3
Rhodes, C.J.4
-
110
-
-
0026313787
-
Proprotein-processing endopeptidases of the insulin secretory granule
-
Bailyes EM, Bennett DL, Hutton JC. Proprotein-processing endopeptidases of the insulin secretory granule. Enzyme. 1991; 45: 301-13.
-
(1991)
Enzyme
, vol.45
, pp. 301-313
-
-
Bailyes, E.M.1
Bennett, D.L.2
Hutton, J.C.3
-
112
-
-
0035201145
-
Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells
-
Barg S, Ma X, Eliasson L et al. Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. Biophys J. 2001; 81: 3308-23.
-
(2001)
Biophys J
, vol.81
, pp. 3308-3323
-
-
Barg, S.1
Ma, X.2
Eliasson, L.3
-
113
-
-
0027467712
-
Pancreatic beta-cells express a low affinity glucose transporter: Functional consequences in normal and diabetic states
-
Marshall MO, Thomas HM, Seatter MJ, Greer KR, Wood PJ, Gould GW. Pancreatic beta-cells express a low affinity glucose transporter: Functional consequences in normal and diabetic states. Biochem Soc Trans. 1993; 21: 164-8.
-
(1993)
Biochem Soc Trans
, vol.21
, pp. 164-168
-
-
Marshall, M.O.1
Thomas, H.M.2
Seatter, M.J.3
Greer, K.R.4
Wood, P.J.5
Gould, G.W.6
-
114
-
-
0027479441
-
Glucose sensing in pancreatic islet beta cells: The key role of glucokinase and the glycolytic intermediates
-
German MS. Glucose sensing in pancreatic islet beta cells: The key role of glucokinase and the glycolytic intermediates. Proc Natl Acad Sci USA. 1993; 90: 1781-5.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1781-1785
-
-
German, M.S.1
-
115
-
-
0028859374
-
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression
-
De Vos A, Heimberg H, Quartier E et al. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest. 1995; 96: 2489-95.
-
(1995)
J Clin Invest
, vol.96
, pp. 2489-2495
-
-
De Vos, A.1
Heimberg, H.2
Quartier, E.3
-
116
-
-
21144484250
-
Safety and efficacy of adeno-associated viral vector-mediated insulin gene transfer via portal vein to the livers of streptozotocin-induced diabetic Sprague-Dawley rats
-
Park YM, Woo S, Lee GT et al. Safety and efficacy of adeno-associated viral vector-mediated insulin gene transfer via portal vein to the livers of streptozotocin-induced diabetic Sprague-Dawley rats. J Gene Med. 2005; 7: 621-9.
-
(2005)
J Gene Med
, vol.7
, pp. 621-629
-
-
Park, Y.M.1
Woo, S.2
Lee, G.T.3
-
117
-
-
0035032259
-
Hepatic insulin expression improves glycemic control in type 1 diabetic rats
-
Dong H, Morral N, McEvoy R, Meseck M, Thung SN, Woo SL. Hepatic insulin expression improves glycemic control in type 1 diabetic rats. Diabetes Res Clin Pract. 2001; 52: 153-63.
-
(2001)
Diabetes Res Clin Pract
, vol.52
, pp. 153-163
-
-
Dong, H.1
Morral, N.2
McEvoy, R.3
Meseck, M.4
Thung, S.N.5
Woo, S.L.6
-
118
-
-
0030946203
-
Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats
-
Muzzin P, Eisensmith RC, Copeland KC, Woo SL. Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats. Mol Endocrinol. 1997; 11: 833-7.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 833-837
-
-
Muzzin, P.1
Eisensmith, R.C.2
Copeland, K.C.3
Woo, S.L.4
-
119
-
-
0031730473
-
Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice
-
Short DK, Okada S, Yamauchi K, Pessin JE. Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice. Am J Physiol. 1998; 275: E748-56.
-
(1998)
Am J Physiol
, vol.275
-
-
Short, D.K.1
Okada, S.2
Yamauchi, K.3
Pessin, J.E.4
-
120
-
-
0033765795
-
Regulated hepatic insulin gene therapy of STZ-diabetic rats
-
Thule PM, Liu JM. Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther. 2000; 7: 1744-52.
-
(2000)
Gene Ther
, vol.7
, pp. 1744-1752
-
-
Thule, P.M.1
Liu, J.M.2
-
121
-
-
0034707028
-
Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
-
Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature. 2000; 408: 483-8.
-
(2000)
Nature
, vol.408
, pp. 483-488
-
-
Lee, H.C.1
Kim, S.J.2
Kim, K.S.3
Shin, H.C.4
Yoon, J.W.5
-
122
-
-
0034778099
-
Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia
-
Shifrin AL, Auricchio A, Yu QC, Wilson J, Raper SE. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Ther. 2001; 8: 1480-9.
-
(2001)
Gene Ther
, vol.8
, pp. 1480-1489
-
-
Shifrin, A.L.1
Auricchio, A.2
Yu, Q.C.3
Wilson, J.4
Raper, S.E.5
-
123
-
-
1542374880
-
Gene therapy of streptozotocin-induced diabetes by intramuscular delivery of modified preproinsulin genes
-
Croze F, Prud'homme GJ. Gene therapy of streptozotocin-induced diabetes by intramuscular delivery of modified preproinsulin genes. J Gene Med. 2003; 5: 425-37.
-
(2003)
J Gene Med
, vol.5
, pp. 425-437
-
-
Croze, F.1
Prud'homme, G.J.2
-
124
-
-
0031005505
-
Toward the biologic release of human insulin from skeletal muscle
-
Bartlett RJ, Secore SL, Denis M et al. Toward the biologic release of human insulin from skeletal muscle. Transplant Proc. 1997; 29: 2199-200.
-
(1997)
Transplant Proc
, vol.29
, pp. 2199-2200
-
-
Bartlett, R.J.1
Secore, S.L.2
Denis, M.3
-
125
-
-
33748289497
-
Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle
-
Mas A, Montane J, Anguela XM et al. Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle. Diabetes. 2006; 55: 1546-53.
-
(2006)
Diabetes
, vol.55
, pp. 1546-1553
-
-
Mas, A.1
Montane, J.2
Anguela, X.M.3
-
126
-
-
33644524068
-
Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus containing insulin gene
-
Oh TK, Li MZ, Kim ST. Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus containing insulin gene. Diabetes Res Clin Pract. 2006; 71: 233-40.
-
(2006)
Diabetes Res Clin Pract
, vol.71
, pp. 233-240
-
-
Oh, T.K.1
Li, M.Z.2
Kim, S.T.3
-
127
-
-
0035976865
-
Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y) mice
-
Nagamatsu S, Nakamichi Y, Ohara-Imaizumi M et al. Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y) mice. FEBS Lett. 2001; 509: 106-10.
-
(2001)
FEBS Lett
, vol.509
, pp. 106-110
-
-
Nagamatsu, S.1
Nakamichi, Y.2
Ohara-Imaizumi, M.3
-
128
-
-
34547701718
-
Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy
-
Ren B, O'Brien BA, Swan MA et al. Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy. Diabetologia. 2007; 50: 1910-20.
-
(2007)
Diabetologia
, vol.50
, pp. 1910-1920
-
-
Ren, B.1
O'Brien, B.A.2
Swan, M.A.3
-
129
-
-
0028963345
-
Gene therapy for diabetes mellitus in rats by hepatic expression of insulin
-
Kolodka TM, Finegold M, Moss L, Woo SL. Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc Natl Acad Sci USA. 1995; 92: 3293-7.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 3293-3297
-
-
Kolodka, T.M.1
Finegold, M.2
Moss, L.3
Woo, S.L.4
-
130
-
-
0011269588
-
In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I
-
Nicolau C, Le Pape A, Soriano P, Fargette F, Juhel MF. In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I. Proc Natl Acad Sci USA. 1983; 80: 1068-72.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 1068-1072
-
-
Nicolau, C.1
Le Pape, A.2
Soriano, P.3
Fargette, F.4
Juhel, M.F.5
-
131
-
-
0024338253
-
Introduction and expression of the human insulin gene in adult rat liver
-
Kaneda Y, Iwai K, Uchida T. Introduction and expression of the human insulin gene in adult rat liver. J Biol Chem. 1989; 264: 12126-9.
-
(1989)
J Biol Chem
, vol.264
, pp. 12126-12129
-
-
Kaneda, Y.1
Iwai, K.2
Uchida, T.3
-
132
-
-
77957309983
-
Hepatic-directed vesicle insulin: A review of formulation development and preclinical evaluation
-
Geho WB, Geho HC, Lau JR, Gana TJ. Hepatic-directed vesicle insulin: A review of formulation development and preclinical evaluation. J Diabetes Sci Technol. 2009; 3: 1451-9.
-
(2009)
J Diabetes Sci Technol
, vol.3
, pp. 1451-1459
-
-
Geho, W.B.1
Geho, H.C.2
Lau, J.R.3
Gana, T.J.4
-
133
-
-
0346333313
-
Intramuscular injection of naked plasmid DNA encoding human preproinsulin gene in streptozotocin-diabetes mice results in a significant reduction of blood glucose level
-
Wang LY, Sun W, Chen MZ, Wang X. Intramuscular injection of naked plasmid DNA encoding human preproinsulin gene in streptozotocin-diabetes mice results in a significant reduction of blood glucose level. Sheng Li Xue Bao. 2003; 55: 641-7.
-
(2003)
Sheng Li Xue Bao
, vol.55
, pp. 641-647
-
-
Wang, L.Y.1
Sun, W.2
Chen, M.Z.3
Wang, X.4
-
134
-
-
0016139325
-
The interactions of proinsulin with insulin receptors on the plasma membrane of the liver
-
Freychet P. The interactions of proinsulin with insulin receptors on the plasma membrane of the liver. J Clin Invest. 1974; 54: 1020-31.
-
(1974)
J Clin Invest
, vol.54
, pp. 1020-1031
-
-
Freychet, P.1
-
135
-
-
0347359054
-
Enhanced expression of a furin-cleavable proinsulin
-
Hay CW, Docherty K. Enhanced expression of a furin-cleavable proinsulin. J Mol Endocrinol. 2003; 31: 597-607.
-
(2003)
J Mol Endocrinol
, vol.31
, pp. 597-607
-
-
Hay, C.W.1
Docherty, K.2
-
136
-
-
65749099780
-
Glucose-responsive gene expression system for gene therapy
-
Won JC, Rhee BD, Ko KS. Glucose-responsive gene expression system for gene therapy. Adv Drug Deliv Rev. 2009; 61: 633-40.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 633-640
-
-
Won, J.C.1
Rhee, B.D.2
Ko, K.S.3
-
137
-
-
0034984540
-
Auto-regulated hepatic insulin gene expression in type 1 diabetic rats
-
Chen R. Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol Ther. 2001; 3: 584-90.
-
(2001)
Mol Ther
, vol.3
, pp. 584-590
-
-
Chen, R.1
-
138
-
-
79952183409
-
Remission of diabetes by insulin gene therapy using a hepatocyte-specific and glucose-responsive synthetic promoter
-
Han J, McLane B, Kim E-H, Yoon J-W, Jun H-S. Remission of diabetes by insulin gene therapy using a hepatocyte-specific and glucose-responsive synthetic promoter. Mol Ther. 2010; 19: 470-8.
-
(2010)
Mol Ther
, vol.19
, pp. 470-478
-
-
Han, J.1
McLane, B.2
Kim, E.-H.3
Yoon, J.-W.4
Jun, H.-S.5
-
139
-
-
34249993578
-
Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells
-
Lan MS, Wang H-W, Chong J, Breslin MB. Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells. Mol Cell Biochem. 2006; 300: 191-6.
-
(2006)
Mol Cell Biochem
, vol.300
, pp. 191-196
-
-
Lan, M.S.1
Wang, H.-W.2
Chong, J.3
Breslin, M.B.4
-
140
-
-
0032508718
-
The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism
-
Scott DK, O'Doherty RM, Stafford JM, Newgard CB, Granner DK. The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. J Biol Chem. 1998; 273: 24145-51.
-
(1998)
J Biol Chem
, vol.273
, pp. 24145-24151
-
-
Scott, D.K.1
O'Doherty, R.M.2
Stafford, J.M.3
Newgard, C.B.4
Granner, D.K.5
-
141
-
-
0025028899
-
Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence
-
Forest CD, O'Brien RM, Lucas PC, Magnuson MA, Granner DK. Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol Endocrinol. 1990; 4: 1302-10.
-
(1990)
Mol Endocrinol
, vol.4
, pp. 1302-1310
-
-
Forest, C.D.1
O'Brien, R.M.2
Lucas, P.C.3
Magnuson, M.A.4
Granner, D.K.5
-
142
-
-
0025160127
-
Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription
-
O'Brien RM, Lucas PC, Forest CD, Magnuson MA, Granner DK. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science. 1990; 249: 533-7.
-
(1990)
Science
, vol.249
, pp. 533-537
-
-
O'Brien, R.M.1
Lucas, P.C.2
Forest, C.D.3
Magnuson, M.A.4
Granner, D.K.5
-
143
-
-
46549088585
-
Detailed molecular analysis of the induction of the L-PK gene by glucose
-
Eckert DT, Zhang P, Collier JJ, O'Doherty RM, Scott DK. Detailed molecular analysis of the induction of the L-PK gene by glucose. Biochem Biophys Res Commun. 2008; 372: 131-6.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 131-136
-
-
Eckert, D.T.1
Zhang, P.2
Collier, J.J.3
O'Doherty, R.M.4
Scott, D.K.5
-
144
-
-
70349321711
-
cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP
-
Burke SJ, Collier JJ, Scott DK. cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP. FASEB J. 2009; 23: 2855-65.
-
(2009)
FASEB J
, vol.23
, pp. 2855-2865
-
-
Burke, S.J.1
Collier, J.J.2
Scott, D.K.3
-
145
-
-
0036328505
-
Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer
-
Auricchio A, Gao GP, Yu QC et al. Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer. Gene Ther. 2002; 9: 963-71.
-
(2002)
Gene Ther
, vol.9
, pp. 963-971
-
-
Auricchio, A.1
Gao, G.P.2
Yu, Q.C.3
-
146
-
-
0034603114
-
Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum
-
Rivera VM, Wang X, Wardwell S et al. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science. 2000; 287: 826-30.
-
(2000)
Science
, vol.287
, pp. 826-830
-
-
Rivera, V.M.1
Wang, X.2
Wardwell, S.3
-
147
-
-
42749092251
-
Insulin-secreting L-cells for the treatment of insulin-dependent diabetes
-
Bara H, Sambanis A. Insulin-secreting L-cells for the treatment of insulin-dependent diabetes. Biochem Biophys Res Commun. 2008; 371: 39-43.
-
(2008)
Biochem Biophys Res Commun
, vol.371
, pp. 39-43
-
-
Bara, H.1
Sambanis, A.2
-
148
-
-
77951463380
-
Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut
-
Fujita Y, Asadi A, Yang GK, Kwok YN, Kieffer TJ. Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut. Am J Physiol Gastrointest Liver Physiol. 2010; 298: G608-14.
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
-
-
Fujita, Y.1
Asadi, A.2
Yang, G.K.3
Kwok, Y.N.4
Kieffer, T.J.5
-
149
-
-
79961181175
-
Reprogramming gut and pancreas endocrine cells to treat diabetes
-
Tuduri E, Kieffer TJ. Reprogramming gut and pancreas endocrine cells to treat diabetes. Diabetes Obes Metab. 2011; 13(Suppl. 1): 53-9.
-
(2011)
Diabetes Obes Metab
, vol.13
, Issue.SUPPL. 1
, pp. 53-59
-
-
Tuduri, E.1
Kieffer, T.J.2
-
150
-
-
0034623757
-
Glucose-dependent insulin release from genetically engineered K cells
-
Cheung AT, Dayanandan B, Lewis JT et al. Glucose-dependent insulin release from genetically engineered K cells. Science. 2000; 290: 1959-62.
-
(2000)
Science
, vol.290
, pp. 1959-1962
-
-
Cheung, A.T.1
Dayanandan, B.2
Lewis, J.T.3
|