Exocytotic properties of human pancreatic β-cells

Annals of the New York Academy of Sciences

Volumn 1152, Issue , 2009, Pages 187-193

  Braun, Matthias ^a   Ramracheya, Reshma ^a   Johnson, Paul R ^b   Rorsman, Patrik ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Capacitance; Exocytosis; Human; Insulin; cells

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CYCLIC AMP; INSULIN;

AMPEROMETRY; CALCIUM CURRENT; CALCIUM TRANSPORT; CONFERENCE PAPER; CONTROLLED STUDY; DEPOLARIZATION; EXOCYTOSIS; HUMAN; HUMAN CELL; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PATCH CLAMP; VOLTAGE CLAMP;

RODENTIA;

EID: 58549115712     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03992.x     Document Type: Conference Paper

References (22)

1. Kahn, S.E. 2003. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46 : 3 19.
2. Zeggini, E. et al. 2008. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet. 40 : 638 645.
3. MacDonald, P.E., J.W. Joseph & P. Rorsman. 2005. Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans. R. Soc. Lond. B. Biol. Sci. 360 : 2211 2225.
4. Gustavsson, N. et al. 2008. Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc. Natl. Acad. Sci. USA 105 : 3992 3997.
5. Iezzi, M. et al. 2005. Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets. FEBS Lett. 579 : 5241 346.
6. Ohara-Imaizumi, M. et al. 2007. Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis. J. Cell Biol. 177 : 695 705.
7. Olofsson, C.S. et al. 2002. Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch. 444 : 43 51.
8. Bratanova-Tochkova, T.K. et al. 2002. Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes 51 (Suppl 1 S83 S90.
9. Rorsman, P. & E. Renstrom. 2003. Insulin granule dynamics in pancreatic beta cells. Diabetologia 46 : 1029 1045.
10. Braun, M. et al. 2008. Voltage-gated ion channels in human pancreatic beta-cells: Electrophysiological characterization and role in insulin secretion. Diabetes 57.
11. Misler, S., A. Dickey & D.W. Barnett. 2005. Maintenance of stimulus-secretion coupling and single beta-cell function in cryopreserved-thawed human islets of Langerhans. Pflugers Arch. 450 : 395 404.
12. Zhang, Q. et al. 2007. R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nat. Cell Biol. 9 : 453 460.
13. Johnson, J.D. et al. 2004. Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion. FASEB J. 18 : 878 880.
14. Henquin, J.C., D. Dufrane & M. Nenquin. 2006. Nutrient control of insulin secretion in isolated normal human islets. Diabetes 55 : 3470 3477.
15. Ämmälä, C., F.M. Ashcroft & P. Rorsman. 1993. Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells. Nature 363 : 356 358.
16. Seino, S. & T. Shibasaki. 2005. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol. Rev. 85 : 1303 1342.
17. Barg, S. et al. 2002. A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells. Diabetes 51 (Suppl 1 S74 S82.
18. Heinemann, C. et al. 1994. Kinetics of the secretory response in bovine chromaffin cells following flash photolysis of caged Ca2+. Biophys. J. 67 : 2546 2557.
19. Katz, B. 1966. Nerve, muscle and synapse. McGraw-Hill. New York.
20. Eliasson, L. et al. 1997. Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells. J. Physiol. 503 (Pt 2 399 412.
21. Michael, D.J. et al. 2007. Human Insulin Vesicle Dynamics During Pulsatile Secretion. Diabetes 56 : 1277 1288.
22. Voets, T., E. Neher & T. Moser. 1999. Mechanisms underlying phasic and sustained secretion in chromaffin cells from mouse adrenal slices. Neuron 23 : 607 615.